ライフサイエンスコーパス: tetanus toxin

1 ell binding and intracellular trafficking of tetanus toxin.

2 ct mice from challenge with a lethal dose of tetanus toxin.

3 sary component of the receptor mechanism for tetanus toxin.

4 ffected by pretreatment of synaptosomes with tetanus toxin.

5 he complex was insensitive to proteolysis by tetanus toxin.

6 neurotoxin serotypes A, B, and C, as well as tetanus toxin.

7 carboxyl-terminal 34 amino acid residues of tetanus toxin.

8 f protection against a lethal challenge with tetanus toxin.

9 to define the ganglioside-binding domains of tetanus toxin.

10 by unilateral intrahippocampal injection of tetanus toxin.

11 e remaining BoNT serotypes B-G, anthrax, and tetanus toxin.

12 nd ionotropic glutamate receptor blockers or tetanus toxin.

13 or when synaptic transmission is blocked by tetanus toxin.

14 trafficked similarly but not identically to tetanus toxin.

15 with labeling densities similar to those of tetanus toxin.

16 other neurons, similar to the known route of tetanus toxin.

17 radiolabeled GDNF, BDNF, and CT-1 as well as tetanus toxin.

18 E) complexes as judged by its sensitivity to tetanus toxin.

19 nt were protected from lethal challenge with tetanus toxin.

20 lease, as did treatment of the cultures with tetanus toxin (300 ng/ml) to block endogenous neurotrans

21 relative to mice given the control peptide, tetanus toxin-(830-843).

22 he observation that transgenic expression of tetanus toxin, a blocker of neurotransmitter release via

23 5-HT(2A/2C) receptor agonist, was blocked by tetanus toxin, a substance that prevents vesicular neuro

24 Although tetanus toxin accumulated rapidly (within 8 h) at presyn

25 ptic transmission of select PVT neurons with tetanus toxin activated via retrograde trans-synaptic tr

26 In contrast to control cultures, tetanus toxin added to fumonisin B(1)-treated cultures d

27 Tetanus toxin also inhibits NT-3 release, suggesting tha

28 In addition, CEDE is blocked by tetanus toxin, an inhibitor of regulated exocytosis, and

29 Transient expression of the light chains of tetanus toxin and botulinum toxin A did not disrupt the

30 Mutant tetanus toxin and botulinum toxins, which cleave t-SNARE

31 We have studied the effects of tetanus toxin and botulinus toxin A on neurotransmitter

32 ion or alpha-latrotoxin and was inhibited by tetanus toxin and by phenylarsine oxide, a phosphoinosit

33 with BRD937 or BRD847 were solidly immune to tetanus toxin and salmonella.

34 onella expressing TetC are protected against tetanus toxin and virulent salmonella challenge.

35 strain which expresses fragment C (ToxC) of tetanus toxin, and (ii) soluble tetanus toxoid (TT) with

36 g the pE88 plasmid, which encodes the lethal tetanus toxin, and thus a potential target for drug desi

37 e this, we exposed a domain of the microbial tetanus toxin antigen (TTCF) to disrupted lysosomes that

38 Using the tetanus toxin antigen, we show that the introduction of

39 To determine which amino acids in tetanus toxin are involved in ganglioside binding, homol

40 Tetanus toxin attenuated the response to the second of t

41 We developed a generally applicable tetanus toxin-based method for transgenic mice that perm

42 living motor neurons using a chimera of the tetanus toxin binding fragment (TeNT HC) and a pH-sensit

43 Tetanus toxin binds neuronal tissue prior to internaliza

44 Tetanus toxin binds specifically to motor neurons at the

45 Cleavage of VAMP2 and VAMP3 with tetanus toxin blocked cAMP-stimulated renin release from

46 zes with synaptophysin, is not detectable in tetanus toxin-blocked cultures.

47 Furthermore, B-cell responses to tetanus toxin but not influenza hemagglutinin in the ART

48 is inhibited by the presynaptic injection of tetanus toxin, but not by an inactive mutant.

49 rminal fragment of synaptobrevin released by tetanus toxin, but not its C-terminal membrane-anchored

50 terize the fraction of fluorescently labeled tetanus toxin C fragment bound to a ganglioside-populate

51 Protein sequencing of proteolyzed tetanus toxin C fragment co-migrating with that band rev

52 n of both native S. aureus enterotoxin B and tetanus toxin C fragment in spiked dilute serum samples.

53 en, Staphylococcus aureus enterotoxin B, and tetanus toxin C fragment in spiked samples.

54 -specific monoclonal antibody fused with the tetanus toxin C fragment was designed and expressed.

55 When tetanus toxin C fragment was proteolyzed with clostripai

56 licited by an adenovirus vector encoding the tetanus toxin C fragment when administered as a nasal or

57 ng this ligand, we observed radiolabeling of tetanus toxin C fragment which could be specifically inh

58 Furthermore, LTIIa binding was blocked by tetanus toxin C fragment, which binds to gangliosides GD

59 A recombinant protein consisting of a tetanus toxin C fragment-specific monoclonal antibody fu

60 exposed to either cholera toxin B subunit or tetanus toxin C fragment.

61 Intramuscular injections of Tetanus Toxin C-fragment (TTc) labeled with Alexa 790 fl

62 mpetitive immunoassay was also developed for tetanus toxin C-fragment by allowing unlabeled and fluor

63 allowing unlabeled and fluorescently labeled tetanus toxin C-fragment compete to bind to a limited fi

64 owth factor, insulin-like growth factor, and tetanus toxin C-fragment.

65 demonstrate that botulinus toxin type B and tetanus toxin cause a decrease in synaptobrevin II immun

66 ibodies, previously found to protect against tetanus toxin challenge and similar to those observed in

67 Complete protection against in vivo lethal tetanus toxin challenge and the induction of Ag-specific

68 60% of the mice in the BRD937 group survived tetanus toxin challenge if they were preimmunized with B

69 induced protective immune responses against tetanus toxin challenge when applied topically at doses

70 tibodies and were protected against systemic tetanus toxin challenge.

71 Tetanus toxin cleaved platelet vesicle-associated membra

72 Serotype C and tetanus toxin did not bind effectively to T-84 cells, no

73 and AA were released solely from neurons as tetanus toxin did not cleave astrocytic synaptobrevin-2,

74 Tetanus toxin does block the residual release from perme

75 The vaccines incorporate a domain of tetanus toxin (DOM) fused to a sequence encoding a candi

76 y synthesized with the P30 helper epitope of tetanus toxin, elicited robust LeTx-neutralizing immunit

77 ntigens (beta-galactosidase or fragment C of tetanus toxin) encoded by one plasmid to augment respons

78 Earlier studies implicated a coreceptor for tetanus toxin entry into neurons: a ganglioside binding

79 Tetanus toxin entry into vertebrate motorneurons may inv

80 Unexpectedly, tetanus toxin exposure causes an increase in SNAP-25 imm

81 We find that the axons of individual tetanus toxin expressing reticulospinal neurons have few

82 In stark contrast, myelination along tetanus-toxin-expressing CoPA neuron axons is entirely n

83 anding of the neuronal receptors utilized by tetanus toxin for the initial entry into nerve cells.

84 Sequence regions of tetanus toxin-forming CD4+ cell epitopes in 8 HLA-dispar

85 s Typhi and Typhimurium to mucosally deliver tetanus toxin fragment C (Frag C) as a model antigen in

86 HSV) were expressed as C-terminal fusions to tetanus toxin fragment C (TetC) in different Salmonella

87 delivery of a recombinant bacterial vaccine, tetanus toxin fragment C (TTFC) was expressed constituti

88 of recombinant Lactococcus lactis expressing tetanus toxin fragment C (TTFC), which is a known immuno

89 nd spinal cord, we generated a soluble IGF-1:tetanus toxin fragment C fusion protein (IGF-1:TTC) as a

90 In contrast, a similar construct expressing tetanus toxin fragment C under control of the constituti

91 response elicited by CVD 908-htrA expressing tetanus toxin fragment C under the control of the redox-

92 neuronal binding fragment of tetanus toxin (tetanus toxin fragment C, or TTC).

93 ic neuronal binding domain of tetanus toxin (tetanus toxin fragment C, TTC) has been used as a vector

94 on for cholera toxin subunit B and 10 nM for tetanus toxin fragment C.

95 bind plasma proteins, an exogenous protein (tetanus toxin fragment C; TTC), and a viral vector (reco

96 tion stems partly from motor neurone loss, a tetanus toxin fragment-C (TTC) fusion protein was create

97 e have used a pathogen-derived sequence from tetanus toxin (fragment C (FrC)) fused to tumor Ag seque

98 s live vectors for delivery of fragment C of tetanus toxin (FrgC).

99 We conclude that tetanus toxin, GDNF, and BDNF are released from postsyna

100 sis of the dendritic trees revealed that the tetanus toxin group showed a decrease in complexity arou

101 also to be important for the binding of the tetanus toxin H(C) fragment to ganglioside GT1b.

102 e components of the GT1b binding site on the tetanus toxin H(C) fragment.

103 ved X-ray crystallographic structures of the tetanus toxin H(C) fragment.

104 Consistently, tetanus toxin had no effect on secretion from permeabili

105 The carboxyl-terminal region of the tetanus toxin heavy chain (H(C) fragment) binds to di- a

106 rgin females can be blocked by expression of tetanus toxin in Or65a, but not Or67d neurons, demonstra

107 chaemia on the subsequent development of the tetanus toxin-induced epilepsy was studied, using contin

108 oxin-GVIA), intact vesicle fusion processes (tetanus toxin inhibits), and transmitter-filled vesicles

109 A small dose of tetanus toxin injected into the rat hippocampus produces

110 ced TNF exocytosis in BMMCs was dependent on tetanus toxin-insensitive vesicle-associated membrane pr

111 We now find that the v-SNARE tetanus toxin-insensitive vesicle-associated membrane pr

112 ver a period of 3-6 weeks after injection of tetanus toxin into the hippocampus.

113 In close correlation, microinjection of tetanus toxin into the presynaptic neuron produced a blo

114 The domains of tetanus toxin involved in ganglioside binding are known

115 s physiological effect is also observed when tetanus toxin is expressed in the GFs.

116 We propose that this domain of tetanus toxin is sufficient for ganglioside binding.

117 ereas Hirudo synaptobrevin is proteolyzed by tetanus toxin, its SNAP-25 isoform is resistant to botul

118 egion- and cell-type-selective expression of tetanus toxin light chain (TeLC) and compared the functi

119 Silencing BPNs with tetanus toxin light chain (TeNT) increases bilateral mas

120 s blocked by both pan-neuronal expression of tetanus toxin light chain (TeTxLC) and by reduction of a

121 We targeted the expression of tetanus toxin light chain (TeTxLC) to single identified

122 or inhibitory (Galpha(i)) Galpha subunit, or tetanus toxin light chain (TNT) in dopamine and serotoni

123 or targeted astrocyte-specific expression of tetanus toxin light chain (to interfere with vesicular r

124 via combinatorial gene expression to deliver tetanus toxin light chain (tox), an inhibitor of vesicul

125 f serotonergic and raphe neurons in mice for tetanus toxin light chain expression, which prevented ve

126 an adenoviral vector to specifically express tetanus toxin light chain in astrocytes) reduced the HVR

127 using Cre-inducible viral expression of the tetanus toxin light chain in male and female PV-Cre mice

128 culum by injecting a viral vector expressing tetanus toxin light chain in male mice.

129 ng neural activity by targeted expression of tetanus toxin light chain or an inwardly rectifying pota

130 By expressing either tetanus toxin light chain or diphtheria toxin in gal4-de

131 selectively blocked by the expression of the tetanus toxin light chain subunit (TeNT), the regularity

132 naptically silenced by chronic expression of tetanus toxin light chain tagged with cyan fluorescent p

133 nergic neurons, we inactivated them with the tetanus toxin light chain, a genetically encoded inhibit

134 Conditional expression of tetanus toxin light chain, a molecule that inhibits syna

135 , unc-1(dn) has effects opposite to those of tetanus toxin light chain, separating the roles of ADL e

136 aptic connectivity observed previously after tetanus toxin light chain-dependent blockade of evoked s

137 exocytosis as strongly as co-transfection of tetanus toxin light chain.

138 le-cell pairs demonstrated directly that the tetanus toxin-mediated block of exocytosis is accompanie

139 Moreover, tetanus toxin-mediated inactivation of Gr66a- or Gr5a-ex

140 Tetanus toxin-mediated inactivation of Gr68a-expressing

141 In the tetanus toxin model of limbic epilepsy, rats have interm

142 dorant stimuli, optogenetics, and transgenic tetanus toxin neurotransmission block show that elevated

143 thesized with two universal Th epitopes from tetanus toxin (p2p30).

144 Tetanus toxin produces spastic paralysis in situ by bloc

145 p53, HER2-ICD, HER2-ECD, and CEA, but not to tetanus toxin, relative to controls and surgically resec

146 The nontoxic fragment C (HC) of tetanus toxin retains the specific nerve cell binding an

147 th presynaptic vesicle fusion by exposure to tetanus toxin reverted functional to silent transmission

148 ross the nanotube, a membrane-bound protein (tetanus toxin) sees the nanotube as a barrier.

149 ced inhibition of early endosome fusion in a tetanus toxin-sensitive manner and removes Hrs from earl

150 rminus or carboxyl terminus of fragment C of tetanus toxin, separated by a 4-amino-acid hinge region.

151 ed by all subjects: one largely overlapped a tetanus toxin sequence region previously identified as a

152 hetic peptides corresponding to the complete tetanus toxin sequence were used to test, in a prolifera

153 Eight weeks after the injection of tetanus toxin, significantly more "dye-coupled' cells we

154 ',N'-tetraacetic acid, or the SNARE blocker, tetanus toxin, suggesting Ca2+- and SNARE-dependent fusi

155 Tetanus toxin suppressed EPSCs but did not influence OT-

156 copies of a PySSP2 sequence, NPNEPS, and two tetanus toxin T helper epitopes in the adjuvant TiterMax

157 Botulinum neurotoxins (BoNTs) and tetanus toxin (TeNT) are the most potent toxins for huma

158 Cleavage of VAMP2 with tetanus toxin (TeNT) did not prevent delivery of TRPC3 t

159 Tetanus toxin (TeNT) elicits spastic paralysis through t

160 n by different neuronal subtypes, we express tetanus toxin (TeNT) in individual reticulospinal or CoP

161 types of bipolar cells in the retina express tetanus toxin (TeNT).

162 man GDNF to the neuronal binding fragment of tetanus toxin (tetanus toxin fragment C, or TTC).

163 The non-toxic neuronal binding domain of tetanus toxin (tetanus toxin fragment C, TTC) has been u

164 pressing an unrelated antigen (fragment C of tetanus toxin [TetC]) was also used for immunization as

165 Tetanus toxin (TeTx) causes sympathetic hyperactivity, a

166 Six rats received injections of tetanus toxin (TeTX) in the ventral hippocampus that res

167 the basis of these analyses, two regions in tetanus toxin that are structurally homologous with the

168 s a non-toxic 47 kDa polypeptide fragment of tetanus toxin that can be used as a subunit vaccine agai

169 Although di- and trisialogangliosides bind tetanus toxin, their role as productive toxin receptors

170 gliosides completely restores the ability of tetanus toxin to bind to the neuronal surface and to blo

171 ion and postsynaptic specialization, we used tetanus toxin to chronically cleave VAMP2 and inhibit SN

172 Expression of tetanus toxin to cleave VAMP2 in VAMP8 knock-out (-/-) a

173 ely, blocking glutamate release by targeting tetanus toxin to individual synapses increases alpha7-nA

174 f the carboxy-terminal 50 kDa HC fragment of tetanus toxin to polysialogangliosides is important for

175 nditional expression of the light chain from tetanus toxin (tox) in raphe neurons expressing serotone

176 , the motor cortex of rats was injected with tetanus toxin (TT), and gene expression for 67 kDa gluta

177 e separated following rosette formation with tetanus toxin (TT)-coupled immunobeads to study the regu

178 tigated in chronic focal epilepsy induced by tetanus toxin (TT, 20-35 ng) injected in the rat motor c

179 theria toxin (DTx) followed by fragment C of tetanus toxin (TTC).

180 This analysis provides a model for how tetanus toxin utilizes coreceptors for high-affinity bin

181 The gene encoding the C fragment of tetanus toxin was expressed in the aroAD mutant of S. ty

182 On postnatal day 10, tetanus toxin was unilaterally injected into the hippoca

183 of Ca2+ influx, but in a manner sensitive to tetanus toxin, we find that the secretory process is dir

184 or fused to a fragment C (FrC) sequence from tetanus toxin, we induced both anti-Id and anti-FrC anti

185 /C entered cells differently than the HCR of tetanus toxin, which also utilizes dual gangliosides as

186 tion process is the v-SNARE, VAMP-2, because tetanus toxin, which cleaves VAMP-2, inhibited the forma

187 ion of the receptor binding domain (H(C)) of tetanus toxin, which retains the binding and trafficking

188 rface protein 1 and two T-helper epitopes of tetanus toxin (yP2P30Pv20019), formulated in aluminum hy