ライフサイエンスコーパス: tether

1 D5 complex acts as the primary ER-peroxisome tether.

2 ng extremely short (2 nm or less) conductive tethers.

3 ccessive re-attachment of reversibly-binding tethers.

4 are mainly associated with the formation of tethers.

5 signalling ligands from their transmembrane tethers.

6 ules are distributed at the tips of membrane tethers.

7 ose to lactate was significantly higher when tethered.

8 ted when different extracellular ligands are tethered.

9 trikes a balance between filament growth and tethering.

10 ut affecting the function of Sec3 in vesicle tethering.

11 oting membrane fusion in addition to vesicle tethering.

12 n subtelomeric chromatin organization and NE tethering.

13 at (iii) PI(4)P is required during and after tethering.

14 ired for catalytic turnover through covalent tethering.

15 and report a new function for ACBD5 in PO-ER tethering.

16 chment events indicative of multiple binding tethers, (2) vibration amplitudes of adhering bacteria p

17 e substrates can be restored by artificially tethering a region of the substrate, which ultimately be

18 ddition, we demonstrate nucleotide-dependent tethering ability of hGBP1F Furthermore, we report nucle

19 Similar to other membrane-tethered actin structures, we find proteins localize in

20 via its N-terminal CCP module pair (CCP1/2), tethering active IL-33 within necrotic cells, preventing

21 We found that decreasing Ran-GTP levels or tethering active Ran to the equatorial membrane affects

22 The intermolecular DNA tethering activity of RecN protein described previously

23 of intermediates; (ii) the alpha-dicarbonyl tether acts as a chromophore enhancer, extending the con

24 In addition, the mobility of tethered aggrecan drops significantly when the cell coat

25 he length of the extended ectodomain and the tethered agonist of the receptor, but not on its autopro

26 the MLL moiety provided a constitutive PAF1 tether allowing MLL fusions to circumvent H3 competition

27 mbrane protein implicated in ER-mitochondria tethering, also shows reduced expression in Ld-infected

28 inked immunosorbent assay (ELISA) for PEG by tethering an anti-PEG antibody (AGP3) via tethers with d

29 alternative strategy for gene activation by tethering an autonomous transcription activation domain

30 Tethered and functionally active vacuole-mitochondria in

31 These basket-tethered and membrane-tethered proteasomes, which have s

32 Here, we use genetic tethering and disulfide bonding strategies to construct

33 Using tethering and fusion assays combined with HOPS mutants,

34 the vacuolar kinase Yck3, is dispensable for tethering and fusion but can affect tethering if phospho

35 s a common component of MCS involved in both tethering and lipid transfer by binding directly to prot

36 The glycoengineered cells exhibited enhanced tethering and rolling interactions on E-selectin-bearing

37 Rapid membrane fusion requires tethering and Sec1-Munc18 (SM) function to catalyze R-,

38 calable as well as effective for alternative tethers and metal oxide nanoparticles.

39 nistic model for MFN1-mediated mitochondrial tethering, and our results shed light on the molecular b

40 lar contraction (both P<0.001) but a smaller tethering angle (P<0.001) despite a similar leaflet coap

41 Two HOPS subunits bind vacuolar Rabs for tethering, another binds the Qc SNARE, and a fourth HOPS

42 Cyclization of the amidine-tethered anthranilate then affords 2,3-disubstituted-3H-

43 is apparent with photooxidation using a DNA-tethered anthraquinone.

44 faces affect how B cells internalize surface-tethered antigens.

45 rectly excited acceptor fluorophore on a DNA tether are due to a change of its average position in th

46 but factors involved in WPB-plasma membrane tethering are not known.

47 The tethered array of nanoparticles, MnO in this case, bound

48 signaling arrays is mediated by ParP, which tethers arrays to a cell pole anchor, ParC.

49 These weakly tethered assemblies, we propose, are built to relay the

50 GAP promotes rather than terminates vesicle tethering at the trans-Golgi.

51 omoallylic carbamates into [4.1.0]-carbamate-tethered aziridines in good yields and with ee values of

52 We use a tethered-bead assay to provide real-time visualization o

53 menable to a controlled environment in which tethered bees learn visual stimuli, a result that is imp

54 ing a controlled visual environment in which tethered bees walking on a spherical treadmill learn to

55 "Loop domains" form because of tethering between two loci-almost always bound by CTCF a

56 Longer and more flexible tethers between the two aryl rings result in faster redu

57 In addition, N-tethered bicyclic products further transformed into tric

58 The tethered binding time is determined by the entropic barr

59 es annealing of microhomologous sequences to tether broken ends.

60 s with other organelles, where membranes are tethered, but not fused.

61 Sensors consist of a GPCR and G protein tethered by an ER/K linker flanked by FRET probes.

62 al substrate-binding domain (SBD), which are tethered by an interdomain linker.

63 in is dislodged from the complex but remains tethered by an intrinsically disordered linker.

64 s in which the individual polymer chains are tethered by one chain end to a solid interface.

65 ing to C2C promotes E-Syt1-mediated membrane tethering by releasing an inhibition that prevents C2E f

66 Alternatively, external vessel tethering can serve the same purpose when the transmural

67 mily adaptor proteins mediate endocytosis by tethering cargo proteins to the myosin VI motor.

68 DNA sliding clamps are rings that tether certain enzymes to DNA.

69 IP3Rs tethered close to ER-plasma membrane junctions are licen

70 The vesicle-tethering complex exocyst is one of the crucial cell pol

71 The GARP complex is a tethering complex involved in retrograde transport of en

72 ntact site in human cells held together by a tethering complex of VAPA/B (vesicle-associated membrane

73 ion, our data demonstrate that a multivalent tethering complex uses its two Rab bindings to determine

74 we dissected the lysosomal HOPS complex as a tethering complex with just two binding sites for the Ra

75 ng with the conserved oligomeric Golgi (COG) tethering complex, a major coordinator of Golgi vesicula

76 The exocyst, a eukaryotic tethering complex, coregulates targeted exocytosis as an

77 s an endoplasmic reticulum (ER)-mitochondria tether composed of four proteins, three of which contain

78 both extended and coiled conformations, but tethered configurations were not observed.

79 rmation capture techniques, such as Hi-C and tethered conformation capture, can generate chromosomal

80 required for pathway activation in membrane tethered constructs finding that both the DEP and PDZ do

81 ures, leading to a net switch from direct to tethered contacts between the monomeric Abeta and the pr

82 t that the RAM linker is more than a passive tether, contributing local and/or long-range sequence fe

83 larity by clustering progrowth receptors and tethering cytoskeletal machinery necessary for neuronal

84 tably, given the general nature of the silyl-tethered directing group, this method delivers products

85 cules on a surface through complementary DNA tethers directing cells to adhere and spread reversibly

86 Although cohesin functions to tether DNA duplexes, the contribution of its individual

87 y of these platforms rely on thiol groups to tether DNA to gold surfaces, but this method is hindered

88 ound 'closed' state promotes binding to DNA, tethering DNA ends and ATM activation, but prevents nucl

89 this pathway are likely shuttled between two tethered domains to ensure complete methylation.

90 observed these interactions in magnetically tethered Drosophila free to rotate about the yaw axis.

91 Directly tethering Drp1 to the MOM bypasses the need for Mff to e

92 ble for canonical signaling only in membrane-tethered Dsh, but not in untethered/normal Dsh.

93 Cdc14 promotes spindle stability and DSB-SPB tethering during DNA repair, and imply that metaphase sp

94 of the exocyst complex that mediates vesicle tethering during exocytosis, directly interacts with the

95 go intramolecular Diels-Alder reactions with tethered electron-poor dienophiles more rapidly and in h

96 obtained by Sonogashira coupling, led to the tethered enoate-substituted furans 14 and 19.

97 a synthetic linker protein that artificially tethers ER and mitochondria also reduces autophagosome f

98 l tail, which is known to provide a flexible tether essential for FtsZ functions in cell division.

99 mophagocytic lymphohistiocytosis 3, as a WPB-tethering factor.

100 ontaneous and visually elicited turns during tethered flight.

101 bear a hemiacetal aglycon leaving group that tethers fluorochromes in close proximity, also positioni

102 ethod is based on the intensity changes of a tethered fluorophore, diffusing in the exponentially dec

103 These turns can be measured in tethered flying Drosophila [3, 4, 9], which facilitates

104 aging and electrophysiological recordings in tethered flying Drosophila, we have identified a descend

105 -PEG antibodies on cells via variable-length tethers for cell-based sandwich ELISA, therefore, provid

106 mical processes in the cascade; and (iv) the tether forms an additional heterocyclic moiety, imidazol

107 provided in trans In contrast, artificially tethering full-length viral RNAs or surrogate gag-pol mR

108 e formation of ER-PM junctions and the ER-PM tethering function of extended synaptotagmins E-Syt2 and

109 y are a consequence of their ER-mitochondria tethering function.

110 res, respectively, characterized by flexibly tethered globular domains.

111 Glycosylations of 4,6-tethered glucosazide donors with a panel of model accept

112 ple directions, allowing them to accommodate tethered guest molecules.

113 Several tethers have multiple Rab-binding sites with largely unt

114 is correlated with faster attachment of the tethered head from this vulnerable state.

115 , we provide evidence that attachment of the tethered head is irreversible, suggesting a first passag

116 inetic race occurs between attachment of the tethered head to its next binding site and detachment of

117 teractions with divalent ions can be used to tether headgroups in-plane, decreasing surface hydrophil

118 Tethered heterochromatin protein 1 (HP1) induced H3K9me3

119 ly and properly recognized within covalently tethered HIV-1 RT-nucleic acid complexes.

120 depends on the recombination enhancer, which tethers HMLalpha near the DSB.

121 Accordingly, synthetically tethering hnRNPK to Xist RNA lacking XR-PID is sufficien

122 However, tethering Hog1 to the plasma membrane did impact on sign

123 Strikingly, tethering Hog1 to the plasma membrane did not abrogate s

124 igh-affinity interaction acts as a molecular tether, holding XRCC1 and PNKP together and thereby prom

125 Tethering, however, appeared to be unimpaired in all mut

126 buted to establishment of H3K9me3 induced by tethered HP1.

127 uctive strategy using HS-27, a fluorescently-tethered Hsp90 inhibitor, to assay Hsp90 expression on i

128 ls suggesting that gE/gI and US9 function by tethering HSV particles to kinesin microtubule motors.

129 able for tethering and fusion but can affect tethering if phosphorylated.

130 Overall, our results showed how tethering IL2 to its receptor IL2Rbeta eliminates the ne

131 (P(Im); a porphyrin moiety with a covalently tethered imidazole axial "base" donor ligand) has been i

132 Genetic tethering impairs HslV binding and degradation, even for

133 A variety of alkyne-tethered indoles are suitable for this process.

134 large area and micro gold electrode via the tethering interaction of a modified Self-Assembled Monol

135 e these defects, indicating that the peptide tether interferes with HslV interactions.

136 coupled receptor as it utilizes a covalently tethered inverse agonist (11-cis-retinal) as the native

137 of vacuole-mitochondria contact sites, while tethering is mediated by other factors, including Vps39.

138 tra-chromosomal interactions, and centromere tethering is responsible for the inter-chromosomal inter

139 -7-GINS (CMG) helicase binds Pol epsilon and tethers it to the leading strand, and PCNA (proliferatin

140 The impact of tether length and electron density of both the nucleophi

141 ectron density, alkene substitution pattern, tether length and Lewis base functional groups on the ra

142 expressing anti-PEG antibodies with uniform tether lengths.

143 pecific labeling is achieved by presenting a tethered ligand at the synapses of genetically defined n

144 However, targeting PAR1 with an orthosteric-tethered ligand binding-site antagonist results in bleed

145 The novel PAR1-tethered ligand exposed by MMP-2 stimulates PAR1-depende

146 Using the characteristic time for a tethered ligand to bind to a surface receptor, we study

147 ar surface of PAR2, preventing access of the tethered ligand to the peptide-binding site.

148 re for a PAR2 antagonist competing against a tethered ligand.

149 nd release from the cell surface of membrane-tethered ligands is an important mechanism of regulating

150 s retained efficacy against both soluble and tethered ligands with lower cLogP values and an increase

151 ion and used it to study vesicle fusion to a tethered lipid bilayer.

152 Pol epsilon contains two flexibly tethered lobes.

153 By recording the flight tones of multiple, tethered, male Ae. aegypti, we test the hypothesis that

154 ogical signaling processes, including simple tethering mechanism, regulating selectivity in pathways,

155 in-binding dynamics through a direct protein-tethering mechanism.

156 HOPS-tethered membranes and all four vacuolar SNAREs formed a

157 g intermediates and events: 1) Rab- and HOPS-tethered membranes, 2) a HOPS:R:Qa:Qc trans-complex, 3)

158 omplex in the yeast Saccharomyces cerevisiae tethers membranes through its affinities for the membran

159 ely to cellulose microfibril surfaces and to tether microfibrils into a load-bearing network, thereby

160 hat Bik promotes Bak enrichment at the ER to tether mitochondria for efficient calcium transfer.

161 plasmic reticulum [ER]-cortex anchor), which tethers mitochondria to the ER and plasma membrane.

162 ting, which could serve as a paradigm of the tether model.

163 The other is the tether model: force is transmitted via a tether to gate

164 sion, contradicting the "trans-repression by tethering" model.

165 as part of the solvation environment of the tethered molecules.

166 Mucin 4 (MUC4)-tethered mucin is expressed in nasal polyp (NP) epitheli

167 Current evidence suggests that membrane-tethered mucins could mediate corticosteroid efficacy, i

168 norganic system described, and it shows that tethered, multi-step biological pathways can be reconsti

169 e ligand behaved as either a photoswitchable tethered neutral antagonist or inverse agonist.

170 Cation radicals containing tethered nucleophiles that required endocyclic transitio

171 times more slowly than cation radicals with tethered nucleophiles where a large bond angle can be ac

172 virus-host interaction is important for the tethering of BPV E2 to mitotic chromatin and the stable

173 We speculate that intermittent tethering of claudins to actin may allow for accommodati

174 yst, a conserved protein complex involved in tethering of exocytic vesicles to the plasma membrane, r

175 e DNA-binding-independent mechanism involves tethering of GR to the pro-inflammatory transcription fa

176 RPN subfamily, and is thought to be gated by tethering of its ankyrin repeat domain to microtubules o

177 dependent, we provide evidence that ectopic tethering of JIL-1 and subsequent H3S10 phosphorylation

178 Further, Cas9-directed tethering of mutant LDB1 to the beta-globin promoter for

179 Furthermore, via pharmacological tethering of proteasomes to chromatin or the plasma memb

180 Tethering of the arene to the arylsilane provides not on

181 We show that membrane-tethering of the Dsh protein is sufficient to induce can

182 entally simple steps: (i) it allows for fast tethering of the photoactive core to the unsaturated pen

183 The tethering of the secretory vesicles before membrane fusi

184 Tethering of TPP1 to the telomere either via TRF2-TIN2 o

185 olymer hybrid nanoparticles (LPHNs) that are tethered on a chip.

186 n between linoleic acid hydroperoxide (LAHP) tethered on iron oxide nanoparticles (IO NPs) and the re

187 sn-Glycero-3-Phosphoethanolamine (DOPE) were tethered on thiol monolayers in the absence and presence

188 ations, C-terminal extensions, and ribosomal tethering on the structure and stability of three protei

189 terminus may serve as a flexible scaffold to tether PCNA and RPA at the replication fork, and that po

190 cleavage of the N terminus, which unmasks a tethered peptide ligand that binds and activates the tra

191 d independent of deacetylase activity, Hdac3 tethers peripheral heterochromatin containing lineage-re

192 Commonly used tethered photoswitchable ligands, however, require solve

193 somes are large, multiprotein complexes that tether plant biomass-degrading enzymes together for impr

194 -consumptive predator-associated cues: plant-tethered predator cadavers and homogenised shoot-sprayed

195 Thus Munc13-4 is a tethering/priming factor and Ca(2+) sensor for both hete

196 These basket-tethered and membrane-tethered proteasomes, which have similar substrate-proce

197 ctate the spacing, number and composition of tethered protein motors (11-15) .

198 PDZD8 represents a critical ER-mitochondria tethering protein in metazoans.

199 e editing and the construction of doubly DNA-tethered proteins for single-molecule studies.

200 ependent redistribution and clearing of CRY2-tethered proteins within the nucleus.

201 ein do not only showcase the utility of this tethered RCM variant but have also prompted us to sugges

202 As a result, the most complex tethered reaction reported involves only 3 enzymes.

203 Traditional tethered recording systems restrict movement and limit t

204 functional SAM containing PEG moieties and a tethered redox thiol, both markers are detectable across

205 that the mechanism by which the VAPB-PTPIP51 tethers regulate autophagy involves their role in mediat

206 Here, we show that the VAPB-PTPIP51 tethers regulate autophagy.

207 suppressed by truncation of Uso1, a vesicle tether required for endoplasmic reticulum-Golgi traffic.

208 hagosome formation, and that this artificial tether rescues the effects of siRNA loss of VAPB or PTPI

209 Sequential lengthening of the tether results in decreased reactivity, which necessitat

210 A series of new tethered Rh(III)/Cp* complexes containing the N-(p-tolyl

211 ively establish the E,Z-diene part, an ester-tethered ring-closing metathesis/base-induced eliminativ

212 the nature of the substituents on the phenyl tethering ring did not alter the stereochemical outcome

213 bonds regulate the rate by which tumor cells tether, roll, and adhere to vascular walls.

214 Tethered Set1 still requires histone H2B ubiquitylation

215 The ability of cohesin to tether sister chromatids together depends on acetylation

216 ries of haptens with a linker at alternative tethering sites of the boscalid framework, specific anti

217 ly anchored Q-SNAREs were incubated with the tethering/SM protein complex HOPS and the two other solu

218 proton influx through the peptidoglycan (PG)-tethered stator ring MotA/B.

219 that (ii) PI(3)P is required only after the tethering step, and that (iii) PI(4)P is required during

220 A 'direct tethering' strategy attaching the Ezh2 methyltransferase

221 as scaffolds that selectively bind cargo and tether substrates to their cognate proteases to promote

222 tification of various proteins necessary for tethering subtelomeric chromatin to the NE and the silen

223 These results were confirmed using a WIG1 tethering system based on the MS2 bacteriophage coat pro

224 nships among these features using an in vivo tethering system in Neurospora crassa Artificial recruit

225 d by the capsid protein pUL25 and the capsid-tethered tegument protein pUL36.

226 The synthesis of a pyrene-tethered TEMPO derivative (TEMPO=2,2,6,6-tetramethylpipe

227 long ankyrin repeat domain is organized as a tether that can trigger channel gating.

228 The protein is a tether that generates close contacts between these compa

229 del in which IncV acts as one of the primary tethers that contribute to the formation of ER-inclusion

230 urfaces through multiple, reversibly-binding tethers that detach and successively re-attach, but not

231 e evidence that these ring-shaped assemblies tether the left and right chromosome arms together while

232 At MCS, specific proteins tether the organelles in close proximity and mediate the

233 We review factors that tether the two membranes, their properties, and their dy

234 D5) and that this interaction is required to tether the two organelles together, thereby facilitating

235 nds, preventing their growth and dynamically tethering the branched actin network to the WASP-family

236 ficient processing segment can be rescued by tethering the donor near the break.

237 bination at a number of chromosomal sites by tethering the natural Spo11 protein to various DNA-bindi

238 lipoprotein determines periplasmic width by tethering the outer membrane to the peptidoglycan layer.

239 Tethering the redox-active iodophenyl subunit to a tetra

240 ACAGAGA sequence forms a hairpin that weakly tethers the 5' splice site.

241 rdware for such studies, however, physically tethers the experimental animal to an external light sou

242 and weakly to Cho because a different H-bond tethers the ligand to misalign the QA and form weaker in

243 TFAM tethers the N-terminal region of mtRNAP to recruit the p

244 Depending on the site of tethering, the ligand behaved as either a photoswitchabl

245 esviruses, maintain their plasmid genomes by tethering them to cellular chromosomes.

246 nhibited the release of enveloped viruses by tethering them to the plasma membrane of infected cells.

247 To do this, virus particles tether themselves to dyneins and kinesins that motor alo

248 he tetramethylcyclam (TMC) macrocycle with a tethered thiolate.

249 ngly, an intact CUE1 domain was required for tethering this remodeler to the nucleus.

250 ts neighboring 25 kb region by independently tethering this TF without coincidental ETS1 binding.

251 the tether model: force is transmitted via a tether to gate the channel.

252 Irradiation of a 1,3-enyne tethered to a 2-pyridone, in the presence of oxygen, lea

253 specificity (Ser/Thr and Tyr) kinase domain tethered to a calmodulin-like domain (CLD) via an autoin

254 gents with substrates containing a 1,3-enyne tethered to a ketone, to give products containing three

255 of programmable DNA-binding ligands flexibly tethered to a small molecule that engages the transcript

256 alpha-Amino nitriles tethered to alkenes through a urea linkage undergo intra

257 substrates containing a Z-allylic phosphate tethered to an alkyne are described.

258 eptors, and adenosine type 1 receptor (A1R), tethered to Galphas-XL, Galphai2, or Galphaq subunits.

259 re captured along microtubule walls and then tethered to microtubule-ends through a multi-step end-on

260 ere we show a complex reaction of 10 enzymes tethered to nanoparticles.

261 ndividually, we demonstrate that they remain tethered to one another subsequent to internalization, a

262 mechanisms by which regions of the ER become tethered to POs are unknown, in particular in mammalian

263 he reduction potential of the carbazole unit tethered to the aminocatalyst.

264 t the cytosolic Hsc70-SGTA-Hsp105 complex is tethered to the ER membrane, where Hsp105 and SGTA facil

265 rimary alkylamine functionalities covalently tethered to the linkers of IRMOF-74-III results in a mat

266 eton consists of spectrin tetramers that are tethered to the lipid bilayer by ankyrin and by actin-ba

267 Escherichia coli comprises filaments of FtsZ tethered to the membrane by FtsA and ZipA.

268 The OM is tethered to the peptidoglycan via the lipoprotein, Lpp.

269 ns were constructed in which Hog1 was either tethered to the plasma membrane or constitutively nuclea

270 sisting of biodegradable polymeric particles tethered to the tumour cell surface via polyethylene gly

271 Electrostatic tethering to framework aluminum centers limits the volum

272 thetase and folliculin, which regulates mTOR tethering to lysosomal membranes.

273 retained by the mother cell, in part through tethering to mitochondria, while the disaggregase Hsp104

274 GEFs and GAPs promotes or terminates vesicle tethering to organelles, respectively.

275 we have harnessed the power of bioorthogonal tethering to SNAP and CLIP protein tags to create a fami

276 lasma membrane as well as retrograde vesicle tethering to the Golgi.

277 in gene gating to nuclear pores, artificial tethering to the nuclear periphery of a transcribed locu

278 e division proto-ring that provides membrane tethering to the septation FtsZ protein.

279 e findings reveal how relaxation of external tethers to the nuclear envelope and internal chromatin-c

280 cRNAs contain some conversed patterns/motifs tethered together by non-conserved regions.

281 In most cases, many of these proteins are tethered together by synaptic scaffold proteins.

282 Sister chromatids are tethered together by the cohesin complex from the time t

283 Prior to mitosis, duplicated centrosomes are tethered together, which is thought to prevent mitotic d

284 ar envelope and internal chromatin-chromatin tethers, together with microtubule dynamics, can mobiliz

285 , in which proteolytic release of a membrane-tethered transcription factor (TF) requires both a PPI t

286 In plants, the membrane-tethered transcription factor bZIP28 and the ribonucleas

287 , is a liver-enriched, endoplasmic reticulum-tethered transcription factor known to regulate the hepa

288 esolution typically requires an animal to be tethered under a microscope, which substantially restric

289 This approach was implemented by tethering vesicles containing a Ca(2+) sensitive fluores

290 Additionally, we demonstrate that TFG tethers vesicles harboring the inner COPII coat, which c

291 Artificially tethering viral mRNAs encoding Gag capsid proteins (gag-

292 rete punctate spots in the nucleus, where it tethers viral episomes to cellular chromatin and interac

293 crimination to the treadmill paradigm with a tethered, walking bee was successful as bees exhibited r

294 les for each subtype at the start and end of tethered-walking turns.

295 n autoinhibited state and to couple membrane tethering with lipid transport.

296 by tethering an anti-PEG antibody (AGP3) via tethers with different dimensions on the surface of 293T

297 ively; and in a feed-forward mechanism, LKB1 tethers with p53 and p73 to get recruited to p53-respons

298 of newly deposited species and how they are tethered within the MOF is critical to understanding how

299 We noted that inhibitory residues tethered within the NAD(+)-binding site by an intramolec

300 have found unexpectedly that peptide linkers tethering WW domains in several HECT family members are