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1 on; however, constructs bearing p12-I63 were tethered.
2 ose to lactate was significantly higher when tethered.
3 ted when different extracellular ligands are tethered.
4 A variety of oxygen-, nitrogen-, and carbon-tethered 1,6-enynes underwent this asymmetric transforma
7 trate produces a covalent cysteine-thioester tethered acyl group that is transferred to the second su
9 he length of the extended ectodomain and the tethered agonist of the receptor, but not on its autopro
13 GPR56 and GPR114/ADGRG5, which have similar tethered agonists, but not the aGPCR GPR110/ADGRF1, M3 m
14 clic or cyclic monoketones with prenyl ether-tethered aldehydes in the presence of 1,8-diazabicyclo[5
17 alkyl/arylzinc reagents derived from olefin-tethered alkyl/aryl halides that undergo radical cycliza
18 Complex 3 reacts with ethylene to form the tethered alkylidene (4) featuring a tetraanionic pincer
19 ed electron-deficient heterodienes bearing a tethered alkyne partner underwent an intramolecular inve
23 The resulting high local concentration of tethered amyloidogenic segments within these alpha-oligo
24 able enthalpic interactions between particle-tethered and free, host polymer chains to create model P
32 viruses expressing silencing-proof, membrane-tethered AREG cytoplasmic and extracellular domains (ARE
33 the dearomatizing spirocyclization of alkyne-tethered aromatics far more effectively than the analogo
36 omoallylic carbamates into [4.1.0]-carbamate-tethered aziridines in good yields and with ee values of
39 menable to a controlled environment in which tethered bees learn visual stimuli, a result that is imp
40 ing a controlled visual environment in which tethered bees walking on a spherical treadmill learn to
42 ntramolecular C-N bond formation of an amide-tethered benzylic/allylic system using DDQ under neutral
45 ternatively, model membrane systems, such as tethered bilayer membranes, have been developed for surf
47 nctional C2-symmetric biphenyl-based diamine-tethered bis(thiourea) organocatalyst, which was tested
55 l in which some but not all ERC vesicles are tethered by contiguous "membrane bridges." Furthermore,
59 rresponding aziridinium intermediates with a tethered carbamate moiety) to give oxazolidin-2-ones was
60 of 3-(chloromethylene)oxindoles from alkyne-tethered carbamoyl chlorides using PdCl2(PhCN)2 as the c
61 f methane are linked to the chemistry of the tethered catalysts, determined by X-ray photoelectron sp
62 for the efficient synthesis of benzothiazole-tethered chromanone/coumarin scaffolds via Claisen rearr
66 rmation capture techniques, such as Hi-C and tethered conformation capture, can generate chromosomal
67 required for pathway activation in membrane tethered constructs finding that both the DEP and PDZ do
69 ures, leading to a net switch from direct to tethered contacts between the monomeric Abeta and the pr
70 teolytic stability relative to its disulfide-tethered counterpart, suggesting good potential for furt
71 t-controlled pharmacological agents that are tethered covalently and specifically to genetically engi
73 at (SS-TR3), we discovered that the membrane-tethered cytokine had a substantially increased activity
76 tably, given the general nature of the silyl-tethered directing group, this method delivers products
77 3 sweet receptor and thaumatin, derived from tethered docking in the framework of the wedge model, co
79 observed these interactions in magnetically tethered Drosophila free to rotate about the yaw axis.
82 go intramolecular Diels-Alder reactions with tethered electron-poor dienophiles more rapidly and in h
85 receptor tyrosine kinases and their membrane-tethered ephrin ligands have very important roles in suc
89 g of the analyte by the sensor displaces the tethered fluorescent competitor from the binding protein
90 ethod is based on the intensity changes of a tethered fluorophore, diffusing in the exponentially dec
92 aging and electrophysiological recordings in tethered flying Drosophila, we have identified a descend
93 record muscle activity and turning torque in tethered flying moths experiencing wide-field visual sti
96 studies involved co-activation of a membrane-tethered GFP lineage label, allowing for direct visualiz
102 , we provide evidence that attachment of the tethered head is irreversible, suggesting a first passag
103 inetic race occurs between attachment of the tethered head to its next binding site and detachment of
105 s in the bound head precedes stepping by the tethered head, leading to a mechanochemical cycle in whi
110 uctive strategy using HS-27, a fluorescently-tethered Hsp90 inhibitor, to assay Hsp90 expression on i
111 (P(Im); a porphyrin moiety with a covalently tethered imidazole axial "base" donor ligand) has been i
113 wo equivalents of carbon monoxide and alkyne-tethered imines into 1,3-dipoles (Munchnones), which und
115 repression functions, while still exerting a tethered indirect transrepression activity and could the
117 GRE)-mediated direct transrepression and for tethered indirect transrepression that is mediated by DN
121 coupled receptor as it utilizes a covalently tethered inverse agonist (11-cis-retinal) as the native
123 gliding microtubule (MT) motility by surface-tethered kinesin-1 motor proteins has been widely studie
124 iboTag, Ai95, and new Cre-dependent membrane-tethered Lck-GCaMP6f knockin mice that we also generated
126 pecific labeling is achieved by presenting a tethered ligand at the synapses of genetically defined n
127 However, targeting PAR1 with an orthosteric-tethered ligand binding-site antagonist results in bleed
129 ical site, exposing a previously undescribed tethered ligand that triggers biased G-protein agonism a
132 aved at an N-terminal arginine to unmask its tethered ligand, is generally regarded as a target for t
136 ceptors can be conjugated to photoswitchable tethered ligands (PTLs) to enable photoactivation, or ph
137 nd release from the cell surface of membrane-tethered ligands is an important mechanism of regulating
138 s retained efficacy against both soluble and tethered ligands with lower cLogP values and an increase
139 functionalized Au surfaces with three thiol-tethered ligands: 2-mercaptopropionic acid, 4-pyridinyle
143 By recording the flight tones of multiple, tethered, male Ae. aegypti, we test the hypothesis that
145 g intermediates and events: 1) Rab- and HOPS-tethered membranes, 2) a HOPS:R:Qa:Qc trans-complex, 3)
148 the ribosome to polyketide synthases, where tethered molecules are passed from active site to active
149 Prototoxins are a diverse family of membrane-tethered molecules expressed in the nervous system that
152 Current evidence suggests that membrane-tethered mucins could mediate corticosteroid efficacy, i
154 norganic system described, and it shows that tethered, multi-step biological pathways can be reconsti
155 genic manipulation of the levels of membrane-tethered neuregulin1 (NRG1-III), a potent activator of S
158 apse elimination, our findings identify axon-tethered NRG1 as a molecular determinant for SC-driven n
160 times more slowly than cation radicals with tethered nucleophiles where a large bond angle can be ac
163 n between linoleic acid hydroperoxide (LAHP) tethered on iron oxide nanoparticles (IO NPs) and the re
164 sn-Glycero-3-Phosphoethanolamine (DOPE) were tethered on thiol monolayers in the absence and presence
166 regions of ER that are zippered together and tethered open-necked double membrane spherules that rese
167 bonds, bonds that form and break between the tethered particle and a substrate due, for instance, to
172 cularly hydrogen-bonded monomers of butylene-tethered PBI spontaneously self-assemble into nanopartic
176 cleavage of the N terminus, which unmasks a tethered peptide ligand that binds and activates the tra
177 es the 7TM N-terminal stalk, which acts as a tethered-peptide agonist permitting receptor-dependent h
181 ted by coronary ligation in another 6 sheep (tethered plus MI), and left ventricular remodeling was l
183 -consumptive predator-associated cues: plant-tethered predator cadavers and homogenised shoot-sprayed
187 progression by releasing regulatory membrane-tethered proteins like TNFalpha, IL6R and EGFR ligands.
189 purified CTR extracellular domain (ECD) and tethered RAMP1- and RAMP2-CTR ECD fusion proteins and an
190 ein do not only showcase the utility of this tethered RCM variant but have also prompted us to sugges
194 functional SAM containing PEG moieties and a tethered redox thiol, both markers are detectable across
196 ibosome nascent chains and the effect of the tethered ribosome on nascent chain folding remain unclea
197 ively establish the E,Z-diene part, an ester-tethered ring-closing metathesis/base-induced eliminativ
200 of intracellular trafficking and consists of tethered stacks of cis, medial, and trans cisternae.
206 , the electrostatic interactions between the tethered TEMPO units and the semiconductor-side, i.e., s
208 eta2 structures show that the alphaI domain, tethered through its N-linker and a disulfide to a stabl
209 chloroplasts and peroxisomes are physically tethered through peroxules, a poorly described structure
211 diated ring opening of a terminal epoxy ring tethered to a butenolide to produce stereoselectively a
212 specificity (Ser/Thr and Tyr) kinase domain tethered to a calmodulin-like domain (CLD) via an autoin
215 gents with substrates containing a 1,3-enyne tethered to a ketone, to give products containing three
217 The present work describes vicinal diols, tethered to a rigid 1,3-diethynylbenzene core, as pivota
218 ent orientations, and the ChlI subunits were tethered to a silica surface; the probability of subunit
219 of programmable DNA-binding ligands flexibly tethered to a small molecule that engages the transcript
220 oxin biosynthesis with a heptaketide mimetic tethered to a stably modified 4'-phosphopantetheine, whi
221 TPM), the motion of a micro- or nanoparticle tethered to a substrate by a macromolecule, is a system
222 However, the individual peptides must be tethered to a tag that preserves their individual identi
225 still made with extensive manual labor, are tethered to bulky control systems, and have cumbersome u
226 rial lipoproteins are extracellular proteins tethered to cell membranes by covalently attached lipids
227 into daughter cells during mitosis, they are tethered to cellular chromatin by the viral E2 protein.
228 e describe the preparation of small peptides tethered to chiral sulfoxide-containing macrocyclic ring
230 in serum can be performed by the RNA aptamer tethered to cysteamine-modified gold electrodes via the
231 perience an opposite EGCG-induced shift from tethered to direct contacts, explaining why EGCG remodel
232 erely defective both in keeping the DSB ends tethered to each other and in repairing a DSB by either
234 eptors, and adenosine type 1 receptor (A1R), tethered to Galphas-XL, Galphai2, or Galphaq subunits.
235 e filament, are known to rotate, having been tethered to glass or marked by latex beads, the rotation
236 bel conjugated to a double-stranded (ds) DNA tethered to gold strongly depend on the charge of the MB
237 e recent advances, soft robots must still be tethered to hard robotic control systems and power sourc
238 red that ERalpha-bound regulatory depots are tethered to heterochromatin protein 1 (HP1) for coordina
239 port a new arthropod with 10 tiny arthropods tethered to its tergites by long individual threads.
240 the electrochemistry of a redox active film tethered to metallic leads and immersed in electrolyte.
241 exert forces on many individual biomolecules tethered to microspheres using a single collimated laser
242 rotubule walls (lateral attachment) and then tethered to microtubule-ends (end-on attachment) through
243 re captured along microtubule walls and then tethered to microtubule-ends through a multi-step end-on
245 ndividually, we demonstrate that they remain tethered to one another subsequent to internalization, a
246 mechanisms by which regions of the ER become tethered to POs are unknown, in particular in mammalian
247 ed theory that PKA catalytic subunits remain tethered to regulatory subunits during cAMP elevation.
250 easure the diffusion of cadherin ectodomains tethered to supported lipid bilayers at varying Ca(2+) c
251 only by the presence of a fluorescent label tethered to the 5' end of the solution-phase target.
255 In each case, a ferrocene redox probe was tethered to the AuNP surface to evaluate electron transf
256 tion water dynamics within 5-10 A of a label tethered to the biomolecular surface on two separate tim
257 sion of a GFP-tagged ferritin fusion protein tethered to the cation-conducting transient receptor pot
258 that their cognate ligands, the ephrins, are tethered to the cell surface, in contrast to other RTKs
262 t the cytosolic Hsc70-SGTA-Hsp105 complex is tethered to the ER membrane, where Hsp105 and SGTA facil
263 bacterial DNA adenine methyltransferase Dam, tethered to the Gad1 gene promoter in mouse prefrontal c
264 rimary alkylamine functionalities covalently tethered to the linkers of IRMOF-74-III results in a mat
265 eton consists of spectrin tetramers that are tethered to the lipid bilayer by ankyrin and by actin-ba
270 ns were constructed in which Hog1 was either tethered to the plasma membrane or constitutively nuclea
271 ring cell division, kinetochores must remain tethered to the plus ends of dynamic microtubule polymer
272 eficient in cAMP binding, or an Epac1 mutant tethered to the PM, is sufficient to inhibit neurite out
273 olyethylenimine-polyethyleneglycol (PEI-PEG) tethered to the PSMA ligand, 2-[3-(1, 3-dicarboxy propyl
274 uring translation while the protein is still tethered to the ribosome; however, most biophysical stud
276 ide drug loading, functional proteins can be tethered to the surface utilizing bio-orthogonal "click"
277 sisting of biodegradable polymeric particles tethered to the tumour cell surface via polyethylene gly
284 Prior to mitosis, duplicated centrosomes are tethered together, which is thought to prevent mitotic d
285 , in which proteolytic release of a membrane-tethered transcription factor (TF) requires both a PPI t
287 a liver-enriched, endoplasmic reticulum (ER)-tethered transcription factor known to regulate the hepa
288 , is a liver-enriched, endoplasmic reticulum-tethered transcription factor known to regulate the hepa
289 r histone deacetylase 3 (HDAC3), Dex-induced tethered transrepression and the formation of a repressi
290 esolution typically requires an animal to be tethered under a microscope, which substantially restric
294 on, we identified two classes of proteasomes tethered via their Rpn9 subunits to two specific NPC loc
295 crimination to the treadmill paradigm with a tethered, walking bee was successful as bees exhibited r
298 fferent dimensions, shapes and compositions, tethered with various types of polymers and subjected to
299 of newly deposited species and how they are tethered within the MOF is critical to understanding how
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