ライフサイエンスコーパス: tetracyclines

1 ranslation (e.g. clindamycin, macrolides and tetracyclines).

2 o overcome problems of resistance to earlier tetracyclines.

3 tively blocked by the oral administration of tetracyclines.

4 along with other eukaryotes, is resistant to tetracyclines.

5 -2 expression, which is distinct from other tetracyclines.

6 tein, TetA, responsible for active efflux of tetracyclines.

7 ally effective 100-200 mg/day dose for these tetracyclines.

8 ugh to the present day examples, such as the tetracyclines.

9 , alkaloids, prostaglandins, macrolides, and tetracyclines.

10 lly, without accompanying aminoglycosides or tetracyclines.

11 idespread resistance to clinically important tetracyclines.

12 ons, while M errors were often observed with tetracyclines.

13 ng/mL for beta-lactams, 0.04-0.98 ng/mL for tetracyclines, 0.08-2.0 ng/mL for quinolones, and 0.1-3.

14 All 6 tetracyclines (2 mg/day) inhibited periodontal breakdown

15 of quinolones (42.0%), sulfonamides (24.0%), tetracyclines (38.0%), and penicillins (38.0%), mainly d

16 Patients were prescribed tetracyclines (49%), aminoglycosides (47%), and fluoroqu

17 ethod covers the analytes from the groups of tetracyclines (6), fluoroquinolones (11), sulphonamides

18 Tetracyclines, a class of antibiotics that target bacter

19 and was significantly more active than other tetracyclines against Burkholderia cepacia, Escherichia

20 uinolones and other compounds (Nor pumps) or tetracyclines alone (Tet38), but the natural substrates

21 ive pathogens with resistance to macrolides, tetracyclines and fluoroquinolones.

22 The most popular are antibiotics such as tetracyclines and fluoroquinolones.

23 minocycline has greater activity than other tetracyclines and glycylcyclines against various MDR pat

24 llebrand disease (vWD), and the results with tetracyclines and monoclonal antibody VP-1 offer new str

25 the binding of aminoglycosides, macrolides, tetracyclines and other antibiotics provide opportunitie

26 Tetracyclines and tetracycline analogues are prepared by

27 and resistance determinants for quinolones, tetracyclines, and beta-lactamases are shared between aq

28 ses such as new quinolones, aminoglycosides, tetracyclines, and beta-lactams have been designed to ev

29 -lactams, fluoroquinolones, aminoglycosides, tetracyclines, and carbapenems and susceptible only to p

30 nd the repertoire of enzymes that can modify tetracyclines, and facilitate engineered biosynthesis of

31 ms, aminoglycosides, quinolones, macrolides, tetracyclines, and glycopeptides were similar to those a

32 such as MMP inhibitors, chemically modified tetracyclines, and subantimicrobial formulations of tetr

33 tibiotics, the anticollagenolytic effects of tetracyclines, and the effect of non-steroidal anti-infl

34 sulfonamides, 3 macrolides, 7 quinolones, 6 tetracyclines, and trimethoprim in chlorine-disinfected

35 Tetracyclines are a group of natural products sharing a

36 Tetracyclines are antibiotics with pleiotropic cytoprote

37 Tetracyclines are aromatic polyketides biosynthesized by

38 Oral tetracyclines are commonly used for acne and other condi

39 Large numbers of tetracyclines are now possible via these reactions, incl

40 The nonantimicrobial chemically modified tetracyclines are potent inhibitors of MMPs, preventing

41 covered nonantimicrobial chemically modified tetracyclines are potent inhibitors of several classes o

42 Tetracyclines are used in periodontal therapy as antimic

43 se TetR mutants were identified that require tetracyclines as co-repressors.

44 on more effectively than either of the other tetracyclines at comparable dose levels.

45 mmatory drugs, immunosuppressive agents, and tetracyclines, attenuate the activity of NO and PGE2.

46 or ultrasensitive and selective detection of tetracyclines, based on M-shape structure of aptamer (Ap

47 of CMTs is distinct from that observed with tetracyclines because 1) CMT-3-mediated inhibition of PG

48 The transport of minocycline and other tetracyclines by isolated human neutrophils was characte

49 Transport of tetracyclines by neutrophils could potentially enhance t

50 at is unclear, systemic fluoroquinolones and tetracyclines can attain higher levels in gingival fluid

51 Fluoroquinolones and tetracyclines can penetrate epithelial cells, but the me

52 Translation inhibitors (such as tetracyclines, clindamycin and macrolides) and gyrase in

53 Chemically modified tetracyclines (CMTs), devoid of antimicrobial activity,

54 In contrast, chemically modified tetracyclines (CMTs), such as CMT-3 and -8 (but not CMT-

55 nsport provide a mechanism by which systemic tetracyclines could be preferentially distributed to gin

56 te et al. propose in this issue that topical tetracyclines could become safe, efficacious therapy for

57 Tetracyclines (doxycycline and minocycline) augmented (o

58 Tetracyclines (doxycycline and minocycline) inhibit indu

59 ic toxic effect which can be counteracted by tetracyclines, drugs able to hinder the formation of lar

60 e women, consistent with previous studies on tetracyclines (e.g., doxycycline) in organ culture and a

61 Among the most potent inhibitors, tetracyclines emerged as a new class of inhibitors.

62 als is implicated in differential potency of tetracyclines, enzyme assays were performed in the prese

63 The cyclohexenone ring A of tetracyclines exhibits unique structural features not ob

64 as a surrogate for the susceptibility other tetracyclines fails to detect minocycline-susceptible is

65 al are effective against mycoplasmas, namely tetracyclines, fluoroquinolones and macrolides.

66 A follow-up of antibiotics (tetracyclines, fluoroquinolones, cephalosporins, penicil

67 hich could be explained by the common use of tetracyclines for control of sheep abortions in the Unit

68 carbon nanotubes (RACNTs) in the analysis of tetracyclines from milk samples, in a multidimensional l

69 A disadvantage of these systems is that tetracyclines function as transcriptional inducers and h

70 Tetracyclines had no significant effect on the levels of

71 The C-8 position of the tetracyclines has been largely underexplored because of

72 The use of tetracyclines has declined because of the appearance of

73 ation of palladium-coupling reactions to the tetracyclines has yielded new tetracycline classes with

74 significance now that minocycline and other tetracyclines have been proposed as therapeutic options

75 Tetracyclines have recently been shown to have "chondrop

76 Various tetracyclines have reduced the severity of osteoarthriti

77 was also used to determine sulfonamides and tetracyclines in 16 out of 107 samples, all previously a

78 zed the accumulation of fluoroquinolones and tetracyclines in cultured human gingival fibroblast mono

79 m homeostasis, we caution against the use of tetracyclines in experimental approaches.

80 techniques for detection and quantitation of tetracyclines in food products are greatly in demand.

81 has been evaluated for the determination of tetracyclines in infant foods based on meat and vegetabl

82 udies to evaluate the mechanism of action of tetracyclines in RA are indicated.

83 adjunctive usage of the chemically-modified tetracyclines in the treatment of periodontal diseases c

84 mination of 13 antibiotics (sulfonamides and tetracyclines) in catfish.

85 ication of 14 antimicrobials (quinolones and tetracyclines) in fish.

86 We hypothesized that tetracyclines, in addition to their antimicrobial functi

87 ays with truncated IN mutants indicated that tetracyclines inhibit the IN catalytic core domain.

88 macrophages (RAW 264.7) stimulated with LPS, tetracyclines inhibited NO release and increased PGE2 pr

89 tional (antimicrobial) and non-antimicrobial tetracyclines inhibited periodontal bone resorption indu

90 About 10 years ago we first reported that tetracyclines inhibited the aggregation of prion protein

91 indicate that a novel mechanism of action of tetracyclines is to inhibit the expression of NOS.

92 In contrast to tetracyclines, L-NMMA at low concentrations (< or = 100

93 sis inhibitors (macrolides, aminoglycosides, tetracyclines, lincosamides, and chloramphenicol), DNA s

94 rugs in several different classes, including tetracyclines, macrolides, ketolides, lincosamides, and

95 enicillins, cephalosporins, aminoglycosides, tetracyclines, macrolides, quinolones, trimethoprim and

96 Neuroprotective tetracyclines may be effective in preventing or slowing

97 Our results suggest that tetracyclines may have a dual therapeutic effect in Lyme

98 unique to the United States, and the use of tetracyclines may have facilitated selection of this hig

99 ed the potential therapeutic efficacy of two tetracyclines, minocycline and the newer generation tige

100 clinical use, and in contrast to most older tetracyclines, minocycline has high activity against Aci

101 Tetracyclines moderate inflammatory responses of various

102 Antibiotics, such as tetracyclines, needed for the treatment of murine typhus

103 servations, the antiamyloidogenic effects of tetracyclines on a variety of amyloidogenic proteins wer

104 r different beta-lactams, ciprofloxacin, and tetracyclines on multiple occasions.

105 umulation, thereby uncoupling the effects of tetracyclines on NO and PGE2 production.

106 cartilage damage, we evaluated the effect of tetracyclines on the expression and function of human OA

107 proteases and determine the effect of pH and tetracyclines on their activity.

108 nd that deactivating microglia in utero with tetracyclines or eliminating microglia from the fetal ce

109 for the selective isolation and clean-up of tetracyclines (oxytetracycline, tetracycline, epi-chloro

110 ally significant resistance to sulfonamides, tetracyclines, penicillins, and ciprofloxacin.

111 tracycline repressor (TetR) and induced with tetracyclines, permitting the construction of conditiona

112 e enzyme coupled with water solubility makes tetracyclines potential candidates for X-ray crystal str

113 Here we find that sub-inhibitory levels of tetracyclines potentiate selection for or against tetrac

114 teriaceae disk diffusion breakpoints for the tetracyclines published in the Clinical and Laboratory S

115 nalysis, the cut-off values of beta-lactams, tetracyclines, quinolones and sulfonamides were determin

116 four families of antibiotics (beta-lactams, tetracyclines, quinolones and sulfonamides) in milk with

117 Systemic fluoroquinolones and tetracyclines reach steady-state levels in gingival crev

118 nas aeruginosa both in vitro and in vivo for tetracyclines reported to date.

119 ry diseases, these observations suggest that tetracyclines should be evaluated as potential therapeut

120 Tetracyclines stain calcium phosphate mineral in bone.

121 the 6-day vermicomposting process, including tetracyclines, sulfonamides, and fluoroquinolones.

122 were exposed to increasing concentrations of tetracyclines, surface expression of the chimeric recept

123 septicemia model show that many of the novel tetracyclines synthesized have potent antibiotic activit

124 onsisting of six sulfonamides (SAs) and five tetracyclines (TCs), which commonly are used for veterin

125 pecific for topoisomerase I, and none of the tetracyclines tested induced topoisomerase I-mediated cl

126 potency against purified IN, all substituted tetracyclines tested showed 5-100-fold increased potency

127 noglycosides, amphenicols, sulfonamides, and tetracyclines) that have perfect nucleotide identity to

128 A new generation of tetracyclines, the glycylcyclines, is being specifically

129 However, all were resistant to tetracyclines, the only antibiotics currently approved i

130 In the absence of tetracyclines, the transfected T cells were shown to exp

131 Gingival fibroblasts actively accumulate tetracyclines, thereby enhancing their redistribution fr

132 s appear to accumulate minocycline and other tetracyclines through a mechanism that has not been full

133 udy indicates a novel mechanism of action of tetracyclines to augment the expression of COX-2 and PGE

134 studies have also shown the promise of using tetracyclines to decrease the rate of spontaneous arteri

135 in the distribution of fluoroquinolones and tetracyclines to the gingiva.

136 nolone-induced DNA damage and the ability of tetracyclines to traverse the outer membrane.

137 Semisynthetic tetracyclines used in the adjunctive treatment of inflam

138 ent of PGE2 production in RAW 264.7 cells by tetracyclines was accompanied by the accumulation of bot

139 Selectivity of tetracyclines was also examined in an assay specific for

140 Efficacy of both tetracyclines was reduced by pre-existing tetracycline r

141 ings, with two exceptions: Longer courses of tetracyclines were associated with reduced tooth loss am

142 Tetracyclines were effective in preventing infection of

143 Limits of quantitation of examined tetracyclines were from 14.5 to 56.6mug/kg significantly

144 d antimicrobials, including sulfonamides and tetracyclines, were measured using liquid chromatography

145 travenous aminoglycosides or long courses of tetracyclines where clinically appropriate.

146 nolones, and moderate susceptibility to most tetracyclines, whereas other contemporary isolates had h

147 f bovine urine revealed frequent presence of tetracyclines, which was related with animal's age.

148 ed aptasensor showed high selectivity toward tetracyclines with a limit of detection as low as 266 pM