ライフサイエンスコーパス: tetraplex

1 ar DNA duplexes, triplexes and quadruplexes (tetraplexes).

2 mer and lie across the narrow grooves of the tetraplex.

3 ucture was established and was found to be a tetraplex.

4 n unusual K+-dependent intrastrand "cinched" tetraplex.

5 nd at higher ionic strength a double-hairpin tetraplex.

6 C-T)10, probably because it is a two-hairpin tetraplex.

7 hibited spectra characteristic of parallel G-tetraplexes.

8 orm several intrastrand structures including tetraplexes.

9 as well as two different unusual intrastrand tetraplexes.

10 metabolism, to destabilize DNA triplexes and tetraplexes.

11 om the 5'-end of each strand in one cytosine tetraplex and from the 3'-end of each strand in the othe

12 and 1.0 M NaCl, we are also able to identify tetraplex and other similar oligomers formation and to m

13 resolves alternate DNA structures including tetraplex and triplex DNA, and Holliday junctions.

14 lmark of previously described intramolecular tetraplexes and contains a number of noncanonical bases

15 erminus, this molecule is capable of forming tetraplexes and other higher order structures in a tempe

16 pands the hydrogen-bonding possibilities for tetraplexes and suggests that the category of sequences

17 p II divalent ions stabilized the parallel G-tetraplexes, and Mg(2+) generally had the weakest stabil

18 Two different types of cytosine tetraplexes are found in the crystal.

19 ctures with loops, cruciforms, triplexes and tetraplexes) as well as microhomologies are postulated t

20 Tetraplexes block DNA polymerase progression and may pro

21 Our demonstration of the stabilization of tetraplexes by hydrogen bonding between adenines and gua

22 tructures, including hairpins, triplexes and tetraplexes, by the tandem repeats.

23 However, since tetraplexes can be thought of as folded hairpins, many o

24 consistent with conversion of a two-hairpin tetraplex directly to single strands.

25 perturb the conformation of nucleic acids in tetraplex, duplex, and single-stranded states was assess

26 The A clusters and the cytosine tetraplexes form two alternating stacking patterns, crea

27 ng extends the range of sequences capable of tetraplex formation as well as our appreciation of the c

28 ures, native gel electrophoresis revealed no tetraplex formation at 37 degrees C, the physiologically

29 In addition, we also prevented tetraplex formation by substitution of 7-deazaguanosine

30 Tetraplex formation in the presence of Na+ requires both

31 We show that tetraplex formation is determined by a complex combinati

32 sitive and specific indicator of intrastrand tetraplex formation that can be used, both to identify s

33 ential and to examine parameters that affect tetraplex formation.

34 at 0.95 A resolution of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) in the pr

35 can be used, both to identify sequences with tetraplex-forming potential and to examine parameters th

36 suggests that the category of sequences with tetraplex-forming potential may be larger than previousl

37 nds, and in particular shows selectivity for tetraplex forms of nucleic acids.

38 In Na+, a tetraplex forms that contains C.C+ pairs, with the adeni

39 f duplex forms, to multistranded triplex and tetraplex forms.

40 triplex (BePI, coralyne, and berberine) and tetraplex [H(2)TmPyP, 5,10,15, 20-tetrakis[4-(trimethyla

41 Sequences with a propensity to form guanine tetraplexes have been found in chromosomal telomers, imm

42 In all cases the tetraplexes have the same overall conformation in which

43 r polymer (in this case, a four-stranded DNA tetraplex, iDNA) modulates the melting temperature of a

44 Four-stranded guanine tetraplexes in RNA have been identified to be involved i

45 ases other than guanine into the stem of the tetraplex, interaction between loop bases and bases in t

46 g this work we have shown that some of these tetraplexes involve unusual base interactions.

47 In the presence of K+, a tetraplex is formed in which the adenines are unpaired a

48 number of sequences with the ability to form tetraplexes is larger than previously thought, and that

49 ondary structures, in particular intrastrand tetraplexes, is an intrinsic property of some of the mor

50 Binding of gene 5 protein to the tetraplex leads to formation of a approximately 170 kDa

51 the number of sequences that can form stable tetraplexes might be much larger than previously thought

52 The tetraplex molecules stack on one another in opposite pol

53 perturb the CD spectra of a series of other tetraplex nucleic acids, indicating that it does not mod

54 le-helical motif of MSR recognizes and binds tetraplex nucleic acids.

55 taH of formation per mole of the two-hairpin tetraplex of -116.9 kcal or -29.2 kcal/mol of G-tetrad.

56 ion exhibited by the native MSR molecule for tetraplex over double-stranded or single-stranded nuclei

57 lect the altered internal dimensions of this tetraplex, perhaps resulting from the ability of the C.C

58 at the triple-helical MSR-1 peptide binds to tetraplex poly(I) in a stoichiometric manner and is capa

59 l reference peptide (POG)10 does not bind to tetraplex poly(I), suggesting that binding requires the

60 the complex between triple-helical MSR-1 and tetraplex poly(I).

61 For the first time, we report a tetraplex polymerase chain reaction (PCR) assay targetin

62 tions between a triple-helical peptide and a tetraplex polynucleotide are proposed on the basis of th

63 the two enzymes are able to unwind G2 and G4 tetraplexes, prompting speculation that failure to resol

64 that forms a complex mixture of hairpins and tetraplexes, r(CGG)22 forms a single stable hairpin with

65 nding water patterns are observed within the tetraplex's helical grooves and clustered about the phos

66 This study illustrates the utility of tetraplex stable isotope coded tags in mass spectrometri

67 The data demonstrate the value of the tetraplex stable isotope tagging approach for producing

68 Here we report the RNA tetraplex structure (UGGGGU)(4) at ultra-high resolution

69 ure, led to the complete disruption of the G-tetraplex structure as detected by NMR and confirmed by

70 On the other hand, tetraplex structure formation was observed at 4 and 23 d

71 ce preference arises from the formation of a tetraplex structure held together by a central block of

72 e, the potential for these sequences to form tetraplex structures at lower temperatures may not be re

73 ne, could justify a regulatory mechanism for tetraplex structures in the expression of human insulin.

74 can traverse template d(CGG)(n) hairpin and tetraplex structures in the presence of WRN.

75 report here that hairpin and G'2 bimolecular tetraplex structures of the fragile X expanded sequence,

76 The DNA triplex helix and G4 tetraplex structures that form by Hoogsteen hydrogen bon

77 iplexes, RPA does not melt intermolecular G4 tetraplex structures.

78 n, is used to demonstrate the utility of the tetraplex tagging strategy.

79 ite directions and locked together to form a tetraplex through intercalation of the 5'-most A-A base

80 consistent with conversion of a two-hairpin tetraplex to a single-hairpin duplex with extrahelical r

81 slipped structures, DNA unwinding elements, tetraplexes, triplexes and sticky DNA) are described.

82 orm unique octaplexes with the neighboring G tetraplexes, whereas the 3'-end uridines are stacked-in

83 ands in the asymmetric unit forms a parallel tetraplex with symmetry-related molecules.

84 These interactions not only generate tetraplexes with novel properties but also lead us to co