ライフサイエンスコーパス: tetravalent

1 er valence cation is divalent, trivalent, or tetravalent.

2 a nuclear waste repository render neptunium tetravalent.

3 In a tetravalent A/C/Y/W-135-DT meningococcal conjugate vacci

4 This series of isolectins is tetravalent (A4), trivalent (A3B), divalent (A2B2), and

5 n vibrational bands are exceedingly rare for tetravalent actinide complexes and reflect the strong bo

6 ar to the log Rd determined for the (solely) tetravalent actinide Th on calcite, suggesting reduction

7 Th(IV), as an analogue for Pu(IV) and other tetravalent actinides [An(IV)], in saturated columns pac

8 However, tetravalent actinides can also become mobile if they occ

9 esin (up to 330 mg of TEVA (abbreviation for tetravalent actinides)) through programmable beads trans

10 The tetravalent, alpha-gal-binding Bandeiraea simplicifolia

11 2,6-(i)Pr(2))(2)) with NH(3) also afforded a tetravalent amide Ar'(2)Ge(H)NH(2) (3), whereas with H(2

12 However the tetravalent amido species Ar(2)Ge(H)NH(2) were obtained

13 ENV HR tetravalent vaccine (HR-Tet) showed a tetravalent anamnestic immune response in 100% (16/16) o

14 Streptavidin is tetravalent and the cross-linking of biotinylated target

15 nning a range of values for the ratio of the tetravalent and trivalent (RE) cation radii.

16 ue mainly to the natural substitution of the tetravalent and trivalent elements in the montmorillonit

17 we generated a novel, potently neutralizing, tetravalent, and bispecific antibody composed of 2 heavy

18 diameters were observed for large trivalent, tetravalent, and pentavalent counterions.

19 8)C(34) indicate the cerium in this phase is tetravalent, and the observed magnetic ordering at T(C)

20 f TV005 dengue vaccine is safe and induces a tetravalent antibody response at an unprecedented freque

21 Expression of a tetravalent antigen fusion construct combining EDIII pol

22 d by the template into shaped NPs that mimic tetravalent atoms but on the length scale of colloids.

23 ween anisotropic particles with well-defined tetravalent binding topology and isotropic particles.

24 or molecular properties over two established tetravalent bispecific formats.

25 duction of an Fc domain-containing, IgG-like tetravalent BsAb, with two antigen-binding sites to each

26 resently licensed meningococcal vaccine is a tetravalent capsular polysaccharide vaccine that induces

27 (ITC) data for the binding of di-, tri-, and tetravalent carbohydrate analogues possessing terminal 3

28 revious report for binding of di-, tri-, and tetravalent carbohydrate analogues possessing terminal 3

29 dimer of cyanovirin-N that represents a new tetravalent carbohydrate binding protein that is stable

30 binding of a series of mono-, bi-, tri- and tetravalent carboxylate ligands to Ca(II) was examined b

31 t labeling efficiency and stability, whereas tetravalent cation (89)Zr(4+) could not label LDH since

32 In such applications the host tetravalent cation is often partially substituted by tri

33 h an increasing energetic preference for the tetravalent cations to have higher oxygen coordination.

34 The presence of both tri- and tetravalent Ce, contrary to formulation, was confirmed u

35 Here we report tetravalent cerium, uranium and thorium bis(carbene) com

36 cetic acid (NTA) group, a group that forms a tetravalent chelate with Ni(II), and a second thiol that

37 AFM13 is a bispecific, tetravalent chimeric antibody construct (TandAb) designe

38 to differentiate antibodies elicited by the tetravalent chimeric yellow fever-17D/dengue vaccine or

39 Brain lesions produced by the tetravalent ChimeriVax-DEN vaccine were significantly le

40 An investigational tetravalent combined measles, mumps, rubella, and varice

41 Despite the tetravalent composition of the vaccine, we observed a ne

42 scopy, and HPLC studies showed that they are tetravalent, configurationally stable B-chiral acylboron

43 h an improved biological half-life makes the tetravalent construct an important reagent for cancer th

44 The in vitro binding properties of the tetravalent construct were analyzed by solid-phase RIA a

45 n NuMA that would convert a NuMA dimer to a "tetravalent" crosslinker of MTs.

46 e both DEN1 and DEN4 viruses suggests that a tetravalent DEN vaccine could be generated by introducti

47 Homogenous di- and tetravalent dendrimers incorporating the alpha7-nicotini

48 rior infection with DENV or vaccination with tetravalent dengue attenuated vaccines (TDLAV) recognize

49 injections of recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV) or placebo at month

50 imeric yellow fever-dengue, live-attenuated, tetravalent dengue vaccine (CYD-TDV) that is currently a

51 jections of a recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV), or placebo, at mon

52 Sanofi Pasteur has developed a tetravalent dengue vaccine (TDV) against the world's mos

53 previously vaccinated with a live attenuated tetravalent dengue vaccine (TDV) and 4 DENV-naive contro

54 We are developing a live-attenuated tetravalent dengue vaccine (TDV) candidate based on an a

55 fety and immunogenicity of a live attenuated tetravalent dengue vaccine (TV003), compared with those

56 th development and licensure of an effective tetravalent dengue vaccine a public health priority.

57 We developed a novel tetravalent dengue vaccine by using virus-like particles

58 To address this, we developed a novel tetravalent dengue vaccine by utilizing virus-like parti

59 high dose) of a live attenuated recombinant tetravalent dengue vaccine candidate (TDV) given in 2 do

60 nogenicity of a live attenuated, recombinant tetravalent dengue vaccine candidate (TDV) were evaluate

61 preplanned interim analyses at 6 months of a tetravalent dengue vaccine candidate (TDV), which is com

62 vaccinated by intramuscular inoculation of a tetravalent dengue vaccine formulated by combining the t

63 These results demonstrate that the tetravalent dengue vaccine formulation provides signific

64 omising vaccine candidate for inclusion in a tetravalent dengue vaccine formulation.

65 In a phase 3 efficacy trial of a tetravalent dengue vaccine in five Latin American countr

66 A safe, effective tetravalent dengue vaccine is a global health priority.

67 A candidate tetravalent dengue vaccine is being assessed in three cl

68 A strategy for the development of a tetravalent dengue vaccine is discussed.

69 This is the first recombinant tetravalent dengue vaccine successfully evaluated in non

70 lity of a single dose of the live attenuated tetravalent dengue vaccine TV003 to induce a suitable ne

71 DENV) in two pivotal phase III trials of the tetravalent dengue vaccine, CYD-TDV, and thereby enabled

72 f a human subject who received an attenuated tetravalent dengue vaccine.

73 tions for the development of live attenuated tetravalent dengue vaccines.

74 ts of a recent phase IIb clinical trial of a tetravalent dengue virus (DENV) vaccine suggest that NAb

75 across multiple species, reveal a promising tetravalent Dengue virus sub-unit vaccine candidate.

76 the protective efficacy of a live attenuated tetravalent DENV vaccine (TDV) candidate against parente

77 to control this threat to global health is a tetravalent DENV vaccine.

78 table tolerability and immunogenicity of the tetravalent DENVax formulations in healthy, flavivirus-n

79 d to assess the safety and immunogenicity of tetravalent DENVax formulations.

80 The tetravalent DENVax vaccine contains a molecularly charac

81 Divalent and tetravalent displays of M2pep ([M2pep]2-Biotin and [M2pe

82 cells (PBMCs) from donors vaccinated with a tetravalent DLAV vaccine (TV005) with pools of dengue vi

83 INTERPRETATION: This tetravalent E coli bioconjugate vaccine candidate was we

84 Fourth, a tetravalent E85-VRP dengue vaccine induced a simultaneou

85 ering, and characterization of a bispecific, tetravalent endoplasmic reticulum (ER)-targeted intradia

86 man IgG Ab forms including tetravalent IgG1, tetravalent F(ab')2, and linear Fab multimers with eithe

87 f Uranyl (U(VI)) to the relatively insoluble tetravalent form (U(IV)) by S. alga strain (BR-Y) were s

88 virus vaccine candidates were compared to a tetravalent formulation of wild-type DEN viruses (T-wt)

89 of these chimeric viruses (as monovalent or tetravalent formulation) developed viremia with magnitud

90 ty and protective efficacy of four different tetravalent formulations were evaluated in cynomolgus mo

91 In tetravalent formulations, DENV-1 and DENV-2 antagonized

92 Two tetravalent formulations, TV-2 and TV-3, possess propert

93 unologically dominant in both monovalent and tetravalent formulations.

94 erference did not occur in recipients of the tetravalent formulations.

95 We recently synthesized a tetravalent guanylhydrazone compound (CNI-1493) that inh

96 ctivation that prevents TNF production, this tetravalent guanylhydrazone could be useful in the devel

97 ry for macrophages to respond to CNI-1493, a tetravalent guanylhydrazone inhibitor of p38 mitogen-act

98 rve firing is also stimulated by CNI-1493, a tetravalent guanylhydrazone molecule that inhibits syste

99 CNI-1493, a tetravalent guanylhydrazone, is an inhibitor of macropha

100 Semapimod, a tetravalent guanylhydrazone, suppresses inflammatory cyt

101 otype-specific antigens in a live attenuated tetravalent human vaccine.

102 We have developed a tetravalent human-bovine rotavirus (UK) reassortant vacc

103 Ar'(2)Ge(H)NH(2) (3), whereas with H(2) the tetravalent hydride Ar'GeH(3) (4) was obtained with Ar'H

104 cribe the production and characterization of tetravalent IgG-like BsAbs that combine the activities o

105 of multivalent human IgG Ab forms including tetravalent IgG1, tetravalent F(ab')2, and linear Fab mu

106 d a novel generic platform for production of tetravalent IgG1-like chimeric bispecific Abs.

107 nerally applicable model of a dual-specific, tetravalent immunoglobulin G (IgG)-like molecule--termed

108 fering can be significantly improved using a tetravalent instead of a divalent molecule, since the te

109 to the stability of polynuclear complexes of tetravalent ions.

110 tical work was carried out for trivalent and tetravalent ions.

111 nd physical properties of two new quaternary tetravalent iridates, MLa10Ir4O24 (M = Sr, Ba).

112 Among the tetravalent lanthanide ions, only Ce(4+) forms stable co

113 4 different admixtures of a live attenuated tetravalent (LATV) dengue vaccine were evaluated in 113

114 n inhibitor in controlling lead release from tetravalent lead corrosion product PbO(2) in chloraminat

115 -dimensional, cross-linked lattice between a tetravalent lectin and a bivalent carbohydrate.

116 ystallographic results showing that a single tetravalent lectin forms distinct cross-linked complexes

117 Immobilization of cortical movement with tetravalent lectins produces similar spindle defects to

118 JBalphaMan, which is outstanding for just a tetravalent ligand.

119 the nonspecific binding to DNA of all these tetravalent ligands is driven primarily by coulombic int

120 The final mono-, di-, and tetravalent ligands were resistant to enzymatic hydrolis

121 study the CD4 T cell responses elicited by a tetravalent live attenuated dengue vaccine and show that

122 udy participants receiving the monovalent or tetravalent live attenuated DENV vaccine (DLAV), develop

123 ize interactions between DENV serotypes in a tetravalent live-attenuated virus vaccine candidate, we

124 Tetravalent (LLP2A-DOTA)(4)-PEG(10,000) (1.1 nM) had tum

125 Surprisingly, both divalent and tetravalent M2pep, without conjugation of any cytotoxic

126 -dimensional tetrahedral networks built from tetravalent (M4+ = Ge4+ or Sn4+, where M = meta) and tri

127 dentified as a manganese feroxyhyte in which tetravalent manganese is homogeneously distributed into

128 ormation of H-type dye aggregates within the tetravalent MAP system.

129 In 2005, a new meningococcal vaccine, tetravalent meningococcal conjugate vaccine (MCV4) was a

130 vention released guidelines for the use of a tetravalent meningococcal conjugate vaccine in adolescen

131 rene sulfonate) brush molecules and cationic tetravalent meso-tetrakis(4-N-methyl-pyridinium)porphyri

132 hrough self-assembly reactions with tri- and tetravalent metal ions such as Ga(III), Fe(III), Ti(IV)

133 valent metals (lanthanum and gadolinium) and tetravalent metals (tin and zirconium) but not divalent

134 cs and plateau level of GDS aggregation by a tetravalent model lectin: the leguminous agglutinin Con

135 nt instead of a divalent molecule, since the tetravalent molecule can form two intramolecular rings w

136 of Ag29(BDT)12(TPP)4, an atomically precise tetravalent nanocluster (NC) (BDT, 1,3-benzenedithiol; T

137 interaction and enhances the ionicity of the tetravalent Nb with unpaired electrons, yielding ferroma

138 Reduction to tetravalent neptunium (Np(IV)) effectively immobilizes t

139 e-containing host rocks (7-8), confirmed the tetravalent Np oxidation state.

140 nsed structures form in the simulations with tetravalent or trivalent counterions.

141 ular hydroamination/cyclization catalyzed by tetravalent organoactinide and organozirconium complexes

142 rsible redox chemistry between trivalent and tetravalent oxidation states.

143 conjugate addition between thiol-terminated tetravalent PEG and multivalent ONDs yielded self-suppor

144 The tetravalent platinum stiboranyl complex [(o-(Ph2P)C6H4)2

145 2Poly(dT) triplex DNA in the presence of the tetravalent polyamine spermine using a centrifugation as

146 at 12 months they received MenACWY, a plain tetravalent polysaccharide vaccine, or no vaccine.

147 monovalent and divalent CD4-based proteins, tetravalent PRO 542 potently neutralizes diverse primary

148 6-Me(3))(2)) with H(2) or NH(3) afforded the tetravalent products Ar(#)(2)GeH(2) (1) or Ar(#)(2)Ge(H)

149 ox equilibrium, and the strong proclivity of tetravalent Pu to hydrolyze and form polymeric species.

150 es, the potency and activity spectrum of the tetravalent R4 dendrimer are comparable to protegrins an

151 A single dose of TV005 elicited a tetravalent response in 90% of vaccinees by 3 months aft

152 who had intussusception after receiving the tetravalent rhesus-human reassortant rotavirus vaccine (

153 The association between the tetravalent rhesus-human reassortant rotavirus vaccine a

154 st licensed rotavirus vaccine, a reassortant-tetravalent, rhesus-based rotavirus vaccine (RRV-TV), le

155 in licensure of the first live oral vaccine, tetravalent, rhesus-based rotavirus vaccine (RRV-TV), wh

156 combined peptide-modified, multiply-labelled tetravalent RNA imaging probes (MTRIPs), targeted to seq

157 e sensitivity, we developed multiply labeled tetravalent RNA imaging probes (MTRIPs).

158 ussusception after vaccination with the live tetravalent rotavirus vaccine RotaShield resulted in vol

159 us vaccine (OPV) and monovalent (RRV-S1) and tetravalent (RRV-TV) rhesus-human rotavirus vaccines was

160 rotavirus vaccine (rhesus rotavirus vaccine-tetravalent (RRV-TV)) to prevent rotavirus-related hospi

161 idin (SA)-AR-modified CEM cells captured the tetravalent SA with one biotin binding site.

162 rationalize the results obtained on regular (tetravalent) SAv.

163 Divalent (sc(Fv)(2)) and tetravalent ([sc(Fv)(2)](2)) scFv's of mAb CC49 were eva

164 Soluble tetravalent selenite is the predominant environmental fo

165 Immunization with a meningococcal tetravalent (serogroup ACWY) glycoconjugate vaccine is r

166 18-55 years old, were immunized once with a tetravalent (serogroups A, C, Y, and W-135) meningococca

167 ional radioimmunotherapy using a recombinant tetravalent single-chain Ab-streptavidin (SA) fusion pro

168 present study, we report the generation of a tetravalent single-chain Fv [[sc(Fv)2]2] of the murine M

169 tumor-targeting ability of an antimesothelin tetravalent single-chain Fv-streptavidin fusion protein

170 We have engineered a tetravalent singlechain 1F5 (scFv)4SA fusion protein and

171 y assemble above a critical concentration of tetravalent spermine and are stable over long times at r

172 valent spermidine, Triquat A, and Triquat 7; tetravalent spermine and Quatro-quat; and hexavalent Qua

173 ThO2, in which thorium is stable only in a tetravalent state, exhibits damage accumulation processe

174 onmental contaminant that accumulates in the tetravalent state, U(IV), in anoxic sediments, such as o

175 Biotinylated IGF-1 was complexed with tetravalent streptavidin and then bound to biotinylated

176 s- and trans-divalent streptavidins retained tetravalent streptavidin's high thermostability and low

177 building blocks to form paucivalent (di- to tetravalent) structures of controlled scaffold architect

178 observed for the binding of mono-, di-, and tetravalent sugars, respectively, to the two lectins.

179 ies established the presence of divalent and tetravalent tin centers in 16.

180 nt' magnetoelectric cross-field control in a tetravalent titanate film.

181 ted in the context of recent studies on both tetravalent transition metal and actinide hexahalides, M

182 For example, DeltaH of a tetravalent trimannoside analog is nearly four times gre

183 plots for the binding of the di-, tri-, and tetravalent trimannoside analogues to both lectins are c

184 anic-rich, reduced sediments that accumulate tetravalent U, U(IV).

185 f hexavalent uranium (U(VI)) to less soluble tetravalent uranium (U(IV)) through enzymatic or abiotic

186 at 23 degrees C, which is consistent with a tetravalent uranium 5f(2) electronic configuration.

187 e reduction of soluble hexavalent uranium to tetravalent uranium can be catalyzed by bacteria and min

188 pe zinc ore deposit indicate substitution of tetravalent uranium for divalent calcium.

189 Thus, tetravalent uranium has a stable location in calcite dep

190 eduction of U(VI) by the pili to mononuclear tetravalent uranium U(IV) complexed by carbon-containing

191 ra for ketimido (azavinylidene) complexes of tetravalent uranium, (C(5)Me(5))(2)U[-N=C(Ph)(R)](2) (R

192 lent vaccination, T cell responses following tetravalent vaccination were, dramatically, focused towa

193 Additionally, the DENV HR tetravalent vaccine (HR-Tet) showed a tetravalent anamne

194 t dose of rhesus-human reassortant rotavirus tetravalent vaccine (RRV-TV) has been studied extensivel

195 al rhesus/rhesus-human reassortant rotavirus tetravalent vaccine (RRV-TV) was licensed in 1998 but wi

196 Three tetravalent vaccine (TV) formulations of previously desc

197 be the promising development of an effective tetravalent vaccine against the prevalent flavivirus.IMP

198 V and was immunized with the live attenuated tetravalent vaccine Butantan-DV, developed by the NIH an

199 NV-seropositive volunteer immunized with the tetravalent vaccine Butantan-DV, which is currently in p

200 In this article, we describe a new tetravalent vaccine candidate based on recombinant dengu

201 Current tetravalent vaccine candidates that are in the final sta

202 Chinchillas were given tetravalent vaccine composed of pneumococcal capsular po

203 Our tetravalent vaccine elicited potent neutralizing antibod

204 erotypes were combined in 16 live-attenuated tetravalent vaccine formulations (N = 64) and administer

205 strate the safety of a recombinant DEN virus tetravalent vaccine in a formal neurovirulence test, as

206 chimeric yellow fever-dengue live-attenuated tetravalent vaccine is now being marketed.

207 the serotype G1 monovalent or serotype G1-G4 tetravalent vaccine seroconverted for at least one of th

208 For this reason, the development of a safe, tetravalent vaccine to produce a balanced immune respons

209 The safety of a tetravalent vaccine was determined and compared to that

210 ine (TV003), compared with those of a second tetravalent vaccine with an enhanced DENV-2 component (T

211 For use as a tetravalent vaccine, DENV1-4 VLPs elicited high levels o

212 assortants with G8 and G9 specificity to the tetravalent vaccine, thereby formulating a "designed" he

213 ions to reduce capillary leakage, and a safe tetravalent vaccine.

214 the chances that one or more live attenuated tetravalent vaccines (LATVs) will be introduced worldwid

215 ity may limit the efficacy of MAb therapy or tetravalent vaccines against DENV, as neutralization pot

216 Nonetheless, it is still unclear if tetravalent vaccines can elicit or recall nAbs.

217 Furthermore, a tetravalent version of this molecule bound specifically

218 Two tetravalent virus formulations, comprised of either PDK5

219 These experiments revealed Pu to be tetravalent, while the strong pre-edge absorption from t

220 When monkeys were boosted with a tetravalent YF/DEN1-4 dose 6 months later, four of nine

221 une and nonimmune monkeys which received the tetravalent YF/DEN1-4 vaccine or between tetravalent YF/

222 ccine and six of six monkeys inoculated with tetravalent YF/DEN1-4 vaccine seroconverted after a sing

223 the tetravalent YF/DEN1-4 vaccine or between tetravalent YF/DEN1-4-immune and nonimmune monkeys which