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1 ne-induced reduction in mGluR5 availability (that is, [(11)C]ABP688 binding) in both MDD and control
3 ol valve made from bovine pericardial tissue that is 14-F compatible with a motorized delivery system
4 demand (30%) compared with INCS daily (22%), that is 8% difference (95% CI -5 to +21%; not significan
7 y by low levels of SA and high levels of FCA-that is a level of SA lower than would be predicted from
8 ), a prototypical G-protein-coupled receptor that is a physiologically relevant target for endogenous
9 homologue 2b (PfRh2b) is an invasion ligand that is a potential blood-stage vaccine candidate antige
10 osine receptor, a G-protein-coupled receptor that is a target for the treatment of Parkinson's diseas
11 ns, the core of tomography remains the same, that is, a mathematical method must be implemented to re
12 an be influenced substantially by providers (that is, a strong process-outcome link exists) and stati
13 time feedback and analysis with an algorithm that is able to distinguish and select the most reactive
14 turation and release of IL-1beta, a response that is absent in SMG cells isolated from mice deficient
16 ZnT8 were mapped to its transmembrane domain that is accessible to extracellular ZnT8 antibody (ZnT8A
18 an increased production of IL-17A, an effect that is accompanied by an increased signal transducer an
20 osome occupancy occurred on the set of genes that is activated by the unfolded protein response (UPR)
21 lial cells via posttranslational mechanisms, that is, activation of Src/Abl kinases and degradation o
26 a redox probe ([Fe(CN)6](3-)/[Fe(CN)6](4-)) that is altered upon binding of PSMA with PSMA-Ab immobi
27 ress-responsive cytoplasmic adapter molecule that is an upstream regulator of both IkappaB kinase (IK
28 rchitecture and fate of stomata in hornworts that is ancient and common to plants without sporophytic
29 wed a lifespan trajectory expression pattern that is anticorrelated with the expression of the full-l
31 ry, leukocytes are near the vascular region, that is, approximately 100-300 mum away from the injury
32 use disorder is a chronic relapsing disorder that is associated with compulsive alcohol-seeking behav
33 ted the proportion of hospitalized influenza that is associated with IAND and IAE, and incidence of I
35 n in virus titer and improvement in survival that is associated with pronounced host antiviral respon
36 acterized by increasing mean and extreme AOD that is attributed to increased local wildfire emissions
40 We propose a novel paradigm of atrial ECC that is based on tandem activation of the RyRs by cytoso
41 ides that is higher and with substrate scope that is broader than those of enzymes containing iron po
42 adhesive model based on the Morse potential that is calibrated by existing in vivo and in vitro expe
44 a pneumoniae (hvKP) is an emerging pathotype that is capable of causing tissue-invasive and organ- an
45 be a combined biological/enzymatic synthesis that is capable of efficiently converting microbially-de
46 rylase, and SVEN_2781 is a pyrophosphorylase that is capable of generating GDP-glucose as well as GDP
47 ilament (NPF) on double-stranded DNA (dsDNA) that is capable of unwrapping the nucleosomal DNA from t
48 r, which results in a vesicle-like structure that is captured in situ through a simple crosslinking r
49 indoles to form 3-benzylated indoles and H2O that is catalyzed, for the first time, by a complex of e
50 s a blood and lymphatic vessel (LV) disorder that is caused by inherited inactivating mutations of th
51 development in Id2/Id3 double-knockout mice that is caused by unchecked expansion of invariant NKT (
52 fic SNP position (230 bp) in the matK region that is characteristic of D. hamiltonii could be used to
54 approximately 5% of primary prostate cancer that is characterized by abbreviated response to androge
59 lation to other emerging schools of thought, that is, concepts such as the exposome, social determina
63 ally attractive neighborhoods-an observation that is consistent with the "invasion" theories of urban
64 y 33%), a delayed viral rebound was observed that is consistent with the establishment of persistent
65 isplacement of an approximately 5-km(2) area that is consistent with the footprint of an estuary iden
67 a concurrent increase in NF-kappaB signaling that is correlated with aneurysm severity in these human
69 R2, it is FGFR1, expressed by all ICM cells, that is critical for establishment of a PrE identity.
70 A) is an essential internal RNA modification that is critical for gene expression control in most org
71 (AIC), a core hub of the "salience network" that is critical for perception of interoceptive signals
72 Interleukin-15 is a pleiotropic cytokine that is critical for the development and survival of mul
73 unidentified ribonucleoprotein (RNP) complex that is critical to the specificity of these small molec
74 bal mapping of the stratigraphy, information that is crucial for evaluation of its authenticity and a
75 y conserved from the first tetrapods to man, that is crucial for higher order structure self-assembly
76 sarcoma-associated herpesvirus (KSHV) mutant that is defective in small capsid protein and is unable
77 course correction to optic flow, a response that is dependent on the spatial structure of the visual
79 followed by longer-lived afterglow radiation that is detected across the electromagnetic spectrum.
81 terestingly, we found genetic heterogeneity (that is, different sets of loci associated with the trai
82 les, and determinants of neuronal morphology that is differentially expressed in specific RGC populat
87 ticular disease is characterized by pouches (that is, diverticulae) due to weakness in the bowel wall
90 carriers and, thus, extremely high-mobility that is due to the character of the band structure that
92 A fragment, we generated the Hex nanocarrier that is efficiently internalized by cells without cytoto
97 erial infection caused by Treponema pallidum that is endemic in low-income countries and and occurs a
99 noncoding intergenic RNA)-Nkx2.1 gene duplex that is essential for buffering Nkx2.1 expression, lung
100 e loop proximal to the dimer-dimer interface that is essential for catalysis (i.e. the "activation lo
107 ling mechanism comprising NF-kappaB and MMP7 that is essential for TNBC cell invasiveness, thereby pr
108 f the true burden and seasonality of disease that is essential to plan the optimal target groups, tim
109 locus is coated with a broad H3K27me3 domain that is established during oocyte growth and persists th
110 compared with continuous noise backgrounds) that is evident for listeners with normal hearing (NH) i
112 e medial and ventrolateral prefrontal cortex that is exclusively engaged in social interaction analys
113 ing translates into divergent cell signaling that is expressed as different brain phosphoprotein prof
114 pe of plasticity at CA1 hippocampal synapses that is expressed by the activation of GluA3-containing
115 a chemokine, stromal cell-derived factor 1, that is expressed in cardiomyocytes and decreases calciu
116 elective 1,1-diarylation of benzyl acrylates that is facilitated by a chiral anion phase transfer (CA
117 fied by a crescent-shaped ssDNA binding claw that is flexibly appended to an APE2 endonuclease/exonuc
120 ave generation in the mid-infrared-something that is forbidden in the absence of free electrons.
123 serial nodulation cycles with a probability that is function of initial inoculum, plant population s
124 and that Lef1 regulates circuit development that is fundamentally important for mediating anxiety in
125 s exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in mainta
126 f rechargeable metal-air batteries, an issue that is gaining increasing interest in recent years.
127 modeled even in advanced fibrosis, a disease that is generally regarded as static and slowly progress
128 gh a key aminium radical cation intermediate that is generated via electron transfer between an excit
130 ursuit of an evolutionary science of culture that is grounded in both biological and evolutionary the
131 regular tendency or practice, especially one that is hard to give up" and also "an automatic reaction
132 tigate GFAP turnover in a mouse model of AxD that is heterozygous for a disease-causing point mutatio
133 reduction of the azides to the sulfonamides that is higher and with substrate scope that is broader
135 e RBC deformability (a mechanical biomarker) that is highly correlated with the infection status.
136 C-4 is an intracellular Cl(-)/H(+) exchanger that is highly expressed in the brain and whose dysfunct
137 rgetic proton generates a time-varying field that is highly localized and heterogeneous at the molecu
138 lele-specific molecular detection technology that is highly sensitive, robust, and high-throughput ha
139 ible for the regulation of stomatal aperture that is hijacked by bacterial COR to promote infection.
140 Cape Verde, an island nation off West Africa that is home to individuals with a broad range of phenot
142 r damage may be incurred by oxidative stress that is imparted by high iron status in early life.
143 data revealed a YtfE orthologue, Ddes_1165, that is implicated in the repair of nitrosative damage.
144 , also takes place outside the plaque areas, that is, in areas of normal-appearing white matter (NAWM
145 ucture information in the optical near field that is inaccessible to other optical microscopy methods
146 th these compounds confirm a mode of binding that is indeed reflective of the transition state at the
147 ays a critical role in airway SM contraction that is independent and distinct from the function of SM
148 ctivation might be a general coping strategy that is independent of age, task content and brain regio
149 ecognized contributor to Alzheimer's disease that is independent of neuronal hypometabolism, predates
150 nantioselective off-on fluorescence response that is independent of the enantiomeric sample compositi
151 parasites have an intrinsic circadian clock that is independent of the host, and which regulates par
152 ential and the diastolic depolarization rate that is independent of the maximum upstroke velocity, a
157 nt inbred lines but have an epigenetic state that is inherently less stable within the A. thaliana sp
158 essed medulloblastoma driven by a mutant SMO that is inherently resistant to existing SMO inhibitors,
159 dge on the mode of activation and processing that is initiated by IFN-1, in perspective of the result
160 Rho family-independent, actin stabilization that is integral to the formation of one RhoGEF array.
161 mine, 5-HT) is a well-known neurotransmitter that is involved in a growing number of functions in per
162 s a key blue light receptor in Chlamydomonas that is involved in both circadian timing and life cycle
164 coded by SPRTN, is a nuclear metalloprotease that is involved in the repair of DNA-protein crosslinks
166 nhibitor is promoted by a regulatory protein that is itself inhibited by the cell-cycle activator, th
167 sylation poses great challenges for analysis that is key to understand structure and function of glyc
168 ), which contains a hydrophobic triad W1L4L8 that is known to be important in the interaction with ce
169 er's phase-relationship to sleep in a manner that is known to cause switches from depression to mania
171 and end-stage kidney disease, an association that is largely attributed to two common genetic variant
172 with respect to free triplets with an energy that is largely material independent ( approximately 30
174 tations are predicted to result in a product that is less effective in neutralizing negatively charge
177 onditions and geographic location, a process that is likely to be repeated in other reef systems.
178 a putative active site responsible for SOAT1 that is located on the cytosolic side of the ER, while B
180 of about 2% in the model domain-a threshold that is low enough for observing subtle near-surface cha
182 r characterized by abnormal bone development that is mainly due to defective intramembranous bone for
183 tg mice exhibit peripheral immune activation that is manifested by higher numbers of granulocytes, pl
184 leave a "covalent record" of the interaction that is measured with mass spectrometry and because it i
185 blue light-sensitive current in human scWAT that is mediated by melanopsin coupled to transient rece
186 itions operates under cholinergic constraint that is mediated by muscarinic receptor-dependent regula
187 crease in the projection of this fingerprint that is mirrored in multiple observational surface tempe
189 ylococcus aureus Further, a mutant S. aureus that is more sensitive to antimicrobial peptides was kil
190 ative-to-reproductive transition, suggesting that is most active and key for Bailinggu development.
191 und to the immunoglobulin domain of nectin-2 that is most distal from the membrane with an affinity o
192 5E, the inositol polyphosphate-5-phosphatase that is mutated in the developmental disorders Joubert a
194 n (LANA) is a conserved Rhadinovirus protein that is necessary for long-term chronic infection by the
195 as a regulator of a chromatin-based pathway that is necessary for maintenance of the leukaemic state
196 tes under the control of a PBel(CGRP) switch that is necessary to arouse animals from hypercapnia.
197 non-translating mRNPs, and recapping is all that is needed for their return to the translating pool.
198 rs can deliver the rapid bacterial detection that is needed in many fields including food safety, cli
199 khead box O1 (FoxO1), a transcription factor that is negatively regulated by Akt, was activated, tran
202 MLCP dephosphorylates pCPI-17 at a slow rate that is, nonetheless, both sufficient and necessary to e
203 the existence of a rapid subcortical pathway that is nonselective in terms of the spatial frequency o
206 terminal domain of CaV1 LTCC alpha1 subunits that is not conserved in CaV2 or CaV3 voltage-gated Ca(2
207 latency or sequestration in an anatomic site that is not effectively exposed to antiretroviral therap
208 defined by intra-aortic pressure monitoring that is not feasible in clinical practice, and as such l
210 mice display a collodion membrane phenotype that is not observed in flaky tail mice or in newborn in
214 disease-specific physiomarker was identified that is now used to investigate adaptive closed-loop sti
216 polycomb repressive complex 1 (PRC1) complex that is overexpressed in breast and other cancers, and p
217 Epstein-Barr virus (EBV)-encoded oncoprotein that is packaged into small extracellular vesicles (EVs)
218 is mediated by a positively charged surface that is partially masked by its intramolecular interacti
219 riatic arthritis might be a distinct disease that is particularly severe when its onset affects child
220 rroptosis is a form of programmed cell death that is pathogenic to several acute and chronic diseases
221 loss of 4-5 kJ/mol/protomer in the N3 domain that is peripheral to the membrane-spanning C domain in
222 e pursued in order to provide cancer therapy that is personalized to the patient and his or her uniqu
223 th the encrypted hologram of a pinhole image that is positioned at the same depth as the sectional im
224 e an approach for generating skeletal muscle that is potentially applicable to other pluripotent cell
227 er of the cysteine protease inhibitor family that is present at notably high concentrations in cerebr
229 n specialized vasculature maintained by VEGF that is produced by neighboring epithelial cells, the re
230 y to pool primary and secondary outcomes.INT that is provided by a dietitian compared with dietary ad
231 by a dietitian compared with dietary advice that is provided by other health professionals leads to
232 and-to-metal charge-transfer ((2)LMCT) state that is rarely seen for transition-metal complexes.
233 es developed for this problem, a superiority that is reflected particularly in the absolute true rate
234 mechanism for Smo activation by sumoylation that is regulated by Hh and Smo interacting proteins.
235 l mechanism of DENND3 intramolecular binding that is regulated by the phosphorylation of a single tyr
236 een intracellular and interstitial pressures that is related to the volume of the interstitial fluid.
237 ence to nutritional stress, a characteristic that is relevant to organismal viability in evolution an
240 s the expression of 3BP2, an adapter protein that is required for activation of SRC tyrosine kinase a
241 transcription factor of the Forkhead family that is required for cell proliferation of normal cells.
242 aplobank identified PLA2G16 as a host factor that is required for cytotoxicity by rhinoviruses, which
245 face implicated in SNARE complex interaction that is required for rapid synchronization and Ca(2+) co
246 oma-6 (Bcl-6) is a transcriptional repressor that is required for the differentiation of T follicular
249 onolayers involves cell-to-cell transmission that is resistant to tetherin but that virion disseminat
250 ate a transcriptional interference mechanism that is responsible for inhibiting expression of the cod
251 pper complex as the metabolite of disulfiram that is responsible for its anti-cancer effects, and pro
252 (carb)3](-) serves as the persistent radical that is responsible for predominant cross-coupling.
253 ing to the Apicomplexan AP2 (ApiAP2) family, that is responsible for regulating the expression of gen
254 re, we show that constitutive NIK expression that is restricted to Tregs via a Cre-inducible transgen
255 ose ([(18)F]-FDG) is commonly used in PET/CT that is retained by metabolically active inflammatory ce
256 on and relocate to a non-native brain region that is rich in neurosecretory neurons, including those
258 n propagated calls relies on a neural coding that is robust to intensity changes, signals' quality, a
260 preferentially involve the PrP(Sc) component that is sensitive to digestion with proteases (senPrP(Sc
261 he right and an area in left auditory cortex that is sensitive to individual differences in the timin
262 ne an IEC transcriptional regulatory network that is shared between fish and mammals and establish an
264 sthma is associated with airway microbiology that is significantly different from that seen in patien
265 transgenic mouse develops a form of leukemia that is similar to the aggressive type of human B-CLL, a
266 that these patients may develop lung injury that is similar to the ventilator-induced lung injury ob
267 istone methyltransferase activity, a finding that is similar to what has been observed for other BAF
268 ac phenotype and response to ischemic stress that is similar to wild-type aged hearts (i.e., impaired
269 or HER in this series, with initial activity that is slightly worse compared to the pristine metallic
270 ue debris producing a single cell suspension that is sorted using magnetic-activated cell sorting tec
272 ropose that it calls upon a response pattern that is specific to each underlying associative structur
273 smalemmal vesicle-associated protein (Plvap) that is specifically localized to endothelial caveolae i
275 perception from faces has unfolded in a way that is strikingly reminiscent of Jussim's narrative in
276 ionally, we evaluated the (-)-JQ1 enantiomer that is structurally incapable of inhibiting BET bromodo
277 onmental factors, develop an immune response that is subsequently triggered by the ingestion of glute
278 between the radius-of-gyration and Q-length that is substantially below expected values for compact
279 earity probed via second harmonic generation that is sufficient to achieve d33>10 pm V(-1), when inco
285 ) is a bona fide Ser/Thr protein phosphatase that is targeted to the mitochondrial intermembrane spac
286 velopmental genetic studies in grass models, that is that inflorescence branching is regulated by nov
288 ascribed to minor differences in covalency, that is, the degree to which electrons are shared betwee
290 othelin-2 (EDN2) is a potent vasoconstrictor that is transiently produced prior to follicle rupture b
291 Here, we examined the effects of jet lag, that is, travel that shifts the alignment of 24-h enviro
293 by a conserved novel E3 ligase (NEL) domain that is unique to Gram-negative pathogens and whose acti
295 l HCs) at the expense of another (short HCs) that is usually located furthest from the Wnt9a source.
296 te that for the top 20 meters the V S models that is well constrained by the data, we obtain time-lap
297 correlations between neurons has a strength that is well within the strongly correlated regime and d
298 when analyzing data using a mixed approach, that is, when comparing individuals of different species
299 Paullinia cupana is a plant native to Brazil that is widely used in traditional medicine as a physica
300 nce known as an Ultraconserved Element (UCE) that is within the retained intron and overlaps the alte
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