ライフサイエンスコーパス: that

1 e the 'Asgard' superphylum, a group of uncultivated archaea that, as well as Lokiarchaeota, includes Thor-, Odin- and Hei

2 efforts toward development of small molecules and biologics that could be of therapeutic use.

3 five factors, including the HIV co-receptors CD4 and CCR5, that are required for HIV infection yet are dispensable for c

4 cations and the permanent microporosity are characteristics that are shared with zeolites.

5 omonas chlororaphis phage 201phi2-1 assembled a compartment that separated viral DNA from the cytoplasm.

6 e identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-ex

7 at P15 despite the profound vestibular functional deficits that persist with treatment at this later time.

8 r4(-/-) mice, and human immune cell culture, we demonstrate that hRetn binds the LPS receptor Toll-like receptor 4 (TLR4)

9 We demonstrate that the Co(III)2(IV)2 cubane may be electrochemically genera

10 oma are classified according to the line of differentiation that these neoplastic cells most closely resemble: the endoth

11 hagnome Project encompasses a genus-level sequencing effort that represents a new type of model system driven not only by

12 oteomic profiling of over 100 different cytokines, we found that Lipocalin-2 (LCN2) was the most substantially elevated p

13 We found that our paradigm is well tolerated in children as young as 6

14 We found little support for the alternative hypothesis that forest loss is most detrimental in already fragmented la

15 Therefore, we hypothesized that certain PCSK9 genetic variants may modify the associatio

16 isordered proteins, resulting in a predominant form of iC3b that features high structural flexibility.

17 Our findings indicate that HIV infection and replication rely on a limited set of h

18 However, the transcriptional mechanisms that specify human microglia phenotypes are largely unknown.

19 letion of follow-up studies, we developed the working model that synaptic plasticity in the nucleus accumbens is central

20 will require a mechanistic understanding of the trade-offs that determine trait diversity.

21 fic activation of Smad3 has contrasting functional outcomes that may involve activation of an integrin/reactive oxygen ax

22 Here a closed-loop cavitation controlling paradigm that sustains stable cavitation while suppressing inertial ca

23 on climate change - a quintessential intertemporal problem that implicates inequities and extrinsic mortality risk - doc

24 tal observations and DFT calculations, evidence is provided that these Mn(IV) species comproportionate with a Mn(II) prec

25 Here, we report that mammalian RNase H1 enriches in nucleoli and co-localizes

26 Here, we report that super-enhancers drive the biogenesis of master miRNAs cr

27 We previously reported that HCA2 in A431 epithelial cells transduced Gbetagamma-prot

28 This model offers a depiction of concomitant resistance that provides an improved theoretical basis for tumor growth

29 followed by inhibitor and antibody-blocking assays revealed that the arthropod HSP70-like molecule contributes to differe

30 transplantation assays using Zfp521-deficient mice revealed that ZFP521 regulates HSC self-renewal and differentiation.

31 ticipants based on global gene expression profiles revealed that participants with significantly higher serum vitamin D3

32 The structure of a QuiC1 enzyme from P. putida reveals that the protein is a fusion of two distinct modules: an N-te

33 Here we show that mice with an adipose-tissue-specific knockout of the mic

34 Using the Xenopus system, we show that RARbeta2 plays a specific role in somite number and size

35 Here, we show that Tomt/Comt2, the murine ortholog of LRTOMT, has an unexpe

36 s obtained from simulated and real genotype datasets showed that the ELS algorithm was able to accurately estimate freque

37 Results showed that deficiency of the Tgr5 gene in mice alleviated fasting-i

38 rescence microscopy and cryo-electron tomography, we showed that Pseudomonas chlororaphis phage 201phi2-1 assembled a com

39 Interestingly, siRNAs that selectively reduced CSLC only were found to target genes

40 the neural circuit supporting the trace-trained memory, so that it better reflects the circuit supporting delay fear.

41 emagglutinin, revealing distinct features and specificities that can aid in global surveillance of such viruses for poten

42 rm of ARGs under Finnish limited antibiotic use and suggest that such practices could help reduce the load of antibiotic-

43 rely on a limited set of host-dispensable genes and suggest that these pathways can be studied for therapeutic interventi

44 Collectively, these findings suggest that the combined treatment of curcumin and essential turmeri

45 product lactate or antioxidant N-acetylcysteine, suggesting that Y10 phosphorylation-mediated LDHA activity promotes canc

46 Our data suggests that RARgamma initiates the formation of death signaling comp

47 ked in open and closed states, respectively, which suggests that their actions are mediated mainly by modulation of KCNQ1

48 ighly disordered CUB, which has acquired a state similar to that of intrinsically disordered proteins, resulting in a pre

49 animal models and provide extensive, step-by-step tutorials that demonstrate how to fit such models in a variety of softw

50 paradigm is well tolerated in children as young as 6 years, that children show intact fear and extinction learning, and s