ライフサイエンスコーパス: the ability of @1 to

1 perturb the protein under investigation, and the ability of nitriles to accept hydrogen bonds, which

2 The ability of antibodies to accumulate affinity-enhanci

3 ith RHAU helicase activity have demonstrated the ability of BC200 to act as an acceptor of unwound qu

4 matched CD4(+) T cells to diligently assess the ability of MCs to act as antigen-presenting cells.

5 The effect is explained by the ability of MTERF1 to act as a directional contraheli

6 These findings indicate that the ability of sloughing to act as an effective immune d

7 ectopic expression of mutant alleles support the ability of AKT to activate HSF1 and demonstrate cont

8 delivery via both itineraries and determines the ability of beta2AR to activate its cognate G protein

9 The ability of BNN27 to activate the TrkA receptor and r

10 Crumbs promotes the ability of Expanded to activate the pathway but also

11 Blocking NMDAR activity inhibited the ability of leptin to activate AMPK, induce KATP and

12 We find that the DCB/HUS domain amplifies the ability of Sec7 to activate Arf1 on the membrane sur

13 We also tested the ability of NDs to adsorb and modulate the release of

14 Altogether, the ability of AhAI to affect the growth of C. chinensis

15 Thus, the ability of 1C8 to alter the SRSF10-dependent splicin

16 upted the pTRS1 interaction with PKR ablated the ability of pTRS1 to antagonize PKR activation by dsR

17 the teachers, led to a large improvement in the ability of children to assess claims about the effec

18 hoices podcast led to a large improvement in the ability of parents to assess claims about the effect

19 The Health Choices Programme to help improve the ability of people to assess claims about the benefit

20 gs reveal that modification of Y192 inhibits the ability of CD45 to associate with Lck in cells and d

21 Strigolactones (SLs) influence the ability of legumes to associate with nitrogen-fixing

22 ation of both xCT and GLT-1 are essential to the ability of ceftriaxone to attenuate cue-induced rein

23 Based on the ability of Cg to attenuate Eya-So transcriptional ou

24 The ability of LAP to attenuate autoimmunity likely occu

25 osteocytic Rankl/Opg (TNFRSF11B) ratio, and the ability of osteocytes to attract osteoclast precurso

26 o drug-sensitive parent cells, demonstrating the ability of MEAN to be effective in cells resistant t

27 nding shows the important connection between the abilities of p33 to bind to sterol and to support TB

28 r arginine with alanine completely abrogated the ability of CouR to bind DNA.

29 ed by sequencing indicates that ERG inhibits the ability of ERF to bind DNA at consensus ETS sites bo

30 P associated IRF6 missense mutations disrupt the ability of IRF6 to bind the NME proteins and result

31 In summary, we demonstrate that the ability of Lon to bind DNA is determined by its ATPa

32 We also show that the ability of LSH to bind ATP and the cellular concentr

33 The ability of Pdc to bind to Gtbetagamma is inhibited t

34 This requires the ability of Protrudin to bind PtdIns3P.

35 ed peptide (TRTRVSRLY) significantly reduced the ability of RRV to bind and infect cells.

36 We rationalize these findings by the ability of calcium to block a highly specific intera

37 cer aggressiveness, and we have investigated the ability of Chrdl1 to block BMP-induced increases in

38 disruptive peptide selectively counteracted the ability of galanin to block the dendritic dopamine r

39 se; therefore, we tested the hypothesis that the ability of ATP to blunt alpha1 -adrenergic vasoconst

40 sis, and Na(+) /K(+) -ATPase would not alter the ability of ATP to blunt alpha1 -adrenergic vasoconst

41 deletion of LMP2A alone has little effect on the ability of EBV to cause lymphomas but delays tumor o

42 Due to the ability of HSV to cause a persistent, lifelong infec

43 of the oocyst wall to digestive enzymes and the ability of oocysts to cause parenteral infections, t

44 coding in the core during training predicted the ability of rats to change behavior after the reward

45 e expression during infection is critical to the ability of pathogens to circumvent the immune respon

46 It also highlights the ability of NGS to clarify molecular microevolutionar

47 elated surface proteins, which contribute to the ability of streptococci to colonize and cause diseas

48 ckout of plin6 in zebrafish severely impairs the ability of CD to concentrate carotenoids and prevent

49 sin-II activity in the actin cortex controls the ability of cells to contract and bleb during a varie

50 rts BAK into peroxisome membranes, revealing the ability of BAK to control peroxisome membrane integr

51 The ability of C1INH to control the inflammatory process

52 ptidase 4 (hDPP4) receptor and then analyzed the ability of mice to control MERS-CoV infection.

53 cterized mutations that specifically improve the ability of SecB to control our model TA system witho

54 The ability of EBV to convert human B cells into long-li

55 luoroaryl-cysteine SNAr chemistry to improve the ability of peptides to cross the blood-brain barrier

56 d genetic deletion of the receptor abrogates the ability of GDF15 to decrease food intake and body we

57 f the mechanotransductive pathways abrogated the ability of CAFs to deform the matrix and suppressed

58 med that vibrato-like F0 modulation improves the ability of listeners to detect differences in the fo

59 emerging imaging technique that can enhance the ability of surgeons to detect tumors when compared w

60 upling between adjacent graphene layers, and the ability of reactants to diffuse into the disordered

61 e imaging analysis further demonstrated that the ability of Smy1 to directly control Bnr1 activity is

62 The ability of TrxR1 to directly reduce an oxidized phos

63 Here we argue that the ability of evolution to discover such regularities i

64 This work validates the ability of IDUP to discover ligands for proteins of

65 ns or ablation of Cx36 significantly reduces the ability of mice to discriminate large, global object

66 isode psychosis (FEP) patients, we estimated the ability of PRSs to discriminate case-control status

67 s provide a direct molecular explanation for the ability of EGCG to disrupt P. aeruginosa QS and modi

68 rovide evidence that sialic acid can enhance the ability of pneumococci to disseminate into the CNS a

69 Therefore, we assessed the ability of Salmonella to disseminate to the central

70 hy (DR), but there is limited information on the ability of OCTA to distinguish eyes with DR.

71 The ability of fishers to diversify has become increasin

72 Functional experiments based on the ability of Klotho to down-regulate TRPC6 channel act

73 hat disrupt interaction with HCF-1 attenuate the ability of MYC to drive tumorigenesis in mice.

74 acellular matrix stiffness, whilst observing the ability of PSCs to durotactically respond to stiffne

75 Consistent with the ability of biocrystals to elastically deform, the in

76 The ability of DMP to elevate GSH levels and attenuate L

77 tion [R-E] training) can attenuate/eradicate the ability of cues to elicit learned behaviors.

78 acillus casei CECT 475) in order to evaluate the ability of SPC to encapsulate and protect bacteria f

79 cortex is a brain region believed to support the ability of animals to engage in complex behavior.

80 ells with full-length CaM slightly increased the ability of estrogen to enhance transcriptional activ

81 modern crop cultivars that may have affected the ability of plants to establish beneficial associatio

82 onths after the clearance of viremia suggest the ability of ZIKV to establish persistent infection in

83 ss and virulence potential, thus influencing the ability of pathogens to evolve in the context of nos

84 Intratumor genetic heterogeneity underlies the ability of tumors to evolve and adapt to different e

85 The ability of RVFV to expand geographically outside sub

86 The effect of this stacking on the ability of hPolbeta to extend from 8-oxoG during lon

87 crucial event in Earth's history, increasing the ability of plants to extract water, mine for nutrien

88 restingly, RUVBL1 methylation did not affect the ability of TIP60 to facilitate ATM activation.

89 Therefore, it is imperative to determine the ability of strains to faithfully propagate their str

90 hanges in aggregation kinetics and influence the ability of Abeta to form immunologically and morphol

91 le is known about the mechanisms controlling the ability of chondrocytes to form columns.

92 The ability of CRFRs to form heteromeric complexes in as

93 int inflammation in vivo and greatly impairs the ability of neutrophils to form neutrophil extracellu

94 These distinct effects are due to the ability of ORAI2 to form heteromeric channels with O

95 rated approach has been applied to determine the ability of p17 to form soluble amyloidogenic assembl

96 n HIV-1-seropositive patients, which engages the ability of p17 to form soluble toxic assemblies.

97 Screen proximity assay was used to determine the ability of PROTACs to form the ternary ligase-PROTAC

98 longer depends on fiber orientation; however the ability of protrusions to form closely spaced adhesi

99 rable binding characteristics resulting from the ability of RNA to form stable tertiary folds aided b

100 The ability of ubiquitin to function in a wide range of

101 Biological quorum sensing refers to the ability of cells to gauge their population density a

102 The ability of IVIg to generate pure populations of high

103 ing pathway in cMaSCs significantly improves the ability of cMaSCs to grow as mammospheres and, impor

104 ort of 100%, this can have a major impact on the ability of antibodies to halt viral replication.

105 portions of glycoside hydrolases, indicating the ability of MGIIa_P to hydrolyse glycosidic bonds in

106 We tested the ability of REPTILE to identify enhancers previously

107 The ability of cells to impart forces and deformations o

108 The ability of automakers to improve the fuel economy of

109 ed by the RNase activity of omega1; however, the ability of omega1 to improve metabolic status is rel

110 ter transparency and incident sunlight alter the ability of UV to inactivate waterborne pathogens.

111 that knockdown of ATF4 expression suppressed the ability of CDCA to increase FGF21 gene expression.

112 on of independent test populations confirmed the ability of CompEx to increase event frequencies, pre

113 Finally, the ability of DMP to increase GSH via GCL activation wa

114 However, the ability of FUS3 to increase TAG biosynthesis in othe

115 hepatocytes or mouse livers in vivo reduces the ability of insulin to increase SREBP-1c mRNA.

116 Moreover, the ability of ARF to induce p53-independent tumor growt

117 N1 phosphorylation sites on RBOHD eliminates the ability of ATP to induce stomatal closure.

118 nt of this occupational lung disease through the ability of Be to induce posttranslational modificati

119 tion of either HIF1alpha or TWIST1 inhibited the ability of CPEB2B to induce the acquisition of anoik

120 r LMP1 nor LMP2A is absolutely essential for the ability of EBV to induce B cell lymphomas in the cor

121 e antidepressant action of ECT and implicate the ability of ECS to induce dendritic arborization of d

122 rus uptake by monocytes and lymphocytes, and the ability of HRVs to induce the activation of in vitro

123 ese, only Bim protein levels correlated with the ability of immunotoxins to induce an apoptotic respo

124 STEAP1/4 knockdown also reduced the ability of keratinocytes to induce neutrophil chemot

125 IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1b

126 Gbetagamma-interacting domain of DAT blocked the ability of mSIRK to induce DA efflux, consistent wit

127 In rats, Ro 61-8048 reduced the ability of nicotine to induce dopamine release in th

128 The ability of plasminogen to induce matriptase zymogen

129 xidative stress in host cells by determining the ability of PQS to induce the production of reactive

130 ckout of the gene encoding PLCzeta abolishes the ability of sperm to induce Ca(2+) oscillations in eg

131 complications, hemorrhage, and shock due to the ability of DENV to infect a variety of immune and no

132 The ability of Micromonospora to infect and colonize dif

133 we summarize recent studies that demonstrate the ability of ILCs to influence tissue and systemic met

134 ally, we provide initial evidence supporting the ability of Pfn to influence MKL and SRF expression.

135 LHb lesions also disrupted the ability of animals to inhibit previously encoded sti

136 of Sporozoite Invasion (ISI) assay to assess the ability of antibodies to inhibit sporozoite infectio

137 t the dopamine transporter (DAT) to increase the ability of cocaine to inhibit its function, an effec

138 These findings indicate that the ability of EGCG to inhibit myeloperoxidase activity

139 The ability of MGP to inhibit calcification requires the

140 anism of action at least partially relies on the ability of pCQ to inhibit cell migration mediated by

141 The ability of raffinose to inhibit P. aeruginosa biofil

142 mpacting SOD1 catalytic activity, suppressed the ability of SOD1 to inhibit mitochondrial metabolism

143 by four specific protein substructures; (ii) the ability of PITPalpha to initiate closure around the

144 hat Ca(2+) does not affect ABD1 but inhibits the ability of ABD2 to interact with actin.

145 vity of AMV but not of CMV, correlating with the ability of atALKBH9B to interact (or not) with their

146 Mobilization into foci depends on the ability of ATRX to interact with H3K9me3 histone and

147 hese findings, we propose that DnaC controls the ability of DnaB to interact with primase by modifyin

148 eraction of the beta clamp with Hda controls the ability of Hda to interact with DnaA.

149 nucleic acids (PNA)-based approach to block the ability of HOTAIR to interact with EZH2 and subseque

150 We propose that the ability of IQGAP1 to interact with RHO proteins is b

151 Instead, it depended on the ability of SLAMF7 to interact with integrin Mac-1 an

152 The ability of SmgGDS to interact with UBF and localize

153 from an environmental Bd reservoir increased the ability of Bd to invade an amphibian population and

154 First, we determined the ability of platelets to kill S. aureus directly; and

155 es IDOL-mediated degradation of the LDLR and the ability of IDOL to limit LDL uptake into cells.

156 ly found in fALS exomes, specifically affect the ability of SFPQ to localize in axons.

157 we tested whether the L138P mutation affects the ability of VP1 to localize to viroplasms, which are

158 The ability of CRY to maintain high input resistance in

159 ndrial Ca(2+) uniporter activity compromises the ability of mitochondria to maintain distinct Ca(2+)

160 s to derive effective dispersal distance and the ability of SNPs to make inferences from single indiv

161 h that RTF2 removal is a key determinant for the ability of cells to manage replication stress and ma

162 The ability of metasurfaces to manipulate light at the s

163 r the C-terminal subdomain, which determines the ability of MapZ to mark the division site.

164 The ability of patients to measure their own intraocular

165 ignificance of incomplete neutralization for the ability of bnAbs to mediate protective effects in vi

166 The ability of MukB to mediate DNA catenation underscore

167 We hypothesised that the ability of p17 to misfold may result in the generati

168 The ability of MD to modify neurons within the visual sy

169 synaptic transmission.SIGNIFICANCE STATEMENT The ability of neurons to modify their synaptic connecti

170 Considering the ability of CD31 to modulate the TCR's activation thr

171 Our observation that the ability of dexamethasone to modulate gene expression

172 R1 using siRNA decreased VEGFA and prevented the ability of E2 to modulate its expression.

173 protein to the CovRS system that influences the ability of GAS to modulate gene expression in respon

174 tween DRD2 pre-mRNA and ZRANB2 and abolished the ability of ZRANB2 to modulate short:long isoform-exp

175 The ability of lysosomes to move within the cytoplasm is

176 We show that the ability of MOR to oppose LTP is rapidly impaired by

177 Finally, the ability of ICM to perturb iodide uptake in the thyro

178 We show that CKS proteins greatly enhance the ability of Cdk2 to phosphorylate the key replication

179 ch changes in tau levels are associated with the ability of RanBP9 to physically interact with tau an

180 Mating depends on the ability of cells to polarize up pheromone gradients,

181 d the IL-4-dependent expression of Cox-1 and the ability of macrophages to polarize to M2.

182 e amount of time we spend indoors (~90%) and the ability of buildings to positively or negatively inf

183 l ion-dependent adhesion site motif impaired the ability of VWA to potentiate TMEM16A activity, sugge

184 However, the ability of ICP to predict a fatal outcome remained r

185 The ability of MMc to predict malaria outcomes during ea

186 trains, and vaccine effectiveness depends on the ability of scientists to predict nearly a year in ad

187 Thus, the ability of TE2 to prematurely release fatty acids fr

188 ive importance of both proteins in mediating the ability of ceftriaxone to prevent cue-induced reinst

189 del to predict mutations that should enhance the ability of Cpx to prevent full assembly of the SNARE

190 In the current study, the ability of nanomaterials to prevent drug incompatibi

191 As a proof-of-concept, the ability of niosomes to prevent physical and chemical

192 The ability of pharmacotherapies to prevent relapse and

193 hose from two fluid-invasion methods, due to the ability of neutrons to probe pore spaces inaccessibl

194 Here we show that the ability of Cpf1 to process its own CRISPR RNA (crRNA

195 second pair of jaws in the pharynx, enhances the ability of fishes to process hard and tough prey.

196 RLC) phosphorylation has been shown to alter the ability of muscle to produce force and power during

197 The ability of cells to proliferate, differentiate, tran

198 a1 has a similar cross-suppressive effect on the ability of alpha3beta1 to promote basement membrane

199 Together, these data show that the ability of BCAR3 to promote adhesion disassembly, tu

200 g the chronological age-based differences in the ability of CPCs to promote myocardial recovery via t

201 This surface is important for the ability of ELL2 to promote HIV-1 Tat-mediated provir

202 rge clostridial toxins and have demonstrated the ability of PepB2 to promote cell association and ent

203 pression of Mal activity partially abrogated the ability of pico to promote invasion of Ras(V12) tumo

204 We find that the ability of Sae2 to promote MRX nuclease functions is

205 uctures for the upstream cells that optimize the ability of information to propagate through noisy, n

206 udy, we determined that the mutation reduces the ability of VP1 to properly localize within infected

207 HSV-1 pathogenesis and ocular pathology, yet the ability of Ab to protect against HSV-1 is deemed lim

208 over, knocking down of p21(Waf1/Cip1) blocks the ability of Foxp1 to protect neurons from mut-Htt-ind

209 enomic draft, in which strong linkage limits the ability of selection to purge deleterious mutations.

210 We show, first, that the ability of workers to quickly assess demand for work

211 the error-rate of the mutants higher due to the ability of Polmu to randomly incorporate nucleotides

212 in receptor signaling.SIGNIFICANCE STATEMENT The ability of neurons to rapidly modify synaptic struct

213 ant role in many biological processes due to the ability of protons to rapidly translocate along chai

214 Although the ability of gammaHV to reactivate from latency and re

215 e present a systematic theoretic analysis of the ability of reserves to rebuild fisheries under such

216 The ability of bacteria to recognize kin provides a mean

217 tion with CCR5, providing an explanation for the ability of CCR5 to recognize diverse ligands and gp1

218 ors, caspase-1 and interleukin-1beta, erases the ability of EpSCs to recollect inflammation.

219 In the brain, learning is achieved through the ability of synapses to reconfigure the strength by w

220 Vps34 inhibition impairs the ability of cells to recover this response after prol

221 Here we find that the BBDS mutations augment the ability of FGFR2 to recruit histone-remodeling facto

222 nd that the absence of GCN2 had no effect on the ability of MR to reduce body weight or adiposity, in

223 We tested the ability of cKL to regulate pathways and phenotypes a

224 VEGFA expression in other tissues; however, the ability of E2 to regulate VEGFA in adipose tissue is

225 f and IL-5 is a key checkpoint that modifies the ability of eosinophils to regulate metabolic outcome

226 ndings provide a mechanistic explanation for the ability of lncRNAs to regulate the expression of num

227 changes in receptor phosphorylation underlie the ability of MDFIC to regulate the transcriptional act

228 lminth infection in mice, and also abrogates the ability of mice to regulate brown fat and maintain c

229 In contrast, the ability of MR to regulate lipogenic and integrated s

230 leukin 10, it did not strongly contribute to the ability of MSKs to regulate IFN-beta expression.

231 The ability of NMDARs to regulate potassium channel surf

232 Given the ability of RGS10 to regulate inflammatory signaling,

233 tively, the present observations reveal that the ability of TAAR1 to regulate cocaine effects is link

234 We investigated the ability of H2S to relieve PYK2-mediated eNOS inhibit

235 The objective of this study was to test the ability of WLBU2 to remove Staphylococcus aureus sur

236 form an interaction network that influences the ability of poxviruses to replicate in human cells.

237 However, the ability of SCVs to resist host defenses is largely u

238 We demonstrate the ability of HILIC to resolve hydrophilic variants of

239 The ability of macrophages to respond to chemoattractant

240 overall functional network connectivity, or the ability of neurons to respond to independent pairs o

241 The ability of pathogens to respond to bile is remarkabl

242 ajor regulator of bone development; however, the ability of PEDF to restore bone mass in a mouse mode

243 e anticoagulant properties of aPC, abolished the ability of aPC to restrict Nlrp3 inflammasome activi

244 Mimicking the ability of Salmonella to reverse multidrug resistanc

245 The latter results from the ability of F12 to reversibly bind to the (pro)cataly

246 To study the ability of Eimeria to secrete foreign antigens or di

247 The ability of podocytes to secrete vesicles containing

248 egulation of Ku in DSB repair and illustrate the ability of p97 to segregate even tightly bound prote

249 The ability of PGE2 to selectively autoamplify its own s

250 Finally, the ability of tBPC to selectively potentiate Y4R agonis

251 Here, we investigate the ability of cells to sense and respond to fiber align

252 The ability of cells to sense and respond to mechanical

253 This is the first report demonstrating the ability of OhrR to sense intracellular organic hydro

254 he surface expression of Env and thus boosts the ability of CD4mc to sensitize HIV-1-infected cells t

255 To assess the ability of NFL to serve as a diagnostic biomarker in

256 The ability of microbes to set the immunological tone of

257 mine face recognition ability (specifically, the ability of animals to show a preference for a novel

258 h to assess the potential impact of sTie2 on the ability of Angpt1 to signal.

259 ore, in the present contribution we describe the ability of 30c to significantly improve the outcome

260 We assessed the ability of immunoFISH to simultaneous quantify prote

261 s skeletal muscle EC coupling, but preserves the ability of STAC3 to slow down inactivation of CaV1.2

262 However, little is known about the ability of prebiotics to specifically modify gut mic

263 required for efficient virus replication and the ability of NS5A to spread throughout the cytoplasm o

264 This deformation eliminates the ability of caveolae to stabilize calcium signals med

265 The ability of ACC to stimulate tyloses formation when c

266 mming resulting from LAL deficiency enhances the ability of ECs to stimulate tumor cell proliferation

267 atment with a PKA-selective agonist mimicked the ability of glucagon to stimulate ATF4 and FGF21 expr

268 ORF2 consistently enhanced the ability of HMGA1 to stimulate beta-catenin-dependent

269 and murine hepatocytes and may contribute to the ability of LPS to stimulate liver pathology.

270 This interaction correlated with the ability of ORF2 to stimulate the coactivator functio

271 These methods preserved the ability of yolkin to stimulate human whole blood cel

272 NCE STATEMENT: Learning and memory depend on the ability of synapses to strengthen in response to act

273 ore fucosylation impacted L1CAM cleavage and the ability of L1CAM to support melanoma invasion.

274 In contrast, the ability of GABABRs to suppress GABA release and indu

275 In accordance with this result, deficits in the ability of GABABRs to suppress glutamate release wer

276 signal and that nuclear localization impairs the ability of ICAP1 to suppress integrin activation.

277 ited impaired hepatic insulin action because the ability of insulin to suppress hepatic glucose produ

278 ic glucose production (hGP) was reduced, but the ability of insulin to suppress lipolysis was unalter

279 heta increases and Dlgh1 silencing decreases the ability of iTregs to suppress interferon-gamma produ

280 rmance is considered a key trait determining the ability of fish to survive.

281 To identify genes that dictate the ability of DAT to sustain normal levels of DA cleara

282 The ability of RbmA to switch between open and closed st

283 The ability of troponin to switch actin monomers "on" an

284 The ability of Anc80L65 to target outer hair cells at hi

285 The ability of simvastatin to target CR3 in its ligand b

286 The ability of cohesin to tether sister chromatids toget

287 ARF inhibits the ability of NRF2 to transcriptionally activate its ta

288 situ enzyme activity evaluation was based on the ability of NKA to transform ATP to ADP and free phos

289 The ability of nanodiscs to trap amyloid intermediates a

290 cus reduces quinolone-induced DNA damage and the ability of tetracyclines to traverse the outer membr

291 cessing of the prohormone in vitro, but also the ability of prosystemin to trigger the systemic wound

292 yl disulfide thorium species and illustrates the ability of 2 to undergo controllable, stoichiometric

293 asmic side of the TM helices correlates with the ability of ASR to undergo large conformational chang

294 We show the ability of PSCs to undergo phenotypic transition sol

295 s unknown how such stresses generally affect the ability of cheats to undermine cooperation.

296 The ability of neurons to up-regulate glycolysis has, ho

297 The ability of rats to use flexible and adaptive decisio

298 d that exposure to MA significantly impaired the ability of rats to use negative outcomes effectively

299 uccessful cancer progression is dependent on the ability of cells to utilize its survival pathways fo

300 Acquired stress tolerance defines the ability of plants to withstand stress following an i