ライフサイエンスコーパス: the affinity of @2 (for|to)

1 Thus, the affinity of D5 for 5-Helix arises from extended inte

2 The affinity of 1 for a (CUG)(4) step provided a K(d) of

3 CDR H3 alterations had little effect on the affinity of 2F5 variants for a peptide corresponding

4 Determining the affinity of a ligand for a given protein is a crucia

5 Wettability is the affinity of a liquid for a solid surface.

6 The affinity of Cy3 for a T.A basepair (with the dye att

7 There was a good correlation between the affinity of nucleolin for a SECIS and its effect on

8 Evaluation of their influence on the affinity of RAB11B to a series of binary interactors

9 and water was used in this study to measure the affinity of surfactants to a hydrophobic phase.

10 Surprisingly, the affinity of the capsule for a series of cationic gue

11 e and occurs without a significant change in the affinity of CoASH for AAC.

12 esence of coenzyme A significantly increases the affinity of the antibiotic for AAC.

13 both monomeric and protofibrillar Abeta, but the affinity of HSA for Abeta monomers is lower than for

14 The affinity of Rpe65 to acidic phospholipids was strong

15 the closely related adult skeletal isoforms, the affinity of ADP for actin.myosin (K(AD)) is the char

16 phosphorylation-dependent marked decrease in the affinity of huM3AMD.ATP for actin and the increase i

17 on, phosphorylation of Rlc1 markedly reduced the affinity of Myo2 for actin.

18 egulatory Ca(2+) sites, similar decreases in the affinity of troponin for actin-tropomyosin regardles

19 ent cellular cytotoxicity and did not change the affinity of the antibody for activating Fcgamma rece

20 ikely regulates PRMT8 activity by decreasing the affinity of the enzyme for AdoMet.

21 tions with microtubules significantly weaken the affinity of kinesin-5 for ADP without altering the a

22 Mechanism 2 describes how the affinity of CD8 for agonist pMHCI changes the requir

23 The affinity of these hosts for alkali metal salts were

24 We determined the affinity of hnRNP A1 for all possible sequence varia

25 The affinity of MetJ for all of the DNA sequences studie

26 We quantified the affinity of Myc-Max to all possible 8-mers and compa

27 The affinity of UvrA for all of the lesion duplexes was

28 For the wild-type isoforms, we found that the affinity of MgADP for alpha-S1 (100 muM) is ~ 4-fold

29 The affinity of SIL23 for alpha-syn and its selectivity

30 hat movement into the expanded state reduces the affinity of prestin for anions.

31 BCR-antigen binding are highly sensitive to the affinity of the BCR for antigen.

32 ing this model, we predicted that increasing the affinity of antibodies to antigens greatly increases

33 Dwell-time analysis showed that the affinity of MAP65-1 for antiparallel overlapping MTs

34 duced in the same location, markedly reduced the affinity of TREM2 for ApoE.

35 We found that cofilin binding reduces both the affinity of actin filaments for Arp2/3 complex and t

36 5 have similar affinities for phosphate, but the affinity of PvPht1;3 for arsenate is much greater.

37 Transfer of As(III) increases the affinity of ArsA for As(III), allowing resistance to

38 Interaction with ArsD increases the affinity of ArsA for As(III), conferring resistance

39 We demonstrate that methylation reduces the affinity of DNA to assemble into nucleosomes, and ca

40 Phosphorylation of JNK1beta1 decreased the affinity of the kinase for ATF2 to 11.0 +/- 1.1 muM

41 The presence of ATP increased the affinity of unphosphorylated JNK1beta1 for ATF2 and

42 The substitutions also drastically reduce the affinity of DnaC for ATP as measured by the binding

43 We show that the accessory proteins modulate the affinity of eIF4A for ATP by interacting simultaneou

44 tekeeper" T790M EGFR mutation that increases the affinity of mutant EGFR for ATP and activation of ME

45 TP(4-) binding; diazoxide markedly increases the affinity of Q1178R for ATP(4-) and ATP(4-) augments

46 finity of kinesin-5 for ADP without altering the affinity of the enzyme for ATP in the absence of ATP

47 of TCTP by that of Bax drastically increases the affinity of this hybrid for Bcl-xL, modifying its bi

48 llular GABA, through GAT1 blockade, enhances the affinity of GABAA receptors for benzodiazepine ligan

49 Thus, phosphorylation weakens the affinity of 4.1R for beta-spectrin.

50 Importantly, the affinity of LA domains for betaGRP2 increases nearly

51 e experiments disclosed a marked decrease in the affinity of Na(+) to bind the channel when the confo

52 nker mutations, however, dramatically change the affinity of AraC for binding to two direct-repeat DN

53 arge side chain of methionine decreases both the affinity of oxygen for binding to the mutant hemoglo

54 er, F1236C and Q399C significantly decreased the affinity of QX-314 for binding to its channel recept

55 either terminal domain has little effect on the affinity of chordin for BMP-4 and BMP-7 but C-termin

56 The affinity of 4E17.2A for BoNT/H was increased >500-fo

57 We therefore measured the affinity of Cu(2+) for both monomeric and fibrillar

58 receptor binding, MC2 significantly enhances the affinity of gD for both receptors.

59 0) has functional consequences, as it alters the affinity of the chaperone for both the monomeric and

60 An additional mutation that reduced the affinity of CPM for C-terminal Arg and increased the

61 llular polyamines inhibited Chk2 and reduced the affinity of HuR for c-Myc mRNA; these effects were c

62 Alternative strategies rely on increasing the affinity of monomeric IgG for C1q by introduction of

63 activation has been often neglected, because the affinity of C5a(desArg) for C5aR has been reported t

64 increases in cAMP cause a rapid decrease in the affinity of MLCK for Ca(2+)/CaM.

65 Thus the enhancement of the affinity of TRESK for calcineurin by the incorporati

66 ne of the nine repeats significantly reduced the affinity of the domains for calcium ions.

67 The affinity of amines for calix[5]arene derivatives 1a.

68 Co-assembly with Sur1 doubled the affinity of Trpm4 for calmodulin and doubled its sen

69 ing mode of CaM to Orai1-CMBDs, and quantify the affinity of Orai1 for CaM.

70 ry, and structural analysis, that decreasing the affinity of CAP for cAMP enhances negative cooperati

71 he SL RNA, although the SL does not increase the affinity of eIF4E/G for capped RNA.

72 at the presence of the CBM1 module increases the affinity of HjLPMO9A for cellulose binding, but does

73 hat the nitration of Tyr(247) would decrease the affinity of PKG-1alpha for cGMP, which we confirmed

74 uring the cell division cycle and found that the affinity of Scc2 for chromatin increases biphasicall

75 The affinity of STAT6 to chromatin is reduced in absence

76 ATPase activity but rather appears to reduce the affinity of the factor to chromatin.

77 The affinity of TiO2 nanoparticles for clay is driven by

78 nt of SRP receptor (SR) selectively enhances the affinity of SRP for correct cargos, thus committing

79 on the actin-binding surface of CP decreased the affinity of CBR for CP.

80 Although the affinity of H(2) for [Cp*Ir(TsDPEN)](+) is orders of

81 hase kinase 3 in vivo activity, strengthened the affinity of Smad3 to CREB-binding protein, suggestin

82 n RAM affects its conformational properties, the affinity of NICD to CSL, and Notch transcriptional a

83 is known about how these mutations influence the affinity of cardiac TnC for cTnI (KC-I) or contracti

84 The affinity of ACCA sensor to cyanide is high, coordina

85 nd-binding pocket are sufficient to increase the affinity of IbpA for D-ribose by 10-fold while compl

86 The affinity of C1 domains to DAG varies considerably am

87 The affinity of BMS-986187 for delta-ORs and kappa-ORs i

88 ariables (vapor pressure, wind speed, and on the affinity of aerosols for depositing to the sea surfa

89 the previously defined AICE motif controlled the affinity of BATF-IRF4 for direct binding to DNA.

90 Emerging evidence reveals that the affinity of M2R for distinct ligands varies in a vol

91 , but only the long-chain acyl-ACPs increase the affinity of FabT for DNA.

92 entified acyl-ACP as a ligand that increased the affinity of FabT for DNA.

93 c DNA contact sequence in p65, thus reducing the affinity of NF-kappaB for DNA by a competitive mecha

94 protein interactions and indirectly increase the affinity of p65 for DNA.

95 The affinity of RSCt for DNA is reduced in the presence

96 We have revealed that the affinity of TraI for DNA is negatively correlated wi

97 The active transition metals reduced the affinity of DAT for dopamine.

98 It does so by increasing the affinity of sqADAR2 for dsRNA by 30- or 100-fold in

99 t the high activity is due to an increase in the affinity of the enzyme for dsRNA.

100 AA can bind to E(cat) and E(allo), but the affinity of AA for E(allo) is 25 times that for E(ca

101 particular many experiments fail to measure the affinity of the reactants for each other.

102 oncentrations of Mg2(+) considerably enhance the affinity of dIBS1 for EBS1.

103 igand, and the p.Tyr129Phe variant increases the affinity of the receptor for EDN3, its non-preferred

104 On the other hand, the affinity of the ribosome for EF-G*GTP is increased w

105 The affinity of human 5MP1 to eIF2beta was measured as b

106 BLM increases the affinity of EXO1 for ends, and MRN recruits and enha

107 quantify independently three parameters: (a) the affinity of ligand binding to ER, (b) the affinity o

108 The affinity of isoflavones to ERs was evaluated by mole

109 pendent inactivation of Kir1.1 by decreasing the affinity of the channel for external K independently

110 , suggesting that H2S may act via increasing the affinity of the channel for extracellular Zn(2+) bin

111 F-actin, beta-catenin significantly weakens the affinity of alpha-catenin for F-actin.

112 Because glycosylation alters the affinity of antibodies for Fc receptors, evidence su

113 The affinity of antibody binding to FcgammaRIIIa was als

114 ucosylation of Fc variants further increases the affinity of Fc to FcgammaRIIIA, leading to much high

115 face plasmon resonance was used to determine the affinity of Bbp for Fg.

116 tion, inside-out signaling pathways increase the affinity of alphaIIbbeta3 for fibrinogen and other l

117 raction between ESCRT-II and Vps20 decreases the affinity of ESCRT-II for flat lipid bilayers.

118 r full-length PrP and fragments to determine the affinity of Cu2+ for four different binding modes, w

119 ajority of the risk-associated SNPs modulate the affinity of chromatin for FOXA1 at distal regulatory

120 and fV(DeltaB9/Q3) (0.7 nM) were similar to the affinity of fVa(WT) for fXa (0.3 nM).

121 We also find that the affinity of GluRS for glutamate is significantly inc

122 activation of LPL by ANGPTL4 greatly reduces the affinity of LPL for GPIHBP1.

123 esonance studies were performed to determine the affinity of GIRLRG peptide to GRP78 protein.

124 Notably, EF-Ts attenuates the affinity of EF-Tu for GTP and destabilizes ternary c

125 The affinity of EFL1 for GTP is 10-fold lower than that

126 stabilize the MCM-MeaB complex or influence the affinity of MeaB for GTP but is required for transdu

127 ver, point mutants that increase or decrease the affinity of RhoGDI2 for GTPases abolished its abilit

128 dicate that inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resul

129 uring photorespiration is very high, whereas the affinity of CAT for H2O2 (measured Km approximately

130 Moreover, a single VLD94N mutation improves the affinity of 3I14 to H5 by nearly 10-fold.

131 (3) Although the affinity of the intermediate for hemin (K(d) approxi

132 Our biochemical data also indicate that the affinity of E2 for heparin is influenced by pH: at p

133 moieties of HIP-CoA, dramatically decreased the affinity of KstR2(Mtb) for HIP-CoA but not for its o

134 used in vitro-directed evolution to increase the affinity of human CD4 for HLA-DR1.

135 The affinity of FGF2 for HS with reduced 6-O-sulfation i

136 The affinity of anthocyanins for human serum albumin (HS

137 We show that, although the affinity of NIS for I(-) is low (Kd=224 muM), it inc

138 t TbbTIM results in an ~100-fold decrease in the affinity of TbbTIM for I(3-) at pH < 6 and an ~2 pK

139 The affinity of wildtype TbbTIM for I(3-) increases 20,0

140 of beta2-syntrophin allosterically regulates the affinity of beta2S-PDZ for ICA512, and the disruptio

141 The affinity of the integrin for ICAMs is only partially

142 this interface contributes significantly to the affinity of IFN-beta for IFNAR1, its ability to acti

143 olyubiquitin drives NEMO activity, enhancing the affinity of NEMO for IKKbeta and the kinase substrat

144 IL-15Ralpha substantially increased the affinity of IL-15 for IL-2Rbeta, and this allostery

145 The molecular basis of the affinity of 627-NLS for importins remained unclear f

146 n a host of organisms has been inferred from the affinity of the enzyme for isoaspartyl residues in a

147 (s) of a bound ligand can help in optimizing the affinity of a molecule for its receptor.

148 Third, citrate-Mg(2+) lowers the affinity of AcnR for its target DNA in vitro.

149 alphaTAT1 within the lumen is controlled by the affinity of alphaTAT1 for its acetylation sites, due

150 he apparent Vmax of AtFAAH but did not alter the affinity of AtFAAH for its NAE substrates.

151 The affinity of C60 for its crystal-binding site is esti

152 than 1 million-fold in some assays, and yet the affinity of CD4 for its ligand, peptide-major histoc

153 's two functions is predominant, we measured the affinity of H for its ligands by a solid-phase bindi

154 inhibitor of IL-1beta activity that reduces the affinity of IL-1beta for its signaling receptor and

155 Small molecules that increase the affinity of MIF for its receptor have been recently

156 The affinity of mtHsp70 for its protein clients and its

157 l binding to RBP, yet paradoxically increase the affinity of RBP for its cell surface receptor, STRA6

158 ns explain why ssDNA binding to SSB enhances the affinity of SSB for its partner proteins and suggest

159 he transport capacity for ascorbate, but not the affinity of SVCT-2 for its substrate.

160 esis are approximately 5 times faster, while the affinity of the enzyme for its DNA and dNTP substrat

161 no correlation between disease severity and the affinity of the enzyme for its substrates (K(m)).

162 t DnaJ promotes KplE1 excision by increasing the affinity of TorI for its site-specific recombination

163 ation, R468C, which has been shown to affect the affinity of KaiB for KaiC and lengthen the period in

164 Specifically, S329 phosphorylation reduces the affinity of p50 for kappaB-sites that have a cytosin

165 To improve the affinity of TLM for KasA, a series of TLM analogs ha

166 v1.6 heterodimers than kappaM-RIIIK, whereas the affinity of kappaM-RIIIK to Kv1.2-Kv1.7 heterodimeri

167 utward currents in native tissues, we tested the affinity of HpTx2 for Kv4.3 coexpressed with KChIP2b

168 grins to the actin cytoskeleton and regulate the affinity of integrins for ligands.

169 We provide new insights into the affinity of alpha-Syn for lipid packing defects foun

170 half-maximal regulatory activity (T(50)) and the affinity of the receptor for lysine (K(d)), as well

171 We demonstrate that attenuating the affinity of p31(Comet) for Mad2 by phosphorylation p

172 ferring only a less than twofold increase in the affinity of its hemagglutinin for mammalian receptor

173 that the K218/221Q mutation greatly reduces the affinity of p65 for many promoters and that the K37Q

174 DDK phosphorylation of human Mcm2 decreases the affinity of Mcm5 for Mcm2, suggesting a potential me

175 The affinity of these compounds for MDM2 was improved th

176 Around these thresholds, the affinity of toxins for membrane cholesterol varies b

177 It was previously suggested that the affinity of Rpe65 for membranes is due to palmitoyla

178 ional PKC signaling can be tuned by altering the affinity of this module for membranes.

179 The affinity of TolC to MFPs decreases in the order MacA

180 Surprisingly, the affinity of LIG3 for Mg(2+) was ten times weaker tha

181 it one to two orders of magnitude lower than the affinity of CD8 for MHC-I.

182 We determined the affinity of the CPC for microtubules and demonstrate

183 The affinity of Cu(2+) for monomeric Abeta is highly dis

184 Likewise, the affinity of derm A594 for MORs expressed in mouse em

185 In vitro assessment of the affinity of drug candidates for multidrug resistance

186 orylates N-WASp on Y256, modestly increasing the affinity of Arg for N-WASp, an interaction that does

187 the possibility of using bicelles to measure the affinity of biomolecules for negatively or positivel

188 We have also demonstrated that the affinity of Rh.dTTP for occupancy of the B metal ion

189 %, it is significantly increased by reducing the affinity of STIM1 for Orai1 or by expressing the two

190 However, the affinity of bound SBA for other Tn-PSM molecules dur

191 TonB (residues 33-239) was used to determine the affinity of TonB for outer membrane transporters Btu

192 The affinity of mammalian hemoglobin for oxygen is thoug

193 We also measured the affinity of arrestin-1 for P-Rh* in nanodiscs using

194 e two proteins, which causes them to enhance the affinity of Tat for P-TEFb, a key SEC component, wit

195 We show here that the affinity of binding sites for P22R depends on the te

196 cts of C2alpha-Pb(2+)-membrane interactions: the affinity of C2alpha for Pb(2+) and the association o

197 The affinity of Rad24-RFC for PCNA in the presence of AT

198 The affinity of RFC for PCNA is about an order of magnit

199 o the protein but elicit a minimal change in the affinity of the protein for PEP.

200 Mutating these regions decreased the affinity of RecA to PG and CL in vitro.

201 pyruvate kinase (L-PYK), we have noted that the affinity of the protein for phosphoenolpyruvate (PEP

202 Therefore, the affinity of alpha iteron for pi-bound gamma and not

203 Moreover, the affinity of C2alpha for PIP(2) increases upon progre

204 The affinity of APE1 for Polbeta is higher in the comple

205 Except for Ag-PVP, the affinity of NPs for porous medium, indicated by atta

206 The affinity of HD5 for protein-bound carbohydrates resu

207 mpered by a lack of consensus with regard to the affinity of Cu2+ for PrPC.

208 ng between sites, the total number of sites, the affinity of the sites for Rap1, and over a large con

209 Furthermore, the affinity of binding to rCUG repeats shows incrementa

210 CBD1 determines the affinity of NCX for regulatory Ca(2+), although CBD2

211 ty around the myristoyl group increased both the affinity of GCAP1 for RetGC and maximal activation o

212 Interestingly, the affinity of RF1 for ribosomes programmed with differ

213 EED regulates the affinity of EZH2 for RNA, lending greater specificit

214 at one AT trimer bound to TRAP 11mer reduces the affinity of TRAP for RNA and eliminates TRAP-mediate

215 LGR5 does not contact RNF43 but increases the affinity of RSPO1 to RNF43, supporting LGR5 as an en

216 Deletion of P1 CTD, but not P2 CTD reduced the affinity of the pentamer for RTA.

217 binding between SecA and SecB might decrease the affinity of precursor polypeptides for SecB and faci

218 By measuring the affinity of CTCF for selected sites, we show that si

219 s dysregulation of clathrin function reduces the affinity of membranes for sertraline.

220 observed that cytoprotection correlated with the affinity of the compounds for sigma 1 receptors.

221 The affinity of HD5 for simple sugars covalently bound t

222 have been widely considered to be linked to the affinity of S1 for single-stranded RNA and its corre

223 The affinity of Tmod1 to skeletal striated TM (stTM) is

224 The affinity of BambL for small fucosylated glycans is v

225 nds vacuolar quaternary SNARE complexes, and the affinity of Vps33 for SNARE complexes is greater tha

226 Furthermore, the affinity of carbon nanoparticles for specific cell t

227 measurements demonstrated that CPB-1 alters the affinity of FBF for specific RNA sequences, implying

228 individual arm residues dramatically reduced the affinity of GuNikR for specific DNA.

229 K221 interact directly with DNA to increase the affinity of p65 for specific kappaB sites.

230 cally, DSS1 acts as a DNA mimic to attenuate the affinity of RPA for ssDNA.

231 MPPNP or ADP results in a 3-fold increase in the affinity of TraI for ssDNA.

232 The affinity of lipidots for steroid hormone-rich areas

233 and Q144K were chosen because they decreased the affinity of Tmod1 to stTM, making it similar to that

234 fic SIR3 allele, SIR3-D205N, which increases the affinity of Sir proteins to telomeres, suggesting H2

235 , like its mammalian homolog TPP1, increases the affinity of Pot1 for telomeric single-stranded DNA a

236 ding to 4E-T, and this interaction increases the affinity of 4EHP for the cap.

237 In the presence of the PII-receptor PipX, the affinity of ADP to the first binding site S1 strongl

238 l serine residues that drastically increases the affinity of B55alpha for the PP2A A/C dimer and p107

239 r Ca(2+) bowl-mediated activation by Ca(2+), the affinity of Ba(2+) to the Ca(2+) bowl is reduced abo

240 a) the affinity of ligand binding to ER, (b) the affinity of coactivator binding to the ER.ligand com

241 SNARE complex and/or phospholipids increase the affinity of complexin-I for the SNARE complex, hinde

242 We showed that the affinity of cpSRP43 for the binding motif of LHCP (L

243 e presence of cholesterol strongly decreases the affinity of CPZ for the bilayer in terms of both the

244 A 100-fold increase in the affinity of cyanide binding to the enzyme-substrate

245 The affinity of DAAQ for the CB[7] cavity (Keq = 4 x 10(

246 Thus, the affinity of different enhancers for the BATF-IRF4 co

247 and the methyltransferase is comparable with the affinity of DNA for the methyltransferase.

248 eavage on NNRTI resistance is dependent upon the affinity of each NNRTI to the RT and further influen

249 Recruitment of TC also increases the affinity of eIF1 for the 40 S subunit, but this inte

250 has an important indirect role in increasing the affinity of eIF1A for the 40 S subunit.

251 prebinding of MLC1 to the MyoA neck enhanced the affinity of ELC1 for the MyoA neck 7- and 8-fold, re

252 The affinity of Ets1 for the TAZ1 (or CH1) domain of the

253 Ac or core-fucosylation had little effect on the affinity of Fc to the inhibitory Fcgamma receptor, F

254 Mn(2+) increased the affinity of Fur for the mntH promoter by over 50-fol

255 to this allosteric modulatory site increases the affinity of GABA for the agonist recognition site.

256 yzes chain elongation by strongly increasing the affinity of its E2 for the distal acceptor ubiquitin

257 vide information on the active surface area, the affinity of ligands to the NC surface, and the surfa

258 sm, and its murine equivalent S200L, reduced the affinity of Mal for the IFNGR, thereby compromising

259 The affinity of Nd-ZipA for the FtsZ polymer formed with

260 terically: when Na(+) binds to a Na(+) site, the affinity of NIS for the other Na(+) and for I(-) inc

261 The affinity of NTS1-7m for the antagonist SR48692 was a

262 ate oxidation, and these T residues increase the affinity of NusG to the elongation complex.

263 ese data may also explain, at least in part, the affinity of PCNSL cells for the CNS.

264 he OB domain acts as a sensor that regulates the affinity of Pol III to the clamp in the presence of

265 The K63-linked chains increase the affinity of Prp3 for the U5 snRNP component Prp8, th

266 ion of the RSP3361 gene, partly by affecting the affinity of PrrA binding to the PrrA site 2 within t

267 Despite the affinity of Q203 for the bc1 :aa3 complex, the drug

268 f Ser-7 and nearby residues strongly reduced the affinity of rat DAT for the cocaine analog (-)-2beta

269 In the present work, the affinity of recoverin for the negatively charged pho

270 ically cross-linked at the membrane and (ii) the affinity of sticholysin mixtures for the membrane is

271 Thereby, the affinity of such ligands to the protein of interest

272 This complexin interaction reduces the affinity of synaptobrevin-2 for the 1:1 complex, the

273 herefore, it can be difficult to disentangle the affinity of the agonist for the target from its effi

274 an be selective for analytes on the basis of the affinity of the analyte for the polymer.

275 article surface chemistry can also influence the affinity of the ENPs for the biofilm coating as reve

276 Nonetheless, the affinity of the FERM for the appended tail was simil

277 NA)-dependent ATPase (k(cat) 415 s(-1)), and the affinity of the motor for the ssDNA cofactor increas

278 ing drugs of site 2, but rather they enhance the affinity of the site for the drugs.

279 The affinity of these molecules for the CD44 HA binding

280 methylation where the modification increased the affinity of these sequences for the histone octamer.

281 This method is based on the affinity of this complex for the ubiquitin-like (UBL

282 The affinity of TRIM5alpha for the capsid is a major hos

283 l ubiquitin-associated (UBA) domain enhances the affinity of Ubc1 for the APC/C.

284 However, there are few reports about the affinity of molecular chaperones for their unfolded

285 s out of the cycle must be overexpressed and the affinity of these enzymes to their substrates must b

286 d to measure alpha1-adrenoceptor density and the affinity of CUMI-101 for these receptors in human, m

287 alpha1-adrenoceptor density and the affinity of CUMI-101 for these receptors were simila

288 ) are the principal source of differences in the affinity of NS3h binding to these substrates.

289 The affinity of Smo for these binding sites was modulate

290 nor did these mutations significantly affect the affinity of FH19-20 for three glycosaminoglycans, de

291 and 144 cause cardiomyopathy is by changing the affinity of TnT for Tm within the TNT1 region.

292 We define the affinity of CheA for TNP nucleotides and, by competi

293 Instead, this mutation reduces the affinity of tubulin for TOG domains and colchicine,

294 es BDNF-TrkB signaling in rats by increasing the affinity of BDNF for TrkB, which results in higher t

295 Gln-tRNA(Gln) formation, with GatDE reducing the affinity of ND-GluRS for tRNA(Glu) by at least 13-fo

296 Mutations at these residues altered the affinity of the enzyme for ubiquinol.

297 Moreover, the affinity of antigen for unmutated naive B cell recep

298 The affinity of nanoparticles for various surfaces (alph

299 prevented binding to the capsids or reduced the affinity of receptor binding to various degrees.

300 assays with B16F10 melanoma cells determined the affinity of the compounds for VLA-4.