ライフサイエンスコーパス: the apoptotic

1 The apoptotic actions of p53 require its phosphorylation

2 Cultured rat RPTCs were used to confirm the apoptotic activity and regulation of proapoptotic ge

3 following DA virus infection of HeLa cells; the apoptotic activity depends on the presence of the se

4 in activity and Mcl-1 overexpression blocked the apoptotic activity of ABT-737.

5 Our results provide direct evidence that the apoptotic activity of caspase-2 is necessary for del

6 ussed in terms of the possible modulation of the apoptotic activity of cytochrome c by nitric oxide.

7 The apoptotic activity of N-terminal gelsolin fragments

8 This polymorphism affects the apoptotic activity of p53 but the mechanistic basis

9 ession of constitutively active Akt reversed the apoptotic activity of vesamicol.

10 siRNA-mediated attenuation of VAChT reversed the apoptotic activity of vesamicol.

11 emonstrated a role for PI3K/Akt signaling in the apoptotic and EMT responses.

12 Under hypoxia conditions, the apoptotic and growth inhibitory effects of physapube

13 neration were quantified by determination of the apoptotic and proliferation rates.

14 The apoptotic and proliferative responses to acute UV ra

15 cells to unfolded protein stress, enhancing the apoptotic and senescent fates.

16 We now report an in-depth analysis of the apoptotic and survival signals induced by the 3 HexA

17 proteotoxic stress, leading to activation of the apoptotic arm of the unfolded protein response.

18 Our data indicate that Bnip3 regulates the apoptotic balance as an autophagy receptor that indu

19 nt phagocytic uptake and lysosomal fusion of the apoptotic body harboring the bacterium.

20 es antitumor effects that are dependent upon the apoptotic calcium release machinery.

21 ding on the cellular context, Atg7 represses the apoptotic capability of caspase-9, whereas the latte

22 that C3 deficiency accelerated the fusion of the apoptotic cargo with lysosomes.

23 However, the connections between the apoptotic cascade and events leading to extrusion ar

24 sm of caspase-8 activation and initiation of the apoptotic cascade in response to SKI-I, a pan-sphing

25 Therapies that activate the apoptotic cascade may have potential for use in RA;

26 t/GSK3beta prosurvival pathway and activates the apoptotic cascade, as demonstrated in vivo and in vi

27 from mitochondrial translocation, preventing the apoptotic cascade.

28 s the nodal effector protein BAK to initiate the apoptotic cascade.

29 To establish if proteins of the apoptotic cascades [pro-apoptotic: active caspase 3,

30 Thus, the apoptotic caspase cascade functions to render mitoch

31 in the absence of caspase-9, indicating that the apoptotic caspase cascade is not required for platel

32 These studies demonstrate that the apoptotic caspase cascade is required for the effici

33 number of cancer-associated genes, including the apoptotic caspase CASP3.

34 Using this probe, we discover that the apoptotic caspases are O-GlcNAcylated, which we conf

35 Zinc inhibits cysteine proteases, including the apoptotic caspases, leading to the hypothesis that z

36 The apoptotic cell accumulation was partially due to dec

37 l actin ring (EAAR) that is assembled within the apoptotic cell and drives epithelial extrusion.

38 orchestrated morphological rearrangements of the apoptotic cell and its neighbors.

39 extracellular PS-containing vesicles between the apoptotic cell and neighboring cells, which are abse

40 A better understanding of the apoptotic cell clearance process in healthy and dise

41 How the apoptotic cell clearance process is linked to macrop

42 ndicate that Sertad1 is required to initiate the apoptotic cell cycle pathway since its knockdown blo

43 sed tau-phosphorylation, which culminated in the apoptotic cell death of neurons.

44 ed that Drosophila endocycling cells repress the apoptotic cell death response to genotoxic stress.

45 zes the bacterium and delivers it along with the apoptotic cell debris to the lysosomal compartment.

46 externalization of numerous autoantigens on the apoptotic cell surface, including protein determinan

47 ts of the glycolytic pathway are enriched on the apoptotic cell surface.

48 pe mouse serum, through the C3 deposition on the apoptotic cell surface.

49 ose that contractile stress transmitted from the apoptotic cell through E-cadherin adhesions elicits

50 f CNT-2 alters daughter cell size and causes the apoptotic cell to adopt the fate of its sister cell,

51 hat extrusion is driven by the retraction of the apoptotic cell, which, in turn, triggers a transient

52 e have found that dendritic cells expressing the apoptotic cell-recognizing receptor CD300f play a cr

53 ory response beyond the nearest proximity of the apoptotic cell.

54 The apoptotic cells also expose specific "eat-me" signal

55 s, which in turn leads to plaque necrosis if the apoptotic cells are not rapidly cleared.

56 the CNS, and that microglial phagocytosis of the apoptotic cells generated during adult neurogenesis

57 itis, we recently established a link between the apoptotic cells generated during sepsis and inductio

58 DTH is mediated by tolerogenic properties of the apoptotic cells generated during sepsis.

59 ctly fuse with the healthy myoblasts, rather the apoptotic cells induced a contact-dependent signalli

60 occurs in surrounding cells, but also within the apoptotic cells themselves, suggesting a cell-autono

61 ver, during engulfment, the lipid content of the apoptotic cells triggers the lipid-sensing receptor

62 o different doses, and the immunolabeling of the apoptotic cells using quantum dot reporters.

63 Notably, preopsonization of the apoptotic cells with C3 activation fragments rectifi

64 ces an "immunologically silent" clearance of the apoptotic cells.

65 but they are dispensable for cell death and the apoptotic clearance of cells in vivo.

66 Attacking this adaptation may restore the apoptotic consequences of mitotic damage to permit t

67 es two distinct signaling pathways to induce the apoptotic death cascade in TNBC cells and raises the

68 the generation of self-tolerant lymphocytes: the apoptotic death of B and T cells with overt autoreac

69 eovirus serotype 3 (T3) strains results from the apoptotic death of infected neurons.

70 TbetaRII deficiency significantly increased the apoptotic death of retinal neurons during embryonic

71 c release in MK-STYX-depleted cells, placing the apoptotic deficiency at the level of mitochondrial o

72 gic or genetic inactivation of cIAP1 reverts the apoptotic deficit of LAR-RPTP-deficient embryos.

73 u Nick Translation (ISNT) assays reveal that the apoptotic DNA damage observed in the DNA ladder-defi

74 Ras effector and plays an important role in the apoptotic DNA damage response (DDR).

75 The apoptotic effect of 10 microM YC-1 was enhanced by a

76 d PC3 cells, suggesting that FOXO3a mediates the apoptotic effect of 3beta-Adiol-activated ERbeta.

77 There was no significant difference between the apoptotic effect of [6]-shogaol and the effect of M2

78 es delivered to tumour cells in vivo amplify the apoptotic effect of a subsequent treatment of immune

79 ecule inhibitor of Rac activation, increases the apoptotic effect of ABT-737, indicating the Rac/Bcl-

80 ce via polyethylene glycol linkers, increase the apoptotic effect of an immune cytokine on tumour cel

81 sistant cells (HepG2) to become sensitive to the apoptotic effect of fenretinide in a cancer cell-spe

82 f constitutively active TEL-SYK counteracted the apoptotic effect of HSP90 inhibition.

83 at a protective feedback mechanism mitigates the apoptotic effect of IR-induced ceramide generation.

84 Here, we report that miR-23a promotes the apoptotic effect of p53 in cardiomyocytes.

85 a-regulated genes, FOSL1 and BCL2A1, mediate the apoptotic effect of phorbol esters or the chemothera

86 ducins and rituximab significantly increases the apoptotic effect of rituximab.

87 r function in cellular proliferation and for the apoptotic effect of the hRpn13-targeting molecule RA

88 in renal cancer cells Caki-1 and 786-O; and the apoptotic effect of these drugs was markedly enhance

89 id of HIV-infected patients, we investigated the apoptotic effect of Vpr on monocyte-derived macropha

90 through phosphorylation and inactivation of the apoptotic effector BAD and activation of MEK1/2.

91 action of the tumor suppressor p53 activates the apoptotic effector protein BAX to trigger apoptosis.

92 family of proteins, preventing activation of the apoptotic effectors, BAX and BAK, and promoting cell

93 of TTP dramatically sensitized the cells to the apoptotic effects of alpha-tocopherol, whereas reduc

94 nfected monocytes and rescued the cells from the apoptotic effects of Bcl-2 inhibition.

95 s review describes the mechanisms underlying the apoptotic effects of both extracellular and intracel

96 ression of PRKD2 protected cancer cells from the apoptotic effects of HSP90 abrogation, restoring blo

97 plified cancers and synergistically enhances the apoptotic effects of lapatinib.

98 a subset of the hMSC population resistant to the apoptotic effects of parbendazole.

99 is in malignant cells and further heightened the apoptotic effects of radiation.

100 C enhanced cell proliferation and undermined the apoptotic effects of sorafenib and SC-1, whereas STA

101 The apoptotic effects of soy extracts on both LNCaP and

102 est that ouabain can protect the kidney from the apoptotic effects of Stx2.

103 one receptor-positive breast cancer cells to the apoptotic effects of tamoxifen, but has no effect on

104 ARC2 was shown to protect HeLa cells against the apoptotic effects of the base analog, whereas the in

105 ts demonstrate that celastrol can potentiate the apoptotic effects of TRAIL through down-regulation o

106 efect in Ca(2+) signaling was susceptible to the apoptotic effects of type I interferons (IFN-alpha/b

107 PMF also significantly potentiated the apoptotic effects of Velcade and thalidomide in MM c

108 ein/50 muM genistein significantly increased the apoptotic effects on C4-2B cells although they did n

109 ast, depletion of endogenous SF3B1 abrogated the apoptotic effects, but not the G2/M cell cycle arres

110 a nonspecific nuclease family that includes the apoptotic endonuclease EndoG.

111 Analyzing the apoptotic events, it was found that this effect on c

112 sulted in massive apoptosis, upregulation of the apoptotic factor Bax, increased cleaved caspase-3, a

113 cells, and triggers apoptosis by activating the apoptotic factor Bax.

114 Elucidating the apoptotic factors contributing to the survival of CT

115 domain-containing protein TOE-2 in promoting the apoptotic fate in the Q lineage.

116 By contrast, loss of TOE-2 led to loss of the apoptotic fate in the smaller Q.p daughter but did n

117 uPA activity induced by anti-Ro60 binding to the apoptotic fetal cardiocyte provide a molecular basis

118 acetylation is permissive for generation of the apoptotic form of FOXO3 and the activity of SIRT1 an

119 Nonetheless, retention of the apoptotic function appears insufficient for tumor su

120 beta-catenin-induced SGK1 expression reduces the apoptotic function of FoxO3, resulting in increased

121 act independently or in concert to regulate the apoptotic function of FOXO3.

122 osphorylation-dephosphorylation can regulate the apoptotic function of Noxa, this could be a potentia

123 calcium-dependent and requires activation of the apoptotic gene, ced-4 (Apaf-1).

124 her reveal that the expression signatures of the apoptotic genes BCL2, BCL2L1, and BAD significantly

125 sponded to poor cartilage repair outcomes of the apoptotic hMSC transplants.

126 cellular resistance to cisplatin and reverse the apoptotic hyperactivation in HOIP-depleted cells.

127 SNRs decreased significantly over time for the apoptotic implants (SNRs on the day of matrix-associ

128 The apoptotic index in the distal colon was the greatest

129 Simvastatin reduced the apoptotic index in the livers of mice with burn inju

130 Conversely, the apoptotic index increased progressively after NFP an

131 In addition, the apoptotic index was increased in carcinomas from the

132 has patient specific thresholds, reflecting the apoptotic injury load of the donor organ.

133 of this peptide segment in neurons prevented the apoptotic K(+) current enhancement and cell death fo

134 ere we show that this domain is required for the apoptotic K(+) current enhancement.

135 of interferon alpha (IFN-alpha) and express the apoptotic ligand TRAIL (tumor necrosis factor-relate

136 optosis in pancreatic beta cells (genes from the apoptotic machinery and from MAPK and NFkB pathways)

137 ts instead support a model in which, despite the apoptotic machinery being present in axons, the cell

138 the occurrence of cellular defects involving the apoptotic machinery in many cancers has resulted in

139 Precise control over activation of the apoptotic machinery is critical for development, tis

140 Once the apoptotic machinery is engaged, degradation by caspa

141 Chau et al. demonstrate that mTOR regulates the apoptotic machinery through binding to the ChREBP-Ml

142 They provide a rationale for manipulating the apoptotic machinery to improve sensitivity and overc

143 ermatid individualization, is facilitated by the apoptotic machinery, including caspases, but does no

144 tivity of acid sphingomyelinase and activate the apoptotic machinery.

145 osomal activity with subsequent induction of the apoptotic machinery.

146 e phagocytic clearance, or efferocytosis, of the apoptotic macrophages.

147 Expression levels of the apoptotic marker caspase-3 were increased in odontob

148 marker for cell stress, but 85% coexpressed the apoptotic marker cleaved caspase-3.

149 PE serum-induced increases in the apoptotic markers P53 mRNA expression, IKBKE mRNA ex

150 pport for a role of the Lys-ligated cyt c in the apoptotic mechanism.

151 Here we validate the approach using the apoptotic mediator, caspase-8, and the inflammasome

152 lls was sufficient to increase expression of the apoptotic mediators Fas and Bad and to elevate the s

153 R from the initially cytoprotective phase to the apoptotic mode.

154 s also recruited to the junctional cortex at the apoptotic/neighbor cell interface in an E-cadherin-d

155 suggest that Cebpa is a key regulator within the apoptotic network activated in pancreatic beta cells

156 However, the dogma that the apoptotic nuclear morphology depends on DNA fragment

157 rvoviruses, HBoV1 infection did not activate the apoptotic or necroptotic cell death pathway.

158 viruses kill the airway epithelial cells via the apoptotic or necrotic pathway; involvement of the py

159 Moreover, BCDO2 prevented this induction of the apoptotic pathway by carotenoids.

160 and antioxidant levels in cells to activate the apoptotic pathway for cell death.

161 The apoptotic pathway has been shown to be crucial in th

162 S) generation on PDT in MDA-MB 231 cells and the apoptotic pathway of cell death was illustrated usin

163 ctively deficient in components required for the apoptotic pathway of IRF-3.

164 ne depolarization are critically involved in the apoptotic pathway of the pre-diabetic heart.

165 cule allowed spatial and temporal control of the apoptotic pathway specifically in mature, myelin bas

166 s through alpha-MSH mediating suppression of the apoptotic pathway that is post-Caspase 3, but before

167 ine-aspartic proteases) are induced early in the apoptotic pathway, and so we used their induction to

168 These proteins participate in the apoptotic pathway, and the interaction between them

169 signal-regulating kinase 1 and activation of the apoptotic pathway, as evidenced by p38 MAPK and poly

170 nal death was a consequence of activation of the apoptotic pathway, because the cell death was rescue

171 in mitochondria and a critical component of the apoptotic pathway, contains a heme cofactor covalent

172 tochemical cytotoxic modality that activates the apoptotic pathway, reduced ABCG2 expression to incre

173 ds to alterations of specific checkpoints in the apoptotic pathway, which may represent important mol

174 izes the BAX mRNA and concurrently activates the apoptotic pathway.

175 of caspase 3, the final executor protease of the apoptotic pathway.

176 e (TP53) encodes p53, the central protein in the apoptotic pathway.

177 prolonged mitotic arrest partially activates the apoptotic pathway.

178 ion of caspase 3 and PARP1, and execution of the apoptotic pathway.

179 oxidative cell death by acting downstream on the apoptotic pathway.

180 ic translocation revealed the involvement of the apoptotic pathway.

181 ons, which in turn triggers the induction of the apoptotic pathway.

182 The IAPs are key regulators of the apoptotic pathways and are commonly overexpressed in

183 Molecular approaches to reengage the apoptotic pathways in cancer have been underway for

184 and that Bim knockdown functionally rescues the apoptotic phenotype induced upon loss of Bmi-1.

185 The apoptotic phenotype upon CAS depletion could be reca

186 This study provides a global portrait of the apoptotic phosphoproteome, revealing heretofore unre

187 for the observed structural heterogeneity of the apoptotic pore.

188 Proliferation and the apoptotic potential of individual developmental stag

189 To date, it is unclear what determines the apoptotic potential of the cell.

190 as EGFR, AKT and the MAP kinases that reduce the apoptotic potential of this class of drug.

191 The apoptotic potential of TRAIL-R2 on hHSC was confirme

192 onse to caspase-3/-7, which are activated in the apoptotic process and able to cleave the DEVD moieti

193 that TRPM7 channel activity participates in the apoptotic process and is regulated by caspase-depend

194 y, the vast majority of dying cells arrested the apoptotic process and recovered when the inducer was

195 e specific protein changes were essential to the apoptotic process because ABT-737 did not inhibit Mc

196 CL-2 oncoprotein), suggesting involvement of the apoptotic process in the pathophysiology of cell dea

197 n by interacting with JAK2 and by inhibiting the apoptotic process through downregulation of TRAIL.

198 phoma 2 (BCL-2) family are key regulators of the apoptotic process.

199 ing of loss of normal gene expression during the apoptotic process.

200 from mitochondria significantly accelerates the apoptotic process.

201 patients with rectal carcinoma, we analyzed the apoptotic profile for tumor and noncancerous tissue

202 though the molecular mechanisms that execute the apoptotic program are well defined, less is known ab

203 Taken together, our findings highlight the apoptotic program as a determinant of response to BE

204 Essential for execution of the apoptotic program peroxidase activation of cytochrom

205 The apoptotic program switched on by BeAn virus is simil

206 These cells rely on caspase-7 to execute the apoptotic program, yet binding with XIAP constitutiv

207 moprotein into the cytosol and commitment to the apoptotic program.

208 e controls membrane permeability and thereby the apoptotic program.

209 ined activation of both isoforms accelerates the apoptotic program.

210 The apoptotic properties of SAD were determined to be bo

211 The apoptotic protease-activating factor 1 (Apaf-1) cont

212 While expression of the apoptotic protein machinery is nearly absent by adul

213 tified the differentiation marker, CD24, and the apoptotic protein, PAWR, as direct SRC-1/HOXC11 supp

214 kingly, axon-selective degeneration requires the apoptotic proteins Caspase-9 and Caspase-3 but, in c

215 Furthermore, MSCs decreased the apoptotic rate and increased the proliferation rate.

216 nd STAT1 in cell-based assays, and increases the apoptotic rate of cultured NSCLC cells in a STAT3-de

217 s assessed by measuring glial activation and the apoptotic rate.

218 tion and causes increased phosphorylation of the apoptotic regulation protein Bcl-2/Bcl-X(L) antagoni

219 y of birinapant, a small-molecule mimetic of the apoptotic regulator SMAC, against a diverse set of A

220 Overexpression of the apoptotic regulator, X-linked inhibitor of apoptosis

221 nt evidence has shown that it still requires the apoptotic regulators Bax/Bak, which can regulate the

222 egg cylinder forms from a solid cell mass by the apoptotic removal of inner cells that do not contact

223 identify small molecules that could reverse the apoptotic resistance of hypoxic cancer cells.

224 ts feedback control on p53, thereby limiting the apoptotic response and contributing to cellular surv

225 in vivo, in part through the attenuation of the apoptotic response and upregulation of protein trans

226 ctions in the cytoplasm, directly modulating the apoptotic response at the mitochondrial level.

227 These results indicate that the apoptotic response following reovirus infection is m

228 he relative contribution of cell division to the apoptotic response has been hard to discern in vivo.

229 Understanding the adaptive significance of the apoptotic response has the potential to create new a

230 the coordination of cell proliferation with the apoptotic response in development and disease, inclu

231 siRNA knockdown of BIM significantly blunted the apoptotic response in PTEN+ melanoma cells.

232 y BIM, PUMA, and BCL-XL as key regulators of the apoptotic response induced by MEKi/PI3Ki, with decre

233 mechanisms by which viruses are detected and the apoptotic response is initiated, we examined the ant

234 Notably, miR-124 could restore the apoptotic response of cells resistant to enzalutamid

235 monstrate the importance of surface R-CRT in the apoptotic response of cells, implying that post-tran

236 Blockade of Noxa reduced the apoptotic response of embryonal carcinoma (EC) NTERA

237 regulatory RNAs add a layer of complexity to the apoptotic response of ESCs after DNA damage.

238 ve kinase-dead PKCepsilon mutant potentiated the apoptotic response of PMA and sensitized LNCaP cells

239 ing of meiotic cohesin are also deficient in the apoptotic response of the pachytene checkpoint, and

240 2 levels or venetoclax sensitivity predicted the apoptotic response to ABBV-075 treatment.

241 nto endocycles during oogenesis they repress the apoptotic response to DNA damage caused by ionizing

242 The apoptotic response to DNA damage is dampened in spec

243 xtent to which cell proliferation influences the apoptotic response to DNA damage.

244 r myocytes isolated from RGS6(-/-) mice, and the apoptotic response to doxorubicin in ventricular myo

245 nd distinguishing role for BOK in regulating the apoptotic response to ER stress, revealing--to our k

246 ycle modifications are sufficient to repress the apoptotic response to ionizing radiation independent

247 us elucidation of the molecular mechanism of the apoptotic response to mitotic stress could lead to i

248 s suggest that p21 induction does not affect the apoptotic response to nongenotoxic p53 activation.

249 Depletion of p21 did not increase the apoptotic response to nutlin-3a in all seven cancer

250 ely related Zfy1) is sufficient to reinstate the apoptotic response to the X univalent.

251 e show that downregulation of MDC1 increases the apoptotic response to TRAIL.

252 cogenes that promote cell growth and inhibit the apoptotic response to uncontrolled proliferation.

253 154 expression after WNV infection modulates the apoptotic response to WNV and that cellular miRNA ex

254 monstrated significantly delayed kinetics of the apoptotic response when compared with wild type lymp

255 rance to BETi is driven by the robustness of the apoptotic response, and that genetic or pharmacologi

256 HGDH overexpression significantly suppresses the apoptotic response, whereas RNAi-mediated knockdown

257 ha is a substrate and chaperone of DNA-PK in the apoptotic response.

258 l unfolding of the protein is a precursor to the apoptotic response.

259 In this study, we characterized the apoptotic responses in diverse neuroblastomas using

260 The apoptotic responses were accompanied by activation o

261 c-Myc overexpression dramatically stimulates the apoptotic responses.

262 The "apoptotic ring" is characterized by the phosphoryla

263 Recently, we identified the "apoptotic ring," containing phosphorylated histone

264 vestigated whether HSP90alpha is involved in the apoptotic ring.

265 orylated HSP90alpha and DNA-PK colocalize in the apoptotic ring.

266 icating that this difference may result from the apoptotic role of Trp53.

267 n unstimulated A-T lymphocytes was high, and the apoptotic sensitivity of activated naive and central

268 ial inhibition of GSK-3beta and CDK1 augment the apoptotic sensitivity of hypoxic tumors, and they of

269 We defined the apoptotic set point of neuroblastomas using response

270 ndrial potentiation mechanism that amplifies the apoptotic signal as a wave.

271 poptosis, and that oncogenic Notch overcomes the apoptotic signal to reveal an unexpected pro-prolife

272 hat leads to CAS up-regulation and amplifies the apoptotic signal.

273 the same cell can block the transmission of the apoptotic signal.

274 ipin has been proposed as a primary event in the apoptotic signaling cascade.

275 Exogenous IL-10 reversed all the apoptotic signaling changes induced by whole bacteri

276 Here we show that Pla degrades the apoptotic signaling molecule Fas ligand (FasL) to pr

277 hat genetic or pharmacologic manipulation of the apoptotic signaling network can modify the phenotypi

278 PERK, and ATF6) and allows them to activate the apoptotic signaling pathway.

279 e that Puma might be a critical component of the apoptotic signaling pathways that contribute to vent

280 ical deficits, cells staining positively for the apoptotic signature in the TUNEL reaction were found

281 itching from the limit-cycle oscillations to the "apoptotic" steady state is enabled by the existence

282 (baby mouse kidney cells, hematopoietic) nor the apoptotic stimulus employed (UV-C, cisplatin, and gr

283 Here, we reveal striking dynamics in the apoptotic susceptibilities of different cell types i

284 ed nuclear localization of MRTF-A; increased the apoptotic susceptibility of normal and idiopathic pu

285 ring podocyte injury, and in turn increasing the apoptotic susceptibility of podocytes to TGF-beta1.

286 The apoptotic T cells subsequently triggered macrophages

287 ctions with both the engulfing phagocyte and the apoptotic target cell.

288 m induces only minimal cell death, it lowers the apoptotic threshold in a subset of patient-derived g

289 antiapoptotic proteins is shifted closer to the apoptotic threshold in hESCs than in differentiated

290 cur, which are consistent with a lowering of the apoptotic threshold of the cell.

291 ment proximity of tumor cell mitochondria to the apoptotic threshold, a property called mitochondrial

292 NHE1-PI(4,5)P2 interaction, thereby lowering the apoptotic threshold.

293 optotic priming," the proximity of a cell to the apoptotic threshold.

294 -737 in these lines indicating a lowering of the apoptotic threshold.

295 the tumor tissue and increases the ratio of the apoptotic to anti-apoptotic protein expression.

296 w, this is not due to an inability to induce the apoptotic transcriptional program, because we show t

297 This process, which has been termed the apoptotic volume decrease (AVD) in other cell types,

298 efining feature of apoptosis in all cells is the apoptotic volume decrease or AVD, which has been con

299 f the cytotoxic drug gemcitabine, reflecting the apoptotic volume decrease.

300 We analyzed the cellular identity of the apoptotic white matter profiles and determined the m