ライフサイエンスコーパス: the difficulty of *ing

1 on complexity-theoretic assumptions such as the difficulty of factoring.

2 disability was assessed using a scale rating the difficulty of performing 21 activities.

3 isms remain poorly defined, owing largely to the difficulty of accessing 5HT neurons for experimental

4 These issues are compounded by the difficulty of assessing a smaller number of patients

5 '-tetraacetic acid (BAPTA), thereby reducing the difficulty of catching a small transient rise in NAA

6 l and quantitative MMR assays and because of the difficulty of constructing a multiplicity of MMR sub

7 been a long-standing challenge, hindered by the difficulty of cooling a mechanical mode to its quant

8 This could explain the difficulty of detecting a signature for "placebo res

9 Despite the difficulty of determining a biological 'ground truth

10 onses under parameter variation, emphasising the difficulty of finding a "correct" model.

11 abolic attributes of CAM has been limited by the difficulty of identifying a reliable phenotype for m

12 an the other outbreak isolates, highlighting the difficulty of imposing a simple threshold for the nu

13 lar organism Mycobacterium leprae because of the difficulty of obtaining a genomic DNA template from

14 r the use of Treg immunotherapy in humans is the difficulty of obtaining a highly purified preparatio

15 ncluded in this simulation, and can increase the difficulty of obtaining a solution, especially when

16 In view of the difficulty of obtaining a stable DNA-bound IN at hig

17 orophore-labeled polyamides has demonstrated the difficulty of predicting a priori the nuclear uptake

18 ause of the disease itself, and then through the difficulty of pursuing a strict elimination diet.

19 Using these simplifications, the difficulty of specifying a working beta-lactamase do

20 of wild cetaceans can be challenging due to the difficulty of gaining access to conventional diagnos

21 The difficulty of diagnosing active tuberculosis (TB) an

22 This situation may be explained, in part, by the difficulty of expressing active, functional recombin

23 fficiency of homologous recombination and by the difficulty of manipulating adenine and thymine (A+T)

24 or tumors in unfavorable sites is limited by the difficulty of achieving adequate, prompt collecting

25 The results underscore the difficulty of achieving adequately large improvement

26 hemistry suffers poor reversibility owing to the difficulty of oxidizing AlSx .

27 ulated, testing of this has been hindered by the difficulty of quantifying altered E-cadherin binding

28 However, the difficulty of producing an ensemble of statistically

29 on efforts were abandoned largely because of the difficulty of detecting and delineating infestations

30 d largely a theoretical construct because of the difficulty of identifying and manipulating individua

31 rain activity, however, has been hampered by the difficulty of identifying and recording from individ

32 such as phosphorylation, largely because of the difficulty of isolating and identifying peptides der

33 One limitation of these approaches is the difficulty of isolating and sequencing large, orthol

34 ces, such as the Antarctic ice sheet, due to the difficulty of locating and interrogating suitable ar

35 been hindered by its instability in air and the difficulty of preparing and patterning high-quality

36 However, the difficulty of tracking and modeling the arousal stat

37 esses involved in bnAb generation, including the difficulty of quantifying antigen-specific GC Tfh ce

38 inappropriate services is challenging given the difficulty of defining appropriate care for patients

39 fluorescence microscopy has been limited by the difficulty of preparing appropriate calibration stan

40 ous side effects of antifibrotic therapy and the difficulty of diagnosing asymptomatic patients, suit

41 en conducted exclusively in male mice due to the difficulty of initiating attack behavior directed to

42 nnot achieve the best performance because of the difficulty of obtaining best templates, alignments,

43 The findings of this study may help explain the difficulty of inducing beta cell proliferation and m

44 One of the major impediments has been the difficulty of distinguishing between age-dependent a

45 We conclude that the difficulty of selecting between collapsing and fixed

46 The difficulty of deriving binding ligands to targets id

47 These findings suggest that, despite the difficulty of extracting biochemically accurate mode

48 erapies have proven to be elusive because of the difficulty of translating biologically sound and eff

49 rom three aspects of perinatal ontogeny: (i) the difficulty of giving birth to large-headed neonates

50 , but broad application has been hindered by the difficulty of identifying bispecific antibody format

51 gence owing to its enormous search space and the difficulty of evaluating board positions and moves.

52 nging because of viral genetic diversity and the difficulty of generating broadly neutralizing antibo

53 but these attributes simultaneously increase the difficulty of preparing carbohydrate assemblies and

54 diment to synthesizing compounds from CO2 is the difficulty of forming carbon-carbon (C-C) bonds effi

55 d other cellular functions is unknown due to the difficulty of analyzing cell division in vivo.

56 This is due, in part, to the difficulty of using cell surface markers to identify

57 cle to studying this phenomenon in plants is the difficulty of isolating certain types of cells at de

58 tochondrial H2S is uncertain, in part due to the difficulty of assessing changes in its concentration

59 The difficulty of mixing chemically incompatible substan

60 ister chromatid decatenation but, because of the difficulty of observing chromosome catenation, this

61 been demonstrated experimentally because of the difficulty of realizing CNT-encapsulated molecules a

62 breeding systems, and this study illustrates the difficulty of identifying common ecological or demog

63 yte-macrophage differentiation, highlighting the difficulty of defining complex profiles by a limited

64 n of sensorimotor regions (including PrG) or the difficulty of identifying complex neural representat

65 for human complex I, have been precluded by the difficulty of preparing complex I which is pure, mon

66 ical use has been limited, however, owing to the difficulty of synthesizing components, achieving con

67 Our results indicate the difficulty of maintaining control in phenylketonuria

68 c stem cells has many limitations, including the difficulty of generating DA neurons with high yields

69 r a causal relationship is lacking, owing to the difficulty of inducing defined DNA lesions in cells

70 e is lacking, especially for forests, due to the difficulty of manipulating density on a large-enough

71 romoting neural regeneration are hindered by the difficulty of manipulating desired neural fates in t

72 g episode, warfarin is under-used because of the difficulty of controlling dosage and the fear of ind

73 current drugs for MS are very limited due to the difficulty of delivering drugs into the CNS.

74 al navigation in humans have been stymied by the difficulty of recording during free exploration of c

75 ages of hepatocarcinogenesis are hampered by the difficulty of diagnosing early lesions in humans.

76 eps has not been easy to decipher because of the difficulty of distinguishing early noncovalent steps

77 imitation for such applications, however, is the difficulty of achieving electrical pumping, largely

78 gation of morphogen signaling is hampered by the difficulty of disentangling endogenous signaling fro

79 oughput sequencing is challenging because of the difficulty of distinguishing errors from true mutati

80 lasmodium spp., which cause malaria), due to the difficulty of studying essential genes in these orga

81 The use of such a treatment is limited by the difficulty of treating every patient at risk and by

82 ng other vertebrate families and result from the difficulty of studying evolution among closely relat

83 Given the difficulty of testing evolutionary and ecological th

84 se of a lack of accurate physical models and the difficulty of interpreting experimental results.

85 wever, the vast genotype space, coupled with the difficulty of measuring fitness, has hindered the em

86 Guala is right to draw attention to the difficulty of extrapolating from the experimental ev

87 In this text, I discuss the difficulty of going from association to causation in

88 subunit from two distinct halves, overcoming the difficulty of expressing full-length alpha1C in card

89 ne fold-many functions" paradigm illustrates the difficulty of assigning function through a structura

90 However, owing to the difficulty of performing functional recordings from

91 uantifying antigen-specific GC Tfh cells and the difficulty of tracking GC in human and non-human pri

92 Given the difficulty of applying gene knockout technology to s

93 In part, the difficulty of connecting genes to phenotypes reflect

94 t do illustrate general principles regarding the difficulty of connecting genetic variation to common

95 However, due to the difficulty of integrating genomics data sets, the re

96 thiols, however, remains challenging due to the difficulty of monitoring H2S and thiol levels simult

97 problems with genome assembly resulting from the difficulty of distinguishing haplotype variation fro

98 The results highlight the difficulty of characterizing hemilabile, bifunctiona

99 s an experimental system has been limited by the difficulty of deciphering heterozygous genomes and a

100 al metallofullerenes, and nanotubes has been the difficulty of obtaining high purity samples.

101 The difficulty of analyzing higher order RNA structure,

102 However, its application is limited by the difficulty of obtaining homogeneous enzymes and the

103 bstacle to the wider use of this approach is the difficulty of identifying homologous recombination e

104 Because of the difficulty of assessing HR in mammals, little is kno

105 ans has been reduced mainly as a response to the difficulty of developing human pharmacology models i

106 mune system remain poorly understood, due to the difficulty of studying immune development in infants

107 major bottleneck in producing such models is the difficulty of measuring in vivo rate constants for c

108 entifically has posed a challenge because of the difficulty of measuring individual differences in se

109 The difficulty of predicting individual mutation effects

110 rion strains remains unclear, largely due to the difficulty of creating infectious material from pure

111 siology and diagnosis of this enteropathy is the difficulty of obtaining information about the primar

112 ht into TMD integration has been hampered by the difficulty of characterizing intermediates during th

113 g linear chromosomes are not known, owing to the difficulty of demonstrating intertwining of linear D

114 therapies for IR injury may be partly due to the difficulty of adapting IR injury models to high-thro

115 urdle in studying thermal diffusion has been the difficulty of characterizing it.

116 consequences of this single polymorphism is the difficulty of distinguishing its subtle effects from

117 Given the difficulty of infecting laboratory mice with these d

118 This knowledge gap is in part because of the difficulty of acquiring large numbers of samples ame

119 has not been rigorously assessed because of the difficulty of finding large numbers of well-hidden n

120 To circumvent the difficulty of generating large quantities of CD from

121 as never been achieved experimentally due to the difficulty of maintaining large thermal gradients ov

122 here an approach to compression that reduces the difficulty of managing large-scale sequencing data.

123 ucture and function of membrane proteins are the difficulty of producing large quantities of function

124 ge for quantum many-body problems comes from the difficulty of representing large-scale quantum state

125 The difficulty of engineering light-sensitive proteins r

126 milarity among overweight youth may increase the difficulty of promoting long-term changes because th

127 C. elegans are limited by low throughput and the difficulty of performing longitudinal monitoring of

128 e lung by gene therapy is limited in part by the difficulty of transfecting lung cells in vivo.

129 untargeted metabolomic analysis, however, is the difficulty of identifying metabolites.

130 ena remain poorly understood, in part due to the difficulty of measuring microtubule polarity in spin

131 However, due in part to the difficulty of studying molecular genetic effects in

132 ding specificities remains undefined, due to the difficulty of analyzing multiple, potentially redund

133 polygenicity of all of these conditions and the difficulty of connecting multiple levels of molecula

134 escue titers by >/=3 log units, which offset the difficulty of generating multiple recombinants under

135 anding pre-clinical data on immune activity, the difficulty of obtaining multiple clinical tissue sam

136 erformed starting with a single sample given the difficulty of preparing multiple aliquots in known r

137 However, the difficulty of measuring nanometric displacements wit

138 variation in natural populations and expose the difficulty of using neutral markers as surrogates fo

139 A challenge for HIV-1 immunogen design is the difficulty of inducing neutralizing antibodies (NAbs

140 the 3D structures of an entire genome due to the difficulty of handling noisy and inconsistent inter-

141 ntracellular behaviour is unknown because of the difficulty of observing non-fluorescent small molecu

142 imarily on protein-coding variants, owing to the difficulty of interpreting noncoding mutations.

143 genomic information is hindered, in part, by the difficulty of altering nucleotide sequences and expr

144 In part this is due to the difficulty of cloning of highly repetitive DNA fragm

145 These findings articulate the difficulty of eliminating or reducing the pathogen f

146 Given the difficulty of predicting or measuring entropic and e

147 rative diseases and this is partially due to the difficulty of monitoring pathogenic molecules in pat

148 ed into seizure prediction algorithms due to the difficulty of estimating patient-specific rhythms fr

149 sensory systems is poorly understood, given the difficulty of studying patients with NaBC1 mutations

150 cular basis of their development, as well as the difficulty of drawing pattern homologies across spec

151 full impacts remain poorly understood due to the difficulty of manipulating pCO2 at the ecosystem lev

152 For polyploids, however, the difficulty of determining phase has limited such app

153 osphorylation complexity, thereby increasing the difficulty of extracting physiologically relevant pT

154 riptome of in vivo-grown pollen tubes due to the difficulty of collecting pollen that is elongating w

155 for secondary flavivirus infections, due to the difficulty of differentiating primary from secondary

156 However, this hope has been dampened by the difficulty of replicating promising regions of linka

157 Yet, structural work has been hampered by the difficulty of handling proteins insoluble or prone t

158 ion fluorescence imaging has been limited by the difficulty of labeling proteins in cells with suitab

159 -on system for rating prediction models, and the difficulty of assessing publication bias.

160 ctors influence solubility is limited due to the difficulty of obtaining quantitative solubility meas

161 tanglement is simultaneously responsible for the difficulty of simulating quantum matter on a classic

162 alytic photocycloaddition reactions has been the difficulty of controlling racemic background reactio

163 n the appropriate use of these devices given the difficulty of conducting randomized trials in patien

164 clease-induced cleavage has been hindered by the difficulty of isolating rare clones.

165 hese possibilities is problematic because of the difficulty of determining rates of molecular evoluti

166 by the overall instability of the domain and the difficulty of producing reagents.

167 be an intractable challenge, in part, due to the difficulty of maintaining reduced weight.

168 However, the difficulty of achieving reliable and standardized qu

169 immunodeficiency syndrome (AIDS) epidemic is the difficulty of collecting reliable information about

170 for interpreting connectivity but because of the difficulty of collecting reliable movement data, mos

171 paleobiological systems has been limited by the difficulty of obtaining reliable information about a

172 These complex interactions increase the difficulty of predicting responses to climate change

173 st problems facing microarray experiments is the difficulty of translating results into other microar

174 al. (2017) now present data suggesting that the difficulty of detecting RNAi in virus-infected mamma

175 , associated human infections, demonstrating the difficulty of eliminating salmonella transmission fr

176 This discrepancy highlights the difficulty of modeling salt bridge interactions with

177 y the poor spatial resolution of EEGs and by the difficulty of relating scalp potentials to the activ

178 e of social determinants on oral disease and the difficulty of translating science into action.

179 The difficulty of transplanting sensitized patients incr

180 o specific structural features that increase the difficulty of finding sequences that fold into a tar

181 However, the difficulty of generating sequences of powerful pulse

182 tential mechanisms of release is hampered by the difficulty of measuring SG calcium directly in livin

183 wever, they have been poorly analyzed due to the difficulty of recording simultaneous single neurons

184 for these modifications, but is hindered by the difficulty of isolating site-specifically modified R

185 ddress these questions have been hindered by the difficulty of obtaining site-specifically phosphoryl

186 o observed a significant association between the difficulty of initiating sleep and a lower AHEI scor

187 tasis has always been challenging because of the difficulty of detecting small tumor cell populations

188 mall-molecule binding patterns, highlighting the difficulty of predicting small-molecule binding patt

189 portant but not top-ranked, which was due to the difficulty of identifying smoking history from searc

190 overnment regulations preventing innovation, the difficulty of bucking social norms, and the inadequa

191 w concentration of the precursor species and the difficulty of isolating some of the structured inter

192 mical impact is still largely unclear due to the difficulty of preparing SP-containing oligonucleotid

193 culties, such as the slow growth in culture, the difficulty of obtaining specimens, and the diverse a

194 sperm cell channels have been frustrated by the difficulty of measuring spermatozoan transmembrane i

195 f such logic circuits was rather poor due to the difficulty of controlling spin waves in the input ju

196 metastable nature of the rotating state and the difficulty of applying stable rotating optical latti

197 patients are variable, presumably reflecting the difficulty of using static tests of gene expression

198 This finding underscores the difficulty of inducing subdominant CD8(+) T cells by

199 However, the difficulty of introducing substituents such as bicyc

200 egulatory organizations, which reflects both the difficulty of developing such agents and the fact th

201 le data on wide polymer chemical spaces, and the difficulty of generating such data given time and co

202 revalence of psychosomatic presentations and the difficulty of managing such patients, this article s

203 sted, but never shown to be involved, due to the difficulty of performing such studies in bacteria an

204 This lack of information was due to the difficulty of isolating sufficient viral RNA for stu

205 , accomplishing this task has been slowed by the difficulty of obtaining sufficient amounts of starti

206 mature to erythrocytes have been hampered by the difficulty of obtaining sufficient numbers of cells

207 flammatory therapeutics has been hampered by the difficulty of generating suitable sialylated product

208 ts is important but hardly achievable due to the difficulty of recovering suitable undisturbed sedime

209 The unpredictable course of COPD and the difficulty of predicting survival are barriers to ti

210 le of stepwise progressive goal achievement: the difficulty of training tasks increased depending on

211 ble to evaluate such alternatives because of the difficulty of tracking temperature variations in mov

212 pigenetic inheritance that could account for the difficulty of finding TGCT susceptibility genes in h

213 udied due to the lack of suitable models and the difficulty of assessing Th2 cytokine expression at s

214 Given the difficulty of accessing the colon, modelling can pla

215 enging compared with other complex traits is the difficulty of accessing the relevant tissue.

216 This study demonstrates the difficulty of achieving the desired subbandage press

217 yotic Cu-binding protein, but they highlight the difficulty of altering the exquisite Cu homeostasis

218 To overcome the difficulty of amplifying the diverse and ever-changi

219 ownership, current engineering practices and the difficulty of assessing the cost benefits of data-dr

220 mitation in modeling protein interactions is the difficulty of assessing the over-fitting of the trai

221 ement is particularly problematic because of the difficulty of assessing the phenotype as well as a l

222 hanism of decarboxylation are complicated by the difficulty of assigning the signals associated with

223 impediment to the success of this tactic is the difficulty of building the approximately 5-kb compon

224 This is hard to achieve in many cases due to the difficulty of characterizing the many constituents i

225 To overcome the difficulty of characterizing the structures of the e

226 Due to the toxicity of BeO and the difficulty of containing the very fine powder materi

227 such processes are generally associated with the difficulty of controlling the amount and location of

228 ther reactions such as Michael additions and the difficulty of controlling the enolate geometry make

229 acromolecules remains a challenge because of the difficulty of controlling the structure and interact

230 These observations highlight the difficulty of defining the boundaries of wild popula

231 y problem in quantum physics originates from the difficulty of describing the nontrivial correlations

232 plexity of the NAD(+) metabolic pathways and the difficulty of determining the levels of the intercon

233 ; however, these data are limited because of the difficulty of determining the structure of large pro

234 cal outcome due to broad drug resistance and the difficulty of eradicating the organisms.

235 complex nature of the erosion processes and the difficulty of examining the ice/bedrock interface of

236 Because of the difficulty of following the reduction of ISP optical

237 rthern" ribose have been inaccessible due to the difficulty of generating the sensitive N1-ribosyl li

238 driven forward genetics has been hampered by the difficulty of identifying the specific insertions re

239 a conditional action-selection task in which the difficulty of identifying the stimulus relevant for

240 en the complexity of a biological sample and the difficulty of implementing the appropriate analysis

241 Low Tdap coverage among adult CCs reinforces the difficulty of implementing the cocooning strategy an

242 ar exoskeletal structures are lacking, given the difficulty of inferring the precise segmental affini

243 The difficulty of inferring the secondary or tertiary st

244 human phenotypic specializations, as well as the difficulty of interpreting the consequences of genet

245 edimentary record as a proxy for erosion and the difficulty of isolating the respective contributions

246 g intron-mediated enhancement (IME) has been the difficulty of locating the specific intron sequences

247 y when working with the live Ebola virus and the difficulty of manipulating the RNA genome of Ebola v

248 ing of physiology and disease is hampered by the difficulty of measuring the circuitry and plasticity

249 r an important factor in evolution, owing to the difficulty of monitoring the effects and fates of al

250 d by AS-B, BLS, and CPS, our work highlights the difficulty of predicting the functional outcome of s

251 jor issue in studies of amyloid formation is the difficulty of preparing the polypeptide of interest

252 A significant challenge has been the difficulty of proving the hydriding/dehydriding mech

253 their characterization has been hindered by the difficulty of purifying the viral polymerase from ma

254 The difficulty of segregating the target from the backgr

255 ing is controversial, principally because of the difficulty of separating the effects of motor learni

256 40L is sufficient to activate APCs, owing to the difficulty of separating the effects of pCD40L from

257 However, the difficulty of studying the solid-liquid interface le

258 These lineage-tracing experiments highlight the difficulty of targeting the papilla and presumptive

259 The heterodimer is stabilized in part by the difficulty of threading the glycosylated end of the

260 g behaviours remain poorly understood due to the difficulty of tracking the foraging history of anima

261 hypothesis that -1 frameshifting depends on the difficulty of unfolding the mRNA.

262 sm of action remains unclear, in part due to the difficulty of determining their binding targets.

263 Such systems ought to be common, but the difficulty of finding them, combined with the challe

264 Overcoming the difficulty of delivering therapeutic agents to speci

265 A major challenge in treating cancer is the difficulty of bringing therapy to poorly perfused ar

266 a major bioinformatics gap, whose origin is the difficulty of crystallizing these detergent-solubili

267 a first-order tectonic fabric, we emphasize the difficulty of deciphering these different contributi

268 human development and health, yet because of the difficulty of detecting these critical sequences, we

269 regulating invadopodia has been hindered by the difficulty of examining these dynamic structures in

270 (IMP) structure and function is hampered by the difficulty of handling these proteins.

271 Too often, however, the difficulty of installing these fragments surpasses t

272 eir projections are poorly understood due to the difficulty of labeling these neurons immunohistochem

273 We also assess the difficulty of realizing these geometric structures b

274 on amyloid fibers, in large part because of the difficulty of studying these materials using convent

275 igher energy intermediates involved increase the difficulty of studying these processes experimentall

276 n immunocompromised patients, in part due to the difficulty of diagnosing this infection.

277 However, previous research has demonstrated the difficulty of distinguishing this type of stimulus-i

278 functions of human BRCA2 has been limited by the difficulty of isolating this large protein (3,418 am

279 hitecture and function have been hampered by the difficulty of visualizing this invisible hydrated st

280 nsional (2D) cell culture and are limited by the difficulty of simulating three-dimensional physiolog

281 rly quantified under hemodynamic flow due to the difficulty of setting thrombin fluxes.

282 fective once a patient has already arrested, the difficulty of obtaining thrombolytics at the bedside

283 ental blocks has remained elusive because of the difficulty of taking thymic biopsy specimens from af

284 pathology and receptor activity demonstrates the difficulty of trying to predict nociceptive conseque

285 This fixed relationship helps explain the difficulty of reducing total right ventricular after

286 transitions are also problematic because of the difficulty of detecting transitions in molecular dyn

287 by a low frequency of cellular engraftment, the difficulty of tracing transplanted cells, the rapid

288 This idea has not been evaluated due to the difficulty of separating trimers from nonfunctional

289 However, the difficulty of creating true frontal views of facial

290 Our results highlight the difficulty of identifying type 1 diabetes after age

291 sions and other anthropogenic activities and the difficulty of managing undesirable impacts of non-na

292 erarchically ordered natural polymers due to the difficulty of achieving uniform dispersion of nanopa

293 ly activated STAT3 in many human cancers and the difficulty of finding useful drug candidates aimed a

294 The difficulty of measuring very large contact angles (>

295 at the molecular level has been hampered by the difficulty of identifying VKOR involved in warfarin

296 Because of this similarity, and the difficulty of assigning vocalizations to individuals

297 has also become a major problem, increasing the difficulty of controlling weeds.

298 The difficulty of diagnosing Wernicke's encephalopathy i

299 to successful commercial cultivation include the difficulty of predicting which extracts will remain

300 t the synaptic level is challenging owing to the difficulty of visualizing Zn(2+) at individual synap