ライフサイエンスコーパス: the discovery of

1 A sequencing and PCR technologies, we report the discovery of 10 novel transcripts of GAD1 in the hum

2 We describe herein the discovery of [(11)C]-(R)-3 ([(11)C]-(R)-IPMICF16), a

3 The discovery of 2,6-diaryl-2-acetamidopyridines represe

4 The discovery of 20-HETE-GPR75 pairing presented here pr

5 Structural analyses guided the discovery of a broad, splicing-modulated interaction

6 These findings provide evidence for the discovery of a continuous neutralizing epitope withi

7 tereoelectronic guidelines is illustrated by the discovery of a convenient, ozone-free synthesis of b

8 The discovery of a disintegrin-like and metalloproteinas

9 Here, we report the discovery of a diversified family of fish viruses, d

10 ging approaches, this technology facilitated the discovery of a feature of the ischemic cascade: sele

11 Here we report the discovery of a group of giant viruses (Klosneuviruse

12 This work led to the discovery of a highly selective PI3Kbeta/delta inhib

13 Here, we report the discovery of a hitherto unknown chemical class, dihy

14 We report the discovery of a hitherto unprecedented enzyme-promote

15 The discovery of a large number of p53 target genes, whi

16 The discovery of a link between mutations in GBA1, encod

17 Here we report the discovery of a macrocyclic bis-thiourea derivative t

18 clues to magnetite formation in MTB through the discovery of a mechanism where iron ions accumulate

19 Here this study reports the discovery of a memory effect in both systems, manife

20 After further optimization, the discovery of a minor enantiomeric impurity with agon

21 The discovery of a missense variant in PLEC affecting AF

22 We report the discovery of a multiply imaged, gravitationally lens

23 In this article, we describe the discovery of a new chemical probe, bisamide (CCT2512

24 Here, we report the discovery of a new class of deaminases, predominantl

25 Comparative genomic analysis has led to the discovery of a new class of small self-cleaving ribo

26 The discovery of a new topology regulatory mechanism ope

27 The discovery of a new variation on the Davis-Beirut rea

28 The discovery of a new zinc binding chemotype from scree

29 We here report the discovery of a nonenzymatic counterpart to this reac

30 w insights in the biology of tRNASec, led to the discovery of a novel bacterial selenoprotein family,

31 4), scaffold hopping from delamanid inspired the discovery of a novel class of potent antitubercular

32 The study highlights the discovery of a novel proteolytically stable cyclic p

33 Herein we detail the discovery of a novel series of 4-thiazol-N-(pyridin-

34 campaign against human caspase-7 resulted in the discovery of a novel series of allosteric inhibitors

35 Extensive structural modifications led to the discovery of a number of heterocycloalkyl esters as

36 ne building blocks and additionally enabling the discovery of a number of novel synthetic strategies.

37 A rice (Oryza sativa) mutant led to the discovery of a plant-specific LAZY1 protein that con

38 Herein we describe the discovery of a potent FXIa clinical candidate, 55 (F

39 Here we report the discovery of a pregnant long-necked marine reptile (

40 Here, we report the discovery of a proteolytic regulator of CHS, namely,

41 Here we report the discovery of a proteostatic mechanism involving GRP7

42 Hawks and colleagues report the discovery of a second chamber within the Rising Star

43 Extensive structure-activity studies led to the discovery of a second-generation ozonide, artefenome

44 Here we report on the discovery of a series of 3,6-disubstituted triazolot

45 analysis, using cell culture assays, led to the discovery of a series of compounds belonging to the

46 high-throughput screening (HTS) hits led to the discovery of a series of ligands that bind in the "p

47 The discovery of a single transporter in the bacterium A

48 Here, we describe the discovery of a splice isoform-dependent positive fee

49 The discovery of a third type of photoreceptors in the m

50 Here we present the discovery of a tonoplast localized nitrate/peptide f

51 Here, we report the discovery of a transient, spatially selective neural

52 This led to the discovery of a triazole-containing diphenyl ether wi

53 Our experimental study suggests the discovery of a unique platform to support experiment

54 Here, we disclose the discovery of a very potent and selective non-hydroxa

55 functional genomics research has ushered in the discovery of aberrations in a third category: gain-o

56 (GCTA-COJO) has been successful in allowing the discovery of additional association signals within d

57 The latter approach facilitated the discovery of additional novel metabolic interactions

58 The discovery of alpha-Gal stimulated new discussions an

59 ngivalis-binding sites of ArcA, which led to the discovery of an 11-mer peptide with the native seque

60 The discovery of an electromagnetic counterpart to the g

61 Here, we report the discovery of an ion-specific effect on ice recrystal

62 We report the discovery of an ionic small molecule surfactant that

63 Here, we report the discovery of an MTG from Kutzneria albida (KalbTG),

64 Here we report the discovery of an NADP(H)-dependent reductive aminase

65 This innovative technique led to the discovery of an unexpected record confinement regime

66 We report the discovery of an unprecedentedly large, 2.2 nm diamet

67 based upon the experimental design to aid in the discovery of analytes with statistically different v

68 Exciting recent studies highlight the discovery of at least four distinct kinases (PPKs, C

69 We recently reported the discovery of AT-076 (1), (R)-7-hydroxy-N-((S)-1-(4-(

70 otential for colorectal cancer treatment and the discovery of autophagy induced by X-ray irradiated C

71 The discovery of AvrSr35 provides a new tool for Pgt sur

72 Herein, we describe the discovery of azaindoles as a new class of CSN5 inhib

73 The discovery of beta-RABO shows that through careful sy

74 Here, we resolve this apparent paradox with the discovery of biologically active, nuclear CD24 (nucC

75 Therefore, it is essential for the discovery of biomarkers in ECs to further investigat

76 and provide more supplemental candidates for the discovery of biomarkers.

77 nderstanding the pathogenesis of disease and the discovery of biomarkers; (2) choice of metabolomics

78 We report the discovery of BTSA1, a pharmacologically optimized BA

79 atasets and provides a powerful resource for the discovery of causal variants.

80 (63)Cu-nuclear magnetic resonance, we report the discovery of CDW induced by an in-plane field, setti

81 roughput imaging (HTI) is a powerful tool in the discovery of cellular disease mechanisms.

82 the pioneering work of Elie Metchnikoff and the discovery of cellular immunity, the phagocytic clear

83 of small-molecule libraries have accelerated the discovery of chemical probes for studying biological

84 within a limited set of scaffolds accelerate the discovery of chemical probes of human enzymes.

85 s clustering on all tumor samples-leading to the discovery of clusters of glioblastoma multiforme wit

86 orine in the benzyl moiety eventually led to the discovery of compound 21b, a potent inhibitor of Clk

87 t drug discovery program which culminated in the discovery of compound 34 (PRN1371), a highly selecti

88 a lack of in vivo screening technologies for the discovery of compounds that affect the age-dependent

89 modelling and experimental methods to enable the discovery of compounds which bind to these challengi

90 Excavations at the site in 2014-2015 led to the discovery of cultural remains generally associated w

91 The discovery of cytoplasmic incompatibility factor gene

92 Since the discovery of DDT in the late 1960s, most studies on

93 The discovery of deep-seated seismogenic features couple

94 Whereas the discovery of Dirac- and Weyl-type excitations in ele

95 ded in longitudinal data sets can facilitate the discovery of disease subtypes.

96 annotations into sequencing studies can aid the discovery of disease-associated genetic variants, es

97 he forefront of genetic studies since before the discovery of DNA.

98 ions to therapeutic pressure by BTICs impede the discovery of effective anti-BTIC therapies and limit

99 The discovery of emergent phenomena in 2D materials has

100 115- and MYB134-overexpressing poplar led to the discovery of enhanced flavonoid B-ring hydroxylation

101 Here, the discovery of enhanced material properties associated

102 erefore use ecological context to facilitate the discovery of enzymes in microbial communities.

103 Our findings are bridging the gap between the discovery of epidemiological SNP biomarkers and thei

104 Building this simplified system led to the discovery of essential roles for an internal start s

105 The discovery of extremely halophilic, methyl-reducing m

106 agnet (QHF) is a highly sensitive method for the discovery of fascinating quantum Hall phases; howeve

107 Here, we report the discovery of five cytochrome P450s and two acetyltra

108 With the discovery of fossil melanin [7, 8], it is possible t

109 The discovery of four mushroom forms, most with a comple

110 This analysis led to the discovery of four unique type II-A CRISPR-Cas9 inhib

111 olic differences in tissue that could aid in the discovery of fraud within the food industry.

112 The discovery of FTO as the first m6A mRNA demethylase e

113 The discovery of functional networks within the white-ma

114 Despite the discovery of gammadelta T cells >30 y ago, a proof-o

115 within the pyroptosis field, beginning with the discovery of Gasdermin D (GSDMD) as a substrate of c

116 ological networks are powerful resources for the discovery of genes and genetic modules that drive di

117 association studies (GWAS) have accelerated the discovery of genes contributing to glaucoma, the lea

118 The discovery of genetic variants influencing sleep patt

119 olate from a cystic fibrosis patient, led to the discovery of gladiolin, a novel macrolide antibiotic

120 After the discovery of graphene, two-dimensional nanomaterials

121 a hub for spatial information processing by the discovery of grid, border, and head-direction cells.

122 Here, we report the discovery of habituation-based plasticity utilizing

123 A new epoch started with the discovery of head direction cells and the realizatio

124 For the discovery of hepatitis B virus integration sites fro

125 The discovery of Higgs-boson decays in a background of s

126 engineered into single lattices, leading to the discovery of high-entropy alloys and high-entropy ox

127 ls the potential of the present strategy for the discovery of highly fluorescent probes.

128 opure analogues of viridicatumtoxin B led to the discovery of highly potent, yet simpler analogues of

129 Further exploration led to the discovery of hominin material, now comprising 131 ho

130 The year 2017 marks the 25th anniversary of the discovery of homologues of tubulin and actin in prok

131 It led to the discovery of horizontal genome transfer as an asexua

132 demonstrate the utility of the approach for the discovery of host proteins involved in HIV replicati

133 We report the discovery of HspQ as a new Lon substrate, unique spe

134 of this complex modification and have led to the discovery of hundreds of ADP-ribosylated proteins in

135 each disrupted gene in the genome to enable the discovery of: (i) new leads for gene function, (ii)

136 dy of traditional plant knowledge) has aided the discovery of important medicines.

137 bally overexpressing heparanase (hep-tg) was the discovery of improved glucose homeostasis.

138 ve been elegantly and repeatedly revealed by the discovery of individuals with mutations in cytokine

139 In particular, the discovery of innate lymphoid cells (ILCs) has opened

140 ening has emerged as a powerful approach for the discovery of innovative drug leads.

141 For example, the discovery of inorganic extended solid structures has

142 These include the discovery of interbreeding between anatomically mode

143 The discovery of iridoid biosynthetic genes in the medic

144 ion of the TPE-naphthyridine scaffold led to the discovery of its high sensitivity to silver ions (Ag

145 athogenesis of HCL was recently clarified by the discovery of its underlying genetic cause, the BRAF-

146 of cellular processes in cancer would enable the discovery of key mechanisms underlying its developme

147 enome assemblies are not likely to result in the discovery of large-scale presence/absence variation

148 Since the discovery of long-term potentiation (LTP) in 1973, t

149 Herein we report the discovery of LX2761, a locally acting SGLT1 inhibito

150 indeed possess XY sex chromosomes, based on the discovery of male-specific genetic markers in both s

151 It is now possible to accelerate the discovery of materials with target properties, such

152 To facilitate the discovery of meaningful biological relationships, th

153 In this study, we report on the discovery of MEMS functionality in fibres, thereby o

154 ids at 600-700 degrees C and 1.5-2.5 GPa and the discovery of methane-rich fluid inclusions in metaso

155 The data thus acquired allows the discovery of methylation 'loci'; contiguous regions

156 s intentional and credited to hematologists, the discovery of MGUS is most often incidental and made

157 on sterile cultivation systems, which limits the discovery of microbial breakdown products that act a

158 The discovery of microRNAs (miRNAs) remains an important

159 The discovery of ML290 demonstrated that it is possible

160 Another important and difficult problem is the discovery of molecular disease subtypes characterize

161 e examples of its practical applications for the discovery of molecular mechanisms of disease, focusi

162 The discovery of molecular signatures of Y. pestis in pr

163 describes my early work on viral enzymes and the discovery of mRNA capping, how my training in medici

164 Since the discovery of mu-opioid receptor (MOR) gene two decad

165 Such insight provides a framework to the discovery of much needed drugs that selectively targ

166 ia and accumulate inside these cells, making the discovery of much-needed drugs against these pathoge

167 al projections of model organisms has led to the discovery of multiple proteins that are locally synt

168 The discovery of multiple RNA modifications in the past

169 The discovery of N-Cl-DCAM or, more broadly speaking, N-

170 The discovery of Neandertals at open-air sites during th

171 Ever since the discovery of neural stem cells in the mammalian brai

172 on in host defense in vivo was revealed with the discovery of neutrophil extracellular traps, a speci

173 can serve as a promising starting point for the discovery of new antimelanoma therapeutics.

174 y of herbicides and potentially a target for the discovery of new antimicrobial drugs.

175 ty, and there are unmet clinical demands for the discovery of new biomarkers and development of treat

176 terials is traditionally viewed as requiring the discovery of new chemical compositions through synth

177 scribe two hit finding approaches leading to the discovery of new chemical matter for this pivotal pr

178 rtunities for the structure-based design and the discovery of new chemotypes.

179 on pathway and host response, should lead to the discovery of new drugs for treating infections.

180 ansition metal reactivity, which may lead to the discovery of new f-block catalysis.

181 The discovery of new gigantic molecules formed by self-a

182 nt years, groundbreaking research has led to the discovery of new HCV-specific direct-acting antivira

183 The discovery of new materials for separating ethylene f

184 The discovery of new materials is hampered by the lack o

185 peutic targets is a significant challenge in the discovery of new medicines.

186 ther reactions and provides a foundation for the discovery of new modes of reactivity of polyunsatura

187 ate the utility of "admixture screening" for the discovery of new multicomponent heterogeneous Pd cat

188 and across cancer types, which shed light on the discovery of new prognostic GSs in cancers and the u

189 he evolution of nature's enzymes can lead to the discovery of new reactivity, transformations not kno

190 trategy for genome-scale screens, leading to the discovery of new roles for BMP signaling in linking

191 We anticipate that this work will lead to the discovery of new streptogramin antibiotics that over

192 olecular features is critically important in the discovery of new therapeutics.

193 lays an integral role in drug repositioning: the discovery of new uses for existing drugs.

194 Therefore, there is a great interest in the discovery of non-steroidal ligands able to bind to t

195 e center (S)-proline-based lead 7 has led to the discovery of noncovalent reversible and selective hu

196 tion in HIV-1 RT has been a key roadblock in the discovery of nonnucleoside RT inhibitors (NNRTIs).

197 The discovery of nonnucleoside, reversible, small-molecu

198 This study points the way to the discovery of novel anti-influenza molecules targetin

199 r facilitate computational genome mining for the discovery of novel bioactive molecules.

200 ons of gene-sets cause a major limitation in the discovery of novel biological processes from the tra

201 In addition, the discovery of novel biomarkers may not only prove use

202 We report the discovery of novel CO2-based networks stabilized by

203 It will also facilitate the discovery of novel drivers, the study of tumor evolu

204 standing of oncogenic mechanisms, as well as the discovery of novel druggable proteins within the ubi

205 eing considered as a novel lead compound for the discovery of novel effective antitrypanosomal agents

206 mics, and integrative approaches can empower the discovery of novel gene-environment interactions and

207 s the conceptual and technical framework for the discovery of novel inhibitors of this PPI.

208 ed new computational methods and accelerated the discovery of novel ligands and tool compounds, espec

209 of the visual system has greatly facilitated the discovery of novel mechanisms that establish precise

210 We report here the discovery of novel multiple sign changes versus appl

211 neity, which can improve existing methods in the discovery of novel subtypes, pseudo-temporal orderin

212 eted therapies, and frequently recur, making the discovery of novel therapeutic targets for this dise

213 , the elucidation of disease mechanisms, and the discovery of novel therapeutic targets.

214 the era of high-throughput sequencing, when the discovery of novel transcripts far outpaces our know

215 These studies resulting in the discovery of once daily sGC stimulator vericiguat (c

216 sts of enantioselective transformations, yet the discovery of organic catalysts effective at low cata

217 iverse set of genetic approaches have led to the discovery of over 97 loci influencing glycaemic trai

218 The discovery of pathogenic mutations in inherited skin

219 The discovery of PhnH demonstrates that enzymes can be u

220 The discovery of photoreceptors that sense light using 5

221 The discovery of physical laws consistent with empirical

222 The discovery of planets orbiting double stars at close

223 The discovery of poly(ADP-ribose) >50 years ago opened a

224 Structure-activity relationships led to the discovery of potent inhibitors 10 and chemical probe

225 d, hence, it is an appealing methodology for the discovery of potential AEDs.

226 ur analysis provides resources to facilitate the discovery of predictive biomarkers for immunotherapy

227 over a variety of length scales, leading to the discovery of previously unknown phenomena.

228 The basic research observations that led to the discovery of Pt complexes as DNA-binding agents that

229 nesis screen in mice, which was designed for the discovery of Pten-cooperating tumor suppressors.

230 ased analysis of genomic data can accelerate the discovery of rare genetic disorders.

231 The discovery of reef-forming scleractinians in this reg

232 Thus, the discovery of reliable biomarkers for the management

233 racterised by progressive muscle wasting and the discovery of reliable blood-based biomarkers could b

234 is review outlines the historical origins of the discovery of REM sleep, the diversity of REM sleep e

235 ss the local ring currents of its components.The discovery of ring currents around a molecule with a

236 First, the discovery of risk genes and their implications, with

237 is anticipated to improve these parameters, the discovery of selective, direct activators has proven

238 We report the discovery of self-assembly strategies leading to the

239 We report the discovery of sequence-specific interactions between

240 linker-guided strategy can be used to enrich the discovery of sequence/structure/function transitions

241 INTERPRETATION: The discovery of seven novel, clinically significant sub

242 This has led to the discovery of several new compounds produced under va

243 However, in the nearly 25 years since the discovery of single-molecule magnets, hysteresis tem

244 provide evidence in support of this role and the discovery of small natural product molecules that pr

245 These findings will guide us toward the discovery of small reactive peptides to facilitate a

246 For instance, chemical genetics involves the discovery of small-molecule effectors of various cel

247 Altogether, SVGs enable the discovery of some of the likely most abundant and ec

248 These studies resulted in the discovery of some of the most potent epothilones rep

249 Much effort has been devoted to the discovery of specific mechanisms between drugs and s

250 elding model has recently been challenged by the discovery of stable downstream intermediates, which

251 antly, it opens new avenues for accelerating the discovery of stable, atomically precise, colloidal m

252 for developing an effective HIV-1 vaccine is the discovery of strategies to elicit immune responses t

253 The discovery of structured non-coding RNAs (ncRNAs) in

254 These results point toward the discovery of structures that are potent and highly s

255 These data enabled the discovery of subdominant binding motifs and an integ

256 In this paper, we describe the discovery of the 3-hydroxyquinazoline-2,4-dione as a

257 Building on insights gained from the discovery of the antimalarial ozonide arterolane (OZ

258 Herein we report the discovery of the benzo[a]imidazo[2,1,5-c,d]indolizin

259 The discovery of the causative gene for Huntington's dis

260 improving pharmacokinetic properties led to the discovery of the clinical candidate 63 (ABBV-075/miv

261 computational and experimental approach for the discovery of the first small molecule scaffold which

262 n microdose PK data are described leading to the discovery of the first subtype selective NaV1.7 inhi

263 aryotes is more complex than envisioned, and the discovery of the functions of TMTCs provide insight

264 tly, however, studies of keratin have seeded the discovery of the genetic basis for a large number of

265 Notably, those results paved the way for the discovery of the high CO2 uptake (201.6 cm(3) g(-1)

266 The discovery of the hormonally regulated, constitutivel

267 Ever since the discovery of the major histocompatibility complex, s

268 This is a tale of how technology drove the discovery of the molecular basis for signal transduc

269 Here, we describe the discovery of the most potent inhibitor of sirtuin 5

270 biochemical and genetic observations led to the discovery of the neomorphic production of the oncome

271 ago opened a new field, leading the way for the discovery of the poly(ADP-ribose) polymerase (PARP)

272 l optimization of 3 using SBDD culminated in the discovery of the potent and selective Brr2 inhibitor

273 The discovery of the Sry gene in 1990 triggered a revolu

274 The discovery of the TEtra circuit indicates how trophec

275 The discovery of the unexpected anomeric memory effect i

276 The discovery of the unusual melting and solidification

277 ancient origin of retroviruses, but owing to the discovery of their ancient endogenous viral counterp

278 The discovery of thermal and photochemical control by Wo

279 We previously reported the discovery of thieno[3,2-b]pyrrole 1b that displayed

280 Fortified by the discovery of this new scaffold, we sought a broader

281 The discovery of this nongenomic signaling pathway, in w

282 The discovery of this previously unknown cross-talk betw

283 The discovery of this previously unnoticed oscillatory b

284 The discovery of thousands of noncoding RNAs (ncRNAs) ha

285 The discovery of three new plant STSs is reported that p

286 Since the discovery of topological insulators and semimetals,

287 The discovery of translational optic flow detectors in t

288 Herein, we report the discovery of two diverse lead series imidazo[1,2-a]p

289 in drug discovery, and it has already led to the discovery of two FDA-approved (antiviral) ProTides.

290 nthesis of dehaloperophoramidine have led to the discovery of two novel domino processes, the first e

291 to characterize plant promoter sequences and the discovery of two root hair regulatory elements (RHE1

292 Here, we report the discovery of two-dimensional Dirac nodal line fermio

293 The discovery of ubiquitin, E1-like, E2-like and small-R

294 ctivity in vitro and in vivo, culminating in the discovery of unprecedented substituents able to inte

295 dex gastroenteritis case cluster that led to the discovery of VA1, was first passaged in Vero cells.