1 um labeling studies, these studies represent
the first examples of 1,2-hydride shift-enabled pi-allyl
2 Three isomers of [(Cp*Ru)2 C2 B10 H12 ],
the first examples of 14-vertex heteroboranes containing
3 ssible impression of graphene with (i) it is
the first example of 2D atomic crystals, (ii) it demonst
4 ssible impression of graphene with (i) it is
the first example of 2D atomic crystals, (ii) it demonst
5 This work represents
the first example of 3D printed light-guiding sensing pl
6 The first examples of 4-membered thietane-oximines are p
7 nded investigation of 6-substituents as well
the first examples of 7-substituted analogues of this sc
8 This probe is
the first example of a "caged" Si-rhodamine, exhibits hi
9 Complex 2 is
the first example of a [Fe(II){Fe(NO)}(7)] species and i
10 T. terrenum may be
the first example of a bacterium possessing a functional
11 In the present computational work,
the first example of a bifurcating sigmatropic reaction
12 The first example of a biocatalytic [2,3]-sigmatropic re
13 This data provides
the first example of a biorelevant synthetic model for m
14 We report
the first example of a boryl-Heck reaction using an elec
15 Similarly, we now describe
the first example of a carbene that exhibits differing t
16 hiometric quantity of Me2 PhSiH and provides
the first example of a catalytic main-group element-elem
17 The first example of a catalytic Michael addition reacti
18 To the best of our knowledge, this is
the first example of a catalytic reaction triggered in r
19 the nucleus and represents to our knowledge
the first example of a cell adhesion receptor exhibiting
20 soluble degradation-prone segment, providing
the first example of a cholesterol-degron collaboration.
21 Here we report
the first example of a class of additively manufactured
22 This is
the first example of a clathrate compound where the fram
23 a genome-wide association study, we observed
the first example of a common susceptibility locus for g
24 To our knowledge, this is
the first example of a compound based on main group elem
25 Our system-which features
the first example of a covalent CB-DNA conjugate-is high
26 To our knowledge, these findings represent
the first example of a CPG in which precise premotor rhy
27 the natural Watson-Crick geometry in RNA in
the first example of a crystal structure of an RNA molec
28 Herein, we report
the first example of a crystalline metal-donor-fullerene
29 pecies with M2 O2 "diamond" cores, including
the first example of a crystallographically characterize
30 These results provide
the first example of a Cu-based PARACEST magnetic resona
31 te and in solution, which notably represents
the first example of a cyclopropenimine-based fluorescen
32 To our knowledge, this is
the first example of a defensin which inhibits the growt
33 The hydrolysis of MOF-1201 in water makes it
the first example of a degradable porous solid carrier f
34 gBCP1 is essential for cyst formation and is
the first example of a developmental regulation in trans
35 electivity was observed, and this represents
the first example of a diastereoselective enolate hydrog
36 of the parent boratabenzene anion as well as
the first example of a diboron analogue of biphenyl.
37 This is
the first example of a differential requirement for a vi
38 This reaction constitutes
the first example of a direct catalytic enantioselective
39 splatin and triflate concurrently, providing
the first example of a discrete metallosupramolecular ar
40 We report
the first example of a donor-acceptor corannulene-contai
41 Herein we go a step further and report
the first example of a fluid honeycomb mimicking a zeoli
42 Further, we report
the first example of a free carboxylic acid-directed Pd(
43 The first example of a frustrated Lewis pair (FLP) solel
44 The GAL1/pre-BCR interaction is
the first example of a GAL1/unglycosylated protein inter
45 This Article represents
the first example of a homogeneous and selective alkane
46 We provide
the first example of a host tissue-derived signal (Semap
47 ense of its role in cytoskeletal remodeling,
the first example of a kinesin whose function is directl
48 s predicted change in reactivity constitutes
the first example of a kinetic isotope effect that discr
49 The first example of a lanthanide metallocenophane compl
50 f cells under single photon excitation, (ii)
the first example of a lanthanide(III)-based NIR-emittin
51 s herein supported by the study of K4Xe3O12,
the first example of a layered xenon perovskite.
52 Thus, lncRHOXF1 RNA is
the first example of a lncRNA that regulates the host re
53 This study represents
the first example of a manganese-catalyzed environmental
54 MalQ represents
the first example of a mesophilic bacterial amylomaltase
55 alts, readily formed from primary amines, is
the first example of a metal-catalyzed cross coupling vi
56 To our knowledge, this represents
the first example of a MOF capable of separating chiral
57 This is
the first example of a molecular and semiconductor photo
58 ing two {W21} units and the {W56} species is
the first example of a molecular metal oxide cluster con
59 characterized as [(C5Me5)3Th(CO)][BPh4], 5,
the first example of a molecular thorium carbonyl isolab
60 of a [Fe(II){Fe(NO)}(7)] species and is also
the first example of a mononitrosyl diiron(II) complex t
61 sence of Ce(IV) ammonium nitrate constitutes
the first example of a multicomponent carbazole synthesi
62 Here, we describe
the first example of a multifunctional nucleoside probe,
63 lyze an oligosaccharide substrate, providing
the first example of a naturally occurring catalytic ant
64 We note that Rv2633c is
the first example of a non-heme di-iron catalase, and co
65 hosphines to form cyclic phosphine rings and
the first example of a non-metal-catalyzed hydrosilylati
66 We describe here what appears to be
the first example of a nonenveloped viral capsid that ap
67 To our knowledge, DBDPE is
the first example of a nonhydroxylated contaminant inhib
68 gh nNOS is a heme-containing enzyme, this is
the first example of a NOS that catalyzes an S-demethyla
69 This is, to the best of our knowledge,
the first example of a one-electron redox event causing
70 r dendritic cell differentiation and provide
the first example of a patient-derived xenotransplantati
71 The first example of a PBD monomer, the natural product
72 The latter reaction is
the first example of a phosphorus analog of the Buchner
73 To our knowledge 7 represents
the first example of a potent and highly cytotoxic larga
74 In summary, we establish
the first example of a PQM protease, essential for matur
75 Thus, our SirReal-based PROTAC is
the first example of a probe that is able to chemically
76 eEF2K is
the first example of a protein directly involved in a ma
77 Csp1 is
the first example of a protein that stores a metal withi
78 This is
the first example of a quasicrystal composition discover
79 ical-radical cyclization process constitutes
the first example of a radical cascade involving ET redu
80 This is
the first example of a radical SAM-related [4Fe-4S](+) c
81 tonation reaction in water, which represents
the first example of a reaction that critically depends
82 Herein, we report
the first example of a reduction-activated G-quadruplex
83 The first example of a regioselective beta-arylation of
84 The topomerization of 1H[B(Ar(F))4] provides
the first example of a reversible 1,2-H migration along
85 Not only does our hybrid system represent
the first example of a reversible colloidal membrane, bu
86 Reported is
the first example of a rhodium-mediated beta-sulfide eli
87 As an exciting result, it is
the first example of a self-organized monolayer (SOM) ob
88 We report
the first example of a silyl-Negishi reaction between se
89 We believe that this is
the first example of a simple protocell model displaying
90 To our knowledge, this represents
the first example of a single driver rearrangement simul
91 n inhibitory peptidergic identity, providing
the first example of a single transcription factor that
92 Here we present
the first example of a single-site main group catalyst s
93 ed acidity in their excited state, MV(2+) is
the first example of a species with enhanced Lewis acidi
94 )porphyrin, H2 [(CF3 )7 TpFPP], has revealed
the first example of a stable cis tautomer of a free-bas
95 Additionally,
the first example of a stereospecific cross-electrophile
96 ormation of a microporous magnet and provide
the first example of a structurally characterized extend
97 In
the first example of a sugar hybrid cIDPR analogue, "L-c
98 This is
the first example of a supercapacitor made entirely from
99 o 4, the results described herein constitute
the first example of a synthetic cycle for oxygen atom t
100 This is
the first example of a temperature-driven phase change i
101 This system represents
the first example of a ternary protein-metal-organic cry
102 As such, TMX1 is
the first example of a topology-specific client protein
103 The first example of a transition metal (BB)-carboryne c
104 The reaction constitutes
the first example of a transition-metal-catalyzed genera
105 The first example of a transition-metal-catalyzed, meta-
106 We also report
the first example of a triple cavity [Pd4(L)4](8+) cage.
107 ) complex Cs[{U(OSi(OtBu)3)3}2(mu-N)]affords
the first example of a uranium nitride complex containin
108 We report
the first example of a very general Cu-catalyzed cross-c
109 These results suggest that vIRF-1 is
the first example of a viral protein to inhibit mitochon
110 This appears to be
the first example of a viral structural protein that is
111 The work shown here is
the first example of a vIRF being associated with either
112 The first example of a well-defined binary, low-oxidatio
113 cks, allowed the formation of the pbz-MOF-1,
the first example of a Zr(IV)-based MOF with pbz topolog
114 This report represents
the first examples of a catalytic isomerization of N-all
115 size in modern cattle, and represent one of
the first examples of a genomic sweep in livestock that
116 The first examples of a Lewis-acid catalyzed (hetero)are
117 This is one of
the first examples of a motor to be implicated in the es
118 hich was only feasible due to preparation of
the first examples of actinide-based frameworks with "un
119 This cooperativity converts the BC into
the first example of an aborted [3,3] sigmatropic shift
120 MFM-136 is
the first example of an acylamide pyrimidyl isophthalate
121 The first example of an additive cyclocarbonylation proc
122 This experiment delivers
the first example of an AEGIS aptamer that binds to an i
123 The first example of an ammonium derivative that causes
124 Here we provide
the first example of an archaeo-viral transcription fact
125 (thf)4]2[3], in which the dianion 3 contains
the first example of an arsinidene ligand in rare-earth
126 The first example of an asymmetric aminocatalyzed aza-Mi
127 The sensor represents
the first example of an easy-to-wear flexible tattoo-bas
128 etween high-spin metal centers, by providing
the first example of an Fe complex that exhibits double-
129 Our data present
the first example of an HIV-1 group O Vpu that efficient
130 Herein, we present
the first example of an integrated paper-based screen-pr
131 Phloroglucinol is
the first example of an intermediate of antibiotic biosy
132 conclusion the hyperglucosylated adhesin is
the first example of an N-glucosylated native antigen th
133 GOLPH3 is
the first example of an oncogene that functions in secre
134 This is one of
the first examples of an association between human adapt
135 It is essential for growth and was one of
the first examples of an endonuclease that can recognise
136 functioning at the local scale, and provide
the first example of another context-dependent process,
137 sents a full account of this work, including
the first examples of asymmetric anti homocrotylation.
138 and is a component of the carboxysome shell,
the first example of ATPase activity associated with a b
139 The first example of base-metal-catalyzed dehydrogenativ
140 dings are significant because they represent
the first example of behavioural and morphological adapt
141 The reaction represents
the first example of benzylimidates directly converting
142 also allowed us to structurally characterize
the first example of bimetallic An-An nodes.
143 Toward this aim, we show here
the first example of bioengineered charge transport in a
144 To our knowledge, this study represents
the first example of bioisosteric replacement of an acet
145 Here,
the first example of biomacromolecular core-shell crysta
146 protection reaction can be applied to access
the first examples of BN isosteres of dihydrobenzofurans
147 The compounds are
the first examples of boron analogues of diazoalkanes (R
148 ntly, to the best of our knowledge these are
the first examples of C-H bond activation reactions occu
149 This is
the first example of capture beads having more than one
150 Herein we report
the first example of carbonate detection using ultrasens
151 Here we report
the first examples of carotenoid-based coloration in the
152 ur knowledge, this transformation represents
the first example of catalytic couplings between unsatur
153 at room temperature, and the latter provides
the first example of catalytic hydrosilylation of CO2 in
154 The first examples of chiral single component conductors
155 In this work we report one of
the first examples of chirality transfer from a catalyst
156 onally, the synthesis of furans demonstrates
the first example of Co(III)-catalyzed functionalization
157 clonogenic survival in LGSC cells, providing
the first example of co-occurring, growth-promoting muta
158 We present
the first examples of CO2 electro-reduction catalysts th
159 This MOF represents
the first example of combining metal cluster chemistry w
160 In this work, we report
the first example of CRISPR/Cas9 encapsulated by nanosca
161 The first examples of Cu-catalyzed gamma-selective allyl
162 r spliceosome splice sites; however, we find
the first examples of developmentally induced circular R
163 This study represents
the first example of direct molecular mimicry leading to
164 es, containing no solvent molecule, provided
the first examples of direct pi-stacking of carbo-benzen
165 To our knowledge, this is
the first example of distinct activation requirements of
166 ographically equivalent strand, resulting in
the first examples of DNA crystal structures that contai
167 ple of a Type I DyKAT reaction of an allene,
the first example of DyKAT in a cyclocarbonylation react
168 This is
the first example of effective targeted therapy for this
169 st of our knowledge, compounds 25 and 78 are
the first examples of either an 4-aminoquinoline or a te
170 e emission from the self-assembled system is
the first example of electrochemiluminescence (ECL) of P
171 This reaction provides
the first example of enantioselective benzylic gamma-C-H
172 sigma-allyliridium intermediates, represent
the first examples of enantioselective formaldehyde C-C
173 This constitutes
the first example of enantiospecific recognition at the
174 The results of this study provide one of
the first examples of ERT for a metabolic disorder and s
175 This paper provides
the first example of experimentally characterized hydrog
176 This protocol is
the first example of exploiting the catalytic promiscuit
177 These MOFs represent
the first examples of extended porous structures based o
178 This work provides
the first examples of external oxidant-free Au(I)-cataly
179 The new anion represents
the first example of face-fused nine-atom molecular clus
180 Here, we report
the first example of ferromagnetic graphene achieved by
181 to a broad range of nitriles gives access to
the first examples of free 1-aza-2,3,4-triphospholenes i
182 anding cis-1 C60 addition pattern, represent
the first examples of fullerene derivatives which combin
183 This is
the first example of functional characterization of thes
184 This is
the first example of G-quadruplex ligands that show incr
185 Its two Ge9-halves are
the first examples of germanium deltahedra with three no
186 This is
the first example of Golgi export to the plasma membrane
187 g reactions, most notably allowing access to
the first examples of Group 14 metal cations containing
188 ebrush polymer assembly, including access to
the first examples of gyroid phases.
189 This contribution reports
the first example of highly selective reduction of CO2 i
190 This is
the first example of hormonal regulation of temporal fac
191 This study is
the first example of how the new 'Allergic and hypersens
192 The meso oligoureas are
the first examples of hydrogen-bonded foldamers with rev
193 We report the detailed investigations into
the first example of iminium catalysis inside a supramol
194 In this study,
the first example of in situ exfoliated, edge-rich, oxyg
195 xpression and thyroid-related disease; it is
the first example of in vivo PET imaging with a tracer c
196 We present
the first example of intercluster reactions between atom
197 high symmetry and 2 of these bisadducts are
the first examples of intrinsically chiral endohedral co
198 s of polytetracene-based devices demonstrate
the first example of iSF-generated triplet extraction in
199 Here, we report on
the first examples of isolable acyclic, neutral, three-c
200 Reported is
the first example of kinetic resolution by a palladium(I
201 The first examples of kinetically controlled cross-metat
202 rat cardiomyocytes.In conclusion, we report
the first example of left ventricular hypertrabeculation
203 mechanism identified in the pneumococcus and
the first example of lethality from loss of HPr-Ser appr
204 Our pentad provides
the first example of light-driven accumulation of reduct
205 IgT within the gills of fish, thus providing
the first example of locally induced immunoglobulin in t
206 grin and cadherin tension, and demonstrating
the first example of long-term ( approximately 3 days) m
207 These are
the first examples of m4C modification in Type I RM syst
208 We present
the first example of magnetic ordering-induced multiferr
209 oped" polyacetylenes (BPAs), which represent
the first examples of main-chain boron-containing CPs wi
210 The first examples of mannose and biotin ligands coupled
211 Exploiting this property,
the first examples of mechanically interlocked [2]rotaxa
212 We report
the first example of metal-mediated acetylene bicyclopen
213 We present herein
the first example of metal-organic frameworks postfuncti
214 ity, and thus, these two compounds represent
the first example of mirror image opioid receptor ligand
215 They represent
the first examples of MOFs to have the beta-UH3-like, 4,
216 an normal-tension glaucoma cohort, including
the first example of more than 1 extra copy of this gene
217 The method reported here is
the first example of multianalyte/disease diagnosis usin
218 Here, we describe
the first example of NAFLD caused by genetic disruption
219 This is
the first example of nano/bio interfacing with spores an
220 PEGylated-NHC ligands for Au-NP surfaces and
the first example of NHC-functionalized NPs that are com
221 The data shows one of
the first examples of non-invasive, real-time oxygen map
222 These results provide
the first example of noninflammatory renal fibrosis.
223 To the best of our knowledge, this is
the first example of one pair of enantiomers with contra
224 To our knowledge, this work demonstrates
the first examples of one-pot synthesis of nitrones usin
225 These data offer
the first example of optical control of analgesia in viv
226 We report here
the first examples of orthogonally protected furanoid SD
227 The first example of palladium(II)-catalyzed beta-C(sp(3
228 n SH3 domains and, to our knowledge, this is
the first example of peptide-binding of an SH3 domain in
229 This study demonstrates
the first examples of pH-switchable nonelectrogenic anio
230 a selective marker of malignancy in CLL and
the first example of phenotypic continuity between matur
231 To our knowledge, this is
the first example of phenotypic heterogeneity in the exp
232 ubstrates is known, to our knowledge this is
the first example of phosphodegron involvement in gp78-s
233 To our knowledge, this method represents
the first example of photo-induced enzyme promiscuity, a
234 but the reversibility enabled us to perform
the first examples of photochemically induced arene exch
235 The first example of photoredox catalyzed difluoromethyl
236 In the current study, we report
the first example of polydiacetylenes (PDAs), where our
237 The first example of polytypism in the I-II-V semiconduc
238 The first examples of porphyrin analogues incorporating
239 ssed HEK293S GnT I(-/-) cell line represents
the first example of production of fully core-fucosylate
240 This is
the first example of proteasome phosphorylation dependen
241 This work represents
the first examples of pyrazines prepared by RuNPs.
242 ary protein into a functional switch, and is
the first example of rational design in which a small mo
243 These results constitute
the first example of rational engineering of Gram select
244 This is
the first example of relativity being decisive for the n
245 Here, we report on
the first example of robust and modifiable Lewis acids c
246 sible at room temperature and thus represent
the first examples of room-temperature reversible redox
247 kable engraftment of CMML and JMML providing
the first examples of serially transplantable and geneti
248 We report here
the first example of single C(sp(3))-F functionalization
249 Here, we report
the first example of small organism mid-infrared spectro
250 The compounds reported represent
the first examples of small molecules developed specific
251 To our knowledge, NAB1 is
the first example of stimulus-induced denitrosylation in
252 The first examples of stoichiometric dehydrogenative B-H
253 st of our knowledge, these species represent
the first examples of structurally characterized dinucle
254 This is
the first example of such a combination.
255 ree diffusion inside a sphere", representing
the first example of such a mechanism observed in MOFs.
256 We report
the first example of such a process and show that unexpe
257 We now report
the first example of such a process, which was realized
258 Here, we achieve
the first example of such explicit vibrational control t
259 We report here
the first examples of synthetic neutral anion receptors
260 myelocytic leukemia (APL) that is considered
the first example of targeted therapy in cancer, but who
261 Xylogranatumin A (2) represents
the first example of the 9, 10-seco limonoid with an unp
262 This study therefore describes
the first example of the development of a biologically r
263 nary carbon stereogenic centers and provides
the first example of the direct asymmetric alkylation of
264 carbon stereogenic centers and it represents
the first example of the direct enantioselective alkylat
265 The reaction represents
the first example of the direct synthesis of aryl-alpha-
266 This work provides
the first example of the exploitation of the nanoparticl
267 The first example of the fabrication of complex 3D polym
268 This is
the first example of the high-resolution patterning of d
269 The reaction constitutes
the first example of the Ni-catalyzed generation of aryl
270 The first example of the OCPPCO ligand, diisophosphaethy
271 The cascade presents
the first example of the successful de novo design of a
272 This study is
the first example of the thermodynamically controlled so
273 This is
the first example of the use of a molecular rotor, a BOD
274 As
the first example of the use of functional hyper-crossli
275 As
the first example of the use of ligand-receptor interact
276 This is
the first example of the use of non-enzymatic chemical s
277 This method represents
the first example of the use of phenol derivatives as el
278 The present work reports
the first example of the use of the chemistry of radical
279 In addition,
the first examples of the gold mesoionic carbene mediate
280 This study is one of
the first examples of the intentional preorganization of
281 These structures are
the first examples of the Rep_trans Pfam family providin
282 Herein, we disclose
the first examples of the sigma-bond metathesis of silyl
283 imple compared to the complexity of the ECM,
the first examples of these functional supramolecular bi
284 This represents
the first example of this convenient asymmetric access t
285 reparation of a complex natural product, and
the first example of this coupling with a hindered diort
286 This is
the first example of this method being used for the grow
287 ity in mammalian vocalizations [12], this is
the first example of this phenomenon involving sound rhy
288 These results provide
the first examples of trans-QTL effects mediated by prot
289 Our study presents
the first example of transcriptional vitamin-directed me
290 Our study demonstrates
the first example of tunable boron chemistry in a folded
291 The molecular skeleton is formed using
the first examples of two critical construction reaction
292 ransformations of an alcoholic substrate and
the first example of uranium complexes showing catalytic
293 As
the first example of using aromatic-aromatic interaction
294 This work describes
the first example of using chiral catalysts to control s
295 This report describes
the first example of using of ammonia sources with diace
296 We present
the first example of using the identical touchscreen-bas
297 The first example of vinca derivatives 16-18 able to mod
298 ssembly of the superstructures, resulting in
the first examples of water-soluble cylindrical multiblo
299 ular and mass spectromery data demonstrating
the first example of wyosine in mitochondria, a situatio
300 pyrimidine and an ynamide, which constitutes
the first examples of ynamides behaving as electron-rich