ライフサイエンスコーパス: the founding member of

1 They are the founding members of 21 miRNA gene families for 48 mi

2 mily of GPI-linked signaling proteins and is the founding member of a C. elegans gene family with at

3 Myocardin is the founding member of a class of muscle transcription f

4 Onartuzumab, therefore, represents the founding member of a class of therapeutic monovalent

5 Drosophila Roundabout (Robo) is the founding member of a conserved family of repulsive a

6 Drosophila Roundabout (Robo) is the founding member of a conserved family of repulsive a

7 The Drosophila protein MEI-S332, the founding member of a conserved protein family, is es

8 is secreted by Pseudomonas aeruginosa and is the founding member of a distinct class of epoxide hydro

9 Src is the founding member of a diverse family of intracellular

10 Drosophila melanogaster Kelch (KEL) is the founding member of a diverse protein family defined

11 Yeast VPS13 is the founding member of a eukaryotic gene family of growi

12 T4 polynucleotide kinase (Pnk) is the founding member of a family of 5'-kinase/3'-phosphat

13 The Vibrio fischeri LuxR protein is the founding member of a family of acyl-homoserine lacto

14 The yeast SWI/SNF complex is the founding member of a family of ATP-dependent remodel

15 g an active chlorhexidine efflux protein and the founding member of a family of bacterial drug efflux

16 The diaphanous gene is the founding member of a family of Diaphanous-related fo

17 (XPD) is a 5'-3' superfamily 2 helicase and the founding member of a family of DNA helicases with ir

18 GATA-1 is the founding member of a family of DNA-binding proteins

19 inococcus radiodurans RNA ligase (DraRnl) is the founding member of a family of end-joining enzymes e

20 TMC1 is the founding member of a family of genes encoding protei

21 cystine exporter defective in cystinosis, is the founding member of a family of heptahelical membrane

22 ria, indicating that AtBphP2 might represent the founding member of a family of histidine phosphorela

23 lynx1, the founding member of a family of mammalian prototoxins

24 tage-gated H+ channel and establish H(v)1 as the founding member of a family of mammalian VSD protein

25 It is the founding member of a family of MBT domain-containing

26 signal-regulated protein kinase 2 (ERK2) is the founding member of a family of mitogen-activated pro

27 MEI-S332 is the founding member of a family of proteins important fo

28 Zyxin is the founding member of a family of proteins that also in

29 Bcl2 is the founding member of a family of proteins that regulat

30 Slx1 is the founding member of a family of proteins with a predi

31 RACK1 is the founding member of a family of receptors for activat

32 Previous work shows that FGD1 is the founding member of a family of related genes includi

33 lammatory cytokine interleukin 17 (IL-17) is the founding member of a family of secreted proteins tha

34 e speculate that the VEGFA switch represents the founding member of a family of signal-mediated, prot

35 acts through PYRABACTIN RESISTANCE 1 (PYR1), the founding member of a family of START proteins called

36 Oxysterol-binding protein (OSBP) is the founding member of a family of sterol-binding protei

37 tein, TRP (transient receptor potential), is the founding member of a family of store-operated channe

38 The Tec protein tyrosine kinase is the founding member of a family that includes Btk, Itk,

39 ed an alpha-l-rhamnosidase, BT3686, which is the founding member of a glycoside hydrolase (GH) family

40 Drosophila Piwi is the founding member of a gonadal clade of Argonaute prot

41 RcaC is the founding member of a group of large response regulat

42 nzyme from Saccharomyces cerevisiae, Ste14p, the founding member of a homologous family of endoplasmi

43 osphatidylcholine transfer protein Sec14p is the founding member of a large eukaryotic protein superf

44 It is the founding member of a large family of DNA binding pro

45 Sir2p is the founding member of a large family of NAD-dependent d

46 called ubiquitin (APF-1 in these papers), is the founding member of a large family of proteins contai

47 identified T-lineage-restricted protein, is the founding member of a large metazoan protein family.

48 Pdr5 is the founding member of a large subfamily of evolutionari

49 genes are regulated in the testis by Rhox5, the founding member of a large X-linked homeobox gene cl

50 Ada is thus the founding member of a mechanistic class of proteins t

51 We propose domain D2 as the founding member of a new carbohydrate binding module

52 ar receptor for poliovirus CD155 (or PVR) is the founding member of a new class of membrane-associate

53 Diphosphomevalonate (Mev.pp) is the founding member of a new class of potential antibiot

54 es in E. coli been discovered and represents the founding member of a new enzyme family.

55 rties and the genome content support MTIV as the founding member of a new family of archaeal viruses.

56 ther show that the other protein (SpoIID) is the founding member of a new family of lytic transglycos

57 Pyrococcus abyssi NucS is the founding member of a new family of structure-specifi

58 p300/CBP, TATA-binding protein and Lhx2, is the founding member of a new family of transcription fac

59 Murine (m) FIZZ1 is the founding member of a new gene family including two o

60 The CD155 protein is the founding member of a new group of related molecules

61 BPCV1 is the founding member of a new group of viruses that remar

62 We suggest that lin-9 is the founding member of a new protein family that functio

63 e examined whether protein kinase D1 (PKD1), the founding member of a new protein kinase family, play

64 ein of the yeast Saccharomyces cerevisiae is the founding member of a new sub-family of proteins in t

65 SWI2 is believed to be the founding member of a new subfamily of DNA-stimulated

66 Thus, Rv2179c is the founding member of a new, large RNase family with hu

67 Nhx1 is the founding member of a newly emergent cluster of excha

68 anger of Saccharomyces cerevisiae represents the founding member of a newly emerging subfamily of int

69 vered through a metagenomics approach and is the founding member of a novel CBM family, CBM81.

70 he beta-globin locus control region (LCR) is the founding member of a novel class of cis-acting regul

71 consistent with the hypothesis that FAD4 is the founding member of a novel class of fatty acid desat

72 pathway defined here, we show that Rtt109 is the founding member of a novel class of histone acetyltr

73 tial characterization of myosin-XIX (Myo19), the founding member of a novel class of myosin that asso

74 E (SIM) gene of Arabidopsis thaliana encodes the founding member of a novel class of plant-specific c

75 Synaptopodin is the founding member of a novel class of proline-rich act

76 m-negative and gram-positive bacteria and is the founding member of a novel family of flippases.

77 Interleukin (IL)-17 is the founding member of a novel family of inflammatory cy

78 Interleukin (IL)-17 is the founding member of a novel family of inflammatory cy

79 IL-17 is the founding member of a novel family of proinflammatory

80 This study suggests that Rce1 is the founding member of a novel IMP family, the glutamate

81 We propose that phage BcepNazgul is the founding member of a novel phage type, to which Sano

82 We propose that pentamidine is the founding member of a novel pharmacological entity wh

83 DopA is the founding member of a novel protein family required f

84 and Bmp1)-EGF domain-containing protein 1), the founding member of a novel secreted and cell surface

85 the catalytic subunit of SWI/SNF, and it is the founding member of a novel subfamily of the SF2 supe

86 Here we describe the founding member of a novel, structurally distinct fo

87 intain repression2 (RMR2) protein represents the founding member of a plant-specific clade of predict

88 ID1 is the founding member of a plant-specific zinc finger prot

89 This protein, named Tectonic, is the founding member of a previously undescribed family o

90 e with Ub lead us to classify this domain as the founding member of a previously unknown class of deu

91 NgR1, an axonal glycoprotein, is the founding member of a protein family composed of the

92 Crescentin, which is the founding member of a rapidly growing family of bacte

93 MICU1 represents the founding member of a set of proteins required for hi

94 Ikaros is the founding member of a small family of C2H2 zinc-finge

95 s a pro-apoptotic BCL-2 family member and is the founding member of a subfamily of pro-apoptotic prot

96 Kinesin is the founding member of a superfamily of microtubule base

97 GATA-1 is the founding member of a transcription factor family tha

98 These results establish Bye1 as the founding member of a unique family of chromatin tran

99 um-activated malate transporter (TaALMT1) is the founding member of a unique gene family of anion tra

100 Sla2p, also known as End4p and Mop2p, is the founding member of a widely conserved family of acti

101 S2P is the founding member of a widely distributed family of me

102 The predicted SUDD protein is the founding member of a widely expressed protein family

103 Tne2 is the founding member of a widespread family of interbacte

104 TP and lipase consensus sequences present in the founding members of a family of calcium-independent

105 amic acid (Gla) proteins (PRGPs) 1 and 2 are the founding members of a family of vitamin K-dependent

106 hila mesoderm requires Wingless (Wg), one of the founding members of a large family of secreted glyco

107 phatidylinositol kinases, and thus represent the founding members of a new family.

108 TMC1 and a related gene, TMC2, are the founding members of a novel gene family.

109 We propose that these phages comprise the founding members of a novel podophage lineage, the B

110 RcnR and Mycobacterium tuberculosis CsoR are the founding members of a recently identified, large fam

111 omain with a KLCC domain makes both proteins the founding members of a third group of HMG proteins.

112 hich specifically hydrolyses levan, contains the founding member of CBM family 66 (CBM66).

113 ecific carbohydrate-binding module (CBM) and the founding member of CBM family 70.

114 Sirtuin 1 (SIRT1), the founding member of Class III histone deacetylases, r

115 ryotic translation initiation factor eIF4AI, the founding member of DEAD-box helicases, undergoes ATP

116 Ufd2 is the founding member of E4 enzymes that are specifically

117 ETS1, the founding member of Ets transcriptional factor family

118 Human guanylate-binding protein 1 (hGBP1), the founding member of GBPs, is also engaged in the regu

119 mammalian ortholog of Drosophila roadblock, the founding member of LC7/robl/km23 class of dynein lig

120 RhoA, the founding member of mammalian Rho GTPase family, is t

121 The protooncogene c-jun encodes the founding member of the activator protein-1 family an

122 Dril1 is the founding member of the ARID family and is involved i

123 P-glycoprotein, the founding member of the ATP-binding cassette (ABC) fa

124 eukaryotes, and we thus propose that EzrA is the founding member of the bacterial spectrin family.

125 BIK is the founding member of the BH3-only family pro-apoptotic

126 It is the founding member of the CDK family and is conserved a

127 CITED1 is the founding member of the CITED family of cofactors tha

128 The founding member of the class XIVa family, Toxoplasma

129 ribe properties of one such kinase, Clk/Sty, the founding member of the Clk/Sty family of dual-specif

130 vivo sensor, we confirm our hypothesis that the founding member of the conserved Ena/VASP (Enabled/V

131 Drosophila Elav is the founding member of the conserved family of Hu RNA-bi

132 Here, we present the structure of the founding member of the DAN family, neuroblastoma sup

133 RR) and an immunoglobulin (Ig) domain and is the founding member of the Drosophila Kekkon family.

134 V-ets, the founding member of the ETS oncogene family, was orig

135 eyes absent, the founding member of the Eya family is expressed dynam

136 Despite its essential nature and status as the founding member of the F-box protein family, Cyclin

137 fe and death are Bcl-2 family proteins, with the founding member of the family (B-cell lymphoma/leuke

138 DOCK1 is the founding member of the family and acts downstream of

139 s prevailing model of functional division in the founding member of the family, Cdc15, which is essen

140 The founding member of the family, cyclophilin A (CyPA),

141 Mutations in the founding member of the family, human bestrophin-1 (h

142 c principles that underlie the biogenesis of the founding member of the family, IL-12.

143 showed that LATERAL ORGAN BOUNDARIES (LOB), the founding member of the family, is a transcriptional

144 shares significant sequence similarity with the founding member of the family, RhoA.

145 The founding member of the family, TIMING OF CAB EXPRESS

146 E2F1, the founding member of the family, undergoes posttransla

147 However, the founding member of the Frizzled family, Drosophila F

148 hancer- and promoter-binding factor, GATA-1, the founding member of the GATA family.

149 nalogous to that recently reported for E6AP, the founding member of the Hect ligase family.

150 Histone acetyltransferase 1 is the founding member of the histone acetyltransferase sup

151 The multiprotein complex Set1/COMPASS is the founding member of the histone H3 lysine 4 (H3K4) me

152 HIF-1alpha, the founding member of the hypoxia-inducible factor (HIF

153 -1 beta (IL-1 beta)-converting enzyme (ICE), the founding member of the ICE/ced-3 cell death gene fam

154 Interleukin (IL)-17, the founding member of the IL-17 cytokine family, is the

155 The founding member of the inhibitor of apoptosis protei

156 ING1, the founding member of the inhibitor of growth family, e

157 lin-dependent kinase inhibitor p16(INK4a) is the founding member of the INK4 family of tumor suppress

158 g a generic recognition site for furin/SPC1, the founding member of the intracellularly active family

159 rabidopsis thaliana, IQD1 (IQ67 domain 1) is the founding member of the IQD family of putative CaM ta

160 Ste14p is the founding member of the isoprenylcysteine carboxyl me

161 Jarid2/Jumonji, the founding member of the Jmj factor family, critically

162 Here we demonstrate that the founding member of the Jumonji family, JMJ (JUMONJI

163 Bicoid is the founding member of the K50 class of homeodomain prot

164 The frizzled (fz) gene of Drosophila encodes the founding member of the large family of receptors for

165 Lrig1 is the founding member of the Lrig family of transmembrane

166 SIRT1, the founding member of the mammalian family of seven NAD

167 wn regulated gene 4), of which the latter is the founding member of the NEDD4 family of ubiquitin lig

168 The founding member of the NET superfamily, NET1A, is an

169 ino acid sequence identity with uteroglobin, the founding member of the newly formed Secretoglobin (S

170 The Drosophila piwi gene is the founding member of the only known family of genes wh

171 Pem, the founding member of the PEPP subfamily, has undergone

172 rotein (FRAP, also known as mTOR or RAFT) is the founding member of the phosphatidylinositol kinase-r

173 omyces pombe requires the function of Cdc15, the founding member of the pombe cdc15 homology (PCH) fa

174 Rab1 is the founding member of the Rab small GTPase family, whic

175 MitoNEET (mNT) is the founding member of the recently discovered CDGSH fam

176 Sst2 is the founding member of the RGS (regulators of G protein

177 The founding member of the Rhox gene cluster, Rhox5, is

178 ddress the underlying mechanism, we examined the founding member of the Rhox gene cluster-Rhox5-and f

179 The Drosophila runt gene is the founding member of the Runt domain family of transcr

180 SOL1, the founding member of the S. cerevisiae SOL family, was

181 Uteroglobin (UG), the founding member of the Secretoglobin superfamily, is

182 Sir2, a key component of yeast longevity and the founding member of the sirtuin family of deacetylase

183 lly, the NAD(+)-dependent deacetylase SIRT1, the founding member of the sirtuin family, contributes t

184 Anion exchanger 1 (AE1; Band 3; SLC4A1) is the founding member of the solute carrier 4 (SLC4) famil

185 this subfamily based on sequence homology to the founding member of the subfamily, the yeast protein

186 an historical member of the superfamily and the founding member of the subgroup known as ov-serpins

187 brachyury, the founding member of the T-box gene family, is a key g

188 he most extensively studied 4-OT isozyme and the founding member of the tautomerase superfamily.

189 he ten-eleven translocation 1 (TET1) gene is the founding member of the TET family of enzymes (TET1/2

190 NgR1 is the founding member of the three-member NgR family, wher

191 Drosophila Tribbles (Trbl) encodes the founding member of the Trib family of kinase-like pr

192 NOMPC is the founding member of the TRPN subfamily, and is though

193 TSC-22 is the founding member of the TSC-22/DIP/Bun family of leuc

194 lloid 1 (TRPV1), or vanilloid receptor 1, is the founding member of the vanilloid type of TRP superfa

195 scular endothelial growth factor A (VEGF-A), the founding member of the vascular permeability factor

196 Drosophila Wingless (Wg) is the founding member of the Wnt family of secreted protei

197 Here, we report crystal structures of the founding members of the ATP-dependent RNA ligase fam

198 e-specific RNA binding protein and is one of the founding members of the CPEB family of translational

199 b-group transcriptional repressor and one of the founding members of the family of SET domain-contain

200 by switch proteins called Raps, named after the founding members of the family, which were shown to

201 The founding members of the HD-domain protein superfamil

202 ization domain (NOD) proteins NOD1 and NOD2, the founding members of the intracellular NOD-like recep

203 Tc3 of Caenorhabditis elegans is one of the founding members of the Tc1 family which includes DN

204 The founding members of the wwPDB are RCSB PDB (USA), MS

205 r, controversy about the placement of two of the founding members of the Ypt/Rab family, Ypt1 and Ypt

206 Starting from the founding member of this chemical series 1a (notated

207 g C domain in the dodecameric secretin PulD, the founding member of this class, prevents pore formati

208 The founding member of this family from Mycobacterium tu

209 The founding member of this family is Caenorhabditis ele

210 The founding member of this family is the AsiA protein o

211 MKP-1, the founding member of this family of dual-specificity p

212 The identification of mutations in MeCP2, the founding member of this family, as causal for the ne

213 the homologue from Escherichia coli (EcIDH), the founding member of this family, were made.

214 We have characterized Dan, the founding member of this family, with regard to both

215 The RIZ gene is the founding member of this family; it was isolated beca

216 The founding member of this group, walleye dermal sarcom

217 re we present a thorough genetic analysis of the founding member of this novel family of DNA polymera

218 Brachyury (T) is the founding member of this T-box transcription factor f

219 nuclear RNA (snRNA) gene promoters are among the founding members of those recognized by RNA polymera

220 The founding member of TUTase family, RNA editing TUTase