ライフサイエンスコーパス: the intended

1 was found to direct photoadduct formation to the intended 5'-TpA base step next to the PNA-binding si

2 functional contribution of their homologs to the intended action.

3 ed to work with the immune system, enhancing the intended activation of antigen presenting cells (APC

4 00 neurons in the motor cortex, we predicted the intended activity of several of the paralysed muscle

5 methods are easily implemented and preserve the intended alpha level and power.

6 ce and suitability of expression systems for the intended analysis of GPCR properties.

7 ation of IgG antibodies with specificity for the intended analyte.

8 Comparing the intended and final postoperative refractions calcula

9 vocalizations, detects discrepancies between the intended and heard vocalization, and contains inform

10 The method worked well for the intended application in image data management.

11 rtunity to achieve enhanced functionality in the intended application.

12 set of functional properties designed to fit the intended application.

13 Infusion of Nlxz into the intended area reduced food intake by 42.3% below bas

14 d tomography demonstrated dose delivery into the intended area.

15 s a visually specified reference command for the intended arm/hand position trajectory with respect t

16 uided chemoablation with acetic acid enabled the intended arrhythmic substrate, whether deep or super

17 Eighty-four percent of patients received the intended ASCT, and 68% of patients received IL-2 tre

18 The intended audience for this statement includes health

19 The intended audience is physicians and other emergency

20 The intended audiences include researchers, government p

21 that the intended cue for future action and the intended behavior could be decoded from distinct pos

22 on, yet virtually nothing is known about how the intended beneficiaries have used these protections.

23 ndary should be further increased to provide the intended benefits for the people living near the por

24 under what circumstances triage would confer the intended benefits.

25 hopeful monster" differed significantly from the intended (betaalpha)(8)-barrel fold by an extra beta

26 take and compare it with the distribution of the intended biologic target (as visualized with immunoh

27 series was used to demonstrate inhibition of the intended biological target, resulting in apoptosis a

28 een the functional molecules on the MNPs and the intended biological targets.

29 looked a valuable resource, the expertise of the intended biologist users.

30 through an external circuit to interact with the intended biosystem whereas electrons are transported

31 The intended care patterns varied widely across indicati

32 as bound in the active site, interacted with the intended catalytic base in a catalytically relevant

33 ent virus, and each of the viruses expressed the intended chemokine in a dose-dependent manner.

34 he causal mechanisms and interactions within the intended clinical context is needed to develop inter

35 unction with duration of effect suitable for the intended clinical use in acute coronary syndromes.

36 The results did not allow the intended comparison due to an unanticipated effect o

37 ndary structure can prevent the formation of the intended complex before enzymatic ligation can occur

38 tion show that the designed protein folds to the intended configuration, tying itself in a knot in th

39 The solution structure confirmed the intended connectivity and stereochemistry of the oli

40 legislation as written is not likely to have the intended consequences, as it fails to adequately shi

41 a unique, reliable, and valid assessment of the intended construct.

42 liable score measuring all key dimensions of the intended construct; and/or lacked adequate psychomet

43 The key building blocks (6, 7, and 8) for the intended construction of the originally proposed str

44 some scenarios, it is difficult to simulate the intended contact of materials used in food packaging

45 other assessed asthma parameters, reflecting the intended controlled status of the trial subjects.

46 s in group II (76.6%) were within +/-0.5D of the intended correction and 23 eyes (76.6%) in group I a

47 es in group II (50%) were within +/-0.25D of the intended correction.

48 nd 94% (15) eyes were within 1.0 diopters of the intended correction.

49 Multivariate analysis showed that the intended cue for future action and the intended beha

50 criptional rewiring may confer bacteria with the intended desirable properties, such approaches may a

51 optic flow to redirect self-movement toward the intended destination.

52 whether the dicistronic vector produces only the intended dicistronic mRNA.

53 to graft-versus-host disease (GVHD) even if the intended donor's neonatal lymphocytes were unrespons

54 Forty of 42 patients tolerated the intended dose (42 Gy) of preoperative radiation and

55 four patients received three inoculations at the intended dose levels, which elicited antibodies able

56 The intended dose of chemotherapy was given in 100%, 70%

57 The intended dose-intensity of cyclophosphamide was 1,00

58 s, continuing to receive imatinib at 100% of the intended dose.

59 All patients received the intended doses of proton radiotherapy.

60 wn to mimic inhibition of HMG-CoA reductase (the intended drug target) with the same lipids and metab

61 roxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target.

62 he dimeric diaminopyridazine 2a corroborates the intended duplex mode of assembly.

63 lonies propagated without selection harbored the intended edits, of which more than one-half were hom

64 d hypercholesterolemia per se may counteract the intended effect of aromatase inhibitors.

65 of action behind treatment toxicity reflects the intended effect on the treatment target, the toxicit

66 lf-report data also were obtained to confirm the intended effects of script-driven imagery.

67 tablishing whether social interventions have the intended effects on the populations they are presume

68 Palliative sedation with the intended end point of unconsciousness (PSU) is a mor

69 ex (PPC) have previously been used to decode the intended endpoint of a reach, providing the first ev

70 s such as the chicoric acids do not act upon the intended enzymatic target but behave as entry inhibi

71 table toxicity and received more than 80% of the intended first-cycle dose.

72 RH3 adopted the intended fold, which has not been observed previousl

73 nt period and three of four animals survived the intended follow-up period.

74 When the intended foot placement changes during a step, eithe

75 ogels the ability to participate actively in the intended function of the carrier system rather than

76 he mode of secretion seems to be tailored to the intended function of the secreted molecule.

77 gonists, and antagonists in order to achieve the intended functional activity at a GPCR of therapeuti

78 in high yield in Escherichia coli and share the intended functional and structural properties with K

79 eta-catenin promoted endogenous HCC carrying the intended gain-of-function mutations.

80 ng and its relation with the environment and the intended genetic improvement.

81 mited dilution to isolate cell colonies with the intended genomic manipulation.

82 eurons provide multimodal representations of the intended goal of a forthcoming action, encoding a be

83 Patients could be enrolled irrespective of the intended goal of pump support (bridge to transplanta

84 The intended goal of surgical correction of SUI and POP

85 y of reward were decoded simultaneously with the intended goal.

86 te action outcomes and their deviations from the intended goals and to adjust behavior accordingly.

87 ated thoroughly and chosen carefully so that the intended goals are met.

88 t VLPFC may host an abstract "vocabulary" of the intended goals pursued by primates in their natural

89 ts reconsideration to ensure it is achieving the intended goals.

90 stem is effective and efficient in achieving the intended goals.

91 y that one enantiomer of a compound bound to the intended HCV NS5B polymerase target whereas the mirr

92 ors and how to modify them and for assessing the intended health, livelihood, and environmental benef

93 We found that the polypill showed the intended immediate and sustained release profiles ba

94 ted 13 novel receptor variants stabilized in the intended inactive state among which two exhibit an a

95 evels that compete for these antibodies over the intended individual acetylation sites.

96 To extract the intended information from these regulated genes, bio

97 s that are highly unexpected on the basis of the intended layer sequencing.

98 and actions are represented independently of the intended limb in PPC and PMd.

99 Implantation success (1 valve in the intended location) was 98.3%.

100 d addition of an herbicide-tolerance gene at the intended locus in a significant number of isolated e

101 Other than the intended Lys/amino terminal iTRAQ labeling, such mod

102 The intended management before and changes as a conseque

103 ssified as either treatment or nontreatment, the intended management change for each cancer type was

104 (18)F-DOPA PET/CT changed the intended management of 41% of patients with brain tu

105 ct of (18)F-sodium fluoride PET (NaF PET) on the intended management of cancer patients with osseous

106 e-specific membrane antigen (PSMA)-11 PET on the intended management of patients with biochemically r

107 nificant impact of (68)Ga-DOTATATE PET/CT on the intended management of patients with NETs (50% of ch

108 nstrates a substantial impact of DOTATATE on the intended management of patients with neuroendocrine

109 When the intended management plan before PET was treatment, a

110 ore effortful processing needed to interpret the intended meaning of an utterance.

111 h which native speakers are able to identify the intended meanings of common polysemous words.

112 kage assays, and electron microscopy support the intended mechanism of action, which leads to prefere

113 n antisense sequences and thereby may affect the intended mechanism of action.

114 tervention affects the tumor burden process, the intended mechanism through which it is hoped that mo

115 , indicating that it kills cancers cells via the intended mechanism.

116 operation on the inferior rectus rather than the intended medial rectus muscle, and inattention and/o

117 f therapy for relapsed NSCLC did not achieve the intended median survival of 6 months.

118 which allows listeners and readers to infer the intended message (speaker meaning) from the coded me

119 res display semantic information relevant to the intended message [4-6].

120 minishes the amount of ZnCl(2) available for the intended metathesis reaction to take place.

121 therapy, with a significant interaction with the intended method of revascularization (P<0.0001).

122 Randomization was stratified by the intended method of revascularization, coronary arter

123 Even when K(+) channel block is the intended mode of action, block of related channels i

124 ding of the interaction between the GNPs and the intended molecular target is critical for the develo

125 reflecting an inverse model, rather than by the intended motion of the visual cursor (forward model)

126 hen auditory feedback does not correspond to the intended motor gesture.

127 urse of motor pre-programming and release of the intended movement by an acoustic startle stimulus.

128 le lengthening and to detect departures from the intended movement trajectory.

129 genes can be amplified more efficiently than the intended mtDNA target, even when using as template m

130 tion requires a guide RNA targeting close to the intended mutation, whereas heterozygous introduction

131 tributing the observed phenotypic changes to the intended mutation.

132 ed that over 2/3 (24 of 35 designs, 69%) had the intended new site specificity, and that 14 of the 15

133 The intended objectives of improved access to the operat

134 ieve minimal off-targeting while maintaining the intended on-target activity.

135 specifically block infection, independent of the intended on-target effect.

136 arable to (or higher than) those observed at the intended on-target site.

137 sequence space of microRNA seeds instead of the intended on-target space of protein-coding genes.

138 henotypic effects of siRNAs are unrelated to the intended "on-target" mechanism, defined by full comp

139 The intended operations were aborted in all patients fol

140 The intended operations were all subsequently performed,

141 ks (MOFs), metal centres can coordinate with the intended organic linkers, but also with solvent mole

142 The intended outcome of the strategy is to reduce compli

143 nger at Observable and Related outcomes than the Intended outcome when the Communicator used speech.

144 ssessment of interpretation and impact among the intended patient group.

145 se event profile, and severity of illness of the intended patient population.

146 ion of an object drug and consequently alter the intended pharmacologic response and potentially lead

147 reaction involving the oxime did not provide the intended polyheterocyclic fenestrane.

148 ppeared not to have severe renal impairment, the intended population for this dose.

149 ad modest and relatively targeted effects on the intended populations.

150 The intended primary end point was the change in interst

151 primer is extended by 6-9 bases or longer at the intended priming site, which is deliberately selecte

152 roup B, the median time to the initiation of the intended procedure was 1.6 hours; periprocedural hem

153 conditions the cells will experience during the intended process and measure the appropriate physiol

154 ot always the case, with multiple species of the intended product being produced due to amino acid mi

155 ce a vast range of molecular structures, but the intended product must be known at the outset.

156 tive, it was impossible to place patients in the intended programs.

157 obilization reaction is highly selective for the intended protein, the tether is covalent and, hence,

158 t terms used to frame the exercise, 3) state the intended purpose for any proposed set of criteria, a

159 e importance of these six domains depends on the intended purpose for the criteria (clinical care, ba

160 The intended purpose of analytical methods is directly r

161 Abuse-deterrent formulations can have the intended purpose of curtailing abuse, but the extent

162 ly for low-risk studies, may no longer serve the intended purpose of protecting human participants, a

163 ce of these domains of usefulness depends on the intended purpose, of which there are four broad cate

164 oefficients were found to be less suited for the intended purpose, other methods can provide a suitab

165 to inform on their usefulness with regard to the intended purpose.

166 l standards should give serious attention to the intended purposes of such standards, what form they

167 The intended rats for cancer treatment received two succ

168 If unheard by the intended receivers, calls are not beneficial to the

169 re (100%); maintained the ability to bind to the intended receptor; formed a minimal amount of aggreg

170 rs: gender, the relationship of the donor to the intended recipient and the presence of ambivalence a

171 In the event that the intended recipient dies after the donor graft has be

172 l communication in pairs of chimpanzees when the intended recipient was within 10 m of the signaller.

173 een procured and cannot be transplanted into the intended recipient, and if informed consent has been

174 smooth muscle cells that were allogeneic to the intended recipient, using a biomimetic perfusion sys

175 hen seeded with cells that were derived from the intended recipient--either endothelial progenitor ce

176 >/=20/40, and 81.8% of eyes were +/-0.5 D of the intended refraction.

177 a bridge with two carbon atoms should enable the intended regiocontrol within the DNA duplex structur

178 Although the intended regioselectivities were not observed, unusu

179 h may be a product of tissue (heart) or that the intended response was transient.

180 licy recommendations and guidelines that are the intended result of collecting the data in the first

181 52%) of studies, authors were unclear about the intended role of the test, and in 3% (95% CI: 0%, 6%

182 mination in peripheral vision at the goal of the intended saccade.

183 The intended sample size was 900 patients.

184 Only 56% of the intended sample size was recruited.

185 slow recruitment after enrolling only 25% of the intended sample size, leaving it severely underpower

186 ne may be informed by assessing gaps between the intended scope of practice of residents and actual s

187 ts of oligonucleotides are not solely due to the intended sequence-specific interactions with nucleic

188 One such isolate had exactly the intended sequence.

189 tion-specific nucleotide biases that obscure the intended signal and reduce the effectiveness of thes

190 ptors, which is crucial for translation into the intended signaling outputs.

191 that proofreading can remain effective when the intended signaling pathway exhibits high levels of r

192 rvened on, with Melody valve implantation at the intended site in all patients.

193 ve high levels of the activated cytotoxic at the intended site of action.

194 ding a short primer, making it a long one at the intended site only.

195 structure reveals that Ca.CD2 binds Ca2+ at the intended site with the designed arrangement, which v

196 egrees C then accepts the extended primer at the intended site, but not at alternative sites, where t

197 These RNAi lines expressed the intended small interfering RNAs in the anther and sh

198 quent catalytic amplification magnifies only the intended SNV targets.

199 ransfected cells confirmed the production of the intended ssDNAs.

200 Although this was not the intended strategy of the task, it was nonetheless an

201 ask what modifications are necessary to form the intended structure and what potential this approach

202 mize a self-assembly reaction to ensure that the intended structure is kinetically accessible.

203 Both groups displayed substantial damage to the intended structure, with the lateral regions typical

204 no difference in the incidence of IFI during the intended study period (fluconazole 16% versus itraco

205 In addition to the intended substitutions, novel mutations were introdu

206 promote the binding of molecules other than the intended substrate, with the result that such enzyme

207 TNFR1) that normally regulates expression of the intended target (ICAM-1).

208 ctivity (disruption of DNA-LEF-1 binding) at the intended target and site (inhibition of intracellula

209 ven guideline is memorable and actionable by the intended target audience.

210 ctors can be saturated, and genes other than the intended target can be silenced.

211 tive axons across the injured spinal cord to the intended target establishing a critical step for neu

212 When the structure of the intended target is available, one approach is to use

213 gen receptor ligand-binding domain (AR-LBD), the intended target of androgen deprivation therapies in

214 achment to and entry into host cells, and is the intended target of antibody therapeutics.

215 re optimal laboratory performance instead of the intended target of typical performance attained duri

216 Each primer set detected 20 cDNA copies of the intended target per sample and had no reaction with

217 aged 0.78 diopters (0.49-1.07) of error from the intended target refractive outcome.

218 87% of the captured sequence originated from the intended target region with sequencing coverage fall

219 g opportunities to study genomic data beyond the intended target regions.

220 Specific amplification of the intended target requires that primers do not have ma

221 screen, can bind to the survivin protein at the intended target site.

222 at the developed inhibitors do interact with the intended target site.

223 rsor center-out task, tuning to direction of the intended target was well captured by a log-linear co

224 target appearance could be used to classify the intended target with an accuracy of 95% in one parti

225 e the same fluorescence as one equivalent of the intended target, and detection works reliably over a

226 c eye movements consistently fail to land on the intended target, saccade accuracy is maintained by g

227 stent with an acute inactivation of mGluR8a, the intended target, two findings confounded this interp

228 Besides the intended target, unexpected drug off-target interact

229 howed affinity/activity for GPCRs other than the intended target, which could be partly attributed to

230 njected into the DCN to guide graft axons to the intended target.

231 assignment of positive clinical response to the intended target.

232 cretion of soluble cytolytic proteins toward the intended target.

233 d with chemical structure or the identity of the intended target.

234 t differ by as many as five nucleotides from the intended target.

235 e-conferring kinase domain (KD) mutations in the intended target.

236 All labeling signals are specific for the intended targets and are brighter and considerably m

237 movement in paralysed animals by focusing on the intended targets of movement rather than their inter

238 oligomeric SOD1 species in the spinal cord, the intended targets of the immunization strategy.

239 DT) display poor chemical selectivity toward the intended targets, and uptake by cells most likely ar

240 nction of many transmembrane proteins beyond the intended targets.

241 d and their joint velocities decomposed into the (intended) task-relevant and the (spontaneous) task-

242 es in gene expression may sensitize cells to the intended tetracycline-controlled loss or gain of fun

243 e of these designed proteins bind metal with the intended tetrahedral geometry.

244 within 5 +/- 3 d was well tolerated and had the intended therapeutic effect.

245 digm in understanding drug action focuses on the intended therapeutic effects and frequent adverse re

246 river lines display excision activity beyond the intended tissue or cell type, and these data are fre

247 eliver sufficient nanoparticle quantities to the intended tissues.

248 Readthrough of these RNAs into the intended transcriptional unit potently stimulated re

249 ignificantly affects the comparison, as does the intended transportation application.

250 A total of 407 patients received the intended treatment and were available for primary ou

251 The intended treatment duration was 14 days.Main Outcome

252 nce was evaluated, ie, patients who received the intended treatment had a delayed cutaneous hypersens

253 ebo; all randomly assigned patients received the intended treatment), 205 non-responders, and 235 ine

254 In analysis based on the intended treatment, mean +/- SD length and LAZ for t

255 gery in 41% of patients for whom surgery was the intended treatment.

256 Fe horizontal lineO unit (r = 1.661(2) A) in the intended trigonal bipyramidal geometry enforced by t

257 uld be useful, particularly one aligned with the intended ultimate outcome of this scientific effort:

258 at the use of such materials may not achieve the intended uniformity among laboratories measuring CMV

259 onolayers (i) comprised, almost entirely, of the intended unit cell, (ii) exhibiting patterned domain

260 rther comparison under conditions simulating the intended use combined with the criterion of long-ter

261 The intended use of a magnetic material, from informatio

262 d dual target plasmid pRSETMON-02 is fit for the intended use of quantifying MON 810 maize and is a b

263 uate accuracy and precision are achieved for the intended use of the material.

264 the most cost-effective strategy depends on the intended use of the PICC and the need to have the ti

265 cost of fluoroscopy or the IR suite, and (c) the intended use of the PICC.

266 do not perfectly reflect the composition of the intended use population, (2) potential biases that c

267 al showed to be sufficiently homogeneous for the intended use, and storage at -20 degrees C for 5 mon

268 f a specific characterized cultivar based on the intended use, fresh consumption or processed product

269 le to choose the desired pumpkin variety for the intended use.

270 s on its place and date of production and on the intended use.

271 and the risks and benefits of a treatment in the intended-use patient population.

272 The intended users of this action plan are clinicians, p

273 ents for optimal selectivity and efficacy in the intended vascular bed.

274 To produce a word, the intended word must be selected from a competing set