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1 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 x 10(-1
2               These data are consistent with the known 3- to 6-month lag in recovery of specific immu
3 een the two datasets, with 24.7% or 42.5% of the known 49.0 kbp of LGT sequence predicted correctly,
4    All observed density can be attributed to the known 80 subunits of the individual complexes, inclu
5 ntiOxCINs, these molecules take advantage of the known ability of the triphenylphosphonium cation to
6 anches at their 6-positions, consistent with the known acceptor chain specificity of GlgE.
7                                     Thus all the known actin-like polymers are likely to be the desce
8 e in the intramolecular rotation, increasing the known activation energy to rotation from 8.5 to 10.6
9               Despite the small sample size, the known AD risk variant APOE4 reached genome-wide sign
10     The high frequency of this procedure and the known adverse effects of repetitive pain in neonates
11  up into the skin and contributes to many of the known adverse side effects of ATRA treatment, includ
12 widespread zoonotic transmission and adds to the known aetiologies of infectious diseases for this re
13  to an extent comparable to that attained by the known AKR inhibitor epalrestat.
14 ng two weakly mutagenic aromatic amines, and the known alkaloid comutagen norharman along with two re
15                                      Most of the known allergens that were dominant at the T cell lev
16 rature further stabilizes it with respect to the known alpha-B6O structure.
17 ociated with major TAL effectors that target the known alternative S genes OsSWEET14 and OsSWEET13.
18 review, we provide an up to date overview of the known AMPylating enzymes, the regulation of these en
19 e produced several simple models inspired by the known anatomical structures and neuronal responses w
20                             A model based on the known anatomy of layer 4 demonstrates that the known
21           However, this view is at odds with the known anatomy of layer 4 interneurons in visual cort
22  various algorithms and to benchmark against the known ancestral genotypes and ancestral phenotypes.
23            Here, we test the function of all the known and candidate KDMs in myoblast and osteoblast
24                                   Leveraging the known and high-affinity interaction between CB[7] an
25 s review focuses on our current knowledge of the known and potential interaction of the microbiome in
26 ld be used judiciously and with awareness of the known and unknown or potential side effects.
27 conformation is a novel mechanism to explain the known anti-inflammatory effects of this compound, in
28  D4.2 lacks epitopes associated with half of the known antigenic sites, which significantly impacts o
29 gainst P. falciparum parasites comparable to the known antimalarials, chloroquine and mefloquine.
30         Using this pipeline, we have widened the known antimicrobial spectrum for V. odorata cyclotid
31                                              The known ASD risk genes were ranked on average in the 7
32 ly, this peptide motif is sequestered within the known ASF1-H3-H4 interface, raising the question of
33 sease has been relatively neglected, despite the known association between severe tricuspid regurgita
34    Our work is the first to demonstrate that the known association between WT1 expression in breast c
35                              Overall, 26% of the known associations in studies of individuals of Euro
36 he associations with EA are far smaller than the known associations with the biologically proximal en
37                         It is different from the known asteroid binaries in its combination of wide s
38                  Structural modifications of the known autotaxin inhibitor lead compound 1, to attenu
39 ed with BBS did not identify any mutation in the known BBS genes.
40 ially for small groups of cells, emerge from the known behaviors of individual cells.
41     Intergenerational conflict combined with the known benefits conveyed to kin by post-reproductive
42 ndings from during the past decade expand on the known benefits of breastfeeding for women and childr
43 throughput screening hit anthranilic acid 4, the known benzofuran analogue 5, and the benzothiadiazin
44                                    Including the known bias of transformation toward the acquisition
45                       As proof-of-principle, the known binding interaction of Cyclosporine A with cyc
46             The MBM in MKK3 is distinct from the known binding sites for p38 or upstream kinases.
47 luate the role of these RNA molecules within the known biochemical framework of SLE.
48      While cataloguing the profiles based on the known biotypes, all the employed RNA-Seq methods gen
49 The reaction of (C5Me5)3Th, 3, with H2 forms the known (C5Me5)3ThH as the sole thorium-containing pro
50                                      Despite the known cardiotoxic effects of doxorubicin and other a
51 la virus genomes, which represent over 5% of the known cases.
52  response enhancement effect did not require the known catalytic activity of CheR, but did involve a
53                       Sensory deprivation is the known causal mechanism for acquired synaesthesia and
54  breeds to characterize mapping precision of the known causal mutations.
55 ely 15% of resolved cases, respectively) are the known causes of ADPKD.
56 n among HAdV-Ds in a region overlapping with the known CD46 binding site in HAdV-B.
57                                        Given the known clinical relevance of the CD73/adenosine pathw
58 accomplished computationally in reference to the known "closed" apo-PBP2a X-ray crystal structure sta
59 inding to CPSF6, is largely independent from the known cofactors for nuclear entry, and alters integr
60 ulin interacted with the peptides containing the known collagen cross-linking sites and the MMP-1 cle
61 ndent from and have larger effect sizes than the known common variation in these regions.
62 hich Ub adopts a dynamic equilibrium between the known, common Ub conformation and a distinct, second
63 of the BCR signaling network, which captured the known complex cross-talk between the NFkappaB, ERK,
64 %), successfully identifying the majority of the known components of the canonical glycoprotein ERAD
65  micropollutants was within a factor of 2 of the known concentration.
66 that the phenylalanine clamp (varphi-clamp), the known conductance bottleneck in the PA translocase,
67   Its absolute configuration was assigned by the known configurations of the starting compounds and b
68  by prior phosphorylation at Ser204, fitting the known consensus sequence for GSK3 substrates.
69                                              The known consensus sequence is observed to have the hig
70  study provides new mechanistic insight into the known contribution of myeloid cells to muscular dyst
71                               In addition to the known contributions from electric-field and chemical
72                                       Due to the known contributions of N-linked glycosylation to pro
73                        A substantial part of the known correlation between the recombination rate and
74 gent delta power response is consistent with the known cortical degeneration in CLN5(-/-) sheep.
75                                        Among the known custom DNA-binding modules, the nuclease-dead
76                     This Perspective reviews the known CXCR3 antagonists and considers future opportu
77  fungus, Phomopsis sp. (CMB-M0042F), yielded the known cytochalasins J (1) and H (2), together with f
78                                Thus, despite the known cytotoxicity of cobalt and zinc ions, these re
79 ll review the historical data for D4, review the known D4 ligands, and then highlight new data suppor
80 receptor blockade, a finding consistent with the known dependence of this response on the innate cyto
81 ite predictions in ccmB transcripts based on the known determinants of nucleotide base recognition by
82 terial and archaeal DGR lineages that expand the known DGR range by 120% and reveal a history of hori
83                           Particularly given the known difficulties involved in this type of transfor
84  the other sibling pair, targeted testing of the known disease gene for Roifman syndrome (RNU4ATAC) p
85 ons in patients who lack exonic mutations in the known disease genes.
86                         Their number matches the known distinct meteorite parent bodies.
87 ibrary of recombinant CBMs representative of the known diversity of type A modules.
88 ling has only been observed in Ni3TeO6 among the known double corundum compounds to date.
89          We revealed that 23 loci, including the known Dt1, E2, E1, Ln, Dt2, Fan, and Fap loci, as we
90                               Here we review the known ecological and evolutionary implications of sy
91                ExoU is the most cytotoxic of the known effector proteins and has been associated with
92                           Here, we summarize the known effectors, their modes of action, and RNA targ
93 hich suggests that the CFIm complex mediates the known effects of CPSF6 in HIV-1 infection.
94  demonstrate that our methodology can detect the known effects of drug-induced neuronal inactivity an
95 alyses in smokers and non-smokers because of the known effects of smoking on FEV1 decline.
96 eveal binding sites that are consistent with the known effects of these molecules on beta2m amyloid f
97                                      Despite the known effects that TMP-SMX has in reducing clinical
98 fore suggest that a mechanism in addition to the known electron carrier function of ubiquinone is req
99 hey had improved safety profiles compared to the known electrophilic Nrf2 inducers.
100 r outer shells could also exist, but none of the known elements have filled g-orbitals.
101 seudorotaxane stereoisomer in agreement with the known "endo-alkyl rule".
102 ent inhibitor of NMDAR-induced currents than the known endogenous neurosteroid, pregnanolone sulfate
103  of a constitutively active Mek1 (Mek1(DD)), the known ERK activator, restores the tectal stem zone a
104                               In addition to the known ERK deactivation, retinoschisin treatment of r
105                              On the basis of the known esophageal past medical history as well as the
106 vesicle priming process that they control to the known etiological mechanisms of psychiatric and neur
107 tsuokella multacida (PhyAmm) in complex with the known eukaryotic second messengers Ins(1,3,4,5)P4 an
108 termitophile so far discovered, pushing back the known evolutionary history of termitophily by approx
109 stent with previously established trends for the known families of tetrahedral CdSe frameworks.
110 e provides a personal recollection (with all the known faults of self-reporting and retrospective mem
111 species due to multiple protomers, including the known fluoroquinolone protomers and the new finding
112 c progression of male germ cells, similar to the known function of boule in invertebrates.
113                                        Given the known function of mindin, its early expression in th
114                                      Despite the known function of viral envelope glycoproteins in ca
115                   These observations reflect the known functional properties of the PE and PEc, with
116                 These results, together with the known functional relevance of the three genes to LMI
117                                 In line with the known functions of c-Jun, LT also inhibited cell pro
118 f cellular protein levels, which goes beyond the known functions of PRMT5 as a transcription and spli
119                          In the years since, the known functions of Reelin signaling in the brain hav
120 reover, these data also significantly expand the known functions of smORF-encoded microproteins.
121 addition to confirming oncogenic activity of the known fusion oncogenes engineered by our constructio
122           Using this strategy, we engineered the known fusion oncogenes, BCR-ABL1, EML4-ALK, and ETV6
123 -proteins that cannot be easily explained by the known G-protein signaling pathways.
124                                      Besides the known GAPs in the malaria parasite, the complex incl
125                                              The known gas-phase spectrum, including its vibronic str
126 nown Usher genes or in extra-exonic parts of the known genes - to date a largely unexplored possibili
127 revalence of 50% by the age of 50; however, the known genes explain little of the heritability.
128 er syndrome caused by recessive mutations in the known genes.
129    There remains a large discrepancy between the known genetic contributions to cancer and that which
130                                  At present, the known genetic risk loci are largely uncharacterized
131 orrelations represent enzymatic reactions in the known glycosylation pathway, and then predict new bi
132                   This review will summarize the known health effects of PEDs but will also focus on
133                To determine the frequency of the known heritable meningioma- or schwannoma-predisposi
134  patients will be highly variable because of the known heterogeneities in signaling pathways among th
135 jor crossover pathways in plants and some of the known homeostatic mechanisms that act during meiotic
136 entify additional residues in the network of the known hotspot residues of different anti-Ebola antib
137  to play a role distinct from that of Pro in the known HP1beta CSD-PXVXL complexes.
138                                We found that the known hSOD1 mutations G93A and A4V increased the cap
139 s have been isolated from humans, increasing the known human bacterial repertoire by 29%.
140                                 We recovered the known immune evasion molecules PD-L1 and CD47, and c
141 sociated with HIV-1 outcome, consistent with the known impact of classical HLA alleles.
142                  Based on these results, and the known importance of E73 in VDAC physiology, VDAC dim
143                                      Despite the known importance of phospholipids in regulating prot
144                                      Despite the known importance of TGF-betas in promoting disease p
145                 This is not accounted for by the known incidence of chromosomal aneuploidy in miscarr
146 ified 87 cancers in different quadrants than the known index cancer, constituting the basis of this r
147 R imaging-detected multicentric cancers than the known index lesion, and 18 of 73 (25%) (95% CI: 15,
148 eutic and imaging protein conjugates despite the known instability of the resulting products that und
149           Our results reveal a paradigm that the known interaction of many proteins with PARP1 under
150               The overall structure confirms the known interactions, including some that were not pre
151                                    We extend the known inventory of planktonic archaeal lipids to inc
152  in cerebellum appears to be consistent with the known involvement of this brain region in auditory f
153  be related to their known precursors and to the known kinetic isotope effects of enzymes involved in
154 fic lupeol synthases and does not group with the known L. clavatum alpha-onocerin cyclases.
155 has been modeled using DFT calculations from the known LGO precursors levoglucosan and 1,4:3,6-dianhy
156  than 10-fold higher than predicted based on the known ligand affinities.
157 de were found in diverse proteins, including the known ligand high-molecular-weight kininogen (HK), a
158                               In addition to the known light chain myosin tail interacting protein (M
159 openic phenotype of TIEG1 KO mice as well as the known links between TIEG1 expression levels/allelic
160 Chip), combined with conditional analysis in the known lipid loci.
161                                   In view of the known long-term safety profile of PPI, they can be a
162 ain three important elements: in addition to the known (main) binding site, we identified a linker re
163 on coefficients show the maximum value among the known MAX phases, to date and to the author's knowle
164  and although carboxylation of acetyl-CoA is the known mechanism for generating the distinct plastidi
165 aims of this Review Article are to summarize the known mechanisms of protein translational fidelity a
166 describe how this process is consistent with the known mechanisms of TRAP transporters and consider h
167 ialylated cell adhesion molecules, including the known megakaryocytic markers integrinbeta3 and CD44,
168                        The identification of the known MET TKIs, glesatinib and foretinib, as negativ
169             The results substantially expand the known metabolic potential of CPR bacteria, although
170 ts the chemical transformation that converts the known metabolites into the unknown one.
171                However, approximately 90% of the known metabolites reported in metabolomic databases
172 this enhanced IBC migration effect, and that the known metastatic oncogene, RhoC GTPase, is necessary
173 icular emphasis is placed on improvements to the known methodologies and recent advances in the field
174  accumulated to levels equivalent to that of the known MIE transcript later in infection.
175 hat Cys-119 or Cys-162 of p38alpha, close to the known MKK3 docking domain, were relevant for these r
176  consanguineous families with no variants in the known MMIHS-associated genes.
177 e renders H2S synthesis by CSE responsive to the known modulators of CBS: S-adenosylmethionine, NO, a
178  unprecedented polyphosphanes in addition to the known monoinserted product LGaP4 (1) are observed.
179                    In addition to increasing the known morphological disparity of extinct lampreys, a
180 mRNA was isoform 2, which is the ortholog of the known mouse IL-36beta mRNA.
181 way for RER in RNase HII-deficient cells and the known mutagenic profile of DnaE, we propose that mis
182 A488P and R655C mutations were compared with the known mutation V883M.
183 r locations and residue charge profiles with the known native binding proteins.
184 P. anaerolimi, but it appears to lack any of the known natural carbon fixation pathways.
185 d the NRP1 cytoplasmic domain (NCD), but not the known NCD interactor GIPC1.
186 how that it does not bind directly to any of the known netrin-1 receptors.
187 ation in the Drosophila model, we can expand the known network of genes involved in disease pathogene
188 ological organization would reliably reflect the known neurobiology of individual amygdaloid nuclei,
189 tors (TF) associated with gene signatures of the known neuroendocrine/epithelial (NE) and non-neuroen
190                             A combination of the known neuroprotective molecule, pigment epithelium-d
191  crucial for this transformation, unlike for the known nitrogen-directed arylations.
192            AOB phylotypes predominantly from the known Nitrosomonas group were distributed across the
193 n (residues 1-4) of NCC differs from that of the known NOP antagonists, as being slightly slipped dee
194                                           As the known number of AHR-mediated processes grows, so too
195 4 histone Kbhb sites, a figure comparable to the known number of histone acetylation sites.
196 A at five new sites, thus more than doubling the known number of sites.
197 ted PPy-PFOS was adjusted by polarization to the known open-circuit potential of the solid contact in
198 became markedly activated by cyanide (CN) or the known opener P1075 with a current density that was ~
199                   We are summarizing some of the known or reported consequences of such infection dur
200  isolated from whole blood and cultured with the known OSM inducers GM-CSF and follistatin-like 1, an
201 and hence resulting in an underestimation of the known particle height.
202 t bacterial DNA and yielded fewer reads from the known pathogens.
203               Our studies reveal that beyond the known pathways, such as base excision repair, the pr
204 eroxisome division in a manner that requires the known peroxisome division factor PEROXISOME AND MITO
205 compounds were selected for the HTS based on the known phenothiazine Ndh inhibitors, trifluoperazine
206 nt a novel rodent model to reproduce much of the known phenotype of CTEPH, including the pivotal path
207         From sand flies, we isolated most of the known Phlebovirus strains that potentially cause hum
208                                              The known physiologic effects of EDN1 on the vasculature
209  pylori lacks a gene encoding a homologue of the known pimeloyl-ACP methyl ester cleavage enzymes sug
210 ts of volatile compounds, including CO2, and the known plant growth-promoting volatile 2,3-butanediol
211 which can occur with oral quinine because of the known poor adherence to 7-d regimens.
212 ved for MT-2 cells and provide evidence that the known poor infectivity of HTLV-1 particles may corre
213 fects on telomere length could contribute to the known poor performance of later-ovulated family memb
214 ed in the midbrain and hindbrain, increasing the known populations.
215 of strong similarity with the clip region of the known portal proteins.
216                                    Alongside the known postfusion conformation, a novel one was ident
217 endent, G-protein conformational change from the known prefusion conformation to an extended, monomer
218 ents observed were generally consistent with the known profile of lisdexamfetamine.
219 e safety profile of triple therapy reflected the known profiles of the components.
220 e known anatomy of layer 4 demonstrates that the known proportion and connectivity of inhibitory neur
221                                     Based on the known proportion of tree species in neotropical lowl
222 s due to pregnancy are sufficient to explain the known protective effect of full-term pregnancy in ea
223 l innate immune signaling, which complements the known PRRSV-mediated immune-evasion mechanisms.
224                            Having reproduced the known Pten KO phenotype using the CRISPR-Cas9 system
225       This observation fundamentally expands the known range of gas-transport systems in extant arthr
226 ght into C-C-hydrolyzing enzymes and expands the known range of reactions catalyzed by the amidohydro
227 S1 mutations are functionally different from the known recessive Wolfram syndrome-causing mutations,
228 ion in Welwitschia mirabilis to test whether the known regulatory links between LEAFY and its MADS-bo
229 in layer 4 than in subplate, consistent with the known relay of thalamic information to layer 4 by su
230 isease, and correctly flagged all but one of the known repeat expansions.
231                           Our results expand the known repertoire of 'eukaryote-specific' proteins in
232  superior resistance to that demonstrated by the known resistant cultivar Mace.
233                       The structure explains the known restrictions of cis-interactions of some Pcdh
234 ction by MOV10 was unique and independent of the known retinoic acid-inducible gene I/mitochondrial a
235 hreat of hypoxia in the tropics, even though the known risk factors, including eutrophication and ele
236  have an evidence-based discussion regarding the known risk of cutaneous surgical procedures in the s
237 al lesions detected in peripheral fields and the known risks associated with H/Ma and peripheral lesi
238  countries, medical interventions to address the known risks associated with pregnancy and birth have
239 rthermore, OGA is physically associated with the known RNA polymerase II (pol II) pausing/elongation
240 hydroxyapatite (HA) crystals in vitro and on the known role mineralization inhibitors, like PPi, play
241                                   Because of the known role of glycolysis in biosynthesis, we tested
242                                        Given the known role of Mer in contact-dependent inhibition of
243                               In contrast to the known role of NCR peptides as effectors of endosymbi
244 ffect of PDF on clock gene transcription and the known role of PDF in enhancing PER/TIM stability occ
245 e whether connexin phosphorylation regulates the known role of zonula occludens-1 protein (ZO-1) in g
246                    These findings complement the known roles of CASPR2 in brain development, and warr
247  intrinsic antiviral immunity contrasts with the known roles of PIAS proteins as suppressors of innat
248 binding interface that has shifted away from the known RV P-genotype binding sites but is conserved a
249  profile of tremelimumab was consistent with the known safety profile of CTLA-4 inhibitors.
250          Adverse events were consistent with the known safety profile of roflumilast.
251         Safety profiles were consistent with the known safety profiles of these agents.
252 using logistic regression and correcting for the known sampling fractions from stage 1 to stage 2, ov
253                                  Building on the known SAR of this compound series, we now describe a
254 o the control compound prostratin (1), while the known sesterterpenoid alotaketal C (2), isolated fro
255 itu autophosphorylated protein, we expand on the known set of CPK28 autophosphorylation sites, and we
256                                   Because of the known sex differences in neural and behavioral smoki
257                   Finally, an examination of the known SHG active AMCO3F (A = alkali metal, M = alkal
258         This benefit must be weighed against the known side-effect profile of these antimicrobials.
259     In this assay, the compounds behave like the known sigma1 receptor antagonist haloperidol.
260  difference in Gibbs free energy compared to the known similar class of materials to date.
261 within the CPK28 J domain that overlaps with the known site of intramolecular interaction between the
262 lights key similarities and differences from the known solution-phase pathway.
263 e instrumentation system, or to any other of the known sources investigated.
264 olved in this representation overlapped with the known spatial cell types in the circuit, such as pla
265 nalysis were used together to reveal whether the known species of Fargesia represent discontinuous sa
266 d the confirmation of FRET measurements from the known standards.
267 nancy is unknown, but hepcidin regulation by the known stimuli (i.e., iron, erythropoietic activity,
268  also led to dephosphorylation at Ser-555 of the known STING regulator, UNC-51-like kinase 1 (ULK1).
269 e stoichiometry of complex I by reference to the known stoichiometries of complexes III and IV.
270 fied a region that could not be explained by the known stratigraphy.
271                 RNA immunoprecipitation with the known stress granule aggregates TIAR and G3BP1 was p
272 The input patterns reveal boundaries between the known striatal domains.
273                     Even deletions of one of the known structural protein genes that is present in al
274 ar activity to that of Pt(111), in line with the known structure insensitivity of the reaction.
275  structural models for a target protein from the known structure of its homologous template proteins
276                                Provided with the known structures of a protein, our method uncovers a
277 bound pigments are discussed with respect to the known structures of LHCII and CP29.
278 hibitors involved in the pathway, along with the known substrate cleavages and peptidase-inhibitor in
279 ly explained by a microscopic model based on the known surface dynamic behavior under vacuum conditio
280 curs via a degenerative pathway unrelated to the known synapse function of these proteins and involvi
281 ted by the ability of LT-scanner to identify the known targets of FDA-approved kinase inhibitors base
282 these photochemical reactions different from the known thermal chemistry of 1, but the reversibility
283 sor surface were investigated, understanding the known TLR-PAMP interactions, through the exploitatio
284            It has been well-established that the known TMs can be classified by the dimensionality of
285                         Only trace levels of the known toxic metabolite, thio-DMA, were observed, acr
286                                      Despite the known toxicity of some high-molecular-weight azaaren
287  sequence block 3 (CSBIII), just upstream of the known transcription-replication transition point, su
288 these functional data strongly contrast with the known transcriptional regulation of NRT1.1, which is
289  reefs are associated with more than half of the known tropical dead zones worldwide, with >10% of al
290 rmitilis, suggesting for the first time that the known tropism of RNA bacteriophages may include gram
291 d sandsheets were identified and compared to the known tsunami sandsheets.
292 BART miRNA cluster 2, new relationships with the known type 1/type 2 strains are demonstrated, and a
293                                 We show that the known tyrosine kinase inhibitor tyrphostinA23, which
294     Recurrent coding mutations were found in the known UM drivers GNAQ, GNA11, BAP1, EIF1AX, and SF3B
295 While emerging studies are greatly expanding the known universe of RNA-binding proteins, methods for
296                                        Given the known vascular effects of cannabis, this study exami
297                                              The known viral replication proteins, a telomere binding
298                                        Using the known water dimer interaction potential, we estimate
299 f deep evolutionary relationships(3-5) or on the known, well-classified diversity of life with an emp
300 0 gene loci predominantly at W-box elements, the known WRKY binding motif.

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