ライフサイエンスコーパス: the molecular details of

1 The molecular details of 1-->3-beta-glucans, a fungal ce

2 These results help fill in the molecular details of a metabolic process that likely

3 We report here the molecular details of a negative feedback loop wherei

4 Here we describe the molecular details of a nodal point in adult melanocy

5 These findings describe the molecular details of a novel mechanism linking fibri

6 The molecular details of AFP adsorption-inhibition is un

7 However, the molecular details of agonist-bound inactive receptor

8 However, the molecular details of Akt(PHD) interaction with CaM a

9 es is a hallmark of TTR amyloid disease, but the molecular details of amyloidogenesis are poorly unde

10 This structure provides the first look at the molecular details of an effective beta-lactam-resist

11 ry to use more tractable surrogates to probe the molecular details of anesthetic recognition.

12 Although the molecular details of antagonist-BIR domain interacti

13 We unveiled the molecular details of antibody binding to two distinc

14 rter (hSERT) in the treatment of depression, the molecular details of antidepressant drug binding are

15 his kinase, relatively little is known about the molecular details of Atg1 activation.

16 The molecular details of ATM function in the nervous sys

17 The molecular details of ATM function in the nervous sys

18 The structure reveals the molecular details of AZM binding and the charged sta

19 exes will likely aid in our understanding of the molecular details of B. burgdorferi persistence and

20 in mechanistic terms, little is known about the molecular details of bacterium/host interactions.

21 ound showed excellent ligand efficiency, and the molecular details of binding were revealed by the fi

22 The structure provides new insight into the molecular details of biological methane oxidation.

23 d proteins are invaluable tools for studying the molecular details of biological processes, and they

24 the complex provides important insights into the molecular details of both DNA and alpha/beta-type SA

25 The molecular details of caspase-6 dynamics in solution

26 lary hypothesis that better understanding of the molecular details of cCSQ-drug interactions could le

27 biochemical studies that have shed light on the molecular details of CD1d-mediated antigen recogniti

28 learned from crystal structures, determining the molecular details of channel activation, deactivatio

29 atalytic mechanisms of GHs and GTs, not only the molecular details of chemical reactions but also the

30 Although the molecular details of cis interactions remain uncerta

31 gen types bind to and activate the DDRs, but the molecular details of collagen recognition have not b

32 Through genetic and biochemical studies, the molecular details of copper uptake are being elucida

33 This approach examines the molecular details of crossover and noncrossover even

34 is study we were interested in understanding the molecular details of cyclotide-membrane interactions

35 The molecular details of cytotoxic granule-mediated apop

36 However, the molecular details of D-ERK translocation are largely

37 Understanding the molecular details of docking and mechanism of action

38 However, the molecular details of electron transport along heme c

39 However, the molecular details of engulfment are just beginning t

40 Despite spectacular advances in unraveling the molecular details of FA, the origin of the bone marr

41 ments in the use of biosensors to illuminate the molecular details of G-protein-coupled receptor (GPC

42 analysis has yielded important insights into the molecular details of gene regulation.

43 s to become the foundation for understanding the molecular details of genomic variants leading to dis

44 d biosynthesis, advances towards elucidating the molecular details of glycan functions are relatively

45 The molecular details of glycolipid presentation by CD1

46 ractions critical for HCV assembly, to study the molecular details of HCV assembly, and for performin

47 PHP3 peptide in complex with Unc119a reveals the molecular details of high affinity binding and sugge

48 er an important starting point to understand the molecular details of high density lipoprotein biogen

49 However, the molecular details of higher-order organization of ch

50 However, the molecular details of host cell response to Francisel

51 lated to [Fe-S] cluster biosynthesis involve the molecular details of how [Fe-S] clusters are assembl

52 Furthermore, the molecular details of how a local perturbation is tra

53 Based on these observations, understanding the molecular details of how advancing age and exercise

54 However, to understand the molecular details of how ATP hydrolysis is coupled t

55 bound to meropenem shows for the first time the molecular details of how carbapenem antibiotics are

56 The molecular details of how chromatin factors and enzym

57 Elucidating the molecular details of how chromatin-associated factor

58 ar, there are conflicting reports concerning the molecular details of how CsrA may modulate rpoS expr

59 Recent structural studies have provided the molecular details of how dockerin-cohesin interactio

60 elopmental Cell, provide novel insights into the molecular details of how Drosophila NPCs transition

61 h are well appreciated, we know little about the molecular details of how fasting influences synaptic

62 Ensemble measurements occlude the molecular details of how host-guest interactions det

63 However, the molecular details of how hunger triggers changes in

64 By providing further insights into the molecular details of how influenza viruses hijack th

65 The molecular details of how intracellular protozoans ma

66 The molecular details of how lipids influence final topo

67 eractions between them have been identified, the molecular details of how most of these interactions

68 The molecular details of how Munc18a acts to enhance neu

69 However, the molecular details of how SEPT9 interacts with F-acti

70 The molecular details of how TACC proteins function are

71 The molecular details of how the coat proteins deform th

72 Two new studies have elucidated the molecular details of how the Ndc80 complex mediates

73 of the intact ribosome have begun to reveal the molecular details of how the ribosome works.

74 centered on this element may help understand the molecular details of how the viral helicase facilita

75 were discovered, much light has been shed on the molecular details of how these cytoplasmic viral RNA

76 However, the molecular details of how these two proteins interact

77 re well characterized, little is known about the molecular details of how they alter gene expression.

78 features of amyloidogenic intermediates and the molecular details of how they cause aggregation rema

79 actions; however, for many of these peptides the molecular details of how they disrupt and/or translo

80 The molecular details of how urea interacts with, and ev

81 ell biological aspects have been elucidated, the molecular details of HP1 binding to H3K9me3 nucleoso

82 Additionally, we describe the molecular details of human FR in complex with three

83 , researchers have steadily brought to light the molecular details of IFN signaling, catalogued their

84 a feasible experimental model to investigate the molecular details of IFN-induced direct antiviral ac

85 ficiency virus type 1 (HIV-1) infection, but the molecular details of infection may differ between th

86 potential of Raman spectroscopy for defining the molecular details of inhibitor binding to this enzym

87 The molecular details of initiation of germination are n

88 However, little else is known about the molecular details of insect OR architecture.

89 The molecular details of invasion are only recently beco

90 es in the blood prior to vascular injury and the molecular details of its activity enhancement remain

91 al MAC components and subcomplexes; however, the molecular details of its assembly and mechanism of a

92 However, the molecular details of its formation remain unknown.

93 ocalize to the centrosome and the Golgi, but the molecular details of its function at the centrosome

94 ochore localization in the SAC, we delineate the molecular details of its interaction with kinetochor

95 To understand the molecular details of its interaction with tubulin, w

96 There currently is little information about the molecular details of its interaction.

97 erals in the earth's crust, is determined by the molecular details of its interface with the contacti

98 between Drp1 malfunction and human disease, the molecular details of its membrane activity remain po

99 Despite bacitracin's broad use, the molecular details of its target recognition have not

100 e have defined by nuclear magnetic resonance the molecular details of L1-CT binding to two major targ

101 We investigated the molecular details of LFA-1 activation during adhesio

102 To examine the molecular details of ligand activation of G-protein

103 The molecular details of ligand discrimination and diffe

104 The molecular details of ligand recognition and its conn

105 r ligands of NKp30 have been discovered, and the molecular details of ligand recognition by NKp30 are

106 However, the molecular details of ligand uptake and targeted rele

107 Of interest, the molecular details of M1 interaction with lipids and

108 The molecular details of MCM DNA interactions during the

109 These data will prompt a re-evaluation of the molecular details of membrane budding.

110 As for most cell-cell fusion events, the molecular details of membrane fusion during yeast ma

111 ses provide an opportune system for defining the molecular details of membrane penetration by a large

112 R provides a wide range of information about the molecular details of membrane peptide immobilization

113 the mechanism of class A is well understood, the molecular details of methylation by classes B-D are

114 play important roles in gene regulation, but the molecular details of most of these interactions are

115 While many of the molecular details of myogenesis have been investigat

116 ial to provide further insights ranging from the molecular details of neurons up to the functional me

117 More is known about the molecular details of NHEJ than HRR in mammalian cell

118 However, the molecular details of NLRP3 inflammasome assembly are

119 ity, Wun et al. and Mallevaey et al. explore the molecular details of nonself lipid discrimination an

120 To begin to understand the molecular details of nucleosome dynamics, we have in

121 To understand the molecular details of O2 -tolerant hydrogen cycling b

122 The molecular details of OMV biogenesis have not been fu

123 However, the molecular details of P-protein-STAT interaction, and

124 mucosa-associated lymphoid tissue, although the molecular details of persistence or latency of adeno

125 The molecular details of pilus biogenesis at the usher,

126 To understand the molecular details of PKG dimerization and gain insig

127 tudied via crystallography and spectroscopy, the molecular details of polysaccharide chain processivi

128 x of the GH86 at 1.3 A resolution highlights the molecular details of porphyran hydrolysis by this ne

129 lex with its cognate promoter DNA, revealing the molecular details of promoter recognition by sigma(N

130 Despite considerable progress in uncovering the molecular details of protein aggregation in vitro, t

131 hod should provide a useful tool for mapping the molecular details of protein-nucleic acid interactio

132 constructs have been widely used to decipher the molecular details of QS, how those findings translat

133 However, the molecular details of RBP-J/RITA interactions are unc

134 review focuses on recent evidence describing the molecular details of regulation of L-type Ca(2+) cha

135 e may be valuable for further characterizing the molecular details of REL-induced lymphoma in humans.

136 vides a foundation for further understanding the molecular details of self-nonself discrimination in

137 icant advances have been made in elucidating the molecular details of signal cascades initiated by th

138 Insights on the molecular details of soluble- and fibrillar-Cu-alpha

139 Although the molecular details of spindle checkpoint activation a

140 ography, and kinetics, we have characterized the molecular details of SPT inhibition by myriocin.

141 utathione biosynthesis, has revealed many of the molecular details of substrate recognition.

142 ent report in Molecular Cell, we highlighted the molecular details of such a noise-reduction filter,

143 ryotic, viral, and prokaryotic proteins, but the molecular details of such interactions are understoo

144 hese studies have relevance to understanding the molecular details of T cell recognition in murine ex

145 Although little is known regarding the molecular details of tail interactions, it is likely

146 To gain insights into the molecular details of TAR RNA-NC interactions, we car

147 e and M. tuberculosis InhA complexes provide the molecular details of target-drug interactions.

148 To understand the molecular details of TCR-enterotoxin interactions an

149 While the molecular details of the activator complex are relat

150 ucture in its closed conformation, revealing the molecular details of the active conformation of the

151 To understand the molecular details of the apoE-heparin interaction, w

152 The molecular details of the assembly process and the id

153 The molecular details of the BcR-BcR interactions appare

154 en made enantioselectivity in order to probe the molecular details of the binding of 1 and 2 to the o

155 roscopy have been combined to further define the molecular details of the binding of substance P (SP)

156 The molecular details of the biosynthesis and resulting

157 While previous studies have been focused on the molecular details of the bud site selection and pola

158 Here we study the molecular details of the calcium inhibition mechanis

159 Despite this, the molecular details of the catalytic cycle, a cycle th

160 To understand the molecular details of the chemokine-GAG interaction,

161 revealed a curved Y-shaped architecture and the molecular details of the coat nucleoporin interactio

162 es at the heart of this process, yet many of the molecular details of the CRISPR/Cas system remain to

163 Here we use mutagenesis to characterize the molecular details of the E lysis mechanism.

164 sterol acyltransferase and may shed light on the molecular details of the effect of the Milano, Paris

165 l AM receptors is dependent on understanding the molecular details of the effects of RAMPs on CLR.

166 The molecular details of the engulfment of apoptotic cel

167 These results reveal the molecular details of the ERK-Cic interaction and dem

168 els provide a simple framework for exploring the molecular details of the formation of beta-hairpin s

169 lthough the SEFIR is critical for signaling, the molecular details of the functional subdomains withi

170 intensive research, we are still unraveling the molecular details of the host-pathogen interactions

171 o Exo1 nuclease activity and to characterize the molecular details of the human Exo1-DNA interaction.

172 e used to provide a more complete picture of the molecular details of the individual pathways.

173 FD (at 2.4 and 2.3 A, respectively) revealed the molecular details of the inhibitory mechanism.

174 To understand the molecular details of the interaction and to develop

175 sequence found in three regions of SSU rRNA, the molecular details of the interaction are unknown.

176 le in endothelial cell polarity as well, but the molecular details of the interaction are unknown.

177 e has been mapped to the luminal domain, but the molecular details of the interaction between BoNT/A

178 Here, we probe the molecular details of the interaction between PrP(C)

179 We verify the molecular details of the interaction by site-directe

180 and fluorescence spectroscopy to investigate the molecular details of the interaction of IAPP with li

181 The molecular details of the interaction were further cl

182 nhibitors has been informed by insights into the molecular details of the interactions of proteases a

183 The molecular details of the interactions revealed by co

184 w the complete connectivity of the chain and the molecular details of the interactions.

185 cesses are central to cellular function, and the molecular details of the interplay between DNA seque

186 Elucidation of the molecular details of the interplay between membrane

187 We also propose an interpretation of the molecular details of the involved proteins in the ca

188 X-ray crystallographic approaches, we reveal the molecular details of the MDC1/NFBD1-gammaH2AX comple

189 The molecular details of the mechanism of polyrhamnose m

190 and Ross Coppel predicted that research into the molecular details of the mechanisms behind sequestra

191 Now that many of the molecular details of the NF-kappaB pathway are known

192 o the predicted catalytic Lys-171, revealing the molecular details of the PA0743 substrate-binding si

193 d-free apoA-I will be useful for elucidating the molecular details of the pathway.

194 Although it has been studied extensively, the molecular details of the pH-dependent gating and pro

195 Together, our data define the molecular details of the pironetin binding site on a

196 To map the molecular details of the PLN/SERCA interaction, we h

197 tem of ER-associated degradation (ERAD), but the molecular details of the process are poorly characte

198 n the experimental findings by investigating the molecular details of the process computationally.

199 The molecular details of the processes involved in diver

200 However, the molecular details of the PrP(C)-Abeta interaction re

201 Our results provide the molecular details of the rearrangement accompanying

202 o the membrane for full activation, although the molecular details of the regulation mechanism are no

203 The molecular details of the regulation of phytochrome t

204 As part of our efforts to determine the molecular details of the role of NADP(H) in catalysi

205 We confirm the molecular details of the signal relay through the al

206 host immunity and development in plants, but the molecular details of the signalling mechanism are po

207 Using NMR spectroscopy, we have studied the molecular details of the skelemin IgC45 interaction

208 The molecular details of the spontaneously transforming

209 However, at 3.3 AA resolution, the molecular details of the structure are not well defi

210 holine-bound complexes, respectively, reveal the molecular details of the substrate binding sites.

211 f Dtrx is an important step toward revealing the molecular details of the thiol-disulfide oxidoreduct

212 The molecular details of the toxin-cell recognition have

213 The molecular details of the toxin-receptor interactions

214 In order to begin to elucidate the molecular details of the translocation process, we e

215 d state free energy change, which informs on the molecular details of the transmembrane helix self-as

216 Here we identify the molecular details of the YscP binding site on YscU b

217 Few studies describe the molecular details of the Zn(2+)-caspase interaction,

218 central roles in myriad signaling cascades, the molecular details of their activation remain poorly

219 A granules behave like dynamic droplets, but the molecular details of their assembly are poorly under

220 clases have been linked to genetic diseases, the molecular details of their effects on the enzymes re

221 s that are young enough to allow deciphering the molecular details of their evolutionary history.

222 far no evidence has been provided regarding the molecular details of their interaction with CXCR3.

223 To investigate the molecular details of their interaction, we co-crysta

224 However, the molecular details of their interactions are poorly u

225 ysis of these scaffold nucleoporins revealed the molecular details of their interactions with the fle

226 Our understanding of the molecular details of these antibody-antigen interact

227 Our knowledge of the molecular details of these dramatic structural chang

228 However, the molecular details of these effector-host interaction

229 s in several in vitro preparations, although the molecular details of these effects are less clear.

230 des in ticks during the intermolt phase, but the molecular details of these events remain unknown.

231 However, the molecular details of these interactions are unknown.

232 Elucidation of the molecular details of these interactions could highli

233 e mediated by the Gag protein precursor, but the molecular details of these processes remain poorly d

234 sis will be a powerful model for elucidating the molecular details of these processes.

235 It has remained challenging to address the molecular details of these transitions and whether t

236 To better understand the molecular details of this activity, we have determin

237 However, the molecular details of this AR-centered regulatory net

238 y of Mdv1p and Dnm1p into fission complexes, the molecular details of this assembly are not clear.

239 and mammalian cells have begun to elucidate the molecular details of this autophagy process.

240 To gain insight into the molecular details of this binding interaction, apoli

241 To investigate the molecular details of this catalysis we created four

242 To better understand the molecular details of this conformational rearrangeme

243 Our results provide valuable insights into the molecular details of this critical cellular phenomen

244 The molecular details of this difference in sign of volu

245 The molecular details of this dislocation event have not

246 Although the molecular details of this enhancement remain unknown

247 The molecular details of this event are poorly understoo

248 To understand the molecular details of this important process, a previ

249 hway reportedly block angiogenesis; however, the molecular details of this inhibition are largely unk

250 t Shigella requires N-WASP for this process, the molecular details of this interaction and the mechan

251 to biochemically interact with CSL; however, the molecular details of this interaction are only parti

252 t is well established that fVIII binds LRP1, the molecular details of this interaction are unclear as

253 However, the molecular details of this interaction are unknown.

254 However, the molecular details of this interaction have been uncl

255 However, the molecular details of this interaction have not yet b

256 critical for immunity and inflammation, yet the molecular details of this interaction interface rema

257 subunit of Pol II has been established, but the molecular details of this interaction remain unknown

258 it yeast cells to acquire [GAR(+)], although the molecular details of this interaction remain unknown

259 The molecular details of this interaction were further e

260 shown to bind directly with the nucleosome, the molecular details of this interaction were not known

261 ivity assays, and NMR analysis, has revealed the molecular details of this interaction, providing inf

262 Next, to reveal the molecular details of this interaction, we solved the

263 denoviruses establish persistent infections, the molecular details of this lifestyle remain poorly un

264 The molecular details of this ligand discrimination agai

265 However, the molecular details of this linkage could not be resol

266 aptic vesicle stores for subsequent release, the molecular details of this mechanism are not complete

267 The molecular details of this mechanism are not well und

268 The Itk SH3/SH2 structure reveals the molecular details of this nonclassical interaction a

269 Although almost none of the molecular details of this pivotal process are unders

270 However, the molecular details of this proatherogenic mechanism w

271 (PtdSer) and phosphoinositides (PtdIns)) but the molecular details of this process are not fully unde

272 ate disrupted tip links and restore hearing, the molecular details of this process are unknown.

273 The molecular details of this process are, however, unkn

274 Unraveling the molecular details of this process is vital in the de

275 But the molecular details of this process remain poorly unde

276 patially segregated subcellular domains, but the molecular details of this process remain unclear.

277 de a framework for future studies to dissect the molecular details of this process.

278 However, the molecular details of this promiscuity have remained

279 To date, little is known about the molecular details of this receptor ligand system.

280 shift mapping has provided information about the molecular details of this recognition event.

281 ins to prepare H2AY57p efficiently and study the molecular details of this regulation.

282 cAMP-dependent protein kinase, PKA, although the molecular details of this relationship are poorly un

283 netic protein (BMP)-dependent signaling, but the molecular details of this signaling pathway remain p

284 The molecular details of this structure, complemented by

285 er to understand the consequences and reveal the molecular details of this substitution we have deter

286 pite great efforts and significant progress, the molecular details of this synchronized and fine-tune

287 To investigate the molecular details of this trafficking pathway, we cr

288 ognized by PG9 and PG16, and we investigated the molecular details of those binding interactions.

289 The structure reveals the molecular details of three distinct divalent cation-

290 To elucidate the molecular details of Tm flexibility in relation to i

291 s predicted the observed variability; hence, the molecular details of transcription dictate variabili

292 g a framework for increased understanding of the molecular details of transcription termination contr

293 However, the lack of knowledge about the molecular details of transglycosylation hampers the

294 el of the ClpY ATPase-SP system to elucidate the molecular details of unfolding and translocation of

295 the first time, researchers are elucidating the molecular details of vector host-seeking behavior, t

296 important for EBOV entry are characterized, the molecular details of virion-TIM-4 interactions have

297 For the majority of such membrane proteins, the molecular details of voltage sensing remain insuffic

298 We questioned the phylogenetic position and the molecular details of when and where glutamate recogn

299 elease on or near the target cell membranes, the molecular details of which are still not well unders

300 To understand the molecular details of zinc binding and inhibition, we