ライフサイエンスコーパス: the necessity for

1 division and differentiation has illuminated the necessity for a cellular machinery that mediates mit

2 work's role in modeling human physiology and the necessity for a community-based consensus reconstruc

3 ged residues in the polar region circumvents the necessity for a Mg(2+), which, by contrast, is a str

4 r of small molecules into cells and point to the necessity for a more complex model.

5 hobic contributions along the interface, and the necessity for a particular orientation of the spectr

6 -9-deaza nucleosides using Heck methodology, the necessity for a pyrrole protecting group was discove

7 evious functional misannotation and supports the necessity for a reclassification of these enzymes un

8 ncreased significantly in the last decade as the necessity for a renewable source of carbon has becom

9 f this segment with the beta subunit explain the necessity for a second highly conserved His residue

10 nts multiple molecular lifetimes, suggesting the necessity for a self-perpetuating signal.

11 errors suggests that the ampakine eliminated the necessity for a shift in response strategy that prod

12 corporation into virus particles and to test the necessity for a specific interaction between Env and

13 ture is facing multiple challenges including the necessity for a substantial increase in production t

14 mposite end points of in-hospital mortality, the necessity for a temporary pacemaker, or the need for

15 ssion of neural crest markers, demonstrating the necessity for a Wnt signal during neural crest induc

16 fic and essential for cell viability, due to the necessity for accurate translation of the genetic co

17 ocks its nuclear translocation, demonstrates the necessity for active ERK1/2 nuclear localization for

18 The necessity for acyl protein thioesterases to have max

19 , sex differences in disease susceptibility, the necessity for adjuvants in experimental animal model

20 e the limits of the neuromuscular system and the necessity for alternate forms of communication.

21 The necessity for an accurate, but at the same time, ine

22 liferate in response to androgen, indicating the necessity for an additional factor not present in vi

23 compounds selectively (see example) without the necessity for an excess of the alkane substrate.

24 These results clearly demonstrate the necessity for an internal standard for quantitative

25 The necessity for an undiscovered series of steps and en

26 Thus, in this age group, the necessity for anticoagulation or its avoidance may b

27 We tested the necessity for appropriate spatial alignment of these

28 Full-length TAP mutagenesis demonstrates the necessity for at least one consensus site, supportin

29 plateau potential in B31/B32 and eliminates the necessity for B63 in B50-elicited motor programs.

30 ve been developed are examined, highlighting the necessity for better data to parameterise and fit th

31 These data emphasize the necessity for biopsy at the first recurrence of FL.

32 re is little mechanistic evidence to support the necessity for blocking H2R, a receptor best characte

33 The necessity for bone marrow aspiration and the lack of

34 o that achieved with other materials without the necessity for bone-graft harvesting or a second proc

35 The necessity for both Cry48Aa1 and Cry49Aa1 components

36 These results emphasize the necessity for both redox-active disulfide centers in

37 cellular cysteine pairs in CSF3R and suggest the necessity for broader screening of CSF3R extracellul

38 Risk factors influenced the necessity for C-CT.

39 These findings strongly imply the necessity for candidate EIAV and other lentivirus va

40 Our findings highlight the necessity for careful upfront cellular enrichment in

41 Thus, the necessity for CD103 emerges in the efferent CD8+ T-c

42 The necessity for CD4 help was overcome, however, if the

43 an target chemokines for degradation without the necessity for cell signaling, and without desensitiz

44 C) express notch and notch ligands; however, the necessity for cell-autonomous notch signaling during

45 We also characterized the necessity for cell-cell contact for these effects.

46 vely studied since the cells' isolation, but the necessity for cell-secreted factors in self-renewal

47 The necessity for changes in allocation in response to c

48 of the aspartase-fumarase enzyme family, and the necessity for chemically reasonable functionalities

49 lecule 3-oxo-C12-homoserine lactone, showing the necessity for cholinergic transmission.

50 extreme shortage of matched organ donors and the necessity for chronic immunosuppression has made it

51 However, the necessity for collecting data at room temperature, e

52 means of communication for learning without the necessity for committing multiple errors across tria

53 1 in different cellular compartments suggest the necessity for complex regulation.

54 s been hampered by functional redundancy and the necessity for conditional inactivation strategies.

55 h OspA, their lack of specificity highlights the necessity for confirming equivocal or positive react

56 We highlight the necessity for consideration of alternative (e.g., hy

57 ly variable changes that we report highlight the necessity for considering local factors such as topo

58 small- and large-scale laboratories suggest the necessity for continued microbiology-based understan

59 ted the effect of competitive pressures, and the necessity for cooperation among nutrition societies.

60 geoengineering"), typically characterized by the necessity for costly new infrastructures and industr

61 This difference may reflect the necessity for DCs to interact with multiple T cells

62 This study emphasizes the necessity for declaration of funding source.

63 s vigilance to permit timely recognition and the necessity for defibrillator implantation and heart t

64 This stresses the necessity for dermatologists to perform comprehensiv

65 This study highlights the necessity for developing a parameterization of dust

66 the proprietary nature of data sources, and the necessity for developing new software), the benefits

67 recruitment of the 43S complex and alleviate the necessity for direct eIF4G/eIF3 interaction.

68 IM1 remotely gates the Orai1 channel without the necessity for direct STIM1 contact with the pore-for

69 s of the hammerhead ribozyme, and emphasizes the necessity for dynamic structural fluctuations in the

70 The necessity for earlier genetic alterations before bia

71 This highlights the necessity for efficient glutamate clearance from the

72 the effects of activity blockade, indicating the necessity for endogenous neurotrophins for developme

73 ound that lack of NFATc2 and NFATc3 obviates the necessity for engagement of CD28 on naive cells and

74 The approach removes the necessity for evenly spaced samples, an advantage il

75 flexibility of the filter that demonstrates the necessity for extended simulations to study conducti

76 e in burn depth and area would likely reduce the necessity for extensive surgical debridement as well

77 Moreover, the method eliminates the necessity for extensive thermodynamic calculations.

78 e, noninnocent NO ligand in electron uptake, the necessity for Fe'-S bond breaking (or the hemilabili

79 f cells with natural C(16)-ceramide bypassed the necessity for forced antibody cross-linking and enab

80 of SecA via azide treatment, consistent with the necessity for formation of a preprotein-SecB-SecA co

81 aintaining fetal tolerance during pregnancy, the necessity for Foxp3(+) cells with fetal specificity

82 r, the limitation of this type of therapy is the necessity for frequent administration of cytokine pr

83 The necessity for full reperfusion after a preconditioni

84 The necessity for further evaluation, possible treatment

85 omic growth in recent decades, thus implying the necessity for further investigations on both the int

86 This study highlights the necessity for further research focused on recurrence

87 of similarity, and it probably results from the necessity for fusion to occur to establish the prima

88 it is limited by its temporal resolution and the necessity for Hg modified electrodes.

89 However, the necessity for high operating temperatures (800-1,000

90 Here, we sought to define the necessity for histamine receptors in the pathology o

91 f cytotoxicity by alkylating agents includes the necessity for homologous recombination to repair DSB

92 RNA interference strategies confirmed the necessity for Hsp27 as well as both beta-arrestin is

93 consistent platelet product, while reducing the necessity for human donations.

94 scuss how interspecies differences highlight the necessity for human model systems to complement exis

95 Central injection is easy and avoids the necessity for image-guided injection of nonpalpable

96 nable chemicals manufacture is discussed and the necessity for immobilisation of enzymes as a key ena

97 recommendation for a new nutrient, and show the necessity for including nutrient interaction in the

98 tation of metabolic labeling experiments and the necessity for inclusion of additional controls.

99 comprehensive 2D gas chromatography (GCxGC): the necessity for individual compounds to be chromatogra

100 uted tomography (CT) scanning in determining the necessity for initial laryngectomy for advanced lary

101 Their conservation is probably due to the necessity for interaction of proximally bound transc

102 pment of this complication, which emphasizes the necessity for intermittent assessment of parathyroid

103 r of species detected simultaneously without the necessity for internal calibration and indicate the

104 r evasion of the PKR pathway likely explains the necessity for IRS1 or TRS1 for productive infection.

105 n that of the cytoplasmic form, underscoring the necessity for its continuous nuclear transport to ma

106 olution below Rayleigh criterion and without the necessity for labeling with fluorescent probes is pr

107 This extraordinary event highlights the necessity for laboratories to remain vigilant in the

108 on of the mouse model is its small size, and the necessity for laborious histologic analyses to quant

109 hallenges for any future hydrogen economy is the necessity for large scale hydrogen production not in

110 not promote limb regeneration, demonstrating the necessity for limb progenitor cells.

111 erogeneity and non-Mendelian inheritance and the necessity for linkage methods to deal with these iss

112 This study demonstrates the necessity for local information on common mental dis

113 In the MR imaging scenario, the necessity for lymph node dissection was based on MR

114 %) were maintained with disopyramide without the necessity for major non-pharmacologic intervention w

115 oxin concentration and load, which points to the necessity for measuring endotoxin levels in both the

116 This decay indicates the necessity for methods and reagents for the routine m

117 gs of the guide-specific approach highlights the necessity for meticulous guide design and assessment

118 systems will never be completely eliminated, the necessity for minute-to-minute intervention may.

119 ity on Polga and provide genetic evidence of the necessity for mitochondrial Hsp40 in preventing DCM.

120 comparison to adult phase I trials, include the necessity for multiinstitutional participation and t

121 denture, retention of compromised teeth, and the necessity for multiple implant surgeries complicate

122 nation could provide the solution and reduce the necessity for multiple injections to achieve immunit

123 son to the BXSB parental strain, emphasizing the necessity for multiple interactions in the productio

124 needed for maintaining fidelity may reflect the necessity for multiple substrate recognition in vivo

125 ssful in treating hepatocellular carcinomas, the necessity for multiple treatments, injection of larg

126 The necessity for multiple wash steps for accurate quant

127 nse of cells to drugs, this study emphasizes the necessity for new in vitro cancer models and the use

128 atment discontinuation with current therapy, the necessity for new therapies targeting CML stem cells

129 Overall, our results highlight the necessity for open data sharing to provide a more so

130 The necessity for, or redundancy of, distinctive KChIP p

131 The necessity for pathogen recognition of viral infectio

132 These results demonstrate the necessity for peripherin/rds in ROS membrane fusion,

133 The necessity for PET attenuation correction required ne

134 However, the necessity for polyubiquitination of APOBEC3G in this

135 nducer of homeostatic proliferation, without the necessity for prior immunodepletion.

136 ising target for sensitive detection without the necessity for prior in vitro amplification.

137 se of hypothermia for stroke to date include the necessity for proactive antishivering therapy for su

138 The necessity for protection against diverse pathogens,

139 dy administration has limitations, including the necessity for purification and multiple injections f

140 For example, can we definitely prove the necessity for quantum, as opposed to classical, mode

141 ologic fracture, spinal cord compression, or the necessity for radiation or surgery to bone metastasi

142 consequence for the production of fibers is the necessity for realignment by extension in the flow d

143 e sorting and cloning methods by eliminating the necessity for repetitive purification steps and incr

144 nvolvement in these responses does not imply the necessity for resistance to URT infections.

145 Here we investigate the necessity for retinoic acid in motor neurogenesis fr

146 Our study, therefore, draws attention toward the necessity for rigorous characterization of transdiff

147 This review focuses on some of the necessities for screening: sensitive, specific, and

148 This supports the necessity for semantic cognition in internal process

149 ed diagnosis for HCM could potentially avoid the necessity for serial echocardiography in many such r

150 via inhibition of glial TLR4 and illustrate the necessity for sex-specific research and individualiz

151 One problem is the necessity for short- and long-term storage of islets

152 C S1PR2 dependency for chemokine release and the necessity for signal transducer and activator of tra

153 ses to accommodate Mg(2+) and Ca(2+) without the necessity for significant bending of the overall hel

154 These features and the necessity for significant remodeling of the Prx stru

155 spectrum of BM contribution, we demonstrate the necessity for site-specific expression of stromal-de

156 results explain prior modeling failures with the necessity for somatic LOH in a developmentally regul

157 de the development of new therapies, such as the necessity for spatial and temporal control in neural

158 ergies for catalysis of AdoMet formation and the necessity for subsequent PPP(i) hydrolysis to allow

159 nd the severity of illness, which results in the necessity for surgery, there is little information o

160 wn and Vav1 overexpression each circumvented the necessity for synergy because NKG2D or 2B4 alone bec

161 To investigate the necessity for T-B cell contact in MRL autoimmunity,

162 idden within national statistics, confirming the necessity for targeted policies and metrics that rea

163 The data highlight the necessity for temporally and spatially distinct CD4

164 aining the most accurate discrimination, and the necessity for testing discriminatory functions again

165 To determine the necessity for the 4-allyl moiety in (+)-2, this subs

166 The necessity for the activation of one particular kinas

167 uired for virion maturation and infectivity, the necessity for the C-terminal cleavages of Gag is les

168 To directly assess the necessity for the combination of neu-specific cellul

169 findings predict and additional data confirm the necessity for the cooperation of multiple integrin a

170 Inspired by the necessity for the development of a protein drug of h

171 out the safety of consumers, and it suggests the necessity for the development of a sensitive and a r

172 e in human pathogenic bacteria has increased the necessity for the discovery of novel, yet unexplored

173 in the absence of CD4(+) T cells and support the necessity for the expression of distinct effector me

174 omprised exclusively of encoded amino acids, the necessity for the incorporation of unnatural amino a

175 antations, leading to price fluctuations and the necessity for the industry to find high quality coco

176 n of mitotic cells unnecessary and obviating the necessity for the more technically demanding DNA det

177 h prior neuraminidase treatment highlighting the necessity for the presence of available acceptors wi

178 ranial magnetic stimulation (rTMS) to assess the necessity for the short-term retention of spatial in

179 d the splice donor mutation, thus confirming the necessity for the splice donor site for Sag function

180 N, albeit with lower efficiency, challenging the necessity for the Tyr(224) aromatic ring.

181 Furthermore, we show that the necessity for these two closely related, non-redunda

182 change in its function) that likely explains the necessity for tight co-regulation of the ybgF and to

183 gland during early pregnancy, but underscore the necessity for tight control of this signaling molecu

184 These findings highlight the necessity for timely antiretroviral care, for suppor

185 However, the necessity for translation of genetic changes restric

186 e posterior ROP (kappa = 0.35); moderate for the necessity for treatment (kappa = 0.41); and fair for

187 e posterior ROP (kappa = 0.60), moderate for the necessity for treatment (kappa = 0.47), and substant

188 7% for aggressive posterior ROP, and 25% for the necessity for treatment.

189 e show that B7 deprivation in mice overrides the necessity for Tregs in averting systemic autoimmunit

190 We propose that the necessity for two distributions is a criterion for c

191 The necessity for two types of thioredoxins (Trx f and m

192 The necessity for UBE2E3 in RPE proliferation was determ

193 ity to cardiac titins and this may eliminate the necessity for unfolding of Ig domains under physiolo

194 had a percutaneous drainage, and we assessed the necessity for urgent or emergent operation.

195 netic logic scheme at room temperature where the necessity for using a magnetic field clock can be co

196 ing exponential growth due to autolysis, and the necessity for using high starting inocula.

197 The results showed the necessity for using samples with an original concent

198 The necessity for VH 4-34 FR1 explains the almost exclus

199 In the present study, we also addressed the necessity for viral infection and/or replication in

200 nt C-type inactivation involving S4, without the necessity for voltage-dependent opening, allosteric