ライフサイエンスコーパス: the need for

1 al cytopathic effect have failed, indicating the need for a better understanding of the processes reg

2 with meningococcal serogroup B vaccines and the need for a booster dose to sustain individual protec

3 This Viewpoint addresses the need for a centralized fine-root trait database, and

4 individually linked survey also highlighted the need for a comprehensive list of HFs and an analysis

5 lism of glucose during proliferation creates the need for a constant supply of NAD, a co-factor in gl

6 tion makes these trade-offs uncertain, thus, the need for a core outcome set that reflects stakeholde

7 neously assemble into a double helix without the need for a covalently connected linear sequence of n

8 ng a smaller computational footprint, we saw the need for a fast and simple tool for data pre-process

9 We discuss the need for a fully integrated treatment of the modern

10 ection against dengue virus have highlighted the need for a human DENV challenge model to better eval

11 ined that there was substantial agreement on the need for a mixture of push and pull incentives and p

12 s, although this new approach brings with it the need for a more comprehensive subsequent analysis.

13 Our study highlights the need for a more holistic study of climate variabilit

14 These findings raise concerns and suggest the need for a national dialogue about how to judge outc

15 ts are obtained in yields of 41-95 % without the need for a photocatalyst, light, or a strong oxidant

16 catalyze the chemical transformation without the need for a photosensitizer.

17 y eliminate these coupling reactions without the need for a protecting group for the alkyne-functiona

18 ermal history of perishable products without the need for a read-out device.

19 ficient Cas9-mediated genome editing without the need for a repair template.

20 re (<13 of 24 families) were associated with the need for a second HCT or death.

21 This limitation arises from the need for a soft, mechanically compliant interface, w

22 two categories of proteins is the source of the need for a specific handling of membrane proteins, w

23 the DNA concentration is determined without the need for a standard curve.

24 The need for a strong foundation of high-quality genomes

25 chanism of disulfide bond formation obviates the need for a thiol/disulfide oxidoreductase in that co

26 However, beyond the need for a transmembrane domain (TMD), little is kno

27 tients suffering from delirium is limited by the need for a valid/reliable translation of a standardi

28 The need for action-contingent visual feedback is well-e

29 e stabilizes water-in-oil emulsions, without the need for added surfactants or chemical modification

30 chain growth using a single catalyst without the need for addition of exogenous reagents.

31 -replete bone marrow allografting, obviating the need for additional prophylactic immunosuppression.

32 We discuss the need for additional research efforts beyond standard

33 Our findings support the need for additional research on the mitochondrial in

34 with dabrafenib plus trametinib and support the need for additional research to further improve outc

35 These challenges demonstrate the need for advanced cancer imaging informatics tools t

36 The research agenda has defined the need for affordable products (diagnostics, drugs and

37 ty to cure tuberculosis, high mortality, and the need for alternative methods to prevent disease tran

38 The need for an effective vaccine against human tubercul

39 sure was less than 200 kPa, which eliminated the need for an expensive high-pressure pump and chromat

40 d health cobenefits of biochar use highlight the need for an improved understanding of biochar's impa

41 dentials in that an oxidation occurs without the need for an oxidizing agent and hence without the wa

42 onment for RNA viruses to flourish, creating the need for an RNA-targeting antiviral system.

43 This has raised the need for analytical methods that can both perform ra

44 These results highlight the need for and facilitate the development of age-tailo

45 making regarding further investigations and the need for antibiotics.

46 The method obviates the need for any high frequency RF components and has a

47 n chromatography with Sephadex LH-20 without the need for any previous SPE of phenolic compounds usin

48 es uncovered at sub-micrometre level without the need for any staining or contrast agent.

49 ariation of approximately one metre, without the need for any tuning.

50 The main limitation of the study was the need for assumptions concerning knowledge of HIV sta

51 subsequent fragmentation, we could eliminate the need for authentic standards for identification.

52 nome or transcriptome, the findings indicate the need for authentication of VZV by sequencing when th

53 One such example is the need for automated EM image segmentation for neurite

54 accuracy similar to upfront SLNB and reduces the need for axillary lymph node dissection compared wit

55 g the curriculum; experiential learning; and the need for better data on trainees.

56 tanding of the WAF components and highlights the need for better experimental and theoretical approac

57 ble risk factor for stillbirth, highlighting the need for better skilled care during delivery.

58 at clinically effective doses, highlighting the need for better understanding LAM's molecular etiolo

59 d regional and national statistics) indicate the need for better understanding the experimental desig

60 lence of IDH1 mutations in glioma highlights the need for brain-penetrant IDH1 mutant-selective inhib

61 improve biomaterial biocompatibility without the need for broad immunosuppression.

62 nform health planners and raise awareness of the need for cancer control action.

63 chieve superior glycaemic regulation without the need for carbohydrate counting.

64 s show continued increases in longevity, and the need for careful planning for health and social serv

65 These results reaffirm the need for careful selection of transplant recipients

66 Our results have two important implications, the need for caution in the interpretation of mitochondr

67 nce can be detected in less than 2 h without the need for cDNA synthesis or any other enzymatic react

68 ent, the need for reaction to escalation and the need for clinical judgment, and the intermittent nat

69 ric surgery for treating NASH and underscore the need for clinical trials in this area.

70 Results of this research support the need for clinical trials that attempt to further ref

71 er transform spectroscopy (ATR-FTIR) without the need for collimated or polarised incident light, as

72 chemoresistant state and thereby underscore the need for combinatorial approaches to improve treatme

73 edication then reduced symptoms and lessened the need for compensation, thereby normalizing thickness

74 wever, applications to plasma are limited by the need for complex preanalytical sample preparation st

75 nrichment for poly(A) site junctions without the need for complex sample preparation, fragmentation o

76 ional and experimental chemists, emphasizing the need for computation to predict experimental results

77 derived k-mer sequence at once, resulting in the need for computer hardware with large shared memory.

78 PrEP delivery to women can continue without the need for concurrent testing for bacterial vaginosis

79 rences in phenological strategies underscore the need for considering regional climate histories in g

80 nd disease burden of elevated BMI highlights the need for continued focus on surveillance of BMI and

81 Temporal changes in MATS coverage underscore the need for continued monitoring of antigen expression

82 mission in a direct contact model underscore the need for continued study of H7 subtype viruses.

83 These issues highlight the need for continued synthesis between fossil and phyl

84 l and near instantaneous stimulus to measure the need for cooling, for example, it should be easy to

85 optimizing and planning experiments without the need for costly experiments.

86 nal rejection levels autonomously, bypassing the need for costly integrity monitoring and membrane re

87 linical decision rules can help to determine the need for CT imaging in children with head injuries.

88 colytic oscillations in single cells without the need for cyanide.

89 ay not prove to be successful and highlights the need for detailed pharmacogenomic analyses of CS mut

90 ating disease such as cancer has underscored the need for developing comprehensive panels of molecula

91 primary end point was a composite of death, the need for dialysis, or a persistent increase of at le

92 or general health, life dissatisfaction, and the need for disability benefits due to inability to wor

93 The need for dose adjustment and the incidence of torsad

94 ar, for long-range electron exchange without the need for e-pili.

95 long duration of untreated psychosis confirm the need for earlier intervention or targeted social net

96 Findings highlight the need for educational campaigns regarding harms relat

97 sk for psychological disorders, highlighting the need for effective interventions, especially in area

98 ficacy, have safety concerns that underscore the need for effective peripherally acting drugs.

99 of MRSA and MDR bacterial pathogens dictate the need for effective prevention as important as for th

100 l illness polyneuropathy and/or myopathy and the need for effective preventive interventions.

101 ociated with an ageing society, highlighting the need for effective treatment options.

102 useful for stratifying patients according to the need for elective partial colectomy.

103 step with direct chitosan addition, without the need for enzymatic treatment.

104 The need for EPA in MGDG is not understood.

105 erapeutics and diagnostics has brought about the need for establishing innovative standardized test m

106 precipitation and flood magnitude motivates the need for estimation of historical probabilities usin

107 (for example, fibroblasts) and circumventing the need for ex vivo pre-processing.

108 ructure with observed variability suggesting the need for expanded measurements in the future.

109 eal due to the ease of multiplexing, without the need for expensive labelling methods or extensive sa

110 vels into relative transcript counts without the need for experimental spike-in controls.

111 der current and future climate; we highlight the need for experimental studies to identify the mechan

112 We discuss the need for explicit experimental testing of the effect

113 These results highlight the need for explicit quantitative modeling when making

114 , we demonstrate that our MAR assay, without the need for extended culture ex vivo, correctly defines

115 wing for completion of the synthesis without the need for extensive screening.

116 .5 mW) laser source to activate, and without the need for external power supply or signal generation,

117 d and self-rectifying memristor that negates the need for external selectors in large arrays.

118 tocrine feedback loop in which Klotho senses the need for FGF23.

119 tor via short conducting linkages eliminates the need for fillers, resulting in a material which achi

120 There is growing awareness of the need for fishery management policies that are robust

121 These findings highlight the need for focused and pragmatic randomized studies on

122 efficiently enter cells and tissues without the need for formulation.

123 their entire evolutionary histories without the need for fossil data, or molecular phylogenies.

124 Significant progress in meeting the need for FP has been achieved in Senegal, but more n

125 Our findings highlight the need for further analysis of the T cells involved in

126 le post-synthetic addition of Cu(2+) without the need for further chemical modification.

127 sion and non-random X inactivation highlight the need for further culture improvement.

128 encountered in 31% of patients, emphasizing the need for further evaluation in larger series and clo

129 ia in identifying these patients, as well as the need for further investigation of cancer risks in pa

130 tematic bias in GOM measurements, supporting the need for further investigation of measurement techno

131 etes-associated costs as well as to identify the need for further research in low-income regions.

132 These results do not lessen the need for further studies, continuous self-regulation

133 ucity of high-quality evidence, highlighting the need for further targeted research.

134 The need for further work on this class of enzymes is em

135 ent and hospital characteristics, suggesting the need for further work to evaluate the causes of vari

136 uence to neurological disorders and point to the need for future studies to better define specific me

137 This work highlights the need for future study of how changes in urban form a

138 tex may further delineate NCCs, (3) advocate the need for general, objective, brain-based measures of

139 ons using standard approaches and highlights the need for generalized risk prediction methods and the

140 ell sorting is a challenge to better address the need for generating more homogeneous subpopulations

141 cal p53-independent function and may obviate the need for genomic alterations to the p53 pathway duri

142 he natural chloride present in milk, without the need for gradient elution HPLC conditions.

143 TBSA and the need for grafting of the arm, head/neck, and trunk w

144 elieved that eating a healthy diet precluded the need for HCC surveillance, and 34.0% believed that H

145 These results highlight the need for healthcare providers to ensure guidelines a

146 s or systemic steroids, and severe events by the need for hospitalization.

147 oven that real numbers are insufficient, but the need for hyper-complex numbers remains an open quest

148 s to ID programs is occurring at a time when the need for ID providers has never been greater and the

149 ortant injuries, while excluding injury, and the need for imaging in many patients.

150 patient interaction of nurses and emphasizes the need for implementing institutional policies on the

151 A promising approach to meet the need for improved cancer treatment is drug repurposi

152 ecognition, response, and prevention include the need for improved rapid diagnostic methods, the abse

153 ory cytokines produced by T lymphocytes, but the need for improved therapies persists.

154 and CR9114 against H2 viruses and emphasize the need for in vivo evaluation of bNAbs.IMPORTANCE bNAb

155 pidemiological relevance of the pathogen and the need for in-depth investigations towards understandi

156 The need for increasing LRT treatments and lack of alpha

157 atial modes of light simultaneously, without the need for increasing the photon numbers with dimensio

158 nd risk from iron supplementation as well as the need for indicators informative of the full continuu

159 The need for individualized definitions of pathogenic me

160 had institutional review board approval, and the need for informed consent was waived.

161 n and school performance, and thus highlight the need for informed interventions.

162 However, the need for innovation to achieve these goals, sustain

163 pped from 8% (26 of 312) to 0% (0 of 35) but the need for insulin therapy remained constant (9%, thre

164 d HBV among homeless veterans, and reinforce the need for integrated healthcare services along with h

165 and unmet palliative care needs, suggesting the need for integration of palliative care within the l

166 ults support the importance of androgens and the need for intervention with AR agonists to treat DMD-

167 c infection in non-CF patients and highlight the need for interventions to improve their outcome.

168 ers, which limit physiological insight, e.g. the need for intravenous infusions and restriction to sh

169 th-care costs of excess weight and emphasise the need for investment to tackle this public health iss

170 frequency of RNF168 c.640_644del5 indicates the need for its testing in Finnish patients with RIDDLE

171 are important for science policy and support the need for journals to require authentication testing

172 ar studies and cell-surface analysis without the need for labeling processes.

173 so far been identified, strongly indicating the need for larger global studies that investigate both

174 Our findings highlight the need for larger studies and prospective cohorts and

175 ssue stains-but time is saved by eliminating the need for larval dissections and by allowing hundreds

176 iconductor industry, but is often limited by the need for lattice matching between the two material s

177 termining the legality of KPD and highlights the need for legal clarity and flexibility as donation a

178 tnA2 can induce rapid membrane lysis without the need for lipid II binding.

179 tage of HTML5 to be fast, portable and avoid the need for local installation.

180 ative exons exhibit coordination, showcasing the need for long-read transcriptomics.

181 sk to develop bladder carcinomas and support the need for long-term cancer surveillance in these pati

182 Our study underscores the need for long-term clinical trials in adolescents wi

183 However, the need for longer-lasting effects, combined with marke

184 drug resistance are concerning and highlight the need for longer-term follow-up studies.

185 ion in AIDS pathogenesis has been limited by the need for longitudinally sampled viral sequences from

186 oung corals are 'seeded' on the reef without the need for manual attachment to the benthos.

187 Directly tethering Drp1 to the MOM bypasses the need for Mff to evoke cytochrome c release, and occl

188 y to improve the sensitivity of RDTs without the need for modifications or remanufacturing.

189 Our results highlight the need for more detailed studies of tree physiological

190 ecome resistant to bevacizumab, highlighting the need for more effective antiangiogenic drugs with no

191 eads to persistent motor deficits, prompting the need for more effective interventions.

192 The need for more effective therapy prompted a trial wit

193 A pathogenicity in dental wards highlighting the need for more efficient surveillance/infection contr

194 These anomalies highlight the need for more psychological work.

195 Hence, the present study highlights the need for more research focusing on the immunostimula

196 thermore, substantial heterogeneity supports the need for more robust studies in order to pool result

197 NF-kappaB signaling pathway and underscores the need for more selective strategies to therapeuticall

198 This emphasizes the need for much improved implementation of mitigation

199 However, the need for multiple donors to achieve insulin independ

200 Eliminating the need for nephrotoxic immunosuppressive drugs during

201 To address the need for new agents to treat MDR P. aeruginosa, we f

202 Aligned with the need for new broad and easily modifiable platforms f

203 proven to be difficult to predict, spurring the need for new tools to rapidly identify and communica

204 t drugs has led to a concomitant increase in the need for novel antimicrobial agents.

205 ent-distinct effects on growth, underscoring the need for novel risk assessment strategies for this c

206 ectively relieves hot flush symptoms without the need for oestrogen exposure.

207 Performing DALK on DSAEK eliminates the need for open-sky surgery, achieving visual results

208 l for perioperative pain and perhaps obviate the need for oral narcotics.

209 y not have otherwise been detected, reducing the need for other diagnostic tests, reducing unnecessar

210 n of a dihydrazide intermediate 2, bypassing the need for oxidative N-N bond formation in the 1,2,4-t

211 e consuming and uncomfortable, demonstrating the need for pharmacological interventions.

212 of assembled chloroplast genomes and removes the need for pipelines and software on personal hardware

213 In the absence of specialized immune cells, the need for plants to reprogram transcription to transi

214 orm photoactivated depots of insulin without the need for polymers, by linking photolysis to an isoel

215 There was also a difference in the need for postprocedural extracorporeal support in fa

216 Limitations included their sensitivity, the need for practitioner engagement, the need for react

217 pattern of functional connectivity, without the need for pre-existing or hidden pathology.

218 l as arylcuprates at low temperature without the need for precious metal catalysts, ligands, excess r

219 a standard addition method, which eliminated the need for predetermined calibration curves.

220 rigin on aquatic ecosystems have intensified the need for predictive and functional models of their e

221 unselected patient population, and highlight the need for predictive biomarkers in the treatment of e

222 irculatory support patient profiles 1 and 2, the need for preoperative extracorporeal membrane oxygen

223 cing of biomass recalcitrance and therefore, the need for pretreatments.

224 lamines under biomimetic conditions, without the need for protecting groups, yielding powerful syntho

225 tability, as well as ligand binding, without the need for purification.

226 We highlight the need for quantitative flux analysis to study NO in t

227 escents than in young children, highlighting the need for raising public health awareness about the d

228 nesting, phenological shifts might mitigate the need for range shifts.

229 Current methods have not yet satisfied the need for rapid fractionation of size-heterogeneous n

230 asing number of countries on a global scale, the need for rapid, simple and cost-effective methods to

231 ew threats to longer-term use and highlights the need for rational drug development.

232 ivity, the need for practitioner engagement, the need for reaction to escalation and the need for cli

233 the transportation of reagents and mitigates the need for refrigeration of reagents.

234 We emphasize the need for regular and long-term follow-up after pedia

235 The need for renal replacement therapy (five [3.2%] and

236 the reproducibility of research and minimize the need for repetitive calibration.

237 aneous tissue on microneedle performance and the need for representative skin models in microneedle t

238 The need for rescue medication was reduced from 5.55 use

239 These data highlight the need for research into prevention of inflammatory bo

240 es with TSD in a warming world and underline the need for research to extend from a focus on temperat

241 ly and flexibly (hours/weeks/months) without the need for restrictive experimental control.

242 ha-gal syndrome in patients with IA supports the need for routine screening for this sensitivity as a

243 The need for RVAD implantation after LVAD is associated

244 rease the demand for animal-source foods and the need for safer and more efficient animal production.

245 rom its binding protein in situ, eliminating the need for sample preparation.

246 ng peripheral biomarkers that will eliminate the need for scalp biopsies.

247 ng at approximately 60 nm resolution without the need for sectioning or staining.

248 nd prolonged survival have further increased the need for sensitive tumor assessment that can inform

249 These data demonstrate the need for sensory activity in both development and ma

250 attice meets all of these challenges without the need for separate spatial or temporal compensation.

251 ted when studying reproduction, highlighting the need for sex parity in future studies.

252 This finding highlights the need for sex-specific and cycle-specific approaches

253 of CLA(+) T cells in the blood may eliminate the need for skin biopsies.

254 exceeding 300 degrees C, thereby eliminating the need for solar concentrators for mid-temperature sol

255 However, the time-consuming nature and/or the need for sophisticated instrumentation of those meth

256 al discovery of such solitons is hindered by the need for spatial imaging of the 3D fields, which is

257 the inability to respond to visible light or the need for special treatment to recover the original w

258 ues was already recognized in the 1970s when the need for specialized centers with multidisciplinary

259 This suggests the need for specialized designation of rectal cancer ce

260 As global warming progresses, the need for species to compensate or drift under the in

261 vivo and ex vivo on resected tissues without the need for specific biomarker targeting.

262 post-ST-segment-elevation MI edema highlight the need for standardization of CMR timing to retrospect

263 ment delay during the study period highlight the need for standardized diagnostic routines and a bett

264 ical course of burn patients would highlight the need for standardized protocols.

265 pite availability of PCR testing, indicating the need for strategies to improve aetiological diagnosi

266 These short cargo escape times predict the need for strong diffusion barriers in ILVs.

267 gram for youths aging out of foster care and the need for such programs to continue.

268 The limitations lie in the need for such systems to possess functional subsyste

269 aying phage to form silica materials without the need for supplementary components, such as aminoprop

270 Other studies identified the need for support of parents, siblings, and racial an

271 umab treatment led to a greater reduction in the need for surgery and a greater improvement in sympto

272 se activation of deep-brain circuits without the need for surgical implantation of any device.

273 predict the course of disease and, perhaps, the need for surgical intervention.

274 of chikungunya chronic disease and to assess the need for symptom-alleviating treatment.

275 Our results reinforce the need for systematic trials to dissect the efficiency

276 the clinical criteria for sepsis, excluding the need for systemic inflammatory response syndrome (SI

277 diagnosis among young participants points to the need for tailored long-term health-care and preventi

278 ergence of resistant viruses, which includes the need for the compensatory V165I IN substitution, hig

279 zation from global delocalization, obviating the need for the concept of superaromaticity.

280 at more positive potentials, likely avoiding the need for the generation of [Mo(bpy)(CO)4](2-).

281 This study highlights the need for the inclusion of particulate nitrate photol

282 The need for their miniaturization has fuelled the rapid

283 trial was the rate of corneal perforation or the need for therapeutic penetrating keratoplasty.

284 ve are associated with poor tolerability and the need for titration.

285 t sequencing of B cells becomes more common, the need for tools to analyze the large quantity of data

286 HCT outcomes, including survival, and reduce the need for toxic antiviral therapies.

287 .19% in the derivation data set), indicating the need for transdiagnostic prediction of psychosis in

288 These reactions occur without the need for transition metal catalysis or in situ activ

289 These results suggest the need for translational studies to evaluate the poten

290 ion of the thermally injured mice, bypassing the need for translocation, produced similar results.

291 ity, reversal of overdose, and harms, and 2) the need for transport to a health care facility after r

292 at 4-, 8-, or 12-week intervals depending on the need for treatment.

293 lations with reasonable accuracy and without the need for using multiple markers.

294 per handling of samples and data will reduce the need for using solvent masking software (e.g. SQUEEZ

295 olving stroke care networks, the question of the need for vascular imaging at the RHs remains unsolve

296 in treated municipal wastewater, suggesting the need for vigilant monitoring of treated wastewater q

297 The brain transforms the need for water into the desire to drink, but how thi

298 Our findings emphasise the need for well resourced community and hospital-based

299 ith conventional 2-tiered testing, obviating the need for Western blots.

300 ld be easy to match the number of workers to the need for work.