ライフサイエンスコーパス: the observation that

1 However, the observation that 2-AG hydrolysis blockade alters lea

2 The observation that 22.1% of CBTS developed at least on

3 f the PS model is whether it can account for the observation that A and B tones are generally perceiv

4 We pioneered the observation that a common feature of addictive drugs

5 is type of complementation is underpinned by the observation that a disproportionally high number of

6 The observation that a flat second phase in HDV and HBsA

7 e current asthma epidemic, which is built on the observation that a lack of bacterial contact early i

8 Following from the observation that a lncRNA that we call negative regu

9 The observation that a low M-protein concentration at MG

10 to minor groove DNA recognition rationalizes the observation that a single Cascade complex can respon

11 The observation that a single mutation can overcome the

12 The design of FALCON@home is based on the observation that a structural template, especially f

13 The observation that a subset of cancer patients show ev

14 These findings, coupled with the observation that a subset of patients with recurrent

15 The observation that a substantial part of proteins is s

16 The observation that academic hospitals are more likely

17 tic, animal model, and human studies support the observation that accumulation of the beta-amyloid (A

18 nnate-like B cell responses was supported by the observation that administering an mAb directed again

19 The observation that adoptive transfer of peritoneal B c

20 was corroborated in restimulation assays by the observation that Ag-expanded T cells specifically re

21 re intricate substrate requirements, explain the observation that AGO3 has retained the necessary cat

22 This conclusion is based on the observations that Ahr null mice showed increased num

23 This model provides a mechanism for the observations that allosteric enhancers slow the diss

24 The observation that altered activation of Stat3 influen

25 However, this view has been challenged by the observation that an absence of both B-type lamins in

26 This is supported by the observation that an anti-formin drug treatment conve

27 The basis of our approach lies in the observation that anatomical-therapeutic biological a

28 The observation that antisense expression can initially

29 Their translational validity mainly rests on the observation that anxiolytic drugs reduce rodent anxi

30 The observation that aP, which induces an immune respons

31 This is further supported by the observations that apelin promotes the expression of

32 Of particular interest is the observation that apes, including humans, cannot oxid

33 oE3 and ApoE4 may contribute to AD including the observation that ApoE4 is degraded to a greater exte

34 On the basis of the observation that appropriate baseline correction and

35 on and provide a mechanistic explanation for the observation that asthma was a major risk factor duri

36 edictor of immune activation is supported by the observation that asthmatic children seemed to have r

37 ctional adenosine A1 receptors, in line with the observation that ATP is released via connexin 43 hem

38 Consistent with the observation that ATP5G1 is a rate-limiting component

39 Building on the observation that avian influenza A viruses (IAVs) ha

40 This view is based upon the observation that axon diameters correlate with myeli

41 The observation that B. burgdorferi contains a TamB orth

42 s the secretion of a subset, consistent with the observation that B3GLCT mutant phenotypes in PPS pat

43 be required for mammalian infection despite the observations that BB0405 is poorly immunogenic and n

44 f a role for ARF in NSCLC is consistent with the observation that benign adenomas from Arf(+/+) mice

45 red in tumors, we provide an explanation for the observation that beta-TrCP can act as a tumor suppre

46 In support of the latter is the observation that betaPEA and Amph produce similar bu

47 The observation that BFV, a foamy virus, is able to expr

48 athways which provide biological support for the observation that BIMA grafts deliver long-term benef

49 These findings were corroborated by the observation that blocking multiple integrins adverse

50 These findings are consistent with the observation that BMP receptor hyperactivation correl

51 The observation that both interactions are mediated by t

52 The observation that bovine FLUDV replicated in the resp

53 y function on the BRAF pathway, arising from the observation that BRAF levels are decreased upon TRAP

54 he main results supporting this view include the observation that C-type inactivation is not suppress

55 droceramide increase is further supported by the observation that C8-dihydroceramide mimicked gammaTE

56 e long-standing "calcite-aragonite problem"--the observation that calcium carbonate precipitates as t

57 Most troublesome is the observation that cancer cells that survive treatment

58 This review presents evidence that contests the observations that cancer stem cell markers reliably

59 The observation that carbonate diesters solvolyze faster

60 The observation that carrier heating is ultrafast sugges

61 However, the observation that caspase-8 is upregulated in many co

62 Equally important is the observation that CB11 (CN)12 (2-) , which contains o

63 r the antitumor effects of CD19 CARs and for the observations that CD19 CAR T cells incorporating the

64 The observation that Cdc15 could phosphorylate Ser-5, as

65 The observation that cell-associated H pylori can coloni

66 This finding is consistent with the observation that cells lacking a functional respirat

67 The observation that cells respond to unresolved telomer

68 ed from the radial BP waveform by exploiting the observation that central BP waveforms exhibit expone

69 Consistent with the observation that ceramide limits access to both amin

70 factors dissociate from mitotic chromosomes, the observation that certain nuclear factors and chromat

71 tinuous-time Markov chain approach, based on the observation that changes in methylation state over t

72 This is supported by the observation that circulating autoantibodies, includi

73 The observation that circulating basophils are reduced f

74 hese isomerization reactions is supported by the observation that cis-to-trans isomerization occurs e

75 lization and repression of ClaH corroborated the observation that clathrin does not play an important

76 diate during DCM utilization consistent with the observation that CM could not replace DCM as a growt

77 These results corroborate the observation that coastal nitrogen pollution occurred

78 n-coupled receptors (GPCRs), which led us to the observation that commendamide activates the GPCR G2A

79 Furthermore, the observation that "consensus-like" virus sequences co

80 t with the observed contact domains and with the observation that contact domains tend to form inside

81 pectrometry and EPR spectroscopy, along with the observation that cooling a 1:1 mixture of [(L)Cu(II)

82 The observation that crystals with reduced unit-cell vol

83 a Cys-Cu complex in E. huxleyi is drawn from the observation that Cu-limitation significantly enhance

84 Initially, this view was based mainly on the observation that defective NOD2 function can result

85 The observation that Delta45-46 patients have typical DM

86 This concept was further supported by the observation that dental mesenchymal-specific deletio

87 This is corroborated by the observation that differences at the I step in chloro

88 esses influenced by Dig1 in C. albicans, and the observation that Dig1 is one of the few regulatory p

89 The observation that disease associated proteins often i

90 The observation that disease incidence decreased with di

91 The observation that DMF stimulates mitochondrial biogen

92 FP foci form during S phase, consistent with the observation that DNA replication initiation and elon

93 These data were supported by the observation that dnj-14 mutant worm strains expressi

94 The observation that domain size is more sensitive than

95 This conclusion is further supported by the observation that double mutations in TTD that abolis

96 Together with the observation that DV closure occurs through the initi

97 These results together with the observation that E1B-55K-dependent SUMOylation of p5

98 These results and the observation that EB3 promotes rapid hydrolysis of GM

99 However, the observation that ecosystems may become a COS source

100 This mechanistic picture is supported by the observation that electron-rich (donor substituted or

101 Together with the observations that energy-consuming processes (motili

102 systems is a focus of intense research with the observation that entanglement holds interesting info

103 d by the complexity of these communities and the observation that even if populations can be cultured

104 The observation that even ultralow levels of residual an

105 Based on the observation that exogenously supplied p-aminobenzoic

106 rated sufficiently fast, thus accounting for the observation that fast codons are overrepresented in

107 has focused on the "leaky pipeline" problem: the observation that fewer women than men enter science,

108 with that number; support for 25 came from the observation that flagella can assemble and rotate wh

109 TRA and FLT3 TKIs is at least in part due to the observation that FLT3 TKI treatment upregulates the

110 The observation that gene segment 4 is the main differen

111 Led by the observation that genes induced by Aire expression ar

112 turating the immune system, with for example the observation that germ-free animals harbor a poorly d

113 This strategy depends on the observation that glycopeptides and the corresponding

114 This is based on the observation that glycosyltransferases often tolerate

115 The observation that GM1 decreased the bilayer bending r

116 These findings were corroborated by the observation that growth under low Pi conditions as w

117 crophages, thereby providing a mechanism for the observation that helminth infection advances the pro

118 Based on the observation that heteromers are less active than BAF

119 The observation that high doses of Lipopolysaccharide (L

120 This finding was further supported by the observation that high expression of miR-155 sensitiz

121 Our results also reflect the observation that high stress levels (represented by

122 onary signature is acquisition, referring to the observation that holobiont genomes acquire novel gen

123 interaction between TFs, helping to explain the observation that homotypic chains of binding sites e

124 This is based on the observation that humans can perceive depth in stimul

125 The observation that humans perceive depth in half-match

126 The observation that IgE can be complexed with polymeric

127 The observations that immunodominant ligands can be foun

128 ed vesicles; this conclusion is supported by the observation that, in the context of a sensitizing do

129 We present an analysis of the observations that indicates that these smaller-scale

130 Thus, the observation that inhibiting macropinocytosis leads t

131 Instead, we made the observation that intracellular accumulation of treha

132 ntermolecular PARP-1 activation, followed by the observation that intramolecular activation of PARP-1

133 cking of phospholipid to LB was confirmed by the observation that knockdown of StarD10 significantly

134 Ku, X4, and L4 activities, while explaining the observation that Ku80CTR and DNA-PKcs only occur in

135 e site architecture molecular modelling, and the observation that L. japonicus accessions lacking cya

136 e guinea pig and nonhuman primate LD50s, but the observation that L. monocytogenes-induced stillbirth

137 Here, we build on the observation that Langerin-CD11b- migDCs are Fms-like

138 They even recapitulated the observations that large cargo-domains counteract NPC

139 pete for auxin accumulation, consistent with the observation that lateral roots are not initiated opp

140 mplexity of Shp2 signaling is exemplified by the observation that LEOPARD syndrome (LS) patients poss

141 However, the observation that less than half of all angiosperm fa

142 The observation that LFG itself is not located in mitoch

143 These data, together with the observation that liver extracts from Abcb6-deficient

144 Such local functions could explain the observation that lncRNA expression is often correlat

145 Consistent with the observation that lower PDE11A4 expression correlates

146 These data, together with the observation that Lpd accumulated at the interface be

147 Of greater interest was the observation that many RNAi targets increased immunot

148 A paradox in cancer immunology is the observation that many tumor cells often have a drast

149 Despite the observation that mechanical forces affect nuclear ge

150 The observation that mechanisms underlying cocaine memor

151 upon their differentiation, consistent with the observation that Meflin-deficient mice exhibit incre

152 ese differences disappeared, in keeping with the observation that memories become generalized.

153 Despite the observation that merely raising caspase-1 levels is

154 This work is motivated by the observation that merging these two techniques in a c

155 mine cell firing; this is largely because of the observation that midbrain dopamine neurons do not di

156 8 T cell numbers and function also explained the observation that miR-155KO animals were less able th

157 The observation that miRNA does not integrate into the g

158 vely, other prediction methods were based on the observation that miRNAs with similar functions tend

159 The observation that mismatch negativity (MMN) is consis

160 r the latter, additional evidence stems from the observation that Mn(2+) or Cd(2+) accelerated cleava

161 heir allergenicity, which is consistent with the observation that most allergic reactions are in conn

162 Despite the observation that most nanoparticles were taken up by

163 Our results give a logical explanation of the observation that most new tuberculosis drug leads di

164 These results, augmented by the observation that most species-level diversity origin

165 The observations that most responses are, however, parti

166 e of alphabetaT-cells has been expanded with the observation that mucosal-associated invariant T-cell

167 The screen was based on the observation that Myxococcus xanthus nonmotile cells,

168 splicing, and metabolite profiling supported the observation that neoplasm is triggered by a decrease

169 We highlight the observations that neuronal activity can rapidly tune

170 s been demonstrated on human neutrophils and the observation that neutrophils migrate in response to

171 pproximately 20-60%) is in stark contrast to the observation that NH4NO3 microdroplets do not homogen

172 The observation that NHC-boryl radicals abstract cyano g

173 However, this proposal was not supported by the observation that nhTMEM16 does not mediate ion trans

174 The observation that Ni-L is present at all potentials d

175 Finally, the observation that NKG2D-ligand induction is a consequ

176 The observation that Nlrp2 was exclusively expressed in

177 The results are consistent with the observation that non-hybrid endophytes in H. europae

178 The observation that Npc1 and Cstb deletion genetically

179 evance of these findings was demonstrated by the observation that NRG4 and its receptor ErbB4 are pre

180 The observation that O2 formation is fastest in the pres

181 Based on the observation that occlusion/deocclusion reactions of

182 The observation that OCP use was associated with lower s

183 The observation that one can control the microscopic sha

184 he environment on the epigenome may underlie the observation that only a small fraction of a populati

185 loped about two decades ago and derives from the observation that outer hair cell surface area is vol

186 TP yields than the EMP pathway, in line with the observation that oxygenic photosynthesizers are nutr

187 The observations that p110delta inhibitor prolonged mous

188 This difference might be explained by the observation that palmitate esterification influenced

189 The observation that participation can be increased by o

190 cult to reconcile this FliM remodelling with the observation that partner FliN subunits are relativel

191 Our findings fit well with the observation that patients carrying mutations in TREX

192 form of series-tunneling junctions based on the observation that permuting the order of R1 and R2 in

193 The observation that phonological processing abilities w

194 Based on the observations that physical contact between nanorods

195 tumor angiogenesis, which is consistent with the observations that PKM2 in circulation of cancer pati

196 The observation that plasma CatD correlated with NASH de

197 s PPARgamma occupancy of this site, based on the observation that PPARgamma interacts with these sequ

198 The observation that prepandemic sera possess robust blo

199 MAP is based on the observation that preventing crosslinking within and

200 of PRL-2 in cellular magnesium transport is the observation that PRL-2 knockdown results in a substa

201 This view stems from the observation that protein synthesis inhibitors, such

202 However, the observation that proteobacteria encode a large numbe

203 early events in CAC was strongly inferred by the observation that prothrombin deficiency dramatically

204 These findings, in conjunction with the observation that PTHrP expression increases and DKK1

205 Here we exploit the observation that pungent anesthetics activate mammal

206 tive autophagy by radiation was confirmed by the observation that radiation-induced autophagy was non

207 This hypothesis was confirmed by the observation that radiolabeled carboxymycobactin was

208 of LRs in encystation could be supported by the observation that raft inhibitors interrupted the bio

209 The observation that rare structural variants confer sub

210 t of the sensorimotor system is supported by the observation that reafference from twitching limbs re

211 This explanation rests on the observation that real world data is often generated

212 The observation that repression of transcription from th

213 ranscriptional responses are consistent with the observation that restriction enzymes caused extensiv

214 The observation that RFA complex plants dramatically inh

215 The observation that RGCs stratifying most of their dend

216 stent with its sphingomyelinase activity and the observation that Rv0888 levels are increased in the

217 The observation that sequence encoding persists even whe

218 Parallel studies independently converged on the observation that serotonin binds well within the ins

219 This and the observation that SETMAR is not active on nucleosomes

220 en suggested for more than a decade based on the observations that shift work and cancer incidence ar

221 Consistent with the observation that short-chain AHLs, unlike oxo-C14-HS

222 These results and the observation that silencing of other ribosomal stalk

223 ing L11 does not alter kcat, consistent with the observation that single molecule velocities are not

224 Of particular importance is the observation that single-electrolyte isotachophoretic

225 However, the observation that some ALS-linked PFN1 mutants fail t

226 , we also yield a reasonable explanation for the observation that some mammalian transporters have 1:

227 cal and moral attitudes; the second concerns the observation that some responses to threat (i.e., neu

228 However, the observations that some Parkinson's disease patients

229 The observation that specific symbiont lineages infect d

230 ch SP may promote plasticity is indicated by the observations that STIM-1, the sensor of calcium conc

231 The technique is underpinned by the observation that STM images contain atomic-sized fea

232 Consequently the observation that such patients tend to report a grea

233 The observation that such responses occurred only when r

234 The WE is the observation that surgeon-independent patient outcome

235 so provide a molecular-level explanation for the observation that synaptotagmin and otoferlin are not

236 The observation that T-bet expression rendered CD8 T cel

237 Moreover, the observation that TCRs assemble into nanoclusters mig

238 However, the observation that TH2 cytokines abrogate the inductio

239 in the protein filament of inflammasomes and the observation that the active form of vitamin B6 (pyri

240 en, these associations could be explained by the observation that the alleles associated with higher

241 The observation that the alpha4 E loop is involved sugge

242 The dichotomy is reinforced by the observation that the anomalous current is absent in

243 The observation that the antigenicity of the receptor an

244 The observation that the BDNF/TrkB pathway is impaired i

245 The observation that the central clock, and many other p

246 a Stabilized Zirconia (YSZ), associated with the observation that the concentration of defects after

247 elyunquensis was eliminated, consistent with the observation that the culture lost the ability to deg

248 The observation that the cyt b5-substrate-bound CYP2B4 c

249 s supported by some phylogenetic studies and the observation that the distinctive myxozoan structure,

250 This study is based on the observation that the early colonization pattern and

251 The observation that the enzyme telomerase is up-regulat

252 This is supported by the observation that the expression of the unique sRNAs

253 The observation that the genomes of other large DNA viru

254 DNA duplex context, which is consistent with the observation that the geranylated tRNA(Glu) UUC recog

255 Consistent with the observation that the heterogeneous molecular basis o

256 suitable for such risk assessment, based on the observation that the innate restriction factor MxA r

257 terproximal region, which is consistent with the observation that the interproximal region often reve

258 These findings were supported further by the observation that the L858R/T790M EGFR mutant, when t

259 We leveraged the observation that the majority of AML, despite their

260 The observation that the majority of virions exclusively

261 s of the MCG intragroup diversity reinforced the observation that the MCG subgroup 6 was found predom

262 This may result from the observation that the minimum cost of transport is ap

263 We start from the observation that the most widely used techniques for

264 served decrease in KA, which is supported by the observation that the mutant ENTH L6E shows a reduced

265 These results, combined with the observation that the nuclear form of HMR has the sam

266 dence that this is indeed the case relied on the observation that the oxidation rates of the reduced

267 Of special note is the observation that the p53 tumor suppressor protein is

268 This finding, combined with the observation that the phylogenetic distributions of p

269 concept for tauopathies arose initially from the observation that the progressive accumulation of tau

270 metabolism in S. cerevisiae in vivo based on the observation that the sch9Delta mutant displays alter

271 Based on the observation that the segregated phase is strongly af

272 The observation that the sequence context influences the

273 ribing a molecular function is confounded by the observation that the single csoS2 gene yields expres

274 The observation that the single site-7 mutant phenocopie

275 The observation that the soluble factors BAFF, IL-2, and

276 The observation that the spliceosome functions in 3' end

277 The observation that the stereo- and enantioselectivity

278 This is illustrated by the observation that the strong photosensitivity of Chla

279 This conclusion fits the observation that the synaptic targets of isoflurane

280 Based on the observation that the type II TGF-beta family recepto

281 The observation that the unliganded ErbB2 kinase prefere

282 iron reducing bacteria was deduced based on the observations that the aqueous Fe(II) concentrations

283 Based on the observations that the promoter regions of many of th

284 asks supported by the two streams as well as the observation that there is a bias for phonological pr

285 r small size and nonvolatility, coupled with the observation that these particles contain lube-oil-de

286 The observation that, through a titration mechanism, mic

287 have recently been more clearly defined with the observation that Toll-like receptor 3 can sense self

288 nd sequence homology information, based upon the observation that topologically important proteins in

289 The observation that transmission only occurred between

290 The observation that transmissions were identified betwe

291 The observation that tRNA binds to cytochrome c revealed

292 tal C terminus was targeted (in keeping with the observation that truncation variants in this region

293 Furthermore, we discuss the observations that two or more RASopathy mutations of

294 bits unexpected and rich behavior, including the observation that under appropriate conditions the po

295 protein provides a structural rationale for the observation that unfolding is hierarchical and descr

296 Of possible clinical relevance was the observation that V. cholerae in the INT 407-associat

297 C activation has remained unclear because of the observation that various PC paralogues are activated

298 hat RVR1 is upstream of VRN1 is supported by the observations that VRN1 is precociously elevated in a

299 ndings offer a network-level explanation for the observation that we are more readily able to learn n

300 supporting evidence for this idea comes from the observation that when reaching towards multiple pote