ライフサイエンスコーパス: the paucity of

1 Nevertheless, the paucity of 3'-sequencing data in this species preclu

2 genes remain uncharacterized, mainly due to the paucity of a nonpolar gene inactivation system.

3 It is also intriguing mechanistically due to the paucity of acid-base residues at the active center t

4 Thus, the paucity of activated CD103(+) DCs in tumors limits c

5 (CRPC) has been challenging because of both the paucity of adequate frozen tissues and a lack of int

6 Owing to the paucity of alimentary enzymes encoded by the human g

7 The mechanism is unknown in part because of the paucity of animal models displaying this feature of

8 The paucity of animal models exhibiting full pathology o

9 mpediment to novel drug development has been the paucity of animal models that accurately reflect sym

10 Because of the paucity of animal models that directly investigate t

11 major limitation in HNSCC research has been the paucity of animal models to test the validity of cur

12 Given the paucity of anti-VL drugs and the looming threat of r

13 n but is limited by the quality of fixation, the paucity of antibodies and the inaccessibility of ant

14 ease is a challenging pursuit, hallmarked by the paucity of antiviral agents currently prescribed.

15 s system remains ambiguous, partially due to the paucity of appropriate investigative methods.

16 cans remain largely unknown, mainly owing to the paucity of appropriate probing techniques.

17 The paucity of AR programs for consumers with hearing lo

18 Due to the paucity of Aspergillus genomic resources 10 years ag

19 crease in the popularity of e-cigarettes and the paucity of associated longitudinal health-related da

20 Due to the paucity of atmospheric organic N data, the largest u

21 We suggest that the paucity of autoreactive specificities created in the

22 ing the spatial pattern of disease spread is the paucity of available data together with the challeng

23 Given the paucity of available data, the heterogeneity of stud

24 that has not been fully exploited because of the paucity of available genetic tools.

25 ably, the most unexpected aspect of LTTRs is the paucity of available structural information.

26 Because of the paucity of available tissue, little information has

27 interestingly, those experimental models and the paucity of biallelic null mutations or deletions in

28 he human zona proteins have been hampered by the paucity of biological material.

29 We propose that largely due to the paucity of biomarkers for primary psychiatric disord

30 The paucity of biomarkers to predict prostate tumor biol

31 The paucity of bone repair in inflammatory diseases such

32 The paucity of boron-containing heteroalkene complexes p

33 The paucity of both cell types has hampered molecular an

34 controls of river primary production due to the paucity of both long-term studies and of depositiona

35 the extent that ecology has a role, however, the paucity of bottom-heavy clades radiating in the imme

36 Given the paucity of case material, we speculated that this is

37 CD4(+) target cells in the mucosa, and (iii) the paucity of CCR5(+) CD4(+) target cells in infant and

38 tially restored function but did not correct the paucity of CD56(bright) cells.

39 ing and regenerative medicine are limited by the paucity of cell types that can be generated in the l

40 The paucity of cell-free virus associated with BDV infec

41 limitations to Treg clinical application are the paucity of cells and limited knowledge of the mechan

42 tissue injuries have limited repair, due to the paucity of cells at the wound site.

43 Until recently, the paucity of characterization of the epidemiology of v

44 This is partly due to the paucity of chemical techniques that can autonomously

45 The paucity of chemotherapeutic agents that are effectiv

46 The paucity of cis associations with transcripts was con

47 tis than previously believed, in part due to the paucity of clinical symptoms and poor sensitivity of

48 Given the paucity of clinical symptoms in temporomandibular jo

49 failure has not yet been standardized due to the paucity of clinical trial data.

50 ty of evidence that is less than high due to the paucity of clinical trials regarding screening, mana

51 e antimetastatic agents has been hampered by the paucity of clinically relevant preclinical models of

52 At tandem occurrences of either rare codon, the paucity of cognate aminoacyl tRNAs for the second co

53 ve nature of the electron-rich aromatics and the paucity of commercial sources pose some obstacles to

54 reversible reaction directionality is due to the paucity of compartment-specific quantitative metabol

55 evolved through our studies is notable given the paucity of competing reaction pathways observed in t

56 ictive behaviors during adolescence, whereas the paucity of D(1)-expressing projections may reduce ri

57 annual outbreaks of infectious diseases, but the paucity of data about travel behavior and population

58 To determine whether the paucity of data concerning chloroplast splicing fact

59 Because of the paucity of data for FGIDs, we included data for non-

60 state common to all ovarian subtypes and by the paucity of data from early-stage cancers.

61 Key limitations related to the paucity of data from low- and middle-income countrie

62 rimate model in neurodevelopmental research, the paucity of data from more closely related great apes

63 oves clinical outcomes is unclear because of the paucity of data from randomised placebo-controlled t

64 Because of the paucity of data from randomized, prospective, double

65 derstanding of these processes is limited by the paucity of data from undisturbed tropical ecosystems

66 een studied rigorously, which contributes to the paucity of data in children.

67 Given the paucity of data on motility and the absence of direc

68 unding by indication in the African studies, the paucity of data on potential confounders, the limite

69 The paucity of data prevented detailed subgroup analysis

70 Despite the paucity of data regarding the outcomes of heart tran

71 The paucity of data regarding the role of these lymphocy

72 active compounds from soy-based formulas and the paucity of data regarding their bioavailability, the

73 Particularly striking is the paucity of data regarding their cellular and subcell

74 Despite the paucity of data supporting its use, screening upper

75 This investigation seeks to address the paucity of data that reliably quantify this phenomen

76 Acknowledging the paucity of data to support widespread adoption of su

77 l single-institution studies, and because of the paucity of data, the optimal treatment for male brea

78 Recognizing the paucity of data, we advocate participation in clinic

79 This is likely due to the paucity of detailed experimental information describ

80 remains intensely debated, owing in part to the paucity of detailed regional datasets and the comple

81 This likely contributes to the paucity of detectable zoonotic cynomolgi malaria.

82 roup that specifically bind these drugs, but the paucity of direct binding data has limited the numbe

83 erapeutics have been hampered for decades by the paucity of disease models that integrate molecular a

84 The paucity of distance information available from the h

85 However, the paucity of distance restraints >5 A, traditionally d

86 which have unfortunately been limited due to the paucity of donor liver tissues.

87 y the need for chronic immunosuppression and the paucity of donor tissue.

88 because of its transient effect on disease, the paucity of donors, and the requirement for strong im

89 Given the paucity of druggable mutations in high-risk neurobla

90 lytic subunit, Enhancer of zeste (E(Z)), and the paucity of E(z) mutant alleles that alter its SET do

91 d unrecognized phenotypic heterogeneity, and the paucity of early ARDS lung tissue limit some applica

92 Enterococcus (VRE) infections is limited by the paucity of effective antibiotics.

93 To address the paucity of effective new therapies, we undertook a h

94 Given the rising incidence of melanoma and the paucity of effective treatments, there is much hope

95 The paucity of empirical data is a limitation of these f

96 s in different internal organs is to address the paucity of empirical data on thanatomicrobiomic succ

97 oke care delivery remain unanswered owing to the paucity of empirical data, we are convinced that str

98 Does the paucity of empirical evidence of sympatric speciatio

99 mechanistically and employed synthetically, the paucity of enantioselective variants is striking.

100 The paucity of enzymes that efficiently deconstruct plan

101 mechanism of quality control-induced ERAD is the paucity of ERAD substrates being dislocated and dete

102 s in rare cancers remains challenging due to the paucity of established models to perform preclinical

103 opmental heterogeneity of DN1 thymocytes and the paucity of ETPs.

104 Furthermore, the paucity of evidence for some groups of medication do

105 nagement remains similar, largely because of the paucity of evidence from devoted pediatric observati

106 and avoid the use of these agents because of the paucity of evidence in the treatment of cancer-assoc

107 They have highlighted the paucity of evidence underpinning current practice, t

108 in critically ill patients is common despite the paucity of evidence validating its accuracy in criti

109 Two recent reports document the paucity of evidence-based data regarding the effecti

110 The paucity of examples has served as a significant hind

111 basis of phenotypic diversity is limited by the paucity of examples in which multiple, interacting l

112 Due to the paucity of experimental animal models, little is kno

113 The paucity of experimental data directly correlating ac

114 ediate are limited in applicability owing to the paucity of experimental knowledge about its geometri

115 e been refractory to characterization due to the paucity of experimental methods able to probe the mo

116 n on identifying precise mechanisms has been the paucity of experimental systems in which actin funct

117 s from different research groups, leading to the paucity of extrapolations of experimental findings i

118 ntion molecule CCR7, possibly accounting for the paucity of F CTL.

119 The paucity of field observations on SOC under ISA (SOCI

120 is achieved is unknown but essential, given the paucity of foreign pMHC ligands relative to the ubiq

121 hocyte HCV reactivity is not responsible for the paucity of functional cells even in end-stage liver

122 e degeneration of SGNs have been hampered by the paucity of functional data on the role K(v)7 channel

123 The paucity of fundamental studies directed towards unde

124 f neurogenesis from GBCs has been impeded by the paucity of GBC-specific markers.

125 ather than fragile, chromosome site explains the paucity of gene alterations and in frequent loss of

126 coevolution, however, is severely limited by the paucity of genetic and evolutionary studies on the f

127 sitive 5 (ABI5), was identified genetically, the paucity of genetic data for the other family members

128 Unfortunately, the paucity of genetic data from many of these subtypes

129 The paucity of genome-level data for Apocynaceae preclud

130 ual clinical samples is, however, limited by the paucity of genomic DNA available.

131 c and health impact studies are inhibited by the paucity of global, long-term measurements of the che

132 The paucity of good clinical trials highlights the uncer

133 These questions are driven by the paucity of hand fossils in the hominin fossil record

134 es of physiological constraints that explain the paucity of herbivorous reptile species.

135 The paucity of high resolution spatial-temporal influenz

136 The paucity of high-level evidence and the conflicting n

137 Given the paucity of high-quality data before 2001, we relied

138 The guidelines reveal the paucity of high-quality evidence, highlighting the n

139 the care of transgender women is limited by the paucity of high-quality research, and long-term long

140 On the basis of the paucity of high-quality, consistent evidence, there

141 d, which for many years was characterized by the paucity of high-resolution structures.

142 in D. radiodurans Mn(2+) speciation, despite the paucity of holo-SodA.

143 The paucity of homologous character data across disparat

144 Despite the paucity of human AbetaPP expression, quantitative en

145 We confirm the paucity of humoral response in patients with CM-FPIE

146 We explore the reasons for the paucity of I(2) complexes and propose candidates for

147 ular pathology and cognitive impairment, and the paucity of identifiable tractable treatment targets.

148 However, the paucity of identified epitopes to this virus has lim

149 L-13Ralpha1 on neonatal Th1 cells was due to the paucity of IL-12 in the neonatal environment.

150 tudy of these diseases is difficult owing to the paucity of imaging techniques with the sensitivity a

151 This lack of structural data and the paucity of in vitro biochemical data for this kinase

152 astrointestinal tract research is limited by the paucity of in vitro intestinal cell models that reca

153 Our knowledge of HSC biology is limited by the paucity of in vivo data.

154 is hypothesis has remained unverified due to the paucity of in vivo studies of neuronal mechanical be

155 ins a longstanding challenge, in part due to the paucity of incisive experimental probes of electrost

156 mmalian olfactory coding has been impeded by the paucity of information about the odorant receptors (

157 s of developing and adult olfactory systems, the paucity of information available on the aged olfacto

158 The paucity of information concerning the 1-rho interact

159 broken during chromatographic analysis or to the paucity of information obtained from the benchmark m

160 The paucity of information on growth, mortality, and fis

161 Among them is the paucity of information on maize's early morphologica

162 and providers' skills is highlighted, as is the paucity of information on maternity waiting homes an

163 tion, but this strategy has been hindered by the paucity of information on molecular targets of cellu

164 n to subjects with HHV6 has been hindered by the paucity of information on targets of cellular immuni

165 es has been tempered by tumor resistance and the paucity of information on the oncogenic programs reg

166 Our work also highlights the paucity of information on the processes that result

167 y of performing such studies in bacteria and the paucity of information that exists regarding ion tra

168 ased on the data from clinical trials due to the paucity of isolates for which MICs exceed 2 microg/m

169 al and aquatic ecosystems, thus highlighting the paucity of knowledge of the origins and potential bi

170 nfection has been difficult, however, due to the paucity of known epitopes.

171 ogeneous mutations present in all humans and the paucity of known functional variants in more than 90

172 ons for brain health, especially considering the paucity of known protective factors for age-related

173 Because of the paucity of known self lipid-reactive ligands for NKT

174 ling pathways, however, has been hampered by the paucity of known substrates.

175 combat bacterial drug resistance increases, the paucity of leads resulting from target-based antibac

176 ifficult to test this assumption, because of the paucity of long, continuous climate records from the

177 The paucity of long-term studies limits conclusions abou

178 The paucity of longitudinal, serial high-resolution imag

179 This is likely because of the paucity of markers expressed by pericytes and the ab

180 e astrocyte development has been hindered by the paucity of markers that identify astrocytic precurso

181 embryonal arterial cells undergoing EHT and the paucity of markers to enrich for hemogenic endotheli

182 was not blocked at a discrete stage; rather, the paucity of mature thymocytes was due to the inductio

183 able frequencies to wild-type mice, although the paucity of memory B cells translated into a 10-fold

184 loads and rapid disease progression, despite the paucity of memory CD4+ T cells in the peripheral blo

185 ynamic processes in vivo is difficult due to the paucity of methods capable of direct measurements.

186 ture during chemical reactions is limited by the paucity of methods for studying catalytic ensembles

187 of a robust cell culture latency system, and the paucity of MHV68-positive tumor cell lines have limi

188 The paucity of micro-exons (</= 51 nt) suggests that the

189 otor learning is limited, in part because of the paucity of model systems with a tractable learned be

190 The greatest diagnostic hurdle in PGD is the paucity of molecular material in the single embryoni

191 anomas and other tumour types) is limited by the paucity of mouse models for live imaging of distal p

192 e to understanding the pathogenesis of WT is the paucity of mouse models that recapitulate its featur

193 The paucity of multiple comparison corrections in ophtha

194 The paucity of murine memory B cell markers has been a s

195 poorly understood, and this is partly due to the paucity of mutants.

196 The paucity of new antibacterial drugs is evident, and t

197 of the limitations of present treatments and the paucity of new drugs in the pipeline, infection cont

198 cess of this model reflects both "necessity"-the paucity of new therapies introduced through industry

199 Given the paucity of observations in the Arctic, models are us

200 ication Event (GOBE) is currently limited by the paucity of Ordovician exceptionally preserved open-m

201 t to NK cell-mediated cytotoxicity caused by the paucity of other NK cell-activating ligands.

202 al therapies is limited primarily because of the paucity of our understanding of their mechanism of a

203 ic leukemia (APL) remains unknown because of the paucity of outcome data available for patients treat

204 ing for this signature have been hampered by the paucity of palaeomagnetic intensity measurements, by

205 This is due to the paucity of paraxial mesoderm formation during embryo

206 Off-label use has been promoted because of the paucity of patients having approved indications; I r

207 ight of evidence remains somewhat limited by the paucity of pediatric data in this field.

208 mobilization are not surprising in light of the paucity of pediatric-specific evidence.

209 The paucity of peptidase families unique to higher metaz

210 Despite the paucity of peripheral blood memory cells and the pro

211 To date, the paucity of pertinent genetic materials has precluded

212 burgeoning field of cancer immunotherapy and the paucity of PET probes that can reliably differentiat

213 Further analysis suggested that the paucity of PMN accumulation was attributable to atte

214 he replication of both DNA strands, and that the paucity of pol3-L612M-generated errors on the leadin

215 The paucity of polymorphisms in single-copy genes on the

216 This slower refolding was also reflected in the paucity of postfusion six-helix bundle configuration

217 The paucity of postmeiotic genes on the X chromosome has

218 tation to their use for on-field analysis is the paucity of preservation methods for long-term storag

219 The paucity of prophylactics and therapeutics against SU

220 routes and formulations of CSHT, as well as the paucity of prospective cohort studies, limits knowle

221 multiple, auxiliary iron-sulfur clusters and the paucity of protein X-ray structural data.

222 an syphilitic sera, a property attributed to the paucity of proteins in its outer membrane.

223 The paucity of PrP(Sc) deposition in the oral and nasal

224 Given the paucity of quality randomized clinical trial data fo

225 Part of the problem is the paucity of quantitative information on the ability o

226 ut their utility has been greatly limited by the paucity of quantitative temperature reconstructions.

227 Because of the paucity of randomized clinical trials (RCTs) in hemo

228 However, given the paucity of randomized controlled trials, lack of an

229 The paucity of randomized trials comparing curative mana

230 However, evidence is limited by the paucity of randomized trials.

231 The paucity of randomized, controlled trials in either o

232 The paucity of RCTs is a major limitation in the evaluat

233 iation are poorly understood and obscured by the paucity of recombination genes conserved in the M. g

234 The paucity of recombination near transcription start si

235 Interestingly, despite the paucity of recurring mutations in human renal cell c

236 pattern of dominance of this mutation belies the paucity of reports of this disease in the literature

237 in melanoma brain metastasis are hampered by the paucity of reproducible and predictive animal models

238 We note the paucity of research into predictor variables other t

239 actor-kappaB ligand, possibly accounting for the paucity of resorptive cells and the dominance of min

240 t-generation sequencing method that exploits the paucity of ribonucleoside modifications at the 3'-en

241 The paucity of rPFH-VMH Ucn 3 projection is consistent w

242 Despite the paucity of scientific evidence supporting the safety

243 Because of their ephemeral nature and the paucity of scientific observations, an explanation o

244 ecology and metabolism has been hampered by the paucity of sequenced reference genomes.

245 phylogenetic range, this strategy addresses the paucity of sex-specific expression systems (e.g., ea

246 The paucity of shared gut colonizers suggests the existe

247 y the lack of explicit design principles and the paucity of simple high-throughput methods for select

248 we add strong support to the hypothesis that the paucity of SIV infections in wild populations is a g

249 vivo has targeted exclusively mTORC1 due to the paucity of specific inhibitors to S6K1.

250 cells remain poorly characterized because of the paucity of specific molecular markers that permit us

251 The paucity of specific retinal findings associated with

252 mary limitation for this type of analysis is the paucity of specificity data that is available for th

253 ld aid in the study of native Env.IMPORTANCE The paucity of spikes on HIV is a unique feature that ha

254 formance testing is currently complicated by the paucity of standards and comparison metrics, as well

255 One reason for the paucity of structural and biochemical characterizati

256 Recognizing the paucity of structural and biophysical data on NBD2,

257 ing sequence-dependent recognition of DNA is the paucity of structural data for DNA recognition seque

258 ly of G protein-coupled receptors (GPCRs) is the paucity of structural information (1).

259 The paucity of structural information provides a fundame

260 derstood in any detail, not least because of the paucity of structural probes through which to study

261 education initiatives, this module addresses the paucity of structured training or education programs

262 Yet the paucity of studies aimed at understanding hybridizat

263 nt HBV in patients who are HIV-positive, and the paucity of studies in this population.

264 the two situations compare is unclear due to the paucity of studies on clinically silent infection.

265 resent in the extrachromosomal arrays versus the paucity of such templates for repair of chromosomal

266 This challenge is exacerbated by the paucity of suitable approaches to genetically engine

267 ic conditions, however, is challenging given the paucity of suitable live-cell imaging tools.

268 Given the scarcity of organs and the paucity of suitable recipients, prolonged ischemia t

269 ivation remains poorly understood because of the paucity of technical means to produce site-specifica

270 and when cultured in vitro, contrasting with the paucity of "Th1," "Th17," and T follicular helper ce

271 nt trials are needed, especially in light of the paucity of the current biologic treatment agents ava

272 ctive antidotes for lewisite was hampered by the paucity of the exact molecular mechanism underlying

273 s on AMBN have been substantially limited by the paucity of the purified nondegraded protein.

274 However, the paucity of the S1 chymotrypsin/trypsin-like serine p

275 earlier may be due to two factors: mainly to the paucity of the single domain conformer in the OprF p

276 However, the paucity of the understanding of the G-quadruplex sta

277 vance of apraxia stands in stark contrast to the paucity of therapeutic options available.

278 s that constitute the metastatic cascade and the paucity of therapeutic options.

279 The paucity of these V(D)J events has suggested that alt

280 or limitation in studying these responses is the paucity of tools available for detection, quantifica

281 a knowledge gap attributed in large part to the paucity of tools to genetically manipulate these pat

282 itivity for individual PAHs, and we describe the paucity of toxicological literature for many of thes

283 tively strict human tropism of the virus and the paucity of tractable experimental models.

284 The paucity of traditional epidemiological data during e

285 The paucity of transformations that involve the cleavage

286 The paucity of treatments for malaria, coupled with the

287 d trafficking was not solely responsible for the paucity of Tregs in the lungs, as proliferation of b

288 In addition, given the paucity of trials focused on PDD treatment, studies

289 y rapidly decompose in solution underscoring the paucity of uranium phosphido complexes.

290 The paucity of V-ATPases in M1 phagosomes was associated

291 pe is hampered by several factors, including the paucity of variation in the plastid and mitochondria

292 Despite the paucity of VDJ(H) rearrangements, microarray analysi

293 cement of their applications are hindered by the paucity of ways of reducing bandgaps and enhancing p

294 eriod (55-34 Myr ago) are unknown because of the paucity of well-dated records.

295 The paucity of well-defined studies currently renders a

296 Because of the paucity of well-defined synthetic examples, there ar

297 plexity of studying the risk for suicide and the paucity of well-designed research studies, only limi

298 Noting the paucity of wet-bench data regarding combinatorial ef

299 The paucity of whole Y-chromosome sequences precluded co

300 reduction in mangroves can be attributed to the paucity of young elements; the rarity of young LTR-R