ライフサイエンスコーパス: the difficulty of *ing

1 on complexity-theoretic assumptions such as the difficulty of factoring.

2 been a long-standing challenge, hindered by the difficulty of cooling a mechanical mode to its quant

3 at multiple positions dramatically increases the difficulty of designing a DC library and leads to th

4 This could explain the difficulty of detecting a signature for "placebo res

5 onses under parameter variation, emphasising the difficulty of finding a "correct" model.

6 With the difficulty of generating a stable BP in magnetic nan

7 The findings illustrate the difficulty of identifying a decision-maker's strateg

8 an the other outbreak isolates, highlighting the difficulty of imposing a simple threshold for the nu

9 eversed by weight loss and may contribute to the difficulty of maintaining a reduced weight.

10 r the use of Treg immunotherapy in humans is the difficulty of obtaining a highly purified preparatio

11 ncluded in this simulation, and can increase the difficulty of obtaining a solution, especially when

12 In view of the difficulty of obtaining a stable DNA-bound IN at hig

13 ause of the disease itself, and then through the difficulty of pursuing a strict elimination diet.

14 of wild cetaceans can be challenging due to the difficulty of gaining access to conventional diagnos

15 The difficulty of diagnosing active tuberculosis (TB) an

16 This situation may be explained, in part, by the difficulty of expressing active, functional recombin

17 fficiency of homologous recombination and by the difficulty of manipulating adenine and thymine (A+T)

18 The results underscore the difficulty of achieving adequately large improvement

19 hemistry suffers poor reversibility owing to the difficulty of oxidizing AlSx .

20 ulated, testing of this has been hindered by the difficulty of quantifying altered E-cadherin binding

21 However, the difficulty of producing an ensemble of statistically

22 n assessing the severity of MR and emphasize the difficulty of using an integrated approach that inco

23 nary tuberculosis (TB) is challenging due to the difficulty of collecting and testing sputum from chi

24 CPs with the incommensurability arising from the difficulty of contracting and stretching the Ir-Ir c

25 on efforts were abandoned largely because of the difficulty of detecting and delineating infestations

26 r been critically revisited, probably due to the difficulty of gathering and interpreting dispersed a

27 such as phosphorylation, largely because of the difficulty of isolating and identifying peptides der

28 One limitation of these approaches is the difficulty of isolating and sequencing large, orthol

29 ces, such as the Antarctic ice sheet, due to the difficulty of locating and interrogating suitable ar

30 However, the difficulty of tracking and modeling the arousal stat

31 invasions remains incomplete, partly due to the difficulty of tracking and studying behavioural inte

32 esses involved in bnAb generation, including the difficulty of quantifying antigen-specific GC Tfh ce

33 inappropriate services is challenging given the difficulty of defining appropriate care for patients

34 ous side effects of antifibrotic therapy and the difficulty of diagnosing asymptomatic patients, suit

35 en conducted exclusively in male mice due to the difficulty of initiating attack behavior directed to

36 anding how PELs develop has been impaired by the difficulty of infecting B cells with KSHV in vitro,

37 tical but remains challenging, mainly due to the difficulty of probing battery internal temperature w

38 nnot achieve the best performance because of the difficulty of obtaining best templates, alignments,

39 The findings of this study may help explain the difficulty of inducing beta cell proliferation and m

40 r challenge impeding statistical analysis is the difficulty of distinguishing between differential ex

41 We conclude that the difficulty of selecting between collapsing and fixed

42 These findings suggest that, despite the difficulty of extracting biochemically accurate mode

43 erapies have proven to be elusive because of the difficulty of translating biologically sound and eff

44 rom three aspects of perinatal ontogeny: (i) the difficulty of giving birth to large-headed neonates

45 , but broad application has been hindered by the difficulty of identifying bispecific antibody format

46 gence owing to its enormous search space and the difficulty of evaluating board positions and moves.

47 nging targets for small molecules because of the difficulty of achieving both modulator selectivity a

48 nging because of viral genetic diversity and the difficulty of generating broadly neutralizing antibo

49 but these attributes simultaneously increase the difficulty of preparing carbohydrate assemblies and

50 diment to synthesizing compounds from CO2 is the difficulty of forming carbon-carbon (C-C) bonds effi

51 d other cellular functions is unknown due to the difficulty of analyzing cell division in vivo.

52 Human translational studies are limited by the difficulty of obtaining cells taken directly from th

53 cle to studying this phenomenon in plants is the difficulty of isolating certain types of cells at de

54 tochondrial H2S is uncertain, in part due to the difficulty of assessing changes in its concentration

55 The difficulty of mixing chemically incompatible substan

56 ister chromatid decatenation but, because of the difficulty of observing chromosome catenation, this

57 been demonstrated experimentally because of the difficulty of realizing CNT-encapsulated molecules a

58 breeding systems, and this study illustrates the difficulty of identifying common ecological or demog

59 to nudge commuting behaviour highlights both the difficulty of changing commuter behaviour and the im

60 yte-macrophage differentiation, highlighting the difficulty of defining complex profiles by a limited

61 n of sensorimotor regions (including PrG) or the difficulty of identifying complex neural representat

62 ical use has been limited, however, owing to the difficulty of synthesizing components, achieving con

63 c stem cells has many limitations, including the difficulty of generating DA neurons with high yields

64 r a causal relationship is lacking, owing to the difficulty of inducing defined DNA lesions in cells

65 ncompletely understood, partially because of the difficulty of manipulating DeltaPsim with spatiotemp

66 e is lacking, especially for forests, due to the difficulty of manipulating density on a large-enough

67 romoting neural regeneration are hindered by the difficulty of manipulating desired neural fates in t

68 nd settlement patterns, due in large part to the difficulty of identifying discrete resource patches

69 anged core genes with their hosts, adding to the difficulty of placing DPANN in the tree of life.

70 current drugs for MS are very limited due to the difficulty of delivering drugs into the CNS.

71 al navigation in humans have been stymied by the difficulty of recording during free exploration of c

72 ages of hepatocarcinogenesis are hampered by the difficulty of diagnosing early lesions in humans.

73 eps has not been easy to decipher because of the difficulty of distinguishing early noncovalent steps

74 However, the difficulty of establishing effective CRISPRi systems

75 ul treatments for these disorders stems from the difficulty of gaining effective access to the CNS th

76 ittle about gastrulation in humans, owing to the difficulty of obtaining embryos at such early stages

77 gation of morphogen signaling is hampered by the difficulty of disentangling endogenous signaling fro

78 l metagenomics is challenging, mainly due to the difficulty of screening enormous metagenomic librari

79 oughput sequencing is challenging because of the difficulty of distinguishing errors from true mutati

80 se of a lack of accurate physical models and the difficulty of interpreting experimental results.

81 Nevertheless, given the difficulty of predicting extinctions, null models pr

82 major limitation of multivariate analysis is the difficulty of aligning features across brains, which

83 wever, the vast genotype space, coupled with the difficulty of measuring fitness, has hindered the em

84 C) sink may be overestimated globally due to the difficulty of accounting for all C losses across het

85 risk are conflicting and are compromised by the difficulty of controlling for confounders and by rev

86 Guala is right to draw attention to the difficulty of extrapolating from the experimental ev

87 In this text, I discuss the difficulty of going from association to causation in

88 subunit from two distinct halves, overcoming the difficulty of expressing full-length alpha1C in card

89 oforms expressed from common genes, and (ii) the difficulty of obtaining full-length transcript seque

90 However, owing to the difficulty of performing functional recordings from

91 uantifying antigen-specific GC Tfh cells and the difficulty of tracking GC in human and non-human pri

92 In part, the difficulty of connecting genes to phenotypes reflect

93 However, due to the difficulty of integrating genomics data sets, the re

94 thiols, however, remains challenging due to the difficulty of monitoring H2S and thiol levels simult

95 The results highlight the difficulty of characterizing hemilabile, bifunctiona

96 s an experimental system has been limited by the difficulty of deciphering heterozygous genomes and a

97 The difficulty of analyzing higher order RNA structure,

98 bstacle to the wider use of this approach is the difficulty of identifying homologous recombination e

99 ans has been reduced mainly as a response to the difficulty of developing human pharmacology models i

100 mune system remain poorly understood, due to the difficulty of studying immune development in infants

101 major bottleneck in producing such models is the difficulty of measuring in vivo rate constants for c

102 entifically has posed a challenge because of the difficulty of measuring individual differences in se

103 The difficulty of predicting individual mutation effects

104 However, progress has been hindered both by the difficulty of identifying individuals who will event

105 siology and diagnosis of this enteropathy is the difficulty of obtaining information about the primar

106 ht into TMD integration has been hampered by the difficulty of characterizing intermediates during th

107 However, owing to the difficulty of mapping intertidal areas globally, the

108 g linear chromosomes are not known, owing to the difficulty of demonstrating intertwining of linear D

109 otheses have remained inconclusive, owing to the difficulty of disentangling intra-chromatin and chro

110 therapies for IR injury may be partly due to the difficulty of adapting IR injury models to high-thro

111 urdle in studying thermal diffusion has been the difficulty of characterizing it.

112 consequences of this single polymorphism is the difficulty of distinguishing its subtle effects from

113 This may be indicative of the difficulty of replicating its binding interactions.

114 This knowledge gap is in part because of the difficulty of acquiring large numbers of samples ame

115 has not been rigorously assessed because of the difficulty of finding large numbers of well-hidden n

116 as never been achieved experimentally due to the difficulty of maintaining large thermal gradients ov

117 here an approach to compression that reduces the difficulty of managing large-scale sequencing data.

118 ution, but previous efforts were hampered by the difficulty of obtaining large, quantitative data set

119 ucture and function of membrane proteins are the difficulty of producing large quantities of function

120 ge for quantum many-body problems comes from the difficulty of representing large-scale quantum state

121 may improve outcomes, but is limited by both the difficulty of achieving lesion durability and concer

122 The difficulty of engineering light-sensitive proteins r

123 Our work underscores the difficulty of predicting local-scale range dynamics,

124 milarity among overweight youth may increase the difficulty of promoting long-term changes because th

125 C. elegans are limited by low throughput and the difficulty of performing longitudinal monitoring of

126 en our conceptual drive toward mediation and the difficulty of obtaining meaningful evidence.

127 To overcome the difficulty of writing media with a large coercivity,

128 untargeted metabolomic analysis, however, is the difficulty of identifying metabolites.

129 ena remain poorly understood, in part due to the difficulty of measuring microtubule polarity in spin

130 However, due in part to the difficulty of studying molecular genetic effects in

131 underlying theoretical complexity as well as the difficulty of engineering multicellular networks bio

132 polygenicity of all of these conditions and the difficulty of connecting multiple levels of molecula

133 escue titers by >/=3 log units, which offset the difficulty of generating multiple recombinants under

134 anding pre-clinical data on immune activity, the difficulty of obtaining multiple clinical tissue sam

135 erformed starting with a single sample given the difficulty of preparing multiple aliquots in known r

136 However, the difficulty of measuring nanometric displacements wit

137 A challenge for HIV-1 immunogen design is the difficulty of inducing neutralizing antibodies (NAbs

138 the 3D structures of an entire genome due to the difficulty of handling noisy and inconsistent inter-

139 ntracellular behaviour is unknown because of the difficulty of observing non-fluorescent small molecu

140 imarily on protein-coding variants, owing to the difficulty of interpreting noncoding mutations.

141 ve application of antibody therapies lies in the difficulty of generating nonimmunogenic antibodies i

142 genomic information is hindered, in part, by the difficulty of altering nucleotide sequences and expr

143 e, we examine the role of a single variable, the difficulty of training, on the rate of learning.

144 These findings articulate the difficulty of eliminating or reducing the pathogen f

145 Given the difficulty of predicting or measuring entropic and e

146 Finally, to overcome the difficulty of training over very large numbers of ti

147 rative diseases and this is partially due to the difficulty of monitoring pathogenic molecules in pat

148 ed into seizure prediction algorithms due to the difficulty of estimating patient-specific rhythms fr

149 sensory systems is poorly understood, given the difficulty of studying patients with NaBC1 mutations

150 cular basis of their development, as well as the difficulty of drawing pattern homologies across spec

151 full impacts remain poorly understood due to the difficulty of manipulating pCO2 at the ecosystem lev

152 ains poorly quantified, primarily because of the difficulty of determining photobleaching apparent qu

153 osphorylation complexity, thereby increasing the difficulty of extracting physiologically relevant pT

154 riptome of in vivo-grown pollen tubes due to the difficulty of collecting pollen that is elongating w

155 Further, because of the difficulty of studying pregnant patients, high-quali

156 fracture frequency as a relative measure of the difficulty of acquiring prey, and reveals a rapid re

157 ion fluorescence imaging has been limited by the difficulty of labeling proteins in cells with suitab

158 -on system for rating prediction models, and the difficulty of assessing publication bias.

159 ctors influence solubility is limited due to the difficulty of obtaining quantitative solubility meas

160 tanglement is simultaneously responsible for the difficulty of simulating quantum matter on a classic

161 alytic photocycloaddition reactions has been the difficulty of controlling racemic background reactio

162 n the appropriate use of these devices given the difficulty of conducting randomized trials in patien

163 clease-induced cleavage has been hindered by the difficulty of isolating rare clones.

164 lecular correlates remain unknown because of the difficulty of isolating rare neuron subtypes.

165 hese possibilities is problematic because of the difficulty of determining rates of molecular evoluti

166 In recognition of the difficulty of accessing raw genotype and phenotype d

167 by the overall instability of the domain and the difficulty of producing reagents.

168 be an intractable challenge, in part, due to the difficulty of maintaining reduced weight.

169 by de novo sequence assembly have to address the difficulty of linking relatively short sequence cont

170 However, the difficulty of achieving reliable and standardized qu

171 immunodeficiency syndrome (AIDS) epidemic is the difficulty of collecting reliable information about

172 for interpreting connectivity but because of the difficulty of collecting reliable movement data, mos

173 paleobiological systems has been limited by the difficulty of obtaining reliable information about a

174 constraints, one of the most important being the difficulty of assembling reliably in the presence of

175 These complex interactions increase the difficulty of predicting responses to climate change

176 al. (2017) now present data suggesting that the difficulty of detecting RNAi in virus-infected mamma

177 , associated human infections, demonstrating the difficulty of eliminating salmonella transmission fr

178 y the poor spatial resolution of EEGs and by the difficulty of relating scalp potentials to the activ

179 e of social determinants on oral disease and the difficulty of translating science into action.

180 o specific structural features that increase the difficulty of finding sequences that fold into a tar

181 However, the difficulty of generating sequences of powerful pulse

182 es were reported to lack BST-2, highlighting the difficulty of identifying sequences of this extremel

183 tential mechanisms of release is hampered by the difficulty of measuring SG calcium directly in livin

184 a series of cold summers, which illustrates the difficulty of extrapolating short records into longe

185 wever, they have been poorly analyzed due to the difficulty of recording simultaneous single neurons

186 ddress these questions have been hindered by the difficulty of obtaining site-specifically phosphoryl

187 o observed a significant association between the difficulty of initiating sleep and a lower AHEI scor

188 portant but not top-ranked, which was due to the difficulty of identifying smoking history from searc

189 overnment regulations preventing innovation, the difficulty of bucking social norms, and the inadequa

190 eferences is thought to reduce significantly the difficulty of solving societal collective action pro

191 mical impact is still largely unclear due to the difficulty of preparing SP-containing oligonucleotid

192 culties, such as the slow growth in culture, the difficulty of obtaining specimens, and the diverse a

193 f such logic circuits was rather poor due to the difficulty of controlling spin waves in the input ju

194 metastable nature of the rotating state and the difficulty of applying stable rotating optical latti

195 signaling molecule, has been limited due to the difficulty of developing stable pro-drugs with slow

196 Suggesting the difficulty of combining STEM work with caregiving re

197 This finding underscores the difficulty of inducing subdominant CD8(+) T cells by

198 However, the difficulty of introducing substituents such as bicyc

199 le data on wide polymer chemical spaces, and the difficulty of generating such data given time and co

200 ct vertebrates is rare, primarily because of the difficulty of identifying such behaviors with confid

201 revalence of psychosomatic presentations and the difficulty of managing such patients, this article s

202 sted, but never shown to be involved, due to the difficulty of performing such studies in bacteria an

203 This lack of information was due to the difficulty of isolating sufficient viral RNA for stu

204 , accomplishing this task has been slowed by the difficulty of obtaining sufficient amounts of starti

205 esearch in CSC biology is largely limited by the difficulty of obtaining sufficient CSCs.

206 mature to erythrocytes have been hampered by the difficulty of obtaining sufficient numbers of cells

207 flammatory therapeutics has been hampered by the difficulty of generating suitable sialylated product

208 ts is important but hardly achievable due to the difficulty of recovering suitable undisturbed sedime

209 The unpredictable course of COPD and the difficulty of predicting survival are barriers to ti

210 lution of Pancrustacea remains elusive given the difficulty of recognizing synapomorphies between Cam

211 le of stepwise progressive goal achievement: the difficulty of training tasks increased depending on

212 o work with detached host plant material and the difficulty of maintaining that material in a suitabl

213 Given the difficulty of accessing the colon, modelling can pla

214 enging compared with other complex traits is the difficulty of accessing the relevant tissue.

215 This study demonstrates the difficulty of achieving the desired subbandage press

216 yotic Cu-binding protein, but they highlight the difficulty of altering the exquisite Cu homeostasis

217 To overcome the difficulty of amplifying the diverse and ever-changi

218 causation in this population, acknowledging the difficulty of assessing the confounding and contribu

219 ownership, current engineering practices and the difficulty of assessing the cost benefits of data-dr

220 mitation in modeling protein interactions is the difficulty of assessing the over-fitting of the trai

221 ement is particularly problematic because of the difficulty of assessing the phenotype as well as a l

222 hanism of decarboxylation are complicated by the difficulty of assigning the signals associated with

223 tula-toxin action remains elusive because of the difficulty of capturing the functionally relevant fo

224 Due to the toxicity of BeO and the difficulty of containing the very fine powder materi

225 such processes are generally associated with the difficulty of controlling the amount and location of

226 ther reactions such as Michael additions and the difficulty of controlling the enolate geometry make

227 acromolecules remains a challenge because of the difficulty of controlling the structure and interact

228 gn and fabrication remain challenging due to the difficulty of controlling the underlying metric tens

229 y problem in quantum physics originates from the difficulty of describing the nontrivial correlations

230 plexity of the NAD(+) metabolic pathways and the difficulty of determining the levels of the intercon

231 ; however, these data are limited because of the difficulty of determining the structure of large pro

232 cal outcome due to broad drug resistance and the difficulty of eradicating the organisms.

233 complex nature of the erosion processes and the difficulty of examining the ice/bedrock interface of

234 rthern" ribose have been inaccessible due to the difficulty of generating the sensitive N1-ribosyl li

235 driven forward genetics has been hampered by the difficulty of identifying the specific insertions re

236 various microscopic models is limited due to the difficulty of imaging the internal structures of mat

237 en the complexity of a biological sample and the difficulty of implementing the appropriate analysis

238 Low Tdap coverage among adult CCs reinforces the difficulty of implementing the cocooning strategy an

239 dione from 2-diazo-1,3-indandione because of the difficulty of inducing the initial rearrangement.

240 ar exoskeletal structures are lacking, given the difficulty of inferring the precise segmental affini

241 to the biology of regulatory elements due to the difficulty of interpreting the complex features they

242 human phenotypic specializations, as well as the difficulty of interpreting the consequences of genet

243 xperimental studies have been limited due to the difficulty of isolating the interfacial thermal resi

244 x pore structure has remained elusive due to the difficulty of isolating the pore complex.

245 edimentary record as a proxy for erosion and the difficulty of isolating the respective contributions

246 g intron-mediated enhancement (IME) has been the difficulty of locating the specific intron sequences

247 ing of physiology and disease is hampered by the difficulty of measuring the circuitry and plasticity

248 tual decisions.SIGNIFICANCE STATEMENT Due to the difficulty of measuring the sensory input to moving

249 r an important factor in evolution, owing to the difficulty of monitoring the effects and fates of al

250 d by AS-B, BLS, and CPS, our work highlights the difficulty of predicting the functional outcome of s

251 jor issue in studies of amyloid formation is the difficulty of preparing the polypeptide of interest

252 A significant challenge has been the difficulty of proving the hydriding/dehydriding mech

253 their characterization has been hindered by the difficulty of purifying the viral polymerase from ma

254 However, the difficulty of releasing the bond without high temper

255 ylation methodology is currently hampered by the difficulty of removing the directing group.

256 t to current immunotherapies, due in part to the difficulty of reprogramming the highly immunosuppres

257 The difficulty of segregating the target from the backgr

258 40L is sufficient to activate APCs, owing to the difficulty of separating the effects of pCD40L from

259 replication cycle remains challenging due to the difficulty of separating the strands of the product

260 fect of the SASP is poorly understood due to the difficulty of studying the SASP independently of oth

261 These lineage-tracing experiments highlight the difficulty of targeting the papilla and presumptive

262 g behaviours remain poorly understood due to the difficulty of tracking the foraging history of anima

263 but professionals were less satisfied due to the difficulty of treating the images and lack of famili

264 e greater capacity to personalize treatment, the difficulty of using the full array of measurements o

265 SSRs) as genome editing agents is limited by the difficulty of altering their native DNA specificitie

266 ctions in cellular homeostasis is limited by the difficulty of monitoring their activity in vivo.

267 ink parental age and offspring survival, and the difficulty of separating them with currently availab

268 Overcoming the difficulty of delivering therapeutic agents to speci

269 a first-order tectonic fabric, we emphasize the difficulty of deciphering these different contributi

270 regulating invadopodia has been hindered by the difficulty of examining these dynamic structures in

271 (IMP) structure and function is hampered by the difficulty of handling these proteins.

272 Too often, however, the difficulty of installing these fragments surpasses t

273 eir projections are poorly understood due to the difficulty of labeling these neurons immunohistochem

274 One issue has been the difficulty of quantifying these modifications.

275 We also assess the difficulty of realizing these geometric structures b

276 on amyloid fibers, in large part because of the difficulty of studying these materials using convent

277 igher energy intermediates involved increase the difficulty of studying these processes experimentall

278 n immunocompromised patients, in part due to the difficulty of diagnosing this infection.

279 functions of human BRCA2 has been limited by the difficulty of isolating this large protein (3,418 am

280 quencing data are growing exponentially, but the difficulty of marshaling this data has led to its un

281 hitecture and function have been hampered by the difficulty of visualizing this invisible hydrated st

282 nsional (2D) cell culture and are limited by the difficulty of simulating three-dimensional physiolog

283 rly quantified under hemodynamic flow due to the difficulty of setting thrombin fluxes.

284 fective once a patient has already arrested, the difficulty of obtaining thrombolytics at the bedside

285 ental blocks has remained elusive because of the difficulty of taking thymic biopsy specimens from af

286 This fixed relationship helps explain the difficulty of reducing total right ventricular after

287 e processes are still elusive due in part to the difficulty of imaging trace metals together with pro

288 This idea has not been evaluated due to the difficulty of separating trimers from nonfunctional

289 Our results highlight the difficulty of identifying type 1 diabetes after age

290 sions and other anthropogenic activities and the difficulty of managing undesirable impacts of non-na

291 erarchically ordered natural polymers due to the difficulty of achieving uniform dispersion of nanopa

292 ly activated STAT3 in many human cancers and the difficulty of finding useful drug candidates aimed a

293 The difficulty of measuring very large contact angles (>

294 Because of this similarity, and the difficulty of assigning vocalizations to individuals

295 Progress has been constrained by the difficulty of measuring water-use in a field environ

296 ter use is poorly understood, largely due to the difficulty of mapping waterpoints used by khulan thr

297 urthermore, there is little knowledge on how the difficulty of forecasting weather may be affected by

298 has also become a major problem, increasing the difficulty of controlling weeds.

299 The difficulty of diagnosing Wernicke's encephalopathy i

300 t the synaptic level is challenging owing to the difficulty of visualizing Zn(2+) at individual synap