ライフサイエンスコーパス: theca

1 e murine sperm perforatorium and perinuclear theca.

2 n critical for the formation of a functional theca.

3 s are often polyovulatory and have disrupted theca and granulosa cell layers.

4 lands was compared to mRNA levels in ovarian theca and granulosa cells using real-time quantitative p

5 l activity in DF-1, LMH, LMH/2A, and primary theca and granulosa cells.

6 expressed in testis Leydig cells and ovarian theca and luteal cells.

7 2-weighted images, which corresponded to the theca and stromal reaction around the cyst.

8 nsulin-like 3 (INSL3) transcripts in ovarian theca and testicular Leydig cells.

9 ociated membrane protein and the perinuclear theca, and the exclusion of the nuclear mitotic apparatu

10 h the granulosa cell layer and sometimes the theca, but rarely with the stroma.

11 A hallmark of PCOS is excessive theca cell androgen secretion, which is directly linked

12 mutant stromal cells consist of a luteinized theca cell lineage at various differentiation stages inc

13 in impaired granulosa cell proliferation and theca cell recruitment as well as fewer primordial folli

14 r development by antagonizing the actions of theca cell-derived BMPs.

15 overexpressing steroidogenic enzyme CYP17, a theca cell-specific marker.

16 is showing that treatment of cultured bovine theca cells (TC) with BMP6 significantly (>twofold; P <

17 strong mRNA labeling for BMP-4 and -7 in the theca cells and BMP receptor types IA, IB, and II in the

18 Oocyte growth is supported by theca cells and granulosa cells, which establish dynamic

19 he first genetic evidence for the origins of theca cells and reveal a multicellular interaction criti

20 n and insulin resistance persist in cultured theca cells and skin fibroblasts, respectively, from wom

21 g in the development and function of ovarian theca cells and the pathophysiologic effects of hyperins

22 l interactions between ovarian granulosa and theca cells as an approach to cHRT.

23 Here we show that theca cells derive from two sources: Wt1(+) cells indige

24 In this environment, theca cells form, oestrogen is produced and germ cells a

25 Our previous studies demonstrated that theca cells from PCOS ovaries maintained in long term cu

26 Our analysis revealed that PCOS theca cells have a gene expression profile that is disti

27 ved in excess androgen synthesis by the PCOS theca cells in order to identify candidate PCOS genes.

28 Using theca cells isolated and propagated from normal cycling

29 lls, the identification of mutant luteinized theca cells may add crucial evidence in understanding th

30 in expression to Leydig cells of the testis, theca cells of the ovary, and cells of the adrenal corte

31 ocytes and interstitial cells of the testis, theca cells of the ovary, cerebral cortical neurons, and

32 results suggest that GT198 mutant luteinized theca cells overexpressing CYP17 are common in ovarian c

33 Knock-down of DENND1A.V2 in PCOS theca cells reduced androgen biosynthesis and CYP17A1 an

34 orced overexpression of DENND1A.V2 in normal theca cells resulted in a PCOS phenotype of augmented CY

35 genes with increased mRNA abundance in PCOS theca cells were aldehyde dehydrogenase 6 and retinol de

36 defined a stable molecular phenotype of PCOS theca cells, 2) suggested new mechanisms for excess andr

37 anisms for excess androgen synthesis by PCOS theca cells, and 3) identified new candidate genes that

38 ocated in the cytoplasm as well as nuclei of theca cells, suggesting a possible role in gene regulati

39 tly greater amounts of androgens than normal theca cells, suggesting an intrinsic abnormality.

40 Reelin, which is expressed in theca cells, triggers a signal in granulosa cells via ap

41 Human granulosa and theca cells, which express endogenous SF-1, contained mo

42 NA when added to the medium of cultured PCOS theca cells.

43 rotein and mRNA levels are increased in PCOS theca cells.

44 pression and intrinsic abnormalities in PCOS theca cells.

45 ression profile that is distinct from normal theca cells.

46 rian surface epithelium, granulosa cells and theca cells.

47 expression, although both theca interna and theca externa were also positive, interna greater than e

48 erplasia and hypervascularity of the ovarian theca interna and stroma are also prominent features of

49 e found strong expression of EG-VEGF mRNA in theca interna and stroma in most of the specimens examin

50 howed the greatest expression, although both theca interna and theca externa were also positive, inte

51 Sertoli and Leidig cells of the testes; (i) theca interna cells in the ovary; and (j) adrenal cortex

52 titial gland, and in the granulosa cells and theca interna of small to medium-sized antral follicles,

53 sulin receptor (IR) gene specifically in the theca-interstitial (TI) cells of the ovaries (Cyp17IRKO)

54 anulosa) and steroidogenic cells (Leydig and theca-interstitium) are two major somatic cell types in

55 Ovaries lacking Dhh/Ihh exhibit theca layer loss, blunted steroid production, arrested f

56 en, including ovarian follicle granulosa and theca layers.

57 These progenitors acquire theca lineage marker Gli1 in response to paracrine signa

58 either membrane tethering to the perinuclear theca nor the fatty acid composition of sperm.

59 ich resembles tissue dendritic cells, in the theca of antral follicles.

60 c CD8alpha(+) cells were able to home to the theca of follicles in the recipients.

61 cells of veins, either in the inner layer of theca of ovulating follicles during ovulation, or surrou

62 NND1A immunostaining was more intense in the theca of PCOS ovaries.

63 granulosa cells are known, the origin(s) of theca progenitor cells have not been definitively identi

64 The perinuclear theca (PT) is a unique cytoskeletal structure whose ante

65 posure and solubilization of the perinuclear theca (PT), as evidenced by transmission electron micros

66 tivation and being stored in the perinuclear theca, the sperm compartment whose content is first rele

67 be expressed in adult ovarian granulosa and theca tissues.

68 or a single origin of the group's cellulosic theca, which we show coincided with a radiation of cellu