ライフサイエンスコーパス: theophylline

1 sible with an adenosine receptor antagonist (theophylline).

2 ta-agonists, and 1.05 (CI, 0.99 to 1.10) for theophylline.

3 reases in gene expression in the presence of theophylline.

4 s in COPD patients treated with low doses of theophylline.

5 injection of the nonselective Ado antagonist theophylline.

6 re all significantly reduced by about 22% by theophylline.

7 was reversed by coadministration of systemic theophylline.

8 adenosine receptor blocker 8-(p-sulfophenyl)theophylline.

9 retory responses to glucose and glucose with theophylline.

10 f the clinically important drugs digoxin and theophylline.

11 ontaining rolipram, milrinone, zaprinast, or theophylline.

12 c hammerhead ribozymes that are activated by theophylline.

13 Oral terbutaline plus aminophylline or theophylline.

14 recur during outpatient treatment with oral theophylline.

15 group 3,825 recipients of sustained-release theophylline.

16 ccumulation of lipophylic substances such as theophylline.

17 nosine receptor antagonist 8-(p-sulfophenyl)-theophylline.

18 study drug, and again after the infusion of theophylline.

19 infusion, and the effects were diminished by theophylline.

20 sulin/C-peptide in response to D-glucose and theophylline.

21 insulin secretion stimulated by glucose and theophylline.

22 t N(6)-cyclohexyladenosine or the antagonist theophylline.

23 n recovery and can be ameliorated ex vivo by theophylline.

24 ith higher affinity to 3-methylxanthine than theophylline.

25 f adenosine receptors with 8-(p-sulfophenyl) theophylline.

26 r the related methylxanthine present in tea, theophylline.

27 Theophylline (1,3-dimethylxanthine) exhibited an effect

28 denosine A1 receptor antagonists (50 mumol/L theophylline/1 mumol/L 8-cyclopentyl-1,3-dipropylxanthin

29 Theophylline 10(-5) M significantly increased lymphocyte

30 ine receptor blockade with 8-(p-sulphophenyl)theophylline (10 mg kg-1, i.v.) or cyclooxygenase inhibi

31 letely abolished in the presence of 8-phenyl theophylline (10(-5) M), a nonselective adenosine recept

32 nosine receptor antagonist 8-(p-sulfophenyl)-theophylline (100 micromol/L) or by the protein kinase C

33 lxanthine (155 M(-1)), 1,3-dimethylxanthine (theophylline, 157 M(-1)), 1,3,7-trimethylxanthine (CAF,

34 7-2.74], antileukotrienes 4.83 [1.63-14.34], theophylline: 2.46 [1.23-4.91], and oral corticosteroids

35 Administration of theophylline (20 mg/kg, i.v.) had no effect on NMDA-depe

36 inhaled steroids (38%), cromolyn (35%), and theophylline (23%).

37 Adding rolipram (100 microM) or theophylline (3,000 microM) to the STH used for flushing

38 The overall binding constants of DNA-theophylline = 3.5x10(3) M(-1), DNA-theobromine = 1.1x10

39 y the non-selective ADO receptor antagonist, theophylline (30-500 nmol) administered i.t.

40 A1/A2-receptor antagonist [8-(p-sulfophenyl)theophylline, 4 mg/kg intravenous] to determine the pote

41 Theophylline (5.0 micromol/kg, i.p.), a centrally active

42 K(I) values for the antiasthmatic xanthines, theophylline (7.8 microM) and enprofylline (6.4 microM),

43 iers, namely, nicotinic acid, valproic acid, theophylline-7-acetic acid, and choline, were synthesize

44 /kg, i.p.) on EEG, whereas 8-(p-sulfophenyl)-theophylline (8-PST, 150.0 micromol/kg, i.p.), a periphe

45 ive adenosine A1 antagonist 8-(p-sulfophenyl)theophylline (8-SPT) or the adenosine A2 antagonist 3,7-

46 In the presence of 8-(p-sulfophenyl)theophylline (8-SPT), an antagonist of A1 and A2 adenosi

47 osine receptor antagonist, 8-(p-sulfophenyl) theophylline (8-SPT).

48 adenosine receptor antagonist 8-sulphophenyl theophylline (8-SPT, 20 mg kg-1, i.v.) virtually abolish

49 mals receiving intravenous 8-(p-sulfophenyl)-theophylline) (8-SPT), a non-selective adenosine recepto

50 One small molecule, theophylline, 8-[(benzylthio)methyl]-(7CI,8CI) (TPBM), i

51 Theophylline, a competitive inhibitor of cAMP phosphodie

52 Theophylline, a drug known to inhibit several classes of

53 Theophylline, a non-selective phosphodiesterase (PDE) in

54 -12 % during an infusion of either saline or theophylline, a non-specific adenosine receptor antagoni

55 The effect of dilazep was blocked by theophylline, a nonspecific adenosine receptor antagonis

56 is tyrosinephosphorylated in the presence of theophylline, a phosphodiesterase inhibitor that creates

57 annin, the immunosuppressant, rapamycin, and theophylline, a phosphodiesterase inhibitor, promote mar

58 and for a range of other analytes including theophylline, a therapeutic drug, at a concentration as

59 tivity, clinical studies have suggested that theophylline acts as an antitussive agent.

60 8-(p-Sulfophenyl)theophylline administration abolished the cardioprotecti

61 Neither theophylline alone nor caffeine alone (each at 10 mg/kg/

62 Theophylline also improved the increase in perfusate PO(

63 Through this mechanism, theophylline also reverses corticosteroid resistance, an

64 -week, open-label clinical trial, intranasal theophylline (an epithelial membrane transport and proto

65 CBB5 also oxidized theophylline and 1- and 3-methylxanthines to 1,3-dimethy

66 as sole carbon and nitrogen sources but also theophylline and 3-methylxanthine.

67 s increased 76-fold by the administration of theophylline and 8-bromo-cAMP to increase cAMP levels.

68 re facilitated by functional synergy between theophylline and amphetamine.

69 tly prevented by the ADO receptor antagonist theophylline and blockade of NO production by L-NA (100

70 Enzymes involved in theophylline and caffeine degradation were coexpressed w

71 Thus, the theophylline and caffeine N-demethylation pathways conve

72 nonselective adenosine receptor antagonists, theophylline and caffeine, were examined, using the rat

73 an also be achieved by low concentrations of theophylline and curcumin, which act as HDAC activators.

74 that could reverse this resistance, such as theophylline and nortriptyline.

75 HDAC2 expression, which can be achieved with theophylline and phosphoinositide 3-kinase delta inhibit

76 p300) or activators of histone deacetylase (theophylline and resveratrol) and were increased by the

77 nhibitors, 1-methyl-3- isobutyl xanthine and theophylline and rolipram, a specific PDE IV inhibitor.

78 ntained the pharmaceuticals ketoconazole and theophylline and several previously untested chemicals,

79 tween episodes, patients may be treated with theophylline and terbutaline, which clinical experience

80 of the general adenosine receptor antagonist theophylline and the A1 antagonist 8-cyclopentyl-1,3-dip

81 Two aptamers that recognize theophylline and thiamine pyrophosphate were embedded in

82 The effect of 10(-5) M theophylline and, in survivors, change in I(max) during

83 with ICS, 53.3% LTRAs, 64.1% anti-IgE, 10.7% theophylline, and 16.0% oral corticosteroids.

84 hat a group of xanthines including caffeine, theophylline, and dyphylline can dramatically decrease A

85 trosodimethylamine, acetominophen, caffeine, theophylline, and methoxyflurane into the model CYP2E1 e

86 N-Acetylcysteine, theophylline, and other agents have shown inconsistent r

87 aptamer reporters, using both the synthetic theophylline- and naturally occurring thiamine pyrophosp

88 se, activation of HDAC2 expression by use of theophylline, antioxidants, or phosphoinositide-3-kinase

89 anthine complex than what is observed in the theophylline aptamer-theophylline complex.

90 s leukotriene blockers and slow-release oral theophylline are added, with oral corticosteroids and an

91 ilators-beta agonists, anticholinergics, and theophylline-are available and can be used individually

92 olecular markers, caffeine, theobromine, and theophylline, associated with the use of cacao.

93 fter intravenous administration of 1.2 mg of theophylline at 0.6 mg/kg per hour (serum level, 5.6 mic

94 d A7H+-C27 base pair forms in the absence of theophylline at low pH, which explains the unusual pH de

95 ion for the ligands caffeine, aminophylline, theophylline, ATP, and ryanodine but not for Ca(2+) or 4

96 f alpha-aminonitriles with benzimidazole and theophylline backbones has been developed.

97 A new series of theophylline-based analogs as potent ALDH1A1 inhibitors

98 ence spectroscopy to probe the mechanism for theophylline binding in this RNA aptamer.

99 which explains the unusual pH dependence of theophylline binding of the C27 RNA aptamer.

100 The picosecond data show that theophylline binding shifts the equilibrium for conforma

101 to the bronchodilator theophylline, but the theophylline binding site is not stably formed in the ab

102 The kinetics for theophylline binding were measured here by stopped-flow

103 ns in the free state of the RNA that inhibit theophylline binding.

104 of residue 27 is not directly involved with theophylline binding.

105 atform structural motif and therefore blocks theophylline binding.

106 Simultaneously, the local structure of the theophylline-binding core of the molecule was refined un

107 The theophylline-binding RNA aptamer contains a 15 nucleotid

108 The theophylline-binding RNA aptamer forms a very stable str

109 een measured for the bases and sugars in the theophylline-binding RNA aptamer, dissolved in filamento

110 sed here to probe picosecond dynamics of the theophylline-binding RNA aptamer.

111 e of conformations in the free state of this theophylline-binding RNA are discussed and compared with

112 e receptors with 50 microM 8-(p-sulfophenyl) theophylline but was unaffected by addition of 20 nM N6-

113 ate or P1-receptor antagonist sulfonylphenyl theophylline, but not the P2-receptor antagonist suramin

114 e structure when bound to the bronchodilator theophylline, but the theophylline binding site is not s

115 chloroethyl), which enhanced the affinity of theophylline by 6.5-fold to 800 nM.

116 inactive state, whereas neutral antagonists (theophylline, caffeine, and istradefylline) demonstrated

117 Quantified substances were theobromine, theophylline, caffeine, catechin, epicatechin, procyanid

118 substances, namely sparfloxacin, piroxicam, theophylline, caffeine, ibuprofen, acetaminophen (parace

119 ecretory changes caused by prostaglandin E2, theophylline, calcium-ionophore A23187, 8-bromoadenosine

120 with AAH and to address the extent to which theophylline can improve this response.

121 cigarette smokers, and low concentrations of theophylline can increase HDAC activity.

122 eutic concentrations used for asthma relief, theophylline causes lung COX inhibition and decreases ce

123 ion and drug release profiles in a system of Theophylline/cellulose (K15M) demonstrate that API-water

124 nergic receptor blocker 7-(beta-chloroethyl) theophylline (CET; given at 5 x 10-6 M and 10-4 M) had n

125 and is implicated in drug interactions with theophylline, clozapine, and others.

126 olled rate, and the high affinity of the RNA-theophylline complex arises primarily from a slow dissoc

127 not from unfavorable interactions in the RNA-theophylline complex but instead from stable interaction

128 r the structure refinement of an RNA aptamer/theophylline complex for which extensive NOE and residua

129 tic studies showed that formation of the RNA-theophylline complex is over 1000 times slower than a di

130 The RNA-theophylline complex requires divalent metal ions, such

131 the free RNA to mostly unstacked in the RNA-theophylline complex, as observed in the previous NMR st

132 ther refine the overall structure of the RNA-theophylline complex, whose long-range order was poorly

133 ly dynamic in the otherwise well-ordered RNA-theophylline complex.

134 what is observed in the theophylline aptamer-theophylline complex.

135 e days of treatment, the mean (+/-SD) plasma theophylline concentration was 11 +/- 2 microgram per mi

136 tion of the theophylline-RNA complex at high theophylline concentration, indicating that a conformati

137 itors; decreased bioavailability of digoxin, theophylline, cyclosporin, and phenprocoumon when these

138 ession of distinct pathways for caffeine and theophylline degradation in bacteria.

139 t operate in concert as an obligate FMN- and theophylline-dependent molecular switch.

140 an effect similar to ATP and 8-sulphophenyl-theophylline did not block them.

141 which the main components were respectively theophylline, digoxin, 17beta-estradiol, and aldrin.

142 Theophylline (dimethylxanthine) has been used to treat a

143 Similar results were obtained with theophylline-doped PLA films.

144 etramethyl uric acid or TMU, 552 M(-1)), and theophylline ethylenediamine (aminophylline, 596 M(-1)).

145 ine receptor antagonist, aminophylline (AMO; theophylline ethylenediamine) and, for the first time to

146 during normal maturation and in response to theophylline, even though the latter effectively inhibit

147 els during the recovery period, while in the theophylline experiments cerebral blood flow fell below

148 During theophylline experiments, however, there was no signific

149 ing site for FMN is rendered inactive unless theophylline first binds to its corresponding site and r

150 he lungs of four sheep aged 4-13 days, while theophylline given after sotalol had no effect.

151 had no effect on LL absorption rate, whereas theophylline given after sotalol increased LL absorption

152 as observed in the CPA, propentofylline, and theophylline groups.

153 also detected in the crude cell extracts of theophylline-grown CBB5.

154 mine" to the native double helical DNA, and "theophylline>/=theobromine>caffeine to the denatured for

155 the order of binding affinity as "caffeine>/=theophylline>theobromine" to the native double helical D

156 Lungs stored in STH containing rolipram or theophylline had improved function on reperfusion.

157 The administration of theophylline had no significant effect on cerebral blood

158 s (CPA, propentofylline) nor the antagonist (theophylline) had any effect on extracellular glutamate

159 Theophylline has antiinflammatory effects in asthma, and

160 These results suggest that theophylline has antiinflammatory properties that may be

161 Theophylline has been shown to ameliorate impaired stero

162 and reversible, noncompetitive inhibition by theophylline has been studied.

163 Theophylline has been used in the treatment of asthma an

164 Theophylline has been used to treat central apnea associ

165 the use of the adenosine receptor antagonist theophylline, implicating both the nucleoside and its re

166 olamide, riboflavin, sodium fluorescein, and theophylline in 2-hydroxyethyl methacrylate/methacrylic

167 we demonstrated the antitussive activity of theophylline in a cigarette smoke exposure model that ex

168 Because the PDE target for theophylline in CLL remains unknown, we examined the abi

169 cognition regions specific for ATP, FMN, and theophylline in combinations with malachite green bindin

170 ipratropium, long-acting beta-agonists, and theophylline in the 6 months preceding death.

171 nformational selection mechanism for binding theophylline in the absence of Mg(2+).

172 er than 10000-fold reduction in affinity for theophylline in the absence of Mg2+.

173 uppressed by administration of isosorbide or theophylline in the drinking water.

174 A theophylline-independent rate was observed for formation

175 a positive short circuit current response to theophylline indicating intact ion transfer.

176 methylxanthines (caffeine, theobromine, and theophylline) indicative of stimulant drinks, probably c

177 Theophylline induced a sixfold increase in HDAC activity

178 , 5.0, or 10.0 g/L GA to the ORS neutralized theophylline-induced abolition of net sodium and potassi

179 ious demonstration that acutely administered theophylline induces respiratory-related recovery in an

180 The theophylline infusion was begun 30 min prior to and ende

181 trast, the cAMP phosphodiesterase inhibitor, theophylline, inhibited mTOR activity not only when adde

182 Theophylline inhibits capsaicin-induced cough under both

183 Determining how theophylline inhibits cough might lead to the developmen

184 Theophylline is given systemically (orally as slow-relea

185 Theophylline is now usually used as an add-on therapy in

186 ve compression forces; they were composed of theophylline, lactose, and microcrystalline cellulose (P

187 rrences were associated with decreased serum theophylline levels, possibly caused by enzyme induction

188 ventilation, arterial blood gases, and serum theophylline levels.

189 This may be achieved by theophylline-like drugs, more effective antioxidants and

190 Theophylline may also reduce risk for contrast-induced n

191 Theophylline may be a rapid and effective therapy for li

192 In the future, low-dose theophylline may be useful in reversing corticosteroid r

193 Rather, we suggest that theophylline may exert its inhibitory effects on maturat

194 tically significant renoprotective effect of theophylline may result from insufficient data or study

195 mal delivery of small hydrophilic compounds (theophylline, methylene blue, and fluorescein sodium) ac

196 Therefore, theophylline might restore steroid responsiveness in COP

197 terenol effect, whereas forskolin, cAMP, and theophylline mimic it.

198 systems allowing detecting the adenosine and theophylline molecules.

199 3)), well below the sensitivity required for theophylline monitoring where the target range is 10-20

200 o our knowledge, this is the first report of theophylline N demethylation and coexpression of distinc

201 We conclude that theophylline not only induces, but also maintains recove

202 mixing droplets of caffeine with droplets of theophylline on an open DMF device and comparing the pea

203 We measured the effect of theophylline on HDAC activity and inflammatory gene expr

204 of techniques, we investigated the effect of theophylline on human and guinea pig vagal sensory nerve

205 y, the influence of chronically administered theophylline on maintaining recovery was assessed.

206 ht to investigate the inhibitory activity of theophylline on vagal sensory nerve activity and the cou

207 the methylxanthines antagonists caffeine and theophylline, on CBF responses to hypercapnia can potent

208 y to alcohol withdrawal, and in those due to theophylline or isoniazid toxicity.

209 tion were coexpressed when CBB5 was grown on theophylline or on caffeine or its metabolites.

210 blind crossover study, the patients received theophylline or placebo orally twice daily for five days

211 Combination therapy with theophylline or salmeterol may allow clinicians to minim

212 denosine receptor antagonist 8-p-sulfophenyl theophylline or the specific protein kinase C inhibitor

213 denosine receptor antagonist 8-p-sulfophenyl theophylline or with the selective A1-receptor antagonis

214 eine metabolism, and 3 of these metabolites, theophylline (OR for 90th compared with 10th percentiles

215 4 weeks gestation, is treated with caffeine, theophylline, or aminophylline.

216 ia, hypothermia, cyclopentyladenosine (CPA), theophylline, or propentofylline).

217 s with or without long-acting beta agonists, theophyllines, or leukotriene-receptor antagonists, adju

218 s of the parent molecular ion for each drug (theophylline, paracetamol, prednisolone) showed their di

219 mD catalyzed N(1)-demethylation of caffeine, theophylline, paraxanthine, and 1-methylxanthine to theo

220 fraction during the base-line, placebo, and theophylline phases of the study.

221 ty-five patients with COPD were treated with theophylline (plasma level of 9-11 mg/L) for 4 weeks in

222 , parenteral aminophylline, and slow-release theophylline preparations in response to this trend.

223 four sheep aged 6-12 weeks, confirming that theophylline produced its effect of increasing LL absorp

224 However, the nonselective agent, theophylline, provided the best protection of function a

225 transcriptional activation in RA, cAMP, and theophylline (RACT)-treated F9 Rex1(-/-) cells (approxim

226 recipients did not have a greater risk than theophylline recipients of severe nonfatal asthma.

227 800-1600-fold in the presence of 1 mM ATP or theophylline, respectively.

228 ponse of the rationally designed, artificial theophylline riboswitch RS3.

229 ational approach for the design of synthetic theophylline riboswitches based on secondary structure p

230 Tandem fusions of these riboswitches with theophylline riboswitches represent logic gates respondi

231 ndent rate was observed for formation of the theophylline-RNA complex at high theophylline concentrat

232 A regimen of terbutaline and theophylline seems to be effective prophylaxis against t

233 nt adenosine A3 receptors are not blocked by theophylline, selective A1, A2A, and A2B receptor antago

234 After infusion of 2.4 mg of theophylline (serum level, 11.6 microg/mL), Cheyne-Stoke

235 Neutrophils from subjects treated with theophylline showed reduced chemotaxis to N-formyl-met-l

236 reated with 100 micromol/L 8-(p-sulfophenyl) theophylline (SPT), an adenosine receptor antagonist; pr

237 polar A2 antagonist 8-SPT (8-(p-sulfophenyl)theophylline) suggesting that the effects of DMPX on LTP

238 explain a very unusual property of this RNA-theophylline system: slow exchange on the NMR chemical s

239 ent RNA aptamers to sense diverse chemicals (theophylline, tetramethylrosamine, fluoride, dopamine, t

240 are anything more than expensive "designer" theophylline, the archetypal non-selective phosphodieste

241 were also eliminated, as was the response to theophylline, the methylxanthine in tea.

242 The FTIR analysis divulged that theophylline, theobromine and caffeine interact with all

243 naturally occurring methylxanthines such as theophylline, theobromine and caffeine with DNA, using U

244 udy (GWAS) of plasma caffeine, paraxanthine, theophylline, theobromine and paraxanthine/caffeine rati

245 ding profiles of three caffeine metabolites, theophylline, theobromine, and paraxanthine, were also i

246 We studied the effect of short-term oral theophylline therapy on periodic breathing associated wi

247 In patients with stable heart failure, oral theophylline therapy reduced the number of episodes of a

248 Theophylline therapy resulted in significant decreases i

249 the platelet inhibitors prostaglandin E1 and theophylline, these inhibitors had no effect on platelet

250 NAD(P)H-dependent conversion of theophylline to 1- and 3-methylxanthines was also detect

251 exhibits an effector specificity change from theophylline to 3-methylxanthine.

252 theobromine, 3-methylxanthine, caffeine, and theophylline to 7-methylxanthine, xanthine, paraxanthine

253 y diarrhea or luminally exposed to 10 mmol/L theophylline to induce jejunal secretion.

254 ent on and off rate constants for binding of theophylline to its RNA aptamer in the absence of Mg(2+)

255 e mice was 50% of controls, but injection of theophylline, together with glucagon, resulted in a norm

256 In theophylline-treated animals, NMDA responses were comple

257 %) to induced sputum samples obtained during theophylline treatment.

258 confirmed that CBB5 initially N demethylated theophylline via a hitherto unreported pathway to 1- and

259 rding olfactory improvement using intranasal theophylline warrant confirmation in a randomized contro

260 Theophylline was antitussive in a guinea pig model, inhi

261 de-out experiments showed that the effect of theophylline was due to an increase in the open probabil

262 5 cells did not metabolize caffeine, whereas theophylline was metabolized at much reduced levels to o

263 Then, benzimidazole/theophylline was reacted with the latter to generate the

264 Theophylline was then injected i.p. for 3-30 consecutive

265 Theophylline was well tolerated.

266 kg CPA, 5 mg/kg propentofylline, or 20 mg/kg theophylline were administered intravenously.

267 Aptamers that bound adenosine and theophylline were appended to the core structure, and th

268 gly, the U27 and G27 RNAs were found to bind theophylline with low affinity (Kd values > 4 microM).

269 ease in CBFV was significantly attenuated by theophylline, with no significant differences between su