ライフサイエンスコーパス: therapeutic activity

1 of fatty acid and a substantial loss in the therapeutic activity.

2 trials, and the most recent iterations show therapeutic activity.

3 malaria and shows potent in vivo blood-stage therapeutic activity.

4 he compound, indicating tumor cell-selective therapeutic activity.

5 ral fusion, and shows promising postexposure therapeutic activity.

6 cal role for iTreg IL-10 production in their therapeutic activity.

7 esting that the L2 polypeptide vaccines lack therapeutic activity.

8 both the IgV and stalk domains of TIM-1 have therapeutic activity.

9 the same target elicits different levels of therapeutic activity.

10 ing additional SERT substrates for potential therapeutic activity.

11 ication via NF-kappaB, may have considerable therapeutic activity.

12 viral therapy that may confound estimates of therapeutic activity.

13 n of Ab did not make optimal use of the Ab's therapeutic activity.

14 nd selectivity of their DNA interactions for therapeutic activity.

15 ed vaccination resulted in T cells with less therapeutic activity.

16 the patient's weight, determines the desired therapeutic activity.

17 ing in tumor cells that contributes to their therapeutic activity.

18 h low gastrointestinal toxicity and restored therapeutic activity.

19 s that affect stem cells and thus have novel therapeutic activity.

20 ccine-induced cytotoxic T-cell responses and therapeutic activity.

21 gher than the pM concentrations required for therapeutic activity.

22 ck viral entry, suppress viremia, and confer therapeutic activity.

23 was selected as an endpoint associated with therapeutic activity.

24 er the drug's pharmacokinetics to enable its therapeutic activity.

25 re a time-dependent "cold chain" to maximize therapeutic activity.

26 op more potent agents that exhibit increased therapeutic activity.

27 s and contributes to its pharmacological and therapeutic activities.

28 elop screens for NR modulators with specific therapeutic activities.

29 t of a wide variety of natural products with therapeutic activities.

30 alomicin analogues with potentially improved therapeutic activities.

31 target FKBP65 and LH2 may have complementary therapeutic activities.

32 dation through switching between imaging and therapeutic activities.

33 tural units responsible for their pronounced therapeutic activities.

34 he HSA binding capacity without compromising therapeutic activities.

35 has been shown to have cancer-preventive and therapeutic activities.

36 better understand both adverse and favorable therapeutic activities.

37 rafts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors.

38 croorganisms with potential prophylactic and therapeutic activities against gut infections.

39 nge model of mice, only three MAbs exhibited therapeutic activity against a homologous strain when ad

40 Tryptanthrins have potential therapeutic activity against a wide variety of pathogeni

41 resulted in T cells that possessed enhanced therapeutic activity against established pulmonary metas

42 selective lymphotoxic properties and potent therapeutic activity against lupus-like disease in autoi

43 red probiotic shows in vivo prophylactic and therapeutic activity against P. aeruginosa during gut in

44 These modified CAR-T cells show enhanced therapeutic activity against xenografted lymphomas.

45 cross resistance with existing tuberculosis therapeutics, activity against multidrug-resistant (MDR)

46 because the novel IgA antibody demonstrated therapeutic activity also in non-FcalphaRI transgenic mi

47 eveloping the approach to improve CAR T-cell therapeutic activity and also to broaden the range of tu

48 Nivolumab had substantial therapeutic activity and an acceptable safety profile in

49 ing antibody nivolumab has shown substantial therapeutic activity and an acceptable safety profile in

50 Furthermore, this allopeptide has strong therapeutic activity and highlights the importance of TC

51 erimental T cell-induced colitis, GMaMs show therapeutic activity and protect mice from colitis.

52 ght to obtain preliminary information on the therapeutic activity and safety of imetelstat in patient

53 r cells is an attractive approach to achieve therapeutic activity and selectivity.

54 ciently to the target cells to promote their therapeutic activity and several delivery technologies h

55 s, associated with a moderate improvement in therapeutic activity and survival.

56 We investigated the therapeutic activity and underlying mechanisms of adenov

57 Id, despite targeting irradiation and having therapeutic activity as an unconjugated antibody, protec

58 f alpha2delta ligands may help explain their therapeutic activity as supplemental therapy for major d

59 el strategy for the reconstitution of potent therapeutic activity at the site of disease, sparing hea

60 NBI-6024) was further characterized for its therapeutic activity because it consistently induced T-c

61 avasate out of blood vessels is critical for therapeutic activity, because molecular targets for most

62 resulted in a homogeneous ADC with increased therapeutic activity compared to the clinically approved

63 , anti-FcgammaRIIB mAbs demonstrated limited therapeutic activity despite optimized treatment regimen

64 in will expand the utilities of albumin as a therapeutic activity extender to proteins with a complex

65 to increase tumor drug exposure and improve therapeutic activity following intratumoral drug adminis

66 polypeptide (GIP), a protein with potential therapeutic activity for diabetes.

67 combination of peptide amount and pertaining therapeutic activity for each patient.

68 JAK-2-inhibitory activities may broaden the therapeutic activity (i.e. anemia improvement), as has b

69 encephalomyelitis and show that, for optimum therapeutic activity, IL-10 must either access the CNS f

70 Resveratrol has demonstrated preventive and therapeutic activities in a variety of tumors.

71 ble potency that have shown prophylactic and therapeutic activities in animal models.

72 d prolonged in vivo persistence and superior therapeutic activities in models of lymphoma and neurobl

73 tially provide a very beneficial spectrum of therapeutic activities in multiple disease states.

74 ptor coregulatory molecule GITR exert potent therapeutic activities in preclinical tumor models.

75 and provided experimental evidence for their therapeutic activities in vitro and in vivo using precli

76 FGF-20, having demonstrated therapeutic activity in 2 experimental models of intesti

77 mbination with blinatumomab, had significant therapeutic activity in a systemic human diffuse large B

78 macological inhibition of BET proteins shows therapeutic activity in a variety of different pathologi

79 the immune checkpoint receptor PD1 produces therapeutic activity in a variety of solid tumors, but m

80 vo, CD5xDR-CR3 was shown to have significant therapeutic activity in a xenograft model of human leuke

81 nalidomide is an immunomodulatory agent with therapeutic activity in chronic lymphocytic leukemia (CL

82 ted drug delivery showed potent and specific therapeutic activity in CLL, thus providing proof of con

83 indings imply that CHK2 inhibitors may exert therapeutic activity in combination with PARP inhibitors

84 bstrates for the enzyme and showed excellent therapeutic activity in CPG2-expressing MDA MB 361 xenog

85 now been shown to display equally impressive therapeutic activity in eosinophilia-associated chronic

86 Lometrexol had limited therapeutic activity in folate-deficient mice bearing th

87 demonstrated a manageable safety profile and therapeutic activity in heavily pretreated patients with

88 zation potency in vitro and enhanced in vivo therapeutic activity in HIV-1-infected humanized mice.

89 protein (CRP) is an acute-phase protein with therapeutic activity in mouse models of systemic lupus e

90 tion of STING agonists results in remarkable therapeutic activity in mouse models, and STING agonists

91 ge with a wide variety of pathogens, and has therapeutic activity in murine models of cancer and alle

92 all-molecule Usp9x/Usp24 inhibitors may have therapeutic activity in myeloma.

93 homas and autoimmune diseases, demonstrating therapeutic activity in non-Hodgkin lymphoma (NHL) and s

94 , BW1843U89, and Thymitaq, have demonstrated therapeutic activity in patients with advanced cancer.

95 imately 0.1% of serum levels associated with therapeutic activity in patients with systemic non-Hodgk

96 ate and its active metabolite, nitrite, have therapeutic activity in preclinical models of pulmonary

97 ases, or PI3K itself, might have significant therapeutic activity in PTEN-null cancers.

98 which suggests that exogenous IL-11 may have therapeutic activity in RA.

99 However, the mechanisms of therapeutic activity in responding versus nonresponding

100 used to treat breast cancer, but it also has therapeutic activity in several other types of cancer.

101 If rhIL-1ra treatment has any therapeutic activity in severe sepsis, the incremental b

102 ies suggest that melarsoprol shows promising therapeutic activity in these diseases, and a study to e

103 of inducible nitric oxide synthase may have therapeutic activity in these tumors.

104 cribed immunoregulatory cytokine with potent therapeutic activity in various preclinical models of in

105 tumor cell killing and substantially enhance therapeutic activity in vivo.

106 experiments to determine whether Bz-423 had therapeutic activity in vivo.

107 hemoselective albumin conjugation to prolong therapeutic activity in vivo.

108 shown to have a number of pharmacologic and therapeutic activities including antioxidant, anti-micro

109 molecular carrier to deliver molecules with therapeutic activity into ER(+) cells for diagnostic pur

110 Although the biochemical basis for their therapeutic activity is not known, these macrolactones e

111 These results suggested that this therapeutic activity might involve mechanisms in additio

112 ytes or muscle cells may explain some of the therapeutic activities of 4-AP as a neurotransmission en

113 A-induced hepatitis, and alterations in the therapeutic activities of alpha-GalCer.

114 In this regard, the therapeutic activities of cationic dyes, such as rhodami

115 In this study, we investigated the potential therapeutic activity of a formulation of pIC with polyet

116 The potential therapeutic activity of a human monoclonal antibody to t

117 Blood, Yang et al have demonstrated that the therapeutic activity of a targeted therapy, the tyrosine

118 ancing their survival and also the antitumor therapeutic activity of a tumor-specific peptide vaccine

119 omoting the TD Ab response, by improving the therapeutic activity of Ab-mediated effector mechanisms.

120 As a result, NGR-TNF enhanced the therapeutic activity of adoptive and active immunotherap

121 To determine whether the therapeutic activity of alphaB crystallin, small heat sh

122 h the capacity to carry siRNA to enhance the therapeutic activity of an anticancer gene therapy.

123 This study is the first to report therapeutic activity of an APL derived from an islet bet

124 ce requires both activities, we measured the therapeutic activity of an HA-specific MAb (VN and YR) a

125 We therefore evaluated the safety and therapeutic activity of another immunomodulatory drug, p

126 The therapeutic activity of anti-CD73 monoclonal antibody ag

127 t Fc domain interactions are critical to the therapeutic activity of anti-DR5 antibodies and, togethe

128 e immune cells play an important role in the therapeutic activity of anti-ErbB2 mAbs, such as trastuz

129 ide a plausible mechanism for the documented therapeutic activity of anti-TNF-alpha and antiviral che

130 Accordingly, the therapeutic activity of ATROSAB is mediated by shifting

131 lement depletion had no effect on the potent therapeutic activity of B1, a mAb that does not redistri

132 To date, although the therapeutic activity of both direct and indirect inhibit

133 tors and provided mechanistic explanation of therapeutic activity of cholinomimetics in PV patients.

134 Significant in vivo therapeutic activity of combination rituximab and milatu

135 Significant in vivo therapeutic activity of combination treatment was also d

136 Our study provides novel insights on the therapeutic activity of DAC in the backdrop of the newly

137 novel role of CXCL10 in the immunologic and therapeutic activity of DC-based cancer vaccines.

138 one metastasis and, as such, may enhance the therapeutic activity of docetaxel (Taxotere), the most c

139 The novel therapeutic activity of fenofibrate in this mouse model

140 therapy on the gastrointestinal toxicity and therapeutic activity of free and phospholipid-associated

141 These results demonstrate the therapeutic activity of GBS polysaccharide conjugate vac

142 We evaluated the therapeutic activity of human monoclonal antibodies to D

143 To evaluate the safety and potential therapeutic activity of humanized anti-IL-2 receptor mAb

144 y engineering efforts aimed at enhancing the therapeutic activity of immunomodulatory antibodies.

145 The therapeutic activity of lithium required functional IFN-

146 ive to human folate intake, the toxicity and therapeutic activity of lometrexol was studied in mice u

147 we performed a systematic evaluation of the therapeutic activity of over 5,000 pairs of FDA-approved

148 The enhanced therapeutic activity of PD-L1 blockade by ibrutinib was

149 The therapeutic activity of perhexiline was further demonstr

150 compounds that are often associated with the therapeutic activity of plant extracts used in tradition

151 ammation, when LL37 levels are elevated, the therapeutic activity of poly(I:C) will be compromised.

152 sity in the dorsal raphe (DR) attenuates the therapeutic activity of selective serotonin-reuptake inh

153 m of action in vivo is not always known, the therapeutic activity of several approved mAbs depends on

154 in the IFN-I receptor (IFNAR) abolished the therapeutic activity of SFV-IL12, as did a specific anti

155 Heparin also increased the therapeutic activity of SLPI against antigen-induced air

156 beta is likely a key mechanism mediating the therapeutic activity of Tanshinone IIA, because sodium n

157 Here, we investigated whether enhanced therapeutic activity of temperature sensitive liposomes

158 mouse mammary tumor model, the stability and therapeutic activity of the antibody conjugate were affe

159 d, Haroche and colleagues report significant therapeutic activity of the BRAF inhibitor, vemurafenib,

160 While the therapeutic activity of the deoxycytidine analogue decit

161 implications for the carcinogenicity and/or therapeutic activity of the drug.

162 el model system demonstrates that the potent therapeutic activity of the IL-12/pulse IL-2 combination

163 his study, we investigated the targeting and therapeutic activity of the immunocytokine F8-IL4 in the

164 We tested the possible therapeutic activity of the peroxisome proliferator-acti

165 viation of autoreactive T cells, but not the therapeutic activity of the RMTC.

166 The therapeutic activity of these antitumor agents can be co

167 therefore provide a rational to explore the therapeutic activity of these promising agents in CLL.

168 n, and this may be exploited to increase the therapeutic activity of Topo II drugs.

169 he linker-drug and antibody engineering, the therapeutic activity of trastuzumab maytansinoid ADCs ca

170 The therapeutic activity of tumor vaccines is limited by the

171 Hypoxia also is well known to attenuate the therapeutic activity of various therapies in cancer mana

172 stems could thus coincide with the long-term therapeutic activity of vmPFC DBS.

173 We assessed the therapeutic activity of zanamivir in adults with acute i

174 CD4(+) T-cell activities had no significant therapeutic activity on their own; in fact, they were ha

175 se studies indicate that this mAb might have therapeutic activity, particularly in patients with CLL

176 The sCR2-targeting vehicle contributes to therapeutic activity, possibly via modulation of autoimm

177 levels of the activators cover the expected therapeutic activity ranges found in the plasma of patie

178 y to engineer clinical reagents with defined therapeutic activity regardless of FcgammaR expression l

179 Therapeutic activity required tumor antigen specificity

180 nes, may provide improved immunogenicity and therapeutic activity simultaneously.

181 Each compound's potential for preventive and therapeutic activity stems from the compound's potential

182 ed ablation of HMBG1 is sufficient to elicit therapeutic activity, suggesting a novel therapeutic app

183 environment could cooperate to exert maximal therapeutic activity, suggesting a promising clinical st

184 aR interactions are required to achieve full therapeutic activity through clearance of IgG-opsonized

185 lated concepts for determining the amount of therapeutic activity to be administered.

186 that PDE4 inhibition alone is sufficient for therapeutic activity to be realized.

187 d was then used to determine the appropriate therapeutic activity to deliver a specific total-body ra

188 This therapeutic activity was correlated with inhibition of o

189 The therapeutic activity was crucially performed by CD8 T ce

190 d heterologous strains, and prophylactic and therapeutic activity was evaluated with two mouse models

191 This pH-dependent block in therapeutic activity was overcome if the NSAID was preas

192 Their therapeutic activity was validated in the passive transf

193 As a result anti-inflammatory and therapeutic activities were revealed.

194 Tissue distribution and in vivo therapeutic activity were studied using different heatin

195 -type restricted protection, and no reported therapeutic activity, which might be addressed with the

196 load and produced the expected reduction in therapeutic activity with the anti-MHCII, but surprising