ライフサイエンスコーパス: therapeutic approach

1 e rationale of targeting BCL6 as a potential therapeutic approach.

2 ore, there remains an unmet need for a novel therapeutic approach.

3 and depleting this cell type is a successful therapeutic approach.

4 s model, demonstrating the viability of this therapeutic approach.

5 ting this process may be the basis for a new therapeutic approach.

6 rotective response, may provide an alternate therapeutic approach.

7 otype in this line that we use to evaluate a therapeutic approach.

8 rational basis for clinical testing of this therapeutic approach.

9 A growth, may have implications for a better therapeutic approach.

10 activity as a potential future antibacterial therapeutic approach.

11 sample, facilitating the choice of the right therapeutic approach.

12 s in specific cancer subtypes as a potential therapeutic approach.

13 ls with low GFI1 expression level could be a therapeutic approach.

14 the challenges and promises offered by this therapeutic approach.

15 arian cancer may provide a much-needed novel therapeutic approach.

16 8M expression or stability as an alternative therapeutic approach.

17 s the rationale for the development of a new therapeutic approach.

18 of TGF-beta1 and TNF-alpha is desired as its therapeutic approach.

19 is metabolic pathway could represent a novel therapeutic approach.

20 target apoptotic pathways may be a promising therapeutic approach.

21 rienting the MP response may represent a new therapeutic approach.

22 ha using peptide technology provides a novel therapeutic approach.

23 athogenic pathways in AKI may identify novel therapeutic approaches.

24 additional prognostic parameters, and novel therapeutic approaches.

25 opulations, that may ultimately unveil novel therapeutic approaches.

26 uld help clinician-scientists generate novel therapeutic approaches.

27 med by recent research, and implications for therapeutic approaches.

28 e majority of melanomas and is the target of therapeutic approaches.

29 exposure and offer the possibility of novel therapeutic approaches.

30 targets that can be harnessed for innovative therapeutic approaches.

31 model has been widely used for testing novel therapeutic approaches.

32 ients and for assessing the potential of new therapeutic approaches.

33 these findings may be translated into novel therapeutic approaches.

34 thma pathogenesis and the development of new therapeutic approaches.

35 gnostic and predictive biomarkers, and novel therapeutic approaches.

36 ility and may open doors to new prophylactic/therapeutic approaches.

37 nce, there is an urgent need for alternative therapeutic approaches.

38 ctions, which could be translated into novel therapeutic approaches.

39 ostic techniques, management strategies, and therapeutic approaches.

40 croenvironment are expected to lead to novel therapeutic approaches.

41 ion of lung chitinase activity by genetic or therapeutic approaches.

42 or exploring MT chemistry as inspiration for therapeutic approaches.

43 h there is an urgent clinical need for novel therapeutic approaches.

44 CD should be reconsidered in developing new therapeutic approaches.

45 e and update standardized and evidence-based therapeutic approaches.

46 that result in LSC survival and develop new therapeutic approaches.

47 study disease mechanisms and to develop new therapeutic approaches.

48 of pancreatic diseases and may suggest novel therapeutic approaches.

49 ease mechanisms as well as for testing novel therapeutic approaches.

50 in AD patients, and represents an important therapeutic approach against AD and other forms of demen

51 MT and metastasis, and provides an effective therapeutic approach against breast cancer.

52 ts highlight targeting the ETA receptor as a therapeutic approach against ER stress-induced kidney in

53 disease will open new avenues for potential therapeutic approaches against arrhythmias.

54 iven, hormetic pathway providing insight for therapeutic approaches against cholesterol associated ne

55 9's proteolytic function, which could inform therapeutic approaches against its hypercholesterolemic

56 Therapeutic approaches aimed at blocking TLR7/8 activati

57 These data provide a basis for host-directed therapeutic approaches aimed at limiting HIV-1 burden in

58 these findings also open the opportunity for therapeutic approaches aimed at limiting tumour heteroge

59 We also review current therapeutic approaches aimed at modulating MC numbers, i

60 et aggregation and is a validated target for therapeutic approaches and diagnostic imaging.

61 ion targets will be the basis for developing therapeutic approaches and for improved understanding of

62 n this field will form the basis of advanced therapeutic approaches and lead to applications such as

63 ext-generation sequencing provide a route to therapeutic approaches, and integrating DNA and RNA anal

64 urgent need for the development of improved therapeutic approaches, and monoclonal antibody-based dr

65 Purpose Clinical characteristics, therapeutic approaches, and prognosis of late relapse (L

66 Combinatorial therapeutic approaches are an imperative to improve canc

67 steoarthritis (OA) is poorly understood, and therapeutic approaches are limited to preventing progres

68 inhibitors is probably inevitable, and novel therapeutic approaches are needed to target dormant tumo

69 New therapeutic approaches are needed to treat leukemia effe

70 ns a challenge for clinical practice and new therapeutic approaches are urgently needed.

71 e that TRPA1 potentiating may be useful as a therapeutic approach as Ms 9a-1 produces significant ana

72 s may be important for future development of therapeutic approaches associated with neurologic disord

73 cipants debated how to determine appropriate therapeutic approaches based on disease pathophysiology

74 safeguarding term pregnancy and suggest new therapeutic approaches based on IL-33 and PIBF1 to preve

75 phorylated cytochrome c and to develop novel therapeutic approaches based on its prosurvival effects.

76 Rational therapeutic approaches based on synthetic lethality may

77 nd whether these could be rescued by a novel therapeutic approach: brief exposure to gaps in backgrou

78 type 5 (HAdV5) vectors has been tested as a therapeutic approach, but efficiency is hampered by low

79 introduce antagonism of GPR55 as a potential therapeutic approach by illustrating its beneficial effe

80 ls directly addresses limitations of current therapeutic approaches by enabling a localized and speci

81 re incompletely understood, and currently no therapeutic approach can completely reverse the conditio

82 chronic GVHD offer the possibility that new therapeutic approaches can be directed in more precise w

83 This provides proof of principle for a therapeutic approach for allergic disease through ablati

84 B-CNS-B repair may be a new therapeutic approach for ALS.

85 rombin-cleaved OPN as a novel niche informed therapeutic approach for ameliorating HSC phenotypes ass

86 e that SphK2 inhibition may serve as a novel therapeutic approach for attenuating kidney fibrosis.

87 us, targeting eosinophils may be a promising therapeutic approach for BP.

88 R-ketorolac may thus represent a novel therapeutic approach for breast cancer prevention or tre

89 with their interaction could be a potential therapeutic approach for cancer treatment.

90 inhibitors, supporting this combination as a therapeutic approach for cancers.

91 K interacting kinase 1/2, could be used as a therapeutic approach for chronic pain.

92 Targeting this enzyme could be a new therapeutic approach for combating HPV spread and diseas

93 sting that mGluR2/3 may provide an effective therapeutic approach for comorbidity of smoking and thes

94 the reduction of mutant RyR2 may be a novel therapeutic approach for CPVT.

95 gs suggest that SLN reduction is a promising therapeutic approach for DMD.

96 sh inhibition of NF-kappaB c-Rel as a viable therapeutic approach for enhancing checkpoint-targeting

97 est that CDK6 antagonists may be a promising therapeutic approach for Hh-associated medulloblastoma i

98 inity anti-IgE mAbs holds promise as a novel therapeutic approach for IgE-mediated allergic diseases.

99 a5-R7 in insulin secretion may lead to a new therapeutic approach for improving pancreatic beta-cell

100 lan is expected to substantially improve the therapeutic approach for individuals suffering from chro

101 ll-based therapies are promising alternative therapeutic approach for liver failure and different cel

102 naling might provide an effective, trackable therapeutic approach for MS subjects of both sexes.

103 that suppression of miR-29b may represent a therapeutic approach for muscle atrophy induced by diffe

104 An attractive therapeutic approach for obesity is to optimize/maximize

105 inhibiting SIRT3 acetylation may offer a new therapeutic approach for obesity- and aging-related dise

106 st of a serotonin 5-HT2CR PAM as a promising therapeutic approach for obesity.

107 pomethylating agents (HMAs) is an attractive therapeutic approach for patients with acute myeloid leu

108 ical inhibition and establish it as a viable therapeutic approach for patients with AD.

109 gest that DNM2 modulation has potential as a therapeutic approach for patients with CNM and BIN1 defe

110 eptor agonists such as G49 represent a novel therapeutic approach for patients with NASH and particul

111 of ASD and ID, suggesting an individualized therapeutic approach for PMS.

112 and increased sirtuin activity, providing a therapeutic approach for preventing dioxin toxicities in

113 We present local delivery of miR-210 as a therapeutic approach for prevention of atherothrombotic

114 tem cell transplantation (HSCT) is used as a therapeutic approach for primary immunodeficiencies (PID

115 tion of GCGR activity represents a potential therapeutic approach for reducing excess glucose product

116 g CRISPR-based genome editing as a potential therapeutic approach for restoring dystrophic cardiomyop

117 ion of PDGF signaling presents an attractive therapeutic approach for SSc.

118 l inhibition of liver RetSat may represent a therapeutic approach for steatosis.Fatty liver is one of

119 romes and so could therefore provide a novel therapeutic approach for the treatment of anaemia associ

120 eatment of heart disease may provide a novel therapeutic approach for the treatment of asthma.

121 NT In this work, we paved the road for a new therapeutic approach for the treatment of brain tumors,

122 rs with STAT3 signaling inhibitor might be a therapeutic approach for the treatment of GBM.

123 to prevent H3K9 methylation loss is a viable therapeutic approach for the treatment of heart disease.

124 activation and implicate their utility as a therapeutic approach for the treatment of ILC2-mediated

125 miRNA or its targets could represent a novel therapeutic approach for the treatment of PAH.

126 c skin with omega-O-acylceramides might be a therapeutic approach for the treatment of skin symptoms

127 nd immune-modulation and may provide a novel therapeutic approach for TNBC.

128 that activators of AMPK, may be an important therapeutic approach for treating CTS.

129 uppression of mitochondrial fission may be a therapeutic approach for treating macrovascular complica

130 otion of neutrophil apoptosis is a potential therapeutic approach for treating persistent inflammatio

131 A novel therapeutic approach for treating resistant hypertension

132 enous spatiotemporal dynamics is a potential therapeutic approach for treating stress-induced behavio

133 diac progenitor cells (hCPCs) is a promising therapeutic approach for treatment of heart failure (HF)

134 orylation of SIRT1 by CK2 may serve as a new therapeutic approach for treatment of NAFLD and other ob

135 beta-Catenin pathway may provide a potential therapeutic approach for treatment of sepsis.

136 -specific activation of PPARdelta could be a therapeutic approach for treatment of the metabolic synd

137 at these factors activate may be a potential therapeutic approach for virus-induced asthma exacerbati

138 ndicate that WTX101 might be a promising new therapeutic approach for Wilson's disease, with a unique

139 These findings suggest new therapeutic approaches for alpha-synuclein induced neuro

140 sist in the discovery and translation of new therapeutic approaches for cancer.

141 Altogether, these data open new therapeutic approaches for CGD-related inflammatory mani

142 to reduce PMP22 have potential as effective therapeutic approaches for CMT1A and lay the groundwork

143 To identify novel therapeutic approaches for combating these diseases, the

144 ntial for the development of mechanism-based therapeutic approaches for dentine hypersensitivity and

145 These findings may lead to novel therapeutic approaches for individuals with T1D and IAH.

146 ibition of metabolic pathways provides novel therapeutic approaches for KS tumors.

147 ther cells is therefore the main obstacle to therapeutic approaches for limb regeneration.

148 ructural studies could inform antibody-based therapeutic approaches for limiting the effects of IgG-m

149 which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence.

150 ns for organismal health and could offer new therapeutic approaches for neurodegenerative diseases an

151 mprehensive scaffold for strategic design of therapeutic approaches for neurodegenerative disorders.

152 with debates and medical challenges, current therapeutic approaches for prostate cancer (PCa) lack ea

153 model offers a tool for assessing potential therapeutic approaches for skeletal dysplasias related t

154 fication of disease mechanisms and potential therapeutic approaches for SPMS.

155 ctive inhibitors that might be useful in new therapeutic approaches for the treatment of cancer, neur

156 This finding may lead to novel therapeutic approaches for the treatment of demyelinatin

157 of skeletal disorders and suggest potential therapeutic approaches for the treatment of LSDs.

158 Our findings should guide therapeutic approaches for the treatment of TH17-cell-me

159 may offer a novel opportunity for designing therapeutic approaches for these diseases.

160 ggest that this model can be used to advance therapeutic approaches for this currently untreatable di

161 rkers for those whose tumors respond and new therapeutic approaches for those whose tumors do not.

162 tential to revolutionize both preventive and therapeutic approaches for treating cardiovascular disea

163 ld lead to the development of more efficient therapeutic approaches for treating DMD patients.

164 holds the potential for new applications and therapeutic approaches for treating human disease.

165 of these new markers, molecular targets, and therapeutic approaches have been validated and translate

166 So far, therapeutic approaches have largely focused on T lymphoc

167 Immunotherapy is proving to be an effective therapeutic approach in a variety of cancers.

168 K5-mediated effects may offer potential as a therapeutic approach in AD.

169 Syk inhibition has been proposed as a new therapeutic approach in asthma.

170 Furthermore, we identified a novel therapeutic approach in crescentic nephritis, that of gl

171 n-23 via inhibition of p19 might be a viable therapeutic approach in Crohn's disease.

172 Although preliminary, we provide a novel therapeutic approach in form of altered mitochondrial bi

173 gainst tumors are proving to be an effective therapeutic approach in multiple malignancies.

174 proteins and for targeting SGs as a possible therapeutic approach in neurodegenerative and other dise

175 to identify growth inhibitors as a potential therapeutic approach in PD.

176 tin receptor agonists represents a potential therapeutic approach in polycystic liver disease.

177 and should be further explored as potential therapeutic approach in relevant preclinical models of v

178 nome editing technologies offers a promising therapeutic approach in restoring dystrophin protein exp

179 ndent activation of TGF-beta could thus be a therapeutic approach in TGF-beta-dependent vascular dise

180 ay help gauge disease severity and guide the therapeutic approach in those patients.

181 receptor agonists might serve as a promising therapeutic approach in treating allergic diseases by su

182 mal sorting of PC1 and PC2 could lead to new therapeutic approaches in ADPKD.

183 c pathways on which to expand diagnostic and therapeutic approaches in chronic obstructive pulmonary

184 modulating Arc levels may provide promising therapeutic approaches in drug addiction.

185 neurogenesis can help optimize the timing of therapeutic approaches in patients with brain traumas or

186 ns that could replace previous serendipitous therapeutic approaches in refractory PRP.

187 These data may provide important guidance to therapeutic approaches in the HIV cure agenda.

188 Our findings have major implications for therapeutic approaches in TTR amyloidosis.

189 9-mediated ILC2 activation may offer a novel therapeutic approach inducing resolution of inflammation

190 ischarge in CHF could help in developing new therapeutic approaches intended to attenuate the progres

191 While most therapeutic approaches involve potentially toxic immunos

192 An alternative to disease-centric therapeutic approaches is that of 'geroscience', which a

193 ibiting pyroptosis of the cells can be a new therapeutic approach leading to long-term success after

194 A promising therapeutic approach may be classical pathway (CP) inhib

195 t in human lung tumors, indicating that this therapeutic approach may be clinically relevant.

196 igin such as migraine with aura and why this therapeutic approach may not be effective for every migr

197 A WNT therapeutic approach may therefore have utility in the t

198 damage via LRRK2 kinase inhibition or other therapeutic approaches may be useful to slow PD-associat

199 from MECP2 gene duplication, suggesting that therapeutic approaches must restore close to normal leve

200 mmune system, which should be considered for therapeutic approaches of autoimmune diseases.

201 at can potentially be exploited for combined therapeutic approaches of embolotherapy and autophagy in

202 This study shows that our unique therapeutic approach offers a viable alternative for the

203 Among many potential therapeutic approaches, one is the modulation of Abeta c

204 is strategy represents a promising and novel therapeutic approach, particularly under conditions of l

205 f data from clinical trials across different therapeutic approaches play an important role in clinica

206 e that IVIG treatment represents a promising therapeutic approach potentially able to decrease mortal

207 Novel therapeutic approaches require valid biomarkers for stan

208 strengthen the concept of G4 targeting as a therapeutic approach, specifically for targeting HR and

209 nicians to predict the efficacy of different therapeutic approaches, such as determining compatibilit

210 neurodegenerative disorders can suggest new therapeutic approaches, such as immunotherapy and small

211 naling and open new avenues for personalized therapeutic approaches targeting Src or MEK in ERalpha-3

212 suggest mitochondrial protection as a novel therapeutic approach that can arrest the progression of

213 ntington's diseases, our findings identify a therapeutic approach that may have efficacy in multiple

214 Here, we present an alternative therapeutic approach that teaches the immune system to t

215 suggested routes for the development of new therapeutic approaches that address the underlying chain

216 t standard treatment options and present new therapeutic approaches that are supported by preclinical

217 opioid side effects and suggests intriguing therapeutic approaches that could improve both the safet

218 vasive in T cell malignancies suggests novel therapeutic approaches that include antibodies to common

219 Therapeutic approaches that increase KLF2 in the carotid

220 New therapeutic approaches that induce a strong and prolonge

221 Therapeutic approaches that target aging processes may b

222 epidemics and pandemics dictates a need for therapeutic approaches that target viral pathology irres

223 y, there are substantial efforts to identify therapeutic approaches that will eliminate or reduce the

224 Among the anti-Abeta therapeutic approaches, the most extensively developed i

225 ed hepatocarcinogenesis; this suggests a new therapeutic approach through the usage of an anti-IL6 tr

226 ng these signals may provide a new potential therapeutic approach to better treat BPH patients who fa

227 with this Notch-dependent crosstalk may be a therapeutic approach to block metastasis.

228 gs have major implications for advancing our therapeutic approach to childhood ADHD treatment.

229 other conditions, prompt translation of this therapeutic approach to clinical trials is feasible.

230 ignaling using parmodulins may be a feasible therapeutic approach to combat IRI.

231 tenin accumulation may represent a potential therapeutic approach to control breast cancer.

232 eting Cbx3/HP1gamma can represent a rational therapeutic approach to control growth of solid tumors.

233 ials and suggests strategies to improve this therapeutic approach to DMD.Exon skipping is a strategy

234 Therefore, targeting TREM-1 could be a novel therapeutic approach to enhance clearance of the HIV res

235 g enzymes has been considered to be a viable therapeutic approach to enhance their antinociceptive an

236 ation by NK cells and its benefit as a novel therapeutic approach to improve NK-based immunotherapy.

237 suggests that augmenting its levels may be a therapeutic approach to improve skeletal muscle formatio

238 based formulations has the potential to be a therapeutic approach to improve the treatment of MS, or

239 Targeting histones provides a novel therapeutic approach to influenza pneumonia.

240 nt pathway in pericytes might be a potential therapeutic approach to inhibit fibrogenesis and promote

241 s how such a mechanism may be exploited as a therapeutic approach to maintain water homeostasis.

242 activate ERRgamma signaling as a generalized therapeutic approach to manage prostate cancer.

243 Neutralizing antibodies present a possible therapeutic approach to prevent and control ZIKV infecti

244 roperties of diabetic skin, suggesting a new therapeutic approach to prevent diabetic wound recurrenc

245 Inhibition of 12/15-LOX provides a potential therapeutic approach to prevent glycemic deterioration i

246 eremic stage of sepsis could be an important therapeutic approach to prevent sepsis-induced inflammat

247 D3 axis in tumor cells may represent a novel therapeutic approach to prevent the plasticity required

248 /PPARgamma/MCAD pathway might be a promising therapeutic approach to prevent tumor progression.Tumor

249 m has the potential to be exploited as a new therapeutic approach to reduce apoC-III levels and circu

250 ogenic activity is considered as a promising therapeutic approach to reduce obesity and metabolic syn

251 Islet transplantation is a promising therapeutic approach to restore the physical response to

252 mitotic catastrophe, offering an attractive therapeutic approach to selectively kill cells with ampl

253 Thus, targeting Pin1 offers a promising therapeutic approach to simultaneously stop multiple can

254 rection of MCP1 deficiency may thus be a new therapeutic approach to SMA.SIGNIFICANCE STATEMENT Spina

255 ntial use of selective HDAC3 inhibitors as a therapeutic approach to suppress pancreatic islet infilt

256 This study suggests an alternative therapeutic approach to target Hsp90 in cancer, that is,

257 rgeting RyR-mediated Ca(2+) leakage may be a therapeutic approach to treat AD.

258 ophosphate (cAMP) has emerged as a promising therapeutic approach to treat cognitive deficits.

259 nitric oxide synthase (nNOS) is a promising therapeutic approach to treat neurodegenerative diseases

260 t HDAC1 inhibition should be considered as a therapeutic approach to treat schizophrenia.

261 novel target for a mechanistically distinct therapeutic approach to treating psoriasis.

262 oring endothelial AJ activity may be a novel therapeutic approach to vascular ageing.

263 in experimental animals, and development of therapeutic approaches to activate innate reparative res

264 identify targets for the development of new therapeutic approaches to alcohol abuse.

265 ill aid in the development of preventive and therapeutic approaches to combat this painful viral dise

266 V-1 and DCs and may inform the design of new therapeutic approaches to decrease viral dissemination a

267 Current therapeutic approaches to depression fail for millions o

268 ing of the biology of this virus, leading to therapeutic approaches to eliminate infection and block

269 different network configurations may lead to therapeutic approaches to hippocampal-dependent dysfunct

270 ocytes and endothelial cells may lead to new therapeutic approaches to improve blood vessel regenerat

271 Thus, therapeutic approaches to limit tau K280/K281 acetylatio

272 insights that may inform the development of therapeutic approaches to manage CS.

273 ibute to the initiation of inflammation; and therapeutic approaches to modulate inflammation in the c

274 human primate model will advance vaccine and therapeutic approaches to prevent and treat human diseas

275 ic steatohepatitis (NASH) will require novel therapeutic approaches to prevent disease progression to

276 an urgent need for the development of novel therapeutic approaches to prevent or dampen deleterious

277 astatic dissemination, and present potential therapeutic approaches to prevent or target metastatic d

278 alpha-syn aggregation and suggest potential therapeutic approaches to prevent or treat PD and relate

279 mechanisms regulating latency and potential therapeutic approaches to reactivate latent infections i

280 ntly increase cytokine expression suggesting therapeutic approaches to reviving immunosurveillance an

281 le in fear response, revealing new potential therapeutic approaches to target PTSD.

282 mpt to provide suggestions for potential new therapeutic approaches to target the protumorigenic peri

283 ng of mutant IDH function and for optimizing therapeutic approaches to targeting IDH-mutant tumors.

284 Therapeutic approaches to the disease began in the 18th

285 optosis opens new avenues for prognostic and therapeutic approaches to the management of liver fibros

286 in the CA2/CA3a may provide a new target for therapeutic approaches to the treatment of social cognit

287 Therapeutic approaches to these lesions vary based on th

288 ctive clinical trials, and ultimately tailor therapeutic approaches to these patients more effectivel

289 urodegenerative diseases and point to future therapeutic approaches to treat these disorders.

290 mponents in memory processes may lead to new therapeutic approaches to treating addiction.

291 Second, it suggests therapeutic approaches to treatment signal transduction

292 rlying IgE-mediated food allergies and novel therapeutic approaches under investigation for both the

293 Novel therapeutic approaches under investigation include thera

294 RUNX1 activity will greatly enhance current therapeutic approaches using FLT3 inhibitors.

295 Proof of principle for this therapeutic approach was demonstrated in vitro against a

296 Therapeutic approaches were classified under 4 headings:

297 ibition of both ligands provides a preferred therapeutic approach, which maximizes the benefit:risk r

298 oblast formation in vivo, suggesting a novel therapeutic approach with p38 inhibitors for future clin

299 erging data suggest that locoregional cancer therapeutic approaches with oncolytic viruses can lead t

300 weight PSMA ligands for both PET imaging and therapeutic approaches, with a focus on agents that have