ライフサイエンスコーパス: therapeutic dose

1 re mild and had no consistent pattern at the therapeutic dose.

2 elivered in 2 parts, a dosimetric dose and a therapeutic dose.

3 Of 32 patients enrolled, 28 completed the therapeutic dose.

4 esis (comet) assay after administration of a therapeutic dose.

5 ured tissue temperature elevations, ensuring therapeutic dose.

6 infections, judged by treatment duration and therapeutic dose.

7 ts were treated with a single dosimetric and therapeutic dose.

8 millicurie activity required to deliver the therapeutic dose.

9 o minimize thrombosis risk while maintaining therapeutic dose.

10 ment of normal tissue uptake to optimize the therapeutic dose.

11 er drug in a prolonged controlled manner and therapeutic dose.

12 inistered as a dosimetric dose followed by a therapeutic dose.

13 ribution and hence whether to administer the therapeutic dose.

14 hundreds of nanograms per liter to achieve a therapeutic dose.

15 east 4 weeks of antipsychotic treatment at a therapeutic dose.

16 birth, is more than 20-fold higher than its therapeutic dose.

17 nd overlapping on the macula cumulating in a therapeutic dose.

18 8 years (range, 52 to 79 years) received the therapeutic dose.

19 r EPS and prolactin-elevating liabilities at therapeutic doses.

20 xposure level differed from that observed at therapeutic doses.

21 tolerated in primates at levels in excess of therapeutic doses.

22 -regulation, which is difficult to attain at therapeutic doses.

23 d should cause minimal toxicity to humans at therapeutic doses.

24 rum complement activity at minimum effective therapeutic doses.

25 to predict erlotinib tissue distribution at therapeutic doses.

26 mouse models with insignificant toxicity at therapeutic doses.

27 ers a useful strategy for achieving required therapeutic doses.

28 s mediated radioiodine uptake at potentially therapeutic doses.

29 protection against established disease after therapeutic dosing.

30 morbidity and mortality after repeated supra-therapeutic dosing.

31 soluble Apo2L enhanced the lethality of low, therapeutic doses (1-2 Gy) of gamma-irradiation.

32 In the 3 trials evaluating azimilide in therapeutic doses (100 and 125 mg), asymptomatic atrial

33 16 lesions exhibited reduced uptake from the therapeutic dose, 2 remained the same, and in 1 the upta

34 ht not be clinically indicated, but pdhC1INH therapeutic doses (20 U/kg) should be available.

35 g and to estimate dosimetry, followed by the therapeutic dose (4-23 mg and 44-268 mCi), based on the

36 Of 2,649 therapeutic doses, 5 (0.2%) were cancelled because of al

37 Various therapeutic doses (8.25-3,300 mug/kg) of sodium nitrite

38 , but lacking these limiting side effects at therapeutic doses (an anxioselective agent), would repre

39 ia requires alternative anticoagulation at a therapeutic dose and immune thrombocytopenia immunomodul

40 impairment at up to 20 times the recommended therapeutic dose and may represent a useful alternative

41 inimal central effects at potentially useful therapeutic doses and offer useful leads for further dev

42 nown to induce hepatotoxicity when exceeding therapeutic doses and was therefore selected as the test

43 ed, supporting future trial phases examining therapeutic dosing and efficacy.

44 astic syndrome (one who had not received the therapeutic dose) and one with acute myelogenous leukemi

45 Six leiomyomas received full therapeutic doses, and 98.5% of the sonications were vis

46 ld lower than the respective proposed infant therapeutic doses, and tenofovir was not detected in 94%

47 ause free plasma levels of these drugs after therapeutic doses approximate those concentrations that

48 To control vitamin A deficiency, large therapeutic doses are administered in developing countri

49 ns or body compartments and to concentrate a therapeutic dose at a specific site of pharmacological a

50 dministered radioactivity dose and whether a therapeutic dose can be administered.

51 rmed indicates that a previously established therapeutic dose can be delivered effectively to the mac

52 Our study demonstrates Sfrp2 at therapeutic doses can inhibit fibrosis and improve LV fu

53 to the gastrointestinal mucosa when used at therapeutic doses, caused extensive damage to these tiss

54 The safety and tolerability profile at therapeutic doses compare favorably to other oral chelat

55 Ten of the 13 patients received initial therapeutic doses delivering 150-450 cGy to the red marr

56 led tositumomab followed one week later by a therapeutic dose, delivering 75 cGy of radiation to the

57 Fifty-three patients received individualized therapeutic doses, delivering a specified total-body rad

58 istration of PDSinh-C01 to mice at predicted therapeutic doses, determined from serum and urine pharm

59 Alas1-siRNA was well tolerated and a therapeutic dose did not cause hepatic heme deficiency.

60 In mouse liver, at human-equivalence (therapeutic) doses, dose-dependent loss of intercellular

61 At therapeutic doses, eye drop application of the dnG1 retr

62 The single therapeutic dose following a dosimetric dose was adjuste

63 r trials are needed to determine the optimal therapeutic dose for juxtapapillary choroidal melanoma.

64 and may be useful in assessing a beneficial therapeutic dose for RPE65 gene therapy in humans.

65 would be needed for fish to receive a human therapeutic dose for these progestins according to model

66 l-group study of fluoxetine and dothiepin at therapeutic doses for 12 weeks.

67 h 5% particle loading can deliver timolol at therapeutic doses for about a month at room temperature,

68 ediction of erlotinib tissue distribution at therapeutic doses from PET with a microdose of (11)C-erl

69 human intestinal myofibroblasts, aspirin, at therapeutic doses, had the unexpected effect of inducing

70 age (ICH) was not significantly increased at therapeutic doses; however, there was an increase in ICH

71 osimetry is not required for determining the therapeutic dose in patients meeting eligibility criteri

72 assessment of novel drug delivery systems at therapeutic doses in models of diseased skin.

73 cribe systemic temporal response cascades to therapeutic doses in multiple tissues such as liver, ske

74 Chronic administration of both agents at therapeutic doses increased the expression of BAG-1 in r

75 At therapeutic doses, intratumoral or i.p. injection of all

76 of radioactivity in thyroid tissues after a therapeutic dose is <60% of the diagnostic dose in most

77 The percentage uptake of the therapeutic dose is on average only one half of that pre

78 eins, such as monoclonal antibodies, at high therapeutic doses is challenging current production capa

79 ncipal pathway of chronic cardiotoxicity for therapeutic doses, leading to a progressive and irrevers

80 When these drugs are administered at therapeutic dose levels, a significant tumor growth arre

81 nflammatory drugs, AJA is not ulcerogenic at therapeutic doses, making it a promising anti-inflammato

82 Further, interindividual variability in therapeutic dose mandates frequent monitoring until targ

83 al and human studies suggest that lithium in therapeutic doses may improve learning and memory and mo

84 s monotherapy, with its difficult-to-achieve therapeutic dosing, may not be sufficient to maintain lo

85 At therapeutic doses, NSC59984 induces p73-dependent cell d

86 her increased by additional treatment with a therapeutic dose of (131)I (radiovirotherapy) and was as

87 stunning arose from the early effects of the therapeutic dose of (131)I and that the initial uptake o

88 ing"-defined as a reduction in uptake of the therapeutic dose of (131)I caused by some form of cell d

89 Thirty-four patients received a therapeutic dose of (131)I-antibody labeled with 76 to 6

90 After the extravasation of a therapeutic dose of (131)I-metaiodobenzylguanidine that

91 The therapeutic dose of (90)Y ibritumomab tiuxetan was follo

92 mab (dosimetric dose of 5 mCi on day -19 and therapeutic dose of 0.75 Gy on day -12), carmustine 300

93 Infarct volume was reduced at a therapeutic dose of 1 mEq/kg even when administered up t

94 binding of either the diagnostic dose or the therapeutic dose of 111In-pentetreotide.

95 tic tracer dose of 131I on the uptake of the therapeutic dose of 1311 in the ablation of a thyroid re

96 84%) had a successful outcome after a single therapeutic dose of 131I while 71 (16%) did not.

97 A total of 83 patients received a therapeutic dose of 166Ho-DOTMP followed by autologous h

98 The activity to deliver a therapeutic dose of 25 Gy to the marrow was determined.

99 tuximab within 2 h after administration of a therapeutic dose of 500 mg.m(-2) of cetuximab.

100 A therapeutic dose of 75 cGy total-body dose (attenuated t

101 inflammation) occurred at 3000 microg, and a therapeutic dose of 750-1500 microg was established.

102 re treatment, and 7 and 28 d after the first therapeutic dose of a TKI (gefitinib or erlotinib).

103 , which can cause immune pathology, a single therapeutic dose of anti-GITR did not induce splenomegal

104 In the mouse model, one therapeutic dose of antibody 1F2 was more protective tha

105 ivation that occurs in patients prescribed a therapeutic dose of aspirin and may underlie an unknown

106 of illness, duration of treatment, and total therapeutic dose of azathioprine and 6-MP.

107 r at least 4 h after the administration of a therapeutic dose of BMS-275291.

108 n model, peptide therapy combined with a sub-therapeutic dose of cyclosporin A significantly prolonge

109 The therapeutic dose of docetaxel (10 mg/kg/week) was determ

110 nd better informed administration of correct therapeutic dose of drugs used to treat alpha-amylase re

111 in vitro, exposure of volunteers to a single therapeutic dose of each NSAID followed by 325 mg aspiri

112 In addition, the effects of a therapeutic dose of furosemide on glomerular filtration

113 at depth in tissue can be used to deliver a therapeutic dose of heat by using moderately low exposur

114 previous major depressive episodes and on a therapeutic dose of maintenance antidepressants, from pr

115 r and their potential reversal with a single therapeutic dose of methylphenidate.

116 his is the first report demonstrating that a therapeutic dose of nonradioactive iodide has potent eff

117 M administration enables local delivery of a therapeutic dose of PE to the anal sphincter muscle laye

118 Once a therapeutic dose of quetiapine was reached, ventilator s

119 y determine the appropriate patient-specific therapeutic dose of radiolabeled antibody needed to deli

120 rs rendered the tumor cells susceptible to a therapeutic dose of RAI.

121 Treatment with a therapeutic dose of rHuGH can rectify the IGF-1 deficien

122 ants were 100% protected after only a single therapeutic dose of the antibody used to generate the es

123 y i.v. dosed to humans, at T(max) of an oral therapeutic dose of the unlabeled drug, both drugs in pl

124 objective was to begin to accrue data on the therapeutic dose of these growth factors (GFs) required

125 TC entered exploratory clinical studies with therapeutic doses of 131I-labeled NP-4 and MN-14 murine

126 treated with HD-RIT received individualized therapeutic doses of 131I-tositumomab (median, 19.7 GBq

127 metastatic mediastinal 131I uptake following therapeutic doses of 131I.

128 regnancies were in women who received common therapeutic doses of 150 mg (56% of pregnancies) or 300

129 rition, especially fasting demonstrates that therapeutic doses of acetaminophen do not place patients

130 plain some of the variability in response to therapeutic doses of albuterol in children.

131 We now report that therapeutic doses of aspirin suppress lipopolysaccharide

132 ouse blood chemistry profiles indicated that therapeutic doses of bioengineered miR-34a prodrug were

133 , compared with traditional ocular steroids, therapeutic doses of BOL-303242-X elicit a reduced myoci

134 s well with subsequent clinical tolerance of therapeutic doses of carbapenems.

135 Treatment with therapeutic doses of ceftiofur or florfenicol resulted i

136 a pen and subsequent feeding/not feeding of therapeutic doses of chlortetracycline.

137 We observed that therapeutic doses of CsA increased tumor size and VEGF m

138 Our results suggest that therapeutic doses of CsA may not prevent the upregulatio

139 Delivery of alpha1hu70-77-RT1.Aa with therapeutic doses of cyclosporine (CsA) also prevented c

140 Mice were given therapeutic doses of dexamethasone before intracerebral

141 e response for up to 6 months despite weekly therapeutic doses of enzyme in the absence of immunosupp

142 Thus, we found that therapeutic doses of etoposide affect primarily meiotic

143 (+) cell infiltration at clinically relevant therapeutic doses of fingolimod.

144 eurons in the human cortex are suppressed by therapeutic doses of fluoxetine (Prozac).

145 Therapeutic doses of GC induce growth-suppressive and cy

146 All animals tolerated the therapeutic doses of IL-13 toxin without any visible sig

147 d the ability of pulsed microjets to deliver therapeutic doses of insulin across the skin.

148 In hippocampal neurons, therapeutic doses of Li(+) (1-2 mM) increased GIRK basal

149 thrombin and antithrombin in the presence of therapeutic doses of low- and high-molecular-weight hepa

150 He is treated with therapeutic doses of low-molecular weight heparin (LMWH)

151 rrhage associated with the administration of therapeutic doses of low-molecular-weight heparin, we pe

152 In the present study, we evaluated whether therapeutic doses of metformin increase AMPK activity in

153 of dopamine transporter blockade achieved by therapeutic doses of methylphenidate are not known.

154 Therapeutic doses of MLN2704 can be administered safely

155 suggest that developmental exposure to high therapeutic doses of MPH has short-term effects on selec

156 C therapy by allowing on-site cryostorage of therapeutic doses of MSC at hospitals and clinics.

157 aparoid or fondaparinux; all others received therapeutic doses of nonheparin anticoagulants.

158 gent to control their PSII were treated with therapeutic doses of oral tacrolimus.

159 Concerns of potential hepatotoxicity of therapeutic doses of paracetamol have been highlighted i

160 otectin, B. burgdorferi is not eliminated by therapeutic doses of penicillin G; in contrast, doxycycl

161 The therapeutic doses of pimozide and haloperidol were equiv

162 nd after 1 to 14 d of oral administration of therapeutic doses of prednisone.

163 Unexpectedly, therapeutic doses of RA and RA + As(2)O(3) can induce, b

164 n 11 Hodgkin's disease patients who received therapeutic doses of radiation to a mantle field at the

165 tudy indicate that most patients who receive therapeutic doses of radiation to a mantle field experie

166 The administration of therapeutic doses of recombinant cytokines to patients w

167 n AGM T cells in vitro Through administering therapeutic doses of recombinant human interleukin-2 (IL

168 Thus, larger therapeutic doses of specific nutrients may be required

169 cs human development; chronic treatment with therapeutic doses of sustained release MPH did not have

170 se to antigen stimulation in the presence of therapeutic doses of TAC.

171 ormed, but not untransformed, human cells to therapeutic doses of the anticancer agent Taxol, making

172 wn to possess sufficient capacity to deliver therapeutic doses of the potent BT protein.

173 r to those found in the serum of patients on therapeutic doses of this agent.

174 he CML-like illness, mice were maintained on therapeutic doses of this drug and serially monitored.

175 Therapeutic doses of tirofiban (0.35 microg/mL) and epti

176 gnificant adverse effects from inhalation of therapeutic doses of UTP/amiloride.

177 Therapeutic doses of VPA inhibited human cellular prolif

178 These data provide evidence that therapeutic dosing of a TGF-beta antagonist can diminish

179 od Klotho levels can serve as a biomarker of therapeutic dosing of AE, whereas IGF-1 is a key molecul

180 We demonstrate that therapeutic dosing of INCB3344 significantly reduces dis

181 T(H)17 differentiation in vivo and show that therapeutic dosing of the BET inhibitor is efficacious i

182 When given in therapeutic doses over 14 days, acetaminophen produced s

183 king paediatric antibiotic use and find that therapeutic-dose pulsed antibiotic treatment (PAT) with

184 explained four fifths of the variability in therapeutic dose (R(2)(adj) of 79%).

185 ared any of the following antidepressants at therapeutic dose range for the acute treatment of unipol

186 d cancer, but the magnitude of risk over the therapeutic dose range has not been well established.

187 that fractionated radiation therapy within a therapeutic dose range is associated with a dose-related

188 demonstrated that ionizing radiation in the therapeutic dose range stimulates NF-kappaB activity by

189 der follows a flat response curve within the therapeutic dose range.

190 omolar range and no observed toxicity in the therapeutic dose range.

191 MBq; mean, 85.1 MBq; median, 40 MBq) and the therapeutic dose (range, 1.073-5.713 GBq; mean, 2.991 GB

192 AY 50-4798, with human IL-2 (Proleukin) in a therapeutic dosing regimen in chimpanzees, and found tha

193 histologic end points was observed with the therapeutic dosing regimen of BMS-345541, with use of th

194 of 200 mg/kg per day Brd4 inhibitor JQ1 in a therapeutic dosing regimen substantially attenuated lung

195 complex systems ranging from coagulation to therapeutic dosing regimens for monoclonal antibodies.

196 st enzymatic degradation, hence reducing the therapeutic dose required and risk of dose-dependent tox

197 Mechanistic insights are elucidated and therapeutic dose responses are demonstrated.

198 uptake of the diagnostic dose to that of the therapeutic dose results in a slope of 0.42, with a corr

199 survival outcomes for patients treated with therapeutic dose RT plus ADT versus prostatectomy plus A

200 l natural history of disease was defined and therapeutic dose selected based on predegeneration resul

201 ckground ratios and the delivery of a higher therapeutic dose than when antibodies are directly conju

202 otectants for normal tissues also limits the therapeutic doses that can be delivered to treat cancers

203 ssue" component showed minimal uptake of the therapeutic dose, the "ossified component" showed intens

204 Beyond normal therapeutic doses, the drug is hepatotoxic and genotoxic

205 A dose-finding study identified a nontoxic therapeutic dose to be approximately 75 microCi.

206 l uptake and to calculate a patient-specific therapeutic dose to deliver a nominal radiation dose of

207 n in clinical practice today, yet an optimal therapeutic dose to prevent dnDSAs has not been establis

208 117mSn and 33P are more likely to deliver a therapeutic dose to the bone while sparing the bone marr

209 Tracer studies reliably predicted the therapeutic dose to the CSF.

210 cysteine protease inhibitors can be given at therapeutic doses to animals to selectively arrest a par

211 dy was given prior to labeled dosimetric and therapeutic doses to improve biodistribution.

212 the bone marrow and at the same time deliver therapeutic doses to the bone.

213 n reported with arsenic poisoning but not at therapeutic doses used in protocols for hematologic mali

214 A reduced effective therapeutic dose was achieved by selective LAmB delivery

215 The uptake of the therapeutic dose was then expressed as a percentage of t

216 dicted doses were within 20% of their actual therapeutic doses was determined.

217 Neither compound at therapeutic doses was significantly toxic in ex vivo cel

218 agnostic doses were 1.0 mCi (37 MBq) in all; therapeutic doses were 150 and 30 mCi (5,550 and 1,110 M

219 plasma levels of sertraline exceeding human therapeutic doses were accurately modeled from external

220 g steps for DPT to BLs: 5-15-30-50% of daily therapeutic dose (with additional lower steps for index

221 dium-channel blocker, can be administered at therapeutic doses without titration, and has shown good

222 s that treatment with warfarin at recognized therapeutic doses would reduce rates of mortality, hospi