ライフサイエンスコーパス: therapeutic efficacy

1 icine and personalized therapies for optimal therapeutic efficacy.

2 t therapeutic glycoproteins, affecting their therapeutic efficacy.

3 n of multiple targets might provide superior therapeutic efficacy.

4 e optimized to control cell fate and enhance therapeutic efficacy.

5 fragments in the lungs and to improve their therapeutic efficacy.

6 e use disorders and underlying mechanisms of therapeutic efficacy.

7 al tumour changes and can be used to monitor therapeutic efficacy.

8 o obvious protein candidates associated with therapeutic efficacy.

9 er appreciation of factors governing optimal therapeutic efficacy.

10 context-dependent negative impact on overall therapeutic efficacy.

11 tial combinatorial approaches to enhance its therapeutic efficacy.

12 ign considerations that inadequately predict therapeutic efficacy.

13 hereby leading to significant improvement in therapeutic efficacy.

14 induces low MSC engraftment and limits their therapeutic efficacy.

15 ne evaluated the patient outcome efficacy or therapeutic efficacy.

16 to analyze the effects of each parameter on therapeutic efficacy.

17 ral engineering of AAV vectors with improved therapeutic efficacy.

18 ole for IL21 signaling in promoting HER2 mAb therapeutic efficacy.

19 er siRNAs in vivo, and none has demonstrated therapeutic efficacy.

20 solubility and hence low bioavailability and therapeutic efficacy.

21 e which can both reduce toxicity and improve therapeutic efficacy.

22 n how to tailor drug combinations to improve therapeutic efficacy.

23 beam radiotherapy has been shown to increase therapeutic efficacy.

24 population is essential to achieve long-term therapeutic efficacy.

25 radioisotopes to increase and optimize their therapeutic efficacy.

26 mal models and assays effective in assessing therapeutic efficacy.

27 reactive oxygen species (ROS) would enhance therapeutic efficacy.

28 ted at these autoimmune processes could have therapeutic efficacy.

29 ts are limited by off-target effects and low therapeutic efficacy.

30 ht source configurations that would maximise therapeutic efficacy.

31 specificity and hence, potentially, reduced therapeutic efficacy.

32 the AAV capsid protein can, however, affect therapeutic efficacy.

33 nd are highly important in drug delivery and therapeutic efficacy.

34 ased PK can provide better representation of therapeutic efficacy.

35 d CD8(+) effectors that is indispensable for therapeutic efficacy.

36 tomas with an immature phenotype may improve therapeutic efficacy.

37 formulations and eventually lead to improved therapeutic efficacy.

38 eving improved patient outcomes and improved therapeutic efficacy.

39 ignal enhancement is prognostic of long-term therapeutic efficacy.

40 s to target cells ultimately increasing drug therapeutic efficacy.

41 or staging cancer progression and evaluating therapeutic efficacy.

42 ic molecules can improve bioavailability and therapeutic efficacy.

43 t collectively lead to large improvements in therapeutic efficacy.

44 omal rAAV genomes and subsequently a loss in therapeutic efficacy.

45 ing schedule in order to further improve the therapeutic efficacy.

46 alteration is often insufficient to predict therapeutic efficacy.

47 py will likely be required to impart durable therapeutic efficacy.

48 eve high local drug concentrations with good therapeutic efficacy.

49 osomes, which can significantly impair their therapeutic efficacy.

50 affinity to human receptors and enhance its therapeutic efficacy.

51 therapy in HCC, and if so, if it impacts the therapeutic efficacy.

52 er quantitative muscle ultrasound can detect therapeutic efficacy.

53 es display sufficient targeted receptors for therapeutic efficacy.

54 time lag of weeks to months and low rates of therapeutic efficacy.

55 ) with maximum breadth and potency to ensure therapeutic efficacy.

56 in interstitium will be sufficient to ensure therapeutic efficacy.

57 se in ER-dependent transcription that limits therapeutic efficacy.

58 ed for confounders) were performed to assess therapeutic efficacy.

59 shortening treatment duration and increasing therapeutic efficacy.

60 e found to both decisively and subtly effect therapeutic efficacy.

61 101 and 5-fluorouracil producing the highest therapeutic efficacy.

62 iven i.p.), ACT induced a strong increase in therapeutic efficacy; 120days after study start, 42% of

63 To evaluate therapeutic efficacy, 2 groups of mice received the radi

64 i.v.), ACT induced a strong increase in the therapeutic efficacy; 60days after study start 100% of t

65 hydrogels with in vivo stiffening to enhance therapeutic efficacy achieve these requirements.

66 cal and experimental data, including varying therapeutic efficacy across movement disorders.

67 focus is on basic science investigations or therapeutic efficacy, activity and precision are importa

68 ificantly lower systemic toxicity and higher therapeutic efficacy against i.p. chemotherapy-resistant

69 g antibodies targeting this site show potent therapeutic efficacy against lethal EBOV challenge in mi

70 ancer cells, producing a remarkably improved therapeutic efficacy against MDR tumors with minimal sid

71 logy has shown great potential with improved therapeutic efficacy and fewer side effects.

72 he development of nanocarriers with superior therapeutic efficacy and high biocompatibility.

73 nti-PEG Abs has been correlated with loss of therapeutic efficacy and increase in adverse effects in

74 xorubicin-loaded (D)CDX-RBCNPs have superior therapeutic efficacy and markedly reduced toxicity as co

75 an significantly enhance gene expression and therapeutic efficacy and may become an essential option

76 s regarding sex-dependent effects related to therapeutic efficacy and negative health effects of cann

77 (IVIg) in inflammatory diseases, consistent therapeutic efficacy and potency remain major limitation

78 However, persistent AR signalling undermines therapeutic efficacy and promotes progression to lethal

79 -Syt II may improve botulinum neurotoxin B's therapeutic efficacy and reduce adverse effects.

80 ted targeting, with resultant improvement in therapeutic efficacy and reduced toxicity.

81 red therapeutic agents to MM cells improving therapeutic efficacy and reducing side effects in vivo.

82 been shown to be related with limitation of therapeutic efficacy and reduction in tolerance of sever

83 These have improved therapeutic efficacy and safety compared to traditional

84 The improved therapeutic efficacy and safety demonstrate great promis

85 c localization is critical for improving the therapeutic efficacy and safety of drugs.

86 Therapeutic efficacy and safety were evaluated 2 months

87 avir and lamivudine demonstrated noninferior therapeutic efficacy and similar tolerability compared t

88 estrictions directly contribute to decreased therapeutic efficacy and the emergence of drug resistanc

89 Therapeutic efficacy and tumor necrosis area were compar

90 d HMGB1-neutralizing antibody with validated therapeutic efficacy and with a prolonged therapeutic wi

91 he relationships between catalytic activity, therapeutic efficacy, and biocompatibility that are crit

92 barrier to clinical success by compromising therapeutic efficacy, and pathological relevance of mult

93 understanding biological disease mechanisms, therapeutic efficacy, and prognosis in this population.

94 Phage pharmacology, therapeutic efficacy, and resistance were determined.

95 r due to its NTR-targeting ability, enhanced therapeutic efficacy, and safety.

96 Here, we discuss how drug delivery and therapeutic efficacy are greatly hindered by barriers pr

97 ration and absorption, but limited potential therapeutic efficacy as antimicrobials in nasal applicat

98 ddition, HS showed a significantly prolonged therapeutic efficacy as compared to N-acetylcysteine.

99 okine [C-X-C motif] ligand 1) with prolonged therapeutic efficacy as compared to NAC.

100 ized cancer medicine requires measurement of therapeutic efficacy as early as possible, which is opti

101 g attention in recent years on its potential therapeutic efficacy as municipalities and legislative b

102 le the drug-loaded micromotors reach similar therapeutic efficacy as the positive control of free dru

103 elopment of anti-inflammatory therapies with therapeutic efficacy beyond the therapeutic window of th

104 udy, we address the possibility of improving therapeutic efficacy by combining corticosteroid adminis

105 rd chemoradiotherapy significantly increased therapeutic efficacy by inhibiting DNA repair and HIF1al

106 various cancer types, therefore, increasing therapeutic efficacy by providing detailed molecular fea

107 us chemical modification of RNAs can improve therapeutic efficacy by reducing susceptibility to nucle

108 ment cascade, opens up prospects for broader therapeutic efficacy by targeting multiple pathogenic pa

109 However, their therapeutic efficacy can be compromised by NA changes th

110 a Liposome) that inarguably offers superior therapeutic efficacies compared to free drug administrat

111 cle (which we call HerMn) exhibited improved therapeutic efficacy compared to current targeted therap

112 ve local homing of iv-infused MSCs and their therapeutic efficacy compared to iv-infused MSCs alone.

113 nance was not associated with differences in therapeutic efficacy compared with buprenorphine mainten

114 That is, females exhibit superior therapeutic efficacy, defined as extended periods of abs

115 Their therapeutic efficacy depends on rational control and reg

116 ains that further optimize safety could have therapeutic efficacy for adult glioblastoma patients.

117 tivity elucidate the difficulty in achieving therapeutic efficacy for BMs when a single standard acti

118 -PD-L1 immune checkpoint blockade to enhance therapeutic efficacy for human cancers.

119 sm and secondary targets will likely improve therapeutic efficacy for other LSDs with complex patholo

120 genous corepressor ligands to evaluate their therapeutic efficacy for targeting ABC-DLBCL.

121 y strategy with the potential to improve the therapeutic efficacy for the treatment of a variety of d

122 IKs activators may provide therapeutic efficacy for treating long QT syndromes.

123 strong safety profile and increasingly their therapeutic efficacy for treating monogenic diseases.

124 These results demonstrate clinical therapeutic efficacy from gene therapy for ADA-deficient

125 ent clinical reports confirm that sufficient therapeutic efficacy has not yet been achieved.

126 ogeneic icMSCs and icCDCs exhibit comparable therapeutic efficacy in a large animal model of hibernat

127 f an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebo

128 us carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model.

129 Finally, evaluating therapeutic efficacy in an orthotopic model of glioblast

130 s (Tregs) during autoimmune insults may have therapeutic efficacy in autoimmune diseases.

131 cological inhibition has been shown to exert therapeutic efficacy in chronic obstructive pulmonary di

132 recombinant human TRAIL demonstrates limited therapeutic efficacy in clinical trials, possibly due to

133 depression symptoms and might have expanded therapeutic efficacy in comparison with current antipsyc

134 oach could affect nanoparticle targeting and therapeutic efficacy in complex, physiologically related

135 Our simulations suggest that flecainide therapeutic efficacy in CPVT is unlikely to derive from

136 rector and potentiator combinations may have therapeutic efficacy in cystic fibrosis caused by the W1

137 nhibitors targeting the Wnt pathway can have therapeutic efficacy in decreasing metastatic properties

138 a (ERalpha) leading to enhanced anti-hormone therapeutic efficacy in ERalpha-negative breast cancer.

139 This nanosystem showed promising therapeutic efficacy in glioblastoma (GBM) and breast ca

140 as recently surged in response to reports of therapeutic efficacy in human clinical trials, most nota

141 at of complex chemokine mixtures, suggesting therapeutic efficacy in inflammatory disease.

142 the metallo-complex Cu(II)(atsm) tested for therapeutic efficacy in mice expressing SOD1(G93A) on a

143 d in vitro, characterized, and evaluated for therapeutic efficacy in mice subjected to MI.

144 rget of Ebola virus in vivo, and also showed therapeutic efficacy in mice.

145 of approximately 200 nM and demonstrated its therapeutic efficacy in mouse models of constipation.

146 by clioquinol, a compound with demonstrated therapeutic efficacy in multiple PD models.

147 inhibiting or promoting autophagy may confer therapeutic efficacy in patients.

148 ouse osteotomy model validated the micelles' therapeutic efficacy in promoting bone fracture healing

149 tment of diabetic cardiomyopathy and implies therapeutic efficacy in settings of chronic heart failur

150 nt brain metastasis models and assessing the therapeutic efficacy in such models are fundamental for

151 g as a potentially valuable tool for gauging therapeutic efficacy in the disorder.SIGNIFICANCE STATEM

152 We show that ENb-TRAIL has therapeutic efficacy in tumor cells from different cance

153 dramatically improved (by at least 52-fold) therapeutic efficacy in vitro on A431 cell line, compare

154 ment were favorable for both cell types, the therapeutic efficacy in vivo was remarkably different.

155 emonstrate that these micellar agonists have therapeutic efficacy in vivo.

156 nd on discrete neuronal mechanisms for their therapeutic efficacy, information that may help develop

157 eline for enhancing traditional photodynamic therapeutic efficacy integrated with a controlled drug-r

158 dely used chemotherapeutic drug, but limited therapeutic efficacy is achieved due to chemoresistance.

159 Therapeutic efficacy is associated with increases in the

160 en identified with pro-angiogenic behaviors, therapeutic efficacy is limited by poor tissue localizat

161 Despite promising results, therapeutic efficacy is limited by the development of ac

162 of proper nanoscale delivery vehicles, their therapeutic efficacy is still often limited without the

163 T treatment, but its mechanism of action for therapeutic efficacy is unclear.

164 gonist immunotherapies resulting in superior therapeutic efficacy.MEK inhibition in breast cancer is

165 The therapeutic efficacies of our current drug arsenal could

166 The therapeutic efficacy of (103)Pd@Au nanoseeds were assess

167 d compare the tumor-targeting properties and therapeutic efficacy of (213)Bi and (177)Lu for PRIT of

168 Herein, we developed and investigated the therapeutic efficacy of a partly humanized anti-HMGB1 mo

169 This study sought to determine the therapeutic efficacy of a re-engineered adenoassociated

170 pro-allergic Th2 response, we evaluated the therapeutic efficacy of a treatment based on a denatured

171 mediate potential to improve the quality and therapeutic efficacy of adoptive T-cell therapeutics inf

172 In this study, we assessed the therapeutic efficacy of an adeno-associated virus (AAV)

173 ate in a future clinical trial assessing the therapeutic efficacy of an SFD in CD.

174 been proposed as a mechanism for the reduced therapeutic efficacy of anti-CD20 antibodies and confirm

175 st IgE or its receptor, FcepsilonRI, and the therapeutic efficacy of anti-IgE antibodies imply that I

176 surveillance and periodic assessment of the therapeutic efficacy of artemisinin-based combination th

177 icantly alleviates side effects and improves therapeutic efficacy of ATO on CML and xenograft tumor m

178 Improved therapeutic efficacy of beta-lap-dC3 micelles correlated

179 at inter alia can be applied to evaluate the therapeutic efficacy of birch pollen AIT on birch pollen

180 een demonstrated; ACT markedly increases the therapeutic efficacy of both paclitaxel and Abraxane(R)

181 nhibition of BRAF and MEK1/2 (CIBM) improves therapeutic efficacy of BRAF-mutant melanoma.

182 antitumor immune responses essential for the therapeutic efficacy of cancer vaccines.

183 These findings demonstrate the therapeutic efficacy of CAR T cells directed against Tn-

184 This study demonstrates improved therapeutic efficacy of Cas9-edited CAR T cells and high

185 preclinical and clinical data outlining the therapeutic efficacy of CBD for the treatment of motivat

186 occurs frequently in melanoma; however, the therapeutic efficacy of CDK4/6 inhibition remains to be

187 self-tolerance is necessary to increase the therapeutic efficacy of checkpoint immunotherapy.

188 Therefore, we assessed the therapeutic efficacy of CRISPR (clustered regularly inte

189 These results demonstrate the potential therapeutic efficacy of Cucurbitacin D against cervical

190 To define the therapeutic efficacy of current lab-made hepatocytes, we

191 The therapeutic efficacy of Dox in nanosomes was assessed in

192 The therapeutic efficacy of ebselen was evaluated in a mouse

193 To further improve the therapeutic efficacy of exendin-4, we have developed a n

194 ed in a novel synergistic way to enhance the therapeutic efficacy of existing immune-based therapies

195 The mechanism of therapeutic efficacy of flecainide for catecholaminergic

196 Clinical trials testing the therapeutic efficacy of high-dose alphaTOC against strok

197 Figures 4B and 4D tested the therapeutic efficacy of I-BET151 in vivo using mice inje

198 ate the pathogenic role of IFN-gamma and the therapeutic efficacy of IFN-gamma neutralization in an a

199 of innate immune activation in the skin, and therapeutic efficacy of IL-1 blockade in a subset of pat

200 efforts to evaluate the central actions and therapeutic efficacy of IN-OT may be marred by the absen

201 1 prostate cancer mouse tumor models to test therapeutic efficacy of ISCOMATRIX vaccines combined wit

202 caerulein model of CP was used to assess the therapeutic efficacy of Jak1/2 inhibition in vivo.

203 Only one study so far has proven the therapeutic efficacy of L-ALD, in combination with gamma

204 Here, we assessed the therapeutic efficacy of lipid nanoparticle (LNP) deliver

205 We assessed the prophylactic and therapeutic efficacy of m336 by using well-characterized

206 tients, which is consistent with the reduced therapeutic efficacy of microenvironment-modulating IMiD

207 Inactivation of opioid receptors limits the therapeutic efficacy of morphine-like analgesics and med

208 s induce MSC tropism and could influence the therapeutic efficacy of MSC.

209 edicted the role of the mTOR pathway and the therapeutic efficacy of mTOR-targeted agents in KIM-1-me

210 Therapeutic efficacy of N-BPs is hampered by their rapid

211 he diffusion, intratumoral distribution, and therapeutic efficacy of nanocarriers.

212 sion; this will facilitate the validation of therapeutic efficacy of novel antifungals.

213 We tested the targeting and therapeutic efficacy of oAd/DCN/LRP-PEG-NT toward neurot

214 e findings suggest a strategy to enhance the therapeutic efficacy of oncolytic virotherapy in gliobla

215 ing OT under opioid antagonism may boost the therapeutic efficacy of OT for enhancing social cognitio

216 erse chemoresistance and further enhance the therapeutic efficacy of paclitaxel in paclitaxel-resista

217 -L1, enhances antitumour T-cell immunity and therapeutic efficacy of PD-1 blockade in syngeneic mouse

218 Then therapeutic efficacy of photoimmunotherapy was examined

219 P2-dependent processes may contribute to the therapeutic efficacy of PI3K inhibitors in B cell malign

220 ls, an effect thought to partly underlie the therapeutic efficacy of PI3K inhibitors in treatment of

221 s a simple and effective tool to improve the therapeutic efficacy of platelet-derived proteins for wo

222 evaluate the long-term pharmacokinetics and therapeutic efficacy of polycaprolactone intracameral dr

223 The therapeutic efficacy of PRIT might be improved using alp

224 ata show an experimental approach to improve therapeutic efficacy of proangiogenic cells for the trea

225 It is also correlated with therapeutic efficacy of programmed death 1 and PD-L1 inh

226 ws down tumour progression, and improves the therapeutic efficacy of programmed death-ligand 1 (PD-L1

227 dings offer candidate markers to monitor the therapeutic efficacy of psychostimulants or to predict t

228 tract, mediating toxicities restricting the therapeutic efficacy of radiation in cancer and morbidit

229 ecific antibodies, have greatly enhanced the therapeutic efficacy of radioimmunotherapy and diminishe

230 The authors examined the therapeutic efficacy of real-time functional MRI neurofe

231 Our results suggest that the therapeutic efficacy of rhEPO produced in CHO cells can

232 To enhance the therapeutic efficacy of RITs, we conducted a kinome RNAi

233 findings provide evidence for the potential therapeutic efficacy of RNS60 through the promotion of O

234 Further studies to test the therapeutic efficacy of ruxolitinib in CLL are warranted

235 The presence of T472C mutant compromised the therapeutic efficacy of S1 and resulted in replacement o

236 We aimed to investigate the therapeutic efficacy of SAHM1 in a house dust mite (HDM)

237 The aim of this study was to evaluate the therapeutic efficacy of site-specifically conjugated duo

238 We then demonstrate the therapeutic efficacy of SR20 against two murine models o

239 ine model of intradermal MRSA infection, the therapeutic efficacy of synthetic S. caprae AIP was evid

240 We also tested therapeutic efficacy of targeting beta-catenin in an HCC

241 PAK4 in IR-induced EMT and suggest potential therapeutic efficacy of targeting PAK4 to overcome radio

242 ong mechanistic rationale to investigate the therapeutic efficacy of targeting the MALT1-MYC axis in

243 Here, we test the therapeutic efficacy of telomerase activation by using a

244 Finally, the therapeutic efficacy of the 4 different ADCs was assesse

245 To assess the therapeutic efficacy of the Ad/PEGbPHF complex platform,

246 arepvec on cytotoxic T cell infiltration and therapeutic efficacy of the anti-PD-1 antibody pembroliz

247 Therapeutic efficacy of the combination was also observe

248 or permeation that could further enhance the therapeutic efficacy of the delivered drug.

249 infection, which was used to demonstrate the therapeutic efficacy of the isolated antibodies.

250 Here, we studied the combinatorial therapeutic efficacy of the MET/ALK inhibitor crizotinib

251 Our therapeutic study confirms the high therapeutic efficacy of the new delivery system, with no

252 TRIX in the formulation was critical for the therapeutic efficacy of the vaccine.

253 immune response, and how this relates to the therapeutic efficacy of these approaches.

254 urokinase have been developed to improve the therapeutic efficacy of these proteins.

255 at epitope spreading could contribute to the therapeutic efficacy of this BiTE.

256 20FMDV2 as a targeting moiety for L-ALD, the therapeutic efficacy of this therapy can be increased in

257 The onset of therapeutic efficacy of traditional antidepressants is d

258 With the final aim of testing the therapeutic efficacy of UCB in MPS-I mice transplanted a

259 with sunitinib may significantly improve the therapeutic efficacy of venetoclax.

260 We evaluated the therapeutic efficacy of ZIKV-117 in pregnant and non-pre

261 AZD3463 also exhibited significant therapeutic efficacy on the growth of the NB tumors with

262 ptor interactions did not seem necessary for therapeutic efficacy or biodistribution patterns because

263 beta-Lapachone's therapeutic efficacy partially stems from the drug's ind

264 To improve therapeutic efficacy, polymer drug conjugates carrying s

265 FLT3 inhibitors like sorafenib show initial therapeutic efficacy, resistance rapidly develops throug

266 ive normal tissue is believed to enhance the therapeutic efficacy, restrict major escape mechanisms a

267 systemic antiviral therapy may have greater therapeutic efficacy than systemic therapy alone.

268 atment study, PTX loaded BCM showed superior therapeutic efficacy than that of NCM and Taxol.

269 ed with PEG-PDLA copolymer manifested higher therapeutic efficacy than those formed with PEG-PLLA cop

270 KII inhibition, our model predicted superior therapeutic efficacy than with flecainide monotherapy.

271 pharmacodynamics, and providing a marker of therapeutic efficacy that is highly indicative of outcom

272 by cancer and endothelial cells resulting in therapeutic efficacy that is similar to free doxorubicin

273 For therapeutic efficacy, the prodrug must hydrolyze to its

274 provide a rationale for improving anti-EGFR therapeutic efficacy through pharmacological uncoupling

275 and repair offers the opportunity to monitor therapeutic efficacy to detect changes in tumor biology

276 icantly improve its pharmacokinetics and its therapeutic efficacy to inhibit tumor growth in vivo.

277 tic for colorectal neoplasia with comparable therapeutic efficacy to rapamycin free drug and signific

278 s frequent dosing, the Dex-NW has comparable therapeutic efficacy to topically applied Dex eye drops

279 hydrophobic block of block copolymer on the therapeutic efficacy, tumor recurrence, and development

280 y to monitor cancer patients for relapse and therapeutic efficacy using cfDNA.

281 , in tumours with mutant p53 and enhance the therapeutic efficacy using polymeric nanoparticles (NPs)

282 ting levels that correlated with significant therapeutic efficacies, using either the mouse peritonit

283 ir design, synthesis, and application from a therapeutic efficacy viewpoint.

284 Therapeutic efficacy was determined 4 weeks after infusi

285 Therapeutic efficacy was evaluated 2 months after gene d

286 Therapeutic efficacy was preserved over 19 days of chron

287 Therapeutic efficacy was supported further by the preser

288 The therapeutic efficacy was tested in a pseudo-metastatic l

289 Employing these models to investigate therapeutic efficacy, we found that TET2 and cohesin-mut

290 Clinical safety and therapeutic efficacy were evaluated in a phase II study.

291 ferred to muMT mice with EAE, restored their therapeutic efficacy when Amylin 28-33 was administered.

292 psed/refractory patients have shown enhanced therapeutic efficacy when daratumumab and isatuximab are

293 and vancomycin, respectively, show enhanced therapeutic efficacy when delivered by the platelet-mime

294 larities in males and females underlie early therapeutic efficacy, whereas these posttreatment sex di

295 ous or sequential drug treatment has maximal therapeutic efficacy, which is based on a mechanistic ra

296 Therapeutic efficacy, which typically results from inter

297 his gene by EEA-deficient meals retained its therapeutic efficacy while abrogating its toxic effects

298 ealed that this SCF partial agonist retained therapeutic efficacy while exhibiting virtually no anaph

299 rmine the optimal dosing schedule to improve therapeutic efficacy while reducing renal toxicity.

300 Our results demonstrate enhanced therapeutic efficacy with the combination of cetuximab a