ライフサイエンスコーパス: therapeutic index

1 present a general strategy to increase their therapeutic index.

2 st the same cells, thereby displaying a high therapeutic index.

3 ccentuated antitumor efficacy along with the therapeutic index.

4 a targeted strategy likely to have a useful therapeutic index.

5 as a potential solution for improving their therapeutic index.

6 their GVHD activity, leading to an improved therapeutic index.

7 of drug delivery systems to achieve a better therapeutic index.

8 and low cytotoxicity, giving a markedly high therapeutic index.

9 onoclonal antibody (mAb) therapy with a safe therapeutic index.

10 rotection of patients and the improvement of therapeutic index.

11 rovides a remarkable improvement in the drug therapeutic index.

12 esulted in a conjugate (25) with an improved therapeutic index.

13 olerated similarly, thus showing an improved therapeutic index.

14 arkers predictive of benefit may enhance its therapeutic index.

15 ng to reduced systemic toxicity and improved therapeutic index.

16 MM cell lines tested, suggesting a favorable therapeutic index.

17 ively high cytotoxicity, resulting in narrow therapeutic index.

18 rahepatic tissues and thereby to improve the therapeutic index.

19 tability and aqueous solubility and a larger therapeutic index.

20 resistance genes and increase the antibiotic therapeutic index.

21 oduct in the hopes of optimizing potency and therapeutic index.

22 for the activated form could provide a high therapeutic index.

23 tive to extrahepatic tissues and an improved therapeutic index.

24 a drug class associated with an unacceptable therapeutic index.

25 with improved properties, including a higher therapeutic index.

26 eatment of invasive brain tumors due to poor therapeutic index.

27 unities exist for further enhancement of the therapeutic index.

28 ibit in each cancer to maximize efficacy and therapeutic index.

29 roach to lung cancer growth with a favorable therapeutic index.

30 ents, but its utility is limited by a narrow therapeutic index.

31 acid 4 had the best profile with respect to therapeutic index.

32 n of this compound to rationally improve its therapeutic index.

33 efficacy and have the potential for improved therapeutic index.

34 permit therapeutic targeting with favorable therapeutic index.

35 f the TRAIL receptor may provide an enhanced therapeutic index.

36 is a promising anticancer target with a high therapeutic index.

37 e dual EGFr/erbB2 inhibitors in efficacy and therapeutic index.

38 dulation of irinotecan by Cs may improve its therapeutic index.

39 by dietary folate, resulting in an improved therapeutic index.

40 quired drug resistance with a more favorable therapeutic index.

41 me example of a targeted therapy with a high therapeutic index.

42 e active drug and would thereby increase the therapeutic index.

43 bitor, BI6727, suggesting a potentially good therapeutic index.

44 ty, resulting in a 3-fold improvement in the therapeutic index.

45 y toxic side effects that result in a narrow therapeutic index.

46 n has been developed that might improve this therapeutic index.

47 mechanism of action with a potentially high therapeutic index.

48 istration or gene therapy for increasing its therapeutic index.

49 o alter the toxicity profile and improve the therapeutic index.

50 owever, its utility is limited by its narrow therapeutic index.

51 milar to full mGlu5 NAMs, but with a broader therapeutic index.

52 elivery can improve pharmacokinetics and the therapeutic index.

53 corticosteroids) have a relatively favorable therapeutic index.

54 ecent years and the current drugs have a low therapeutic index.

55 e targets, which potentially compromises its therapeutic index.

56 somal selectivity, predictive of an enhanced therapeutic index.

57 drug biocompatibility, and improves the drug therapeutic index.

58 e insulin-sensitizing efficacy with improved therapeutic index.

59 A) before being abandoned because of its low therapeutic index.

60 uded in combination chemotherapy to increase therapeutic index.

61 g/kg or higher), providing a relatively high therapeutic index.

62 iding a remarkable improvement in the drug's therapeutic index.

63 ent and selective siRNA carriers with a wide therapeutic index.

64 fic distribution, systemic toxicity, and low therapeutic index.

65 specific targeting are needed to enhance its therapeutic index.

66 towards developing compounds with a maximal therapeutic index.

67 entification of LXR modulators with improved therapeutic indexes.

68 ar M. tuberculosis MIC values and acceptable therapeutic indexes.

69 ng glioma lines and xenografts with improved therapeutic index, a finding with potential translationa

70 We used the IMS Health National Disease and Therapeutic Index, a nationally representative audit of

71 inical characterization suggests an adequate therapeutic index, aided by low projected human oral pha

72 dermatologists from the National Disease and Therapeutic Index (an IMS Health Incorporated database)

73 This novel molecule demonstrated an improved therapeutic index (analgesia vs adverse effects) in rode

74 monly prescribed anticoagulant with a narrow therapeutic index and a large variation in individual do

75 Warfarin is a drug with a narrow therapeutic index and a wide interindividual variability

76 serum albumin (HSA) may demonstrate a higher therapeutic index and be suitable for treatment of PCa b

77 a tailored approach would maximize both the therapeutic index and cost-effectiveness of treatments.

78 ck liposomal delivery systems to improve the therapeutic index and decrease systemic toxicity.

79 l adrenal hyperplasia (CAH) but has a narrow therapeutic index and dose optimisation is challenging.

80 The improved therapeutic index and elimination of corticosteroid prem

81 ers has the potential to improve further the therapeutic index and extend the spectrum of clinical PD

82 model predicts that they would have a higher therapeutic index and greater antitumour activity than m

83 This selectivity may lead to a broader therapeutic index and help explain the greater antitumor

84 We propose that ormeloxifene has high therapeutic index and in a combination therapy with gemc

85 ndence, leading to a narrowing of the drug's therapeutic index and increased side effects.

86 However, concerns associated with its narrow therapeutic index and its concentration-dependent mechan

87 ouse model, 90Y-DOTA-peptide-ChL6 had a high therapeutic index and LD(50/30) leading to a 79% respons

88 hort path length, potentially increasing the therapeutic index and making them an attractive alternat

89 inhibition of NF-kappaB may have a superior therapeutic index and may constitute a viable therapeuti

90 The available ICSs vary in their therapeutic index and potency.

91 ibition of ERK signalling results in a broad therapeutic index and RAF inhibitors have remarkable cli

92 ic agents is an important way to improve the therapeutic index and reduce side effects.

93 mib nanoparticles that demonstrates improved therapeutic index and the potential to improve patient o

94 Warfarin has a narrow therapeutic index and there is wide interindividual vari

95 prepare material to determine their relative therapeutic index and to gain an oversight as to their p

96 ivity profile that may result in an improved therapeutic index and, consequently, better clinical eff

97 le in human plasma for more than 24 h with a therapeutic index approaching 30000.

98 o group of patients for whom agents of lower therapeutic index are appropriate first-choice antiemeti

99 novel inhibitors of autophagy with a better therapeutic index are needed.

100 ng treatment delivery systems to enhance the therapeutic index are ongoing challenges.

101 nsfer vectors may allow improvement of their therapeutic index, as lower doses can be administered to

102 ly improved potency, working toward a higher therapeutic index at the earliest stages of drug develop

103 and sold as racemates can exhibit a limited therapeutic index because of side effects resulting from

104 n vivo conversion of CPT-11 and increase the therapeutic index, bifunctional derivatives of SN-38 wer

105 Illudins have a low therapeutic index, but acylfulvene derivatives display p

106 nt of patients with cancer could improve the therapeutic index by allowing better individualisation o

107 ounds to particular cell subsets can enhance therapeutic index by concentrating their action on the c

108 s over oral therapies in terms of increasing therapeutic index, by maximizing drug delivery to cartil

109 hibitor of HCV (EC50 = 4.6 nM), with greater therapeutic index (CC50/EC50 > 10000).

110 compound 9 was >100 muM, corresponding to a therapeutic index (CC50/EC50) of approximately 100.

111 the GEMCAP combination does not improve the therapeutic index compared to GEM alone.

112 Thus, this compound has a much wider therapeutic index compared with that of the existing ant

113 the ID regimen has a significantly improved therapeutic index compared with the CD regimen.

114 gh variability in drug response and a narrow therapeutic index complicate warfarin therapy initiation

115 This improvement in therapeutic index correlated with the selective localiza

116 ts level of myelotoxicity indicates that the therapeutic index could be altered by changing the metho

117 to that of wild-type Ad5, thus enhancing the therapeutic index (cytotoxicity in tumor cells versus th

118 tail pharmacies and the National Disease and Therapeutic Index database provided data on patient visi

119 y effectiveness and rational improvements in therapeutic index depend on understanding the mechanism.

120 position that bioequivalence for the narrow therapeutic index drug tacrolimus translates from health

121 that the criteria for registration of narrow therapeutic index drugs are going to change, and bioequi

122 ting that during meropenem treatment, narrow therapeutic index drugs metabolized by these CYPs requir

123 Agency (EMA) acceptance criteria for narrow therapeutic index drugs were also met, with the only exc

124 Among narrow therapeutic index drugs, clinical equivalence was report

125 and for selecting dosing regimens for narrow-therapeutic-index drugs.

126 The enhanced therapeutic index due to folate conjugation was also evi

127 These drugs have a poor therapeutic index due to toxicity caused by additional e

128 Cardiovascular drugs with narrow therapeutic indexes (e.g., antiarrhythmic agents, antico

129 rodents shows it to have at least as good a therapeutic index (efficacy/toxicity) as that of water-s

130 olite, exhibiting reduced toxicity, improved therapeutic index, enhanced pharmacodynamic effect, and

131 orted the long duration of action and a wide therapeutic index following administration to the lung,

132 icient breast cancers and shows a favourable therapeutic index for a novel targeted treatment strateg

133 rovides a remarkable improvement in the drug therapeutic index for cancer, Alzheimer's disease, and o

134 cells supports a mitochondrial basis to the therapeutic index for chemotherapy.

135 demonstrate an in vivo single-dose curative therapeutic index for CV787 of over 1000:1.

136 effective treatment option with a favorable therapeutic index for first-line treatment of advanced o

137 boronic ester bond formation to enhance the therapeutic index for improved patient outcome.

138 ate a modest but definite improvement in the therapeutic index for indolyl-ASC compared with tacrolim

139 tions studies in diabetic minipigs, a higher therapeutic index for MK-2640 (threefold) was observed v

140 delivery (CED) of liposomes may improve the therapeutic index for targeting brain tumors, we conduct

141 n cell line revealed an encouraging in vitro therapeutic index for the most active compounds.

142 e a more straightforward path to an improved therapeutic index for this clinically vital but also hig

143 mum dThdPase upregulation would increase the therapeutic index for this combination.

144 encies, suggesting the possibility of a wide therapeutic index for use of Taspase1 inhibitors in canc

145 cord, concerns remain for approval of narrow therapeutic index generic immunosuppressants, such as ta

146 omolar anti-HIV potencies, with advantageous therapeutic indexes going close to those of the clinical

147 established BCL xenografts leading to cures (therapeutic index > 10).

148 iviral activity against HIV-1 and HBV with a therapeutic index >100000 for our most potent conjugate.

149 ivo to produce agents with a relatively wide therapeutic index (>500) in rodents.

150 otent antibacterial agent with low toxicity (Therapeutic Index>200).

151 among individuals and for the existence of a therapeutic index has remained obscure.

152 Improvements in the therapeutic index have been based mainly on physical imp

153 result in a series of compounds with a good therapeutic index, having potent anticancer activity and

154 r validating new anticancer drugs, assessing therapeutic index, identifying surrogate markers of tumo

155 y bioequivalence testing approach for narrow therapeutic index immunosuppressants in transplant recip

156 , and all SSTR2-expressing organs; thus, the therapeutic index improved considerably.

157 response to CIRT, i.e., CIRT may show a high therapeutic index in EGFR mutation-negative NSCLC.

158 log of ABT-737, navitoclax, has shown a high therapeutic index in lymphoid malignancies; developing a

159 ed on day 1, demonstrates the most favorable therapeutic index in patients with advanced NSCLC.

160 ns may provide the biochemical basis for the therapeutic index in response to flavopiridol.

161 o PMB in vivo, suggesting a lack of improved therapeutic index in spite of apparent in vitro advantag

162 with certain HDAC inhibitors may elevate the therapeutic index in the treatment of hematologic malign

163 emcitabine and PLD seem to have a comparable therapeutic index in this population of Pt-R taxane-pret

164 lar in in vitro activity, SS2 had a superior therapeutic index in vivo with at least 8-fold more bein

165 vitro toxicity assay, and showed an improved therapeutic index, in comparison to the parent drug, MTM

166 tion of specific neural circuits to optimize therapeutic index is an unrealized goal in neurology and

167 The challenge of achieving an optimal therapeutic index is especially augmented in the elderly

168 l for cancer chemotherapy, in which a narrow therapeutic index is frequently observed.

169 d receptor (GR) modulators with an increased therapeutic index is impelling.

170 The enzymatic therapeutic index is only 42 in favoring inhibition of t

171 toxicity suggests that an improvement in the therapeutic index is required.

172 One approach to improving IFN-alpha's therapeutic index is to increase its half-life and tumor

173 terogenous conjugates with relatively narrow therapeutic index (maximum tolerated dose/curative dose)

174 These results suggest that a positive therapeutic index may be generated for other drug combin

175 We used the National Disease and Therapeutic Index (NDTI) (produced by IMS HEALTH, Plymou

176 n replication was approximately 5 nM, with a therapeutic index of >10,000.

177 n EC(50) value of 7.21 x 10(-6) microM and a therapeutic index of >2.08 x 10,(7) which were much bett

178 subcutaneous metrazol (scMET) models with a therapeutic index of 10 for MES activity.

179 The therapeutic index of 131I-Lym-1 was favorable, although

180 linical trials have been conducted, the poor therapeutic index of 5-FU has precluded its clinical use

181 c effect is approximately 2.2 microM, with a therapeutic index of 60, and it is not active against a

182 ld have significant utility in expanding the therapeutic index of a range of clinical and preclinical

183 eavable linkers are unlikely to increase the therapeutic index of ADCs and that resistance based on l

184 In an effort to improve the therapeutic index of adefovir, 1-aryl-1,3-propanyl prodr

185 These findings imply that the therapeutic index of anthracycline cancer chemotherapeut

186 herapies, the data strongly imply a superior therapeutic index of anti-FcmuR CAR T cells for the trea

187 In principal, the therapeutic index of antibodies directed against these a

188 Multistep targeting can improve the therapeutic index of antibody-based targeting, particula

189 l (IP) administration can be used to improve therapeutic index of anticancer drugs used for PC treatm

190 therapy error, and the high toxicity and low therapeutic index of anticancer medications make safety

191 esting that APE1 might have an impact on the therapeutic index of antiviral compounds in this categor

192 The dramatically improved therapeutic index of bispecific antibody pretargeting ap

193 ndamaging blocking peptides may increase the therapeutic index of both IL-2, as well as ITs prepared

194 TLR5 agonists could potentially improve the therapeutic index of cancer radiotherapy and serve as bi

195 gies used to improve the bioavailability and therapeutic index of capsaicin are discussed in detail.

196 lectively to tumor cells, thus improving the therapeutic index of chemotherapeutic agents.

197 This increased delivery increases the therapeutic index of cisplatin and reduces side effects

198 ar permeability in the tumor to increase the therapeutic index of co-administered drugs.

199 or activity, resulting in an increase in the therapeutic index of CPT-11.

200 lationship, leading to improvements upon the therapeutic index of current standard-of-care chemothera

201 t and selective agents should improve on the therapeutic index of currently used drugs.

202 nvironment have been explored to improve the therapeutic index of cytotoxic drugs.

203 The therapeutic index of DDCs was 2-3-fold higher than uncon

204 sed as a potential prodrug for improving the therapeutic index of Dox and potentially many other cyto

205 tic and colorectal cancer cells improved the therapeutic index of doxorubicin with C646 cotreatment.

206 IONS: This review provides evidence that the therapeutic index of drugs is narrowed during hypothermi

207 Systemic injection with iRGD improved the therapeutic index of drugs of various compositions, incl

208 ug-resistant tumor cells and may enhance the therapeutic index of etoposide.

209 t of novel anti-cancer agents and the narrow therapeutic index of existing drugs.

210 tion of antitumor activity, and an increased therapeutic index of FUra administered on single dose, d

211 2, to provide significant improvement of the therapeutic index of FUra alone and in combination with

212 aintenance of tmTNF activity may improve the therapeutic index of future anti-inflammatory agents.

213 lymphocyte infusions, which may optimize the therapeutic index of graft-versus-host reactivity.

214 (ERBB2) signaling translated to an improved therapeutic index of hSGZ treatment.

215 To improve the therapeutic index of IFO, we have designed preactivated

216 nalysis is needed in order to understand the therapeutic index of imatinib in SSc.

217 o facilitate tumor detection and improve the therapeutic index of IPC for peritoneal carcinomatosis.

218 the addition of Apo2L/TRAIL can improve the therapeutic index of irinotecan against both p53-profici

219 The therapeutic index of L-alanosine can be increased by the

220 onducted in an effort to further improve the therapeutic index of Lym-1-based radioimmunotherapy.

221 action and hold great promise to improve the therapeutic index of many drugs.

222 The therapeutic index of many medications, especially in chi

223 selective replication levels to improve the therapeutic index of MV and other viruses in ongoing cli

224 V of ODG-PFA was 0.43+/-0.27 microM, and the therapeutic index of ODG-PFA after intravitreal injectio

225 Fever may therefore augment the therapeutic index of oncolytic viruses by inhibiting rep

226 0 could be a future target for improving the therapeutic index of opioid drugs.

227 alysis justify prospective evaluation of the therapeutic index of PCB regimen in elderly patients.

228 archers and clinicians is how to improve the therapeutic index of present and future therapies, ident

229 ine tumor model systems for the efficacy and therapeutic index of replication-selective oncolytic ade

230 c antigen targeting is likely to enhance the therapeutic index of rNDV owing to tumor-restricted repl

231 as a drug delivery vehicle for improving the therapeutic index of SN-38, the active metabolite of iri

232 Enzyme activation of prodrugs to improve the therapeutic index of specific anticancer agents is an at

233 The therapeutic index of such drugs is theoretically limited

234 This approach may increase the therapeutic index of T cells engineered to express power

235 PNA enhances the therapeutic index of TEMPOL, and the recycling antioxida

236 e cells to circumvent MDR and to enhance the therapeutic index of the chemotherapy.

237 articular interest, as they may increase the therapeutic index of the cytokine payload.

238 ine to cobalamin is expected to increase the therapeutic index of the drug by limiting the side effec

239 The goal of this study was to improve the therapeutic index of the herpes simplex virus-thymidine

240 To determine the factors governing the therapeutic index of the labeled MAb, as well as the fac

241 oring and, perhaps ultimately, the potential therapeutic index of the oral class of GP IIb/IIIa antag

242 test barrier to such treatment is the narrow therapeutic index of the vitamin K antagonists ([VKAs]:

243 about by alkylating agents, to increase the therapeutic index of therapies including BG, and for use

244 th radiotherapy in an attempt to improve the therapeutic index of therapy.

245 cent advances hold promise for improving the therapeutic index of these anti-cancer drugs.

246 rmediate as a means of addressing the narrow therapeutic index of these molecules.

247 The drug interaction and the narrow therapeutic index of this drug combination required care

248 The therapeutic index of V681 was improved 90- and 23-fold a

249 deleterious side effects, and increasing the therapeutic index of virotherapeutic agents.

250 anomolar and low micromolar lethal doses and therapeutic indexes of 500 and 75, respectively.

251 Some are novel bactericidal inhibitors with therapeutic indexes of 9, 38 and 12, significantly highe

252 With the aim of increasing therapeutic indexes of novel cyclic depsinonapeptide pse

253 abine followed by gefitinib may increase the therapeutic index over gemcitabine alone and, combined w

254 108491 exhibited more than 270-fold improved therapeutic index over the naturally occurring VDR ligan

255 superior with a significant increase in the therapeutic index over the other sequences tested.

256 acy while providing a significantly improved therapeutic index over vasodilation (flushing) with resp

257 agnosed glioblastoma (GBM) by increasing the therapeutic index, overcoming common mechanisms of temoz

258 The enhanced therapeutic index provided by the addition of IFN-beta t

259 ns in humans offers the potential to improve therapeutic index, reduce cost of therapy and support a

260 Insulin has a narrow therapeutic index, reflected in a small margin between a

261 Compound 2g displayed a good therapeutic index regarding free fatty acids (FFA) reduc

262 ic brain regions to potentially increase the therapeutic index relative to known non-TARP-dependent A

263 n inhibitors with improved HMGR affinity and therapeutic index relative to statin-induced myalgia.

264 -5-yl) ascomycin derivative with an improved therapeutic index relative to tacrolimus.

265 ay improved potency over MOE and an improved therapeutic index relative to that of LNA antisense olig

266 ly to the site of action and may improve the therapeutic index required to overcome side effects.

267 odies after their infusion can enhance their therapeutic index, resulting in improved therapeutic and

268 However, for drugs with a narrow therapeutic index, serious concerns about generic equiva

269 itaxel derivatives have been shown to have a therapeutic index superior to paclitaxel itself.

270 icate that BAY 50-4798 may exhibit a greater therapeutic index than IL-2 in humans in the treatment o

271 yc4PG-14 and Tyc4PG-15, have a 6-fold better therapeutic index than the natural tyrocidine.

272 gical complications, RBC transfusion holds a therapeutic index that exceeds that of many common medic

273 tent toxin, although at the cost of a narrow therapeutic index that may limit clinical use.

274 While efficacy may be hampered by a narrow therapeutic index, the contribution of biologic heteroge

275 On the basis of their activity and favorable therapeutic indexes, these compounds were identified as

276 cell were also measured in order to assess a therapeutic index (TI) of selectivity.

277 showed stronger anti-HIV activity and higher therapeutic index (TI) values than their dihydrobetulin

278 Thus, the therapeutic index (TI) was >/= 10 for both compounds.

279 d classified as "pass" if a suitable in vivo therapeutic index (TI) was achieved for advancement into

280 (KB) cell line to enable an estimate of the therapeutic index (TI).

281 ivity with little or no motor impairment and therapeutic indexes (TI) of 2.8-44 (mice, ip) were obser

282 from 0.00032 to 0.0057 microM and remarkable therapeutic indexes (TI) ranging from 5.6 x 10(3) to 1.1

283 rticularly in children, achieving an optimal therapeutic index to avoid damage to normal tissue is ex

284 , 4'R)-(+)-cis-khellactone showed EC(50) and therapeutic index values of <5.25 x 10(-5) microM and >2

285 been approved on the basis of efficacy, the therapeutic index varies substantially in different sett

286 which demonstrated a significantly enhanced therapeutic index versus ciprofloxacin for the treatment

287 The therapeutic index was adversely affected by metabolism o

288 ne marrow) absorbed dose ratio, that is, the therapeutic index, was higher in the THW-aided than rhTS

289 To enhance DON's therapeutic index, we utilized a prodrug strategy to inc

290 dentification of GR ligands with an improved therapeutic index, we wished to discover selective nonst

291 To improve their therapeutic indexes, we have now identified and tested 1

292 y to normal cells should also provide a high therapeutic index when used in gene therapy protocols fo

293 4 is significantly attenuated and has a high therapeutic index with a cell specificity of 10,000:1 fo

294 exhibits characteristics predicting a higher therapeutic index with a greater potential to reach maxi

295 pplications such as imaging, determining the therapeutic index with antibody drug conjugates, and dos

296 Although Hsp90 inhibitors have a high therapeutic index with limited effects on normal cells,

297 These results indicate an improved therapeutic index with pretargeted radioimmunotherapy (R

298 release within a tumour results in improved therapeutic index with reduced toxicity.

299 duce apoptosis of CLL cells with a favorable therapeutic index, with enhanced killing of genomically

300 trials to determine whether improvements in therapeutic index within KRAS versus BRAF preclinical mo