ライフサイエンスコーパス: therapeutic potential

1 (UA) has attracted attention because of its therapeutic potential.

2 of MSAs to regulate MT activity and improve therapeutic potential.

3 t transcriptional pathways might offer broad therapeutic potential.

4 2-mediated protection from AKI, bears strong therapeutic potential.

5 eptor function and to support suggestions of therapeutic potential.

6 cts on neuronal physiology, as well as their therapeutic potential.

7 le cyclic peptide scaffold may enhance their therapeutic potential.

8 eens can now readily identify compounds with therapeutic potential.

9 ity of type III interferon signaling and its therapeutic potential.

10 with active ZIKV infection, highlighting its therapeutic potential.

11 ylation inhibitors for fully realizing their therapeutic potential.

12 CRIPTO/GRP78 signaling may have significant therapeutic potential.

13 ectivity, relevant mechanisms of action, and therapeutic potential.

14 nderway to understand its mechanisms and its therapeutic potential.

15 ving yields, and stabilizing conotoxins with therapeutic potential.

16 interest among researchers because of their therapeutic potential.

17 lecular information, with largely unexplored therapeutic potential.

18 tential 'on-off' switch of pDC activity with therapeutic potential.

19 uce axonal chemoattraction, which might have therapeutic potential.

20 ptides and oligonucleotides have significant therapeutic potential.

21 e basis of disease and generating cells with therapeutic potential.

22 ior protein degrading strategies have lacked therapeutic potential.

23 is process is crucial for establishing their therapeutic potential.

24 e, to identify novel molecular circuits with therapeutic potential.

25 e compounds possess similar or even enhanced therapeutic potential.

26 toxic which indicates that p-FTAA might have therapeutic potential.

27 of this peptide with improved stability and therapeutic potential.

28 ply mixing them with cells, to improve their therapeutic potential.

29 ed in many cancers and inhibitors could have therapeutic potential.

30 eceptor subtypes, these compounds might have therapeutic potential.

31 y for the discovery of ZCL278 derivatives of therapeutic potential.

32 targeting Mdm2 in p53-deficient cancers has therapeutic potential.

33 ducts with diverse biological properties and therapeutic potential.

34 eostasis using small molecules has promising therapeutic potential.

35 r-defective skin lesions of AD and indicates therapeutic potential.

36 ation and whether targeting this pathway has therapeutic potential.

37 will be critical to unlocking their ultimate therapeutic potential.

38 loitation of these mechanisms has tremendous therapeutic potential.

39 ntial to maximize their cardioprotective and therapeutic potential.

40 unity, but they have yet to live up to their therapeutic potential.

41 that targeting this signalling axis may have therapeutic potential.

42 l activities of fatty acids hold significant therapeutic potential.

43 identification of compounds for repurposing therapeutic potentials.

44 ctors and also assist in evaluation of their therapeutic potentials.

45 Our results offer insights into the therapeutic potential against ccRCC development by relie

46 novel class of broad-spectrum compounds with therapeutic potential against diverse severe infectious

47 Because neutralizing antibodies to EDE have therapeutic potential against ZIKV, in addition to their

48 studies focused on sex comparisons of their therapeutic potential and abuse liability, two specific

49 of useful pharmacological tools, agents with therapeutic potential, and in drugs of abuse (e.g., hall

50 ng in cardiovascular pathophysiology and its therapeutic potential are discussed, including heart fai

51 n active ligand, recombinant pBMP10 may have therapeutic potential as an endothelial-selective BMP li

52 nsformed biological research and offer great therapeutic potential by enabling the straightforward mo

53 inhibition of either CCL2 or CCR2 might bear therapeutic potential by reducing the inflammatory react

54 This suggests that targeting USP7 may have therapeutic potential even in tumors with defective p53

55 -establishment of immune tolerance and their therapeutic potential following congenic bone marrow tra

56 T-cell receptor (TCR) has shown significant therapeutic potential for both hematological and solid t

57 of PTX3 in response to GroEL, which thus has therapeutic potential for clearance of bacterial infecti

58 ns with TGFbeta may therefore increase their therapeutic potential for clinical applications.

59 use model support both a pathogenic role and therapeutic potential for eIF2alpha pathway perturbation

60 HIV-infected microglia/macrophages, offering therapeutic potential for HAND.

61 n antihypertrophic regulator, underlying its therapeutic potential for HF, and suggest possible benef

62 burden and increases survival, suggesting a therapeutic potential for IL-17A.

63 attenuated inflammatory responses and shows therapeutic potential for inflammatory skin diseases.

64 ough RNA interference (RNAi) has significant therapeutic potential for injuries or diseases of tissue

65 pulation of the miR-155/LXR pathway may have therapeutic potential for IPF.

66 nt of miR-181b and its target genes provides therapeutic potential for limiting the progression of at

67 appaB signalling, suggesting miR-378a-3p has therapeutic potential for liver fibrosis.

68 rs LUAD further indicates its importance and therapeutic potential for lung cancer patients with spec

69 zers can also affect cell fate, suggesting a therapeutic potential for magnetically modulated mechani

70 Glucagon and thyroid hormone (T3) exhibit therapeutic potential for metabolic disease but also exh

71 The data suggest a meaningful therapeutic potential for mGluR5 NAMs in TSC, which warr

72 rowth on neuronal growth cones, indicating a therapeutic potential for neural repair.

73 cocorticoid pathway, suggesting its possible therapeutic potential for neuroinflammation in neurologi

74 thophysiology, especially with regard to the therapeutic potential for neuropsychiatric health.

75 nce of ongoing diabetic injury, suggesting a therapeutic potential for NOX-E36 in diabetic nephropath

76 TRIs also hold therapeutic potential for other indications, with four c

77 quired for dissemination and metastasis, has therapeutic potential for ovarian cancer metastasis, and

78 in ovarian cancer cells, which indicates its therapeutic potential for ovarian cancer.

79 utcomes in a murine model of ICH, suggesting therapeutic potential for patients with acute ICH.

80 tor alpha (RXRalpha) activation has a double therapeutic potential for PD, offering both neuroprotect

81 unction and indicate that mdivi-1 has a high therapeutic potential for PD.

82 mitochondrial respiration could possess any therapeutic potential for PD.

83 2 activity in oligodendrocytes is of obvious therapeutic potential for promoting efficient remyelinat

84 The results suggest that ketamine may have therapeutic potential for protection from ischaemic rena

85 e randomized clinical trials to assess their therapeutic potential for reducing adverse coronary even

86 h muscle cells (SMCs); further, it exhibited therapeutic potential for restenosis by inhibiting SMC a

87 dult hippocampal neurogenesis (AHN) may have therapeutic potential for reversing memory impairments.

88 s9 to either the DNA or the RNA repeats with therapeutic potential for several diseases.

89 that OTR antagonists may have unappreciated therapeutic potential for stress-induced psychiatric dis

90 res following neonatal hyperoxia and suggest therapeutic potential for targeting IL-33, ILC2s, and ox

91 w druggable target and unfolds its promising therapeutic potential for the development of more effect

92 on of the EDA/EDA receptor pathway has clear therapeutic potential for the future treatment of human

93 s, indicates that GPR91 antagonists may have therapeutic potential for the treatment of allergic and

94 GPR120 agonists have therapeutic potential for the treatment of diabetes, but

95 o sustain experiments aimed at assessing its therapeutic potential for the treatment of FGF-dependent

96 ucagon-like peptide-2 receptor agonists have therapeutic potential for the treatment of intestinal di

97 lso demonstrates that inhibition of BMK1 has therapeutic potential for the treatment of melanoma.

98 f certain myeloid cells by emphasizing their therapeutic potential for the treatment of neurological

99 compared with the drug regimens support its therapeutic potential for the treatment of SCD.

100 e farnesoid X receptor (FXR) has indicated a therapeutic potential for this nuclear bile acid recepto

101 diated secretion of MMP-3 into AH could have therapeutic potential for those cases of glaucoma that a

102 ation during inflammation and to explore its therapeutic potential for treating inflammatory diseases

103 suggest that maintaining Erk5 integrity has therapeutic potential for treating metabolic stress-indu

104 d to develop Ag-specific Tregs, which have a therapeutic potential for Treg-based therapies of autoim

105 These data highlight the therapeutic potential for TRPV1 agonism for stroke treat

106 Therefore, Bik peptides may have therapeutic potential in airway diseases associated with

107 we provide the first evidence that IL-3 has therapeutic potential in amelioration of degeneration of

108 abotropic glutamate receptor 5 (mGluR5) have therapeutic potential in autism spectrum disorders (ASD)

109 The inhibition of ENaC may have therapeutic potential in CF airways by reducing sodium h

110 of the epithelial sodium channel (ENaC) have therapeutic potential in CF airways to reduce hyperstimu

111 eplication by VP35-targeting LNP confirm its therapeutic potential in combatting this lethal disease.

112 operative Ang1 supplementation may also have therapeutic potential in conjunction with adjuvant chemo

113 restore airway NO production and may have a therapeutic potential in diseases in which there is a de

114 Tacrolimus repurposing has therefore therapeutic potential in HHT.

115 ad very high engraftment, proliferation, and therapeutic potential in host mouse hearts.

116 erone system previously demonstrated to have therapeutic potential in hypertensive cardiomyopathy whe

117 a potent, selective RORgammat modulator with therapeutic potential in IL-23/IL-17 mediated autoimmune

118 ells have been previously assessed for their therapeutic potential in individuals with heart failure

119 arasite survival or serendipitously, exhibit therapeutic potential in inflammatory disease.

120 tes are recruited to the colon that may have therapeutic potential in intestinal inflammation, IBD, a

121 s in Cln3(Deltaex7/8) mice and support their therapeutic potential in JNCL patients.

122 gs identify the LDTg as a novel nucleus with therapeutic potential in mediating amylin's effects on e

123 myeloid differentiation in leukemia and have therapeutic potential in myelomonocytic and monocytic AM

124 rect germinal activity in the SVZ, which has therapeutic potential in neurodegenerative diseases.

125 Targeting human mINDY may have therapeutic potential in obese patients with nonalcoholi

126 d that modulating this signaling pathway has therapeutic potential in Parkinson disease.SIGNIFICANCE

127 etaminophen detoxification and implicate its therapeutic potential in patients with ALF.

128 and suggest that targeting this pathway has therapeutic potential in Peutz-Jeghers syndrome.

129 xytocin (OT) is increasingly studied for its therapeutic potential in psychiatric disorders, which ar

130 D1L in adipose tissue may have a significant therapeutic potential in reducing obesity and insulin re

131 novel role as an adipogenesis inducer with a therapeutic potential in soft tissue reconstruction and

132 logical functions of ANG and has significant therapeutic potential in solid and hematopoietic cancers

133 ted in cancer, tankyrase inhibitors may have therapeutic potential in targeting this pathway.

134 Signaling through cGMP has therapeutic potential in the colon, where it has been im

135 Thus, CBD may have therapeutic potential in the treatment of alcoholic live

136 omes from iPSC derivatives and discuss their therapeutic potential in the treatment of CVD.

137 odomain-containing protein 9 (BRD9) may have therapeutic potential in the treatment of human malignan

138 including their phosphoramidates, for their therapeutic potential in the treatment of virus infectio

139 d macrophage targeted interventions may have therapeutic potential in these tumors.

140 specific human Tregs markedly enhances their therapeutic potential in transplantation and sets the st

141 gesting that PI3Kdelta inhibition could have therapeutic potential in treating inflammatory diseases.

142 e and functions as a drug sensitizer, with a therapeutic potential, in MLL-rearranged AML.

143 However, since the discovery of its therapeutic potential, no ligand has been successfully d

144 The therapeutic potential of (131)I-CLR1404 was evaluated in

145 study provides experimental evidence for the therapeutic potential of 81.39a against diverse influenz

146 t models, provide the first evidence for the therapeutic potential of a stabilized alphaAnalogue, by

147 In this study, we focus on the therapeutic potential of a synthetic cardio-protective a

148 The therapeutic potential of ACKR3 has also been demonstrate

149 eir anti-leukemia functions and reducing the therapeutic potential of adoptive cell transfers.

150 cclusion models of stroke to investigate the therapeutic potential of adoptive regulatory T cell tran

151 Research into the therapeutic potential of alpha-calcitonin gene-related p

152 These results suggest a therapeutic potential of alpha7nAChR agonists in early r

153 Notably, the therapeutic potential of AMPK is widely recognized and h

154 Moreover, they demonstrate the therapeutic potential of an antibody-drug conjugate targ

155 in clinical trials as a means to extend the therapeutic potential of antibodies.

156 nduced models of colitis and investigate the therapeutic potential of BAR501, a small molecule agonis

157 ies with the R6/2 mice, highlight the strong therapeutic potential of bezafibrate for treatment of HD

158 Finally, to examine the therapeutic potential of blocking the recruitment of bro

159 ble, monodisperse in size, and maximizes the therapeutic potential of both the particles interior and

160 acute ischemic exposure will compromise the therapeutic potential of cell-based insulin replacement.

161 use model suggests that investigation of the therapeutic potential of cerebellar neuromodulation in A

162 cut lung slices were used to investigate the therapeutic potential of CFTR modulation on airway react

163 Highlighting the therapeutic potential of CHK1's role in GOF p53 dependen

164 he goal of this study was to investigate the therapeutic potential of CN-105 in a murine model of clo

165 Here, we examined the therapeutic potential of combining a direct tumor-target

166 ing cell potency assays, and determining the therapeutic potential of conditioned media derived from

167 Our aim was to examine the therapeutic potential of crenolanib, an inhibitor of PDG

168 Here, to investigate the therapeutic potential of CRISPR/Cas9 in a diverse set of

169 Overall, our results demonstrate the therapeutic potential of CXCR4 inhibition in neuroblasto

170 a rationale for further investigation on the therapeutic potential of dacomitinib in treatment of the

171 a high quality chemical probe to explore the therapeutic potential of disrupting the KEAP1-NRF2 inter

172 To investigate the therapeutic potential of ELNs induction, preclinical mod

173 Despite this high potency, the therapeutic potential of GeXIVA is limited, because like

174 Thus, we tested the myocardial therapeutic potential of GHRH stimulation in vitro and i

175 ell established dopaminotrophic effects, the therapeutic potential of glial cell line-derived neurotr

176 These results underscore the therapeutic potential of glycoengineering in vivo.

177 The therapeutic potential of GPR88 therefore extends to cogn

178 rmone glucagon-like peptide-1 highlights the therapeutic potential of gut-derived signals acting via

179 tand the in vivo functions and translational therapeutic potential of hDPSCs and other stem cells, se

180 Here we provide preclinical evidence of the therapeutic potential of high-frequency stimulation of t

181 We investigated the therapeutic potential of human induced pluripotent stem

182 We investigated the therapeutic potential of hydrodynamic isotonic fluid del

183 of action of this cytokine and emphasize the therapeutic potential of IFN-lambda for treating mucosal

184 uld inspire efforts toward investigating the therapeutic potential of IL-1 blockade in MS.

185 uld be Foxp3 independent, and underscore the therapeutic potential of IL-10-secreting CD49b(+) Treg c

186 ntrol of Notch transport and demonstrate the therapeutic potential of inhibiting GnT-III as a treatme

187 ne/chemokine expression, we investigated the therapeutic potential of inhibiting the JAK/STAT pathway

188 rive tumour progression, and we validate the therapeutic potential of inhibiting this pathway with th

189 emotherapy drug cisplatin, demonstrating the therapeutic potential of inhibiting USP7 by this approac

190 hepatic Apob translation and demonstrate the therapeutic potential of inhibiting vigilin for cardiova

191 These findings show a therapeutic potential of intranasal administration of in

192 To test the therapeutic potential of laropiprant, WT mice subjected

193 Our research highlights the therapeutic potential of LB100, and provides new insight

194 on and warrants further investigation of the therapeutic potential of lipoxin using in vitro cell mod

195 erleukin-15 (IL-15), this study explored the therapeutic potential of liver-directed gene transfer of

196 We evaluated the therapeutic potential of mesenchymal stem cell-condition

197 ing to determine ways to further improve the therapeutic potential of mesenchymal stromal cells.

198 the microbiota, as well as highlighting the therapeutic potential of microorganisms in tumourigenesi

199 The therapeutic potential of miRNA (miR) in cancer is limite

200 To address the immense therapeutic potential of miRNAs and their antagomirs, an

201 The therapeutic potential of mitochondrial uncouplers has be

202 ce, suggesting both biological relevance and therapeutic potential of modulating polyadenylation patt

203 Yet, the therapeutic potential of modulation of the microbiota af

204 To evaluate the therapeutic potential of MSCs in the treatment of steroi

205 We here explore the therapeutic potential of naked and adeno-associated viru

206 a represent novel targets for augmenting the therapeutic potential of NK cells.

207 issues, and provide an introduction into the therapeutic potential of periodontal miRNAs.

208 Here we investigate the therapeutic potential of phycocyanin as an anti-PDA agen

209 ro and LADC growth in vivo demonstrating the therapeutic potential of PKCiota-ELF3-NOTCH3 signal inhi

210 This study underscores the therapeutic potential of PrP(C) deletion given that pati

211 provide proof-of-principle evidence for the therapeutic potential of PSC-derived islets generated by

212 Recent studies have assessed the therapeutic potential of psilocybin for various conditio

213 Our results demonstrate the therapeutic potential of PUMA gene therapy as a local tr

214 Furthermore, we explored the therapeutic potential of recombinant Emc10 delivered by

215 Previously, we demonstrated the therapeutic potential of recombinant human TRAIL in expe

216 The therapeutic potential of renal denervation (RDN) for arr

217 Our results reveal the therapeutic potential of reprogramming MO in the context

218 The therapeutic potential of restoring let-7 levels using a

219 per cell polarization and to investigate the therapeutic potential of ruxolitinib in treating autoimm

220 es satellite cell activity, underscoring the therapeutic potential of satellite cells in the preventi

221 cer proliferation, shedding new light on the therapeutic potential of selective ER modulation.

222 oratory study in human cirrhosis suggest the therapeutic potential of selective renal vasodilation us

223 In this study, we examined the therapeutic potential of selinexor (XPO1 inhibitor) agai

224 ical trial is in progress to investigate the therapeutic potential of SGN-CD19B in relapsed/refractor

225 We examined the safety and therapeutic potential of SH-11037, a synthetic derivativ

226 tive role of Shh signaling and highlight the therapeutic potential of Shh mimetics against CNS compli

227 Furthermore, the therapeutic potential of silencing miR-34a in settings o

228 ential prognostic marker and demonstrate the therapeutic potential of SK1 in this gynecologic maligna

229 The therapeutic potential of small molecule Gbetagamma-GRK2

230 These results support the therapeutic potential of small-molecule TFEB activators

231 The therapeutic potential of some of these modulators has be

232 The therapeutic potential of stem cells or their differentia

233 We demonstrate for the first time the therapeutic potential of such a stimulation strategy for

234 The therapeutic potential of targeted ROCK2 inhibition in th

235 The present review highlights the therapeutic potential of targeting B7-H4.

236 These results demonstrate the therapeutic potential of targeting metabolic pathways in

237 ks in ILC2s and TH2 cells, and reinforce the therapeutic potential of targeting miR-19 to alleviate p

238 y more than 100-fold, thus demonstrating the therapeutic potential of targeting mycomembrane biosynth

239 groundwork for future studies assessing the therapeutic potential of targeting Nck in aggressive can

240 gioleiomyomatosis growth and demonstrate the therapeutic potential of targeting Syk in this and other

241 Furthermore, we demonstrate the therapeutic potential of targeting the RBBP4-BCL11A bind

242 Our results highlight the therapeutic potential of targeting the STAT/TET1 axis by

243 ve development and disease and elucidate the therapeutic potential of targeting this pathway to arres

244 urther studies are required to elucidate the therapeutic potential of targeting TSG-6 after CNS injur

245 glucose metabolism, but also highlights the therapeutic potential of targeting YAP-BCAR4-glycolysis

246 it provides new opportunities to harness the therapeutic potential of the cannabinoid system and othe

247 This indicates the therapeutic potential of the CGRP pathway and the possib

248 We tested the therapeutic potential of the clinical-grade alkyl-phosph

249 These results show the therapeutic potential of the first human RGMa antibody f

250 The therapeutic potential of the generated cells was assesse

251 Therefore, we investigated the therapeutic potential of the infiltrated CD163+ macropha

252 We have previously reported the therapeutic potential of the quinoline methanol Vacquino

253 Our study hints at the therapeutic potential of the selective activation of TME

254 In this study, we explored the therapeutic potential of the specialized proresolving me

255 DAR antagonists and therefore highlights the therapeutic potential of these drugs in managing type 2

256 ere is reason to remain optimistic about the therapeutic potential of these drugs.

257 vivo retention of biologic activity and the therapeutic potential of these factors.

258 Therapeutic potential of these liposome-based PAs has be

259 In addition to the therapeutic potential of these molecules for treatment o

260 ematic effort toward harnessing the enormous therapeutic potential of these small molecules will grea

261 In this report, we evaluated the therapeutic potential of these two classes of M2-S31N in

262 d an explosion in research investigating the therapeutic potential of these worms.

263 ls, current investigations aim to assess the therapeutic potential of this approach in pregnancy to e

264 nhibiting tryptophan synthase highlights the therapeutic potential of this enzyme and draws attention

265 teogenic differentiation, which suggests the therapeutic potential of this ion in orthopedics.

266 O-induced sleep disturbances, suggesting the therapeutic potential of this peptide.

267 The therapeutic potential of tocotrienol, a member of the vi

268 These results indicate the therapeutic potential of topical gentamicin for NPPK.

269 sented here provide a roadmap to uncover the therapeutic potential of transcriptional regulators for

270 f Wnt-dependent cancer cells, supporting the therapeutic potential of triptonide.

271 nduced pathology by Sunitinib highlights the therapeutic potential of tyrosine kinase inhibitors for

272 This is the first study to explore the therapeutic potential of using an IL-25 blocking antibod

273 motivation for exploring and evaluating the therapeutic potential of using lipoxins.

274 The therapeutic potential of vagus nerve modulation to atten

275 The therapeutic potential of varenicline would escalate if i

276 t has recently been proposed locally for its therapeutic potential on severely injured areas.

277 0s, there has been renewed interest in their therapeutic potential, particularly for the treatment of

278 cology and their role in catabasis for their therapeutic potential.-Serhan, C.

279 and why alpha4beta2-nAChR agonists may have therapeutic potential.SIGNIFICANCE STATEMENT The acetylc

280 r nectar and it is famous for its tremendous therapeutic potential since ancient times.

281 ions of this new definition as well as novel therapeutic potentials suggested by these advances.

282 d-spectrum antibacterial activity and better therapeutic potential than peptides.

283 ggest that Car enzyme inhibitors may possess therapeutic potential that can be used to treat mast cel

284 Modulating PTEN activity may have high therapeutic potential to alleviating the fibrosis of TM

285 d at preventing mitochondrial oxidation have therapeutic potential to ameliorate the toxic effects of

286 vides a pharmacologic target that could have therapeutic potential to delay DDD.

287 Thus, TanCAR T cells show therapeutic potential to improve glioblastoma control by

288 nd that inhibition of properdin function has therapeutic potential to limit thromboinflammation in di

289 t-Ras-HO-1 axis; and it can have significant therapeutic potential to prevent post-transplantation ca

290 sive and non-compulsive rats, indicating its therapeutic potential to promote abstinence and prevent

291 pothesis, but clinical trials to confirm the therapeutic potential to target inflammation to treat or

292 AGGF1 is an angiogenic factor with therapeutic potential to treat coronary artery disease (

293 ularly profile these cells and examine their therapeutic potential to treat spinal cord injury (SCI).

294 ristics justifying the conclusion that their therapeutic potential vastly outweighs the challenges in

295 ally transplanted to the injured animals and therapeutic potential was determined.

296 Therapeutic potential was most evident via a convection-

297 hysiological functions and validation of its therapeutic potential, we recently developed a new class

298 o the development of new interventions whose therapeutic potential will need to be assessed in adequa

299 rgeting this interaction has anti-thrombotic therapeutic potential with reduced bleeding risk.

300 ar and tissue level and presents significant therapeutic potential without altering the mechanism of