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1 ssion, ideally yielding factor levels in the therapeutic range.
2 l normalized ratio (INR) elevation above the therapeutic range.
3 in serum were within or above the suggested therapeutic range.
4 ged delay in return of the INR to within the therapeutic range.
5 tion of genetically corrected cells into the therapeutic range.
6 tion of genetically corrected cells into the therapeutic range.
7 rates of anticoagulation and similar time in therapeutic range.
8 hours, maintaining plasma levels within the therapeutic range.
9 was established as the lower margin for the therapeutic range.
10 elevant bleeding followed closely by time in therapeutic range.
11 INR variability, followed closely by time in therapeutic range.
12 e was positively associated with time in the therapeutic range.
13 culatory concentration of drugs within their therapeutic range.
14 s effectiveness relies on maintaining INR in therapeutic range.
15 at 1 and 3 months and percentage of time in therapeutic range.
16 thromboplastin time (p = .002) close to the therapeutic range.
17 dard of care, warfarin, by improving time in therapeutic range.
18 alation was 331 ng/mL, within the postulated therapeutic range.
19 e or fewer infusions to be maintained in the therapeutic range.
20 ed well with each other and with established therapeutic ranges.
21 s in whole blood throughout their individual therapeutic ranges.
22 to develop optimal dosing schedules based on therapeutic ranges.
23 from 0.03 to 0.35 microM, which falls in the therapeutic range (0.01-10 microM), and a limit of detec
24 , (2) intravenous heparin maintained in the "therapeutic" range (0.2 to 0.5 U/mL plasma), and (3) "ex
26 than, within, or greater than a prespecified therapeutic range (1.5-2.5 times control), respectively.
27 activity with carbamazepine levels above the therapeutic range (15.4-17.2 mg/ml), but the remaining f
30 ts with liver disease had lower mean time in therapeutic range (53.5%) when compared with patients wi
31 h a score of zero had modestly lower time in therapeutic range (56.7%) and no increase in hemorrhages
32 ersus 42% at 3 months; percentage of time in therapeutic range 69% versus 58%, 71% versus 59%, respec
34 st human tumor xenografts showed an improved therapeutic range (active/toxic dose in mg/kg body weigh
35 INR more than or equal to the lower limit of therapeutic range, adding either early INRs or genotypes
36 leeding was a combination of percent time in therapeutic range and INR variability (odds ratio of 4.3
37 red, drug levels generally remain within the therapeutic range and lactate concentrations are not sub
39 challenging in children because of a narrow therapeutic range and wide inter- and intra-individual v
41 abolized by cytochrome P450 2C, has a narrow therapeutic range, and is a commonly used antiepileptic
42 mus or cyclosporine levels that exceeded the therapeutic range, and none had other clinical evidence
43 vulsant drug levels in the upper half of the therapeutic range, and were not taking any other drugs t
46 widely used anticoagulant that has a narrow therapeutic range because of both genetic and environmen
47 ound a significant difference in the time in therapeutic range between the pharmacogenetic and standa
48 acrolimus trough concentrations in the usual therapeutic range can lead to elevated unbound concentra
50 As antibiotic concentrations decline below a therapeutic range, filamentous bacteria begin to divide
52 chronic treatment (well within the accepted therapeutic range for adults), produced significant depr
55 the test results, and establishment of a PFT therapeutic range for each antiplatelet drug should be c
58 for gamma-globin expression approaching the therapeutic range for sickle cell anemia and beta thalas
61 olimus trough concentration) and TAC time in therapeutic range for the risk of dnDSAs in a cohort of
63 canine factor IX (cFIX) concentrations at a therapeutic range for up to 2.5 months and normalization
64 ernational normalized ratio (INR) was in the therapeutic range from day 4 or 5 through day 28 of ther
69 e initial drug blood serum levels within the therapeutic range in children and adjusted throughout th
70 y and found no difference in the time in the therapeutic range in patients randomized to vitamin K co
71 nced patients assigned warfarin, the time in therapeutic range (international normalized ratio 2.0 to
73 activated partial thromboplastin time (aPTT) therapeutic range is required to ensure administration o
75 onal normalized ratio control (i.e., time in therapeutic range <65%) exhibited a faster decline in GF
76 t of higher rates of dnDSAs, and TAC time in therapeutic range may be a valuable strategy to stratify
77 of anticoagulation in patients to a set INR therapeutic range may be less secure than anticipated.
78 how that CBZ, at concentrations in the human therapeutic range, normalizes the voltage dependence of
82 f response or neurotoxicity by identifying a therapeutic range of 1.5 mg/L (>85% probability of respo
83 me measure was the percentage of time in the therapeutic range of 2.0 to 3.0 for the international no
86 one demonstrated CsA blood levels within the therapeutic range of human renal transplant patients.
87 n the case of epilepsy because of the narrow therapeutic range of most AEDs; clinical principles of p
89 in G6PD-deficient individuals to define the therapeutic range of primaquine to enable the safe roll-
97 thium maintenance therapy (lithium levels in therapeutic range) on the rate of change in eGFR over ti
99 rt continued use of INR variability, time in therapeutic range, or both for research and quality assu
100 a decreased time to the first INR within the therapeutic range (P=0.02) and to the first INR of more
101 ctor of the time to the first INR within the therapeutic range (P=0.57) but was a significant predict
102 n patients with increased individual time in therapeutic range (regression coefficient, 0.03; 95% con
103 (p < .0001 vs. placebo) within or above the therapeutic range, respectively, these did not decrease
105 hat oral methylphenidate at doses within the therapeutic range significantly increases extracellular
106 or IX concentrations, while remaining in the therapeutic range, slowly declined by 95% over a period
107 s on warfarin and amiodarone had time in the therapeutic range that was lower than patients not on am
108 es were the time to the first INR within the therapeutic range, the time to the first INR of more tha
110 sensitivity (time to INR >/= lower limit of therapeutic range; time to INR > 4; and first stable war
111 examine the relationship between time in the therapeutic range (TTR) and clinical outcomes in heart f
113 patients receiving warfarin, percent time in therapeutic range (TTR) and international normalized rat
114 BLED could be improved incorporating time in therapeutic range (TTR) in warfarin-treated patients.
118 comparisons with warfarin arms with times in therapeutic range (TTRs) of 55.2% to 64.9%, making the r
119 4 weeks, the mean percentage of time in the therapeutic range was 45.2% in the genotype-guided group
124 nternational normalized ratio was within the therapeutic range was higher in the intervention group t
125 patients, the mean percentage of time in the therapeutic range was less in the genotype-guided group
126 anticoagulants when the centre-based time in therapeutic range was less than 66% than when it was 66%
127 Frequency of INR testing and time in the therapeutic range were analyzed by age, sex, length of t
128 first in which concentrations of ASA in the therapeutic range were found to significantly reduce int
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