ライフサイエンスコーパス: therapeutic target

1 y establishing the microbiota as a potential therapeutic target.

2 ology is of great importance and a potential therapeutic target.

3 r biology and its utility as a biomarker and therapeutic target.

4 king it a potentially ideal dual-compartment therapeutic target.

5 rgeted therapies, and Mcl-1 as an attractive therapeutic target.

6 atients and therefore could be an attractive therapeutic target.

7 eviously identified as a potential human STS therapeutic target.

8 f diseases and thus represents an attractive therapeutic target.

9 vation of Pol III affirms its potential as a therapeutic target.

10 e in cancer, and its pathway may represent a therapeutic target.

11 is growing interest in LOX-1 as a potential therapeutic target.

12 hogenesis and to evaluate its potential as a therapeutic target.

13 gence between these pathways and a potential therapeutic target.

14 r, and neuropathies, making TRiC a potential therapeutic target.

15 opathic itch and identifying a new candidate therapeutic target.

16 t acid stress pathways represent a potential therapeutic target.

17 , highlighting ASM as a potential multimodal therapeutic target.

18 l-like TNBC and is considered as a potential therapeutic target.

19 BRAF-V600E also represents a new therapeutic target.

20 egulator of ROS induction and may be a novel therapeutic target.

21 M8-dependent manner, making ADAM8 a possible therapeutic target.

22 ures, highlighting HMGB1 as a possible novel therapeutic target.

23 cancer, making the TOR pathway an attractive therapeutic target.

24 ing RRM2B as a hypoxic-specific, anti-cancer therapeutic target.

25 ranged leukemia cells and identify potential therapeutic targets.

26 e, the PDK: E2.E3BP interaction provides new therapeutic targets.

27 highlighting metabolic systems as important therapeutic targets.

28 nic mechanisms hampers the identification of therapeutic targets.

29 duced myofibroblast activation that could be therapeutic targets.

30 ric small molecule acting on these important therapeutic targets.

31 disease and to identify novel biomarkers and therapeutic targets.

32 and have received considerable attention as therapeutic targets.

33 ing mechanisms of ALS and identify potential therapeutic targets.

34 ed in the failing heart and thus have become therapeutic targets.

35 gn and could lead to potential antimicrobial therapeutic targets.

36 d to novel diagnostic tools and reveal novel therapeutic targets.

37 M and its regulated network may be promising therapeutic targets.

38 perturbation on the RN behavior to identify therapeutic targets.

39 cytokines that will serve as biomarkers and therapeutic targets.

40 able proteins with shapes customized to bind therapeutic targets.

41 pic germinal centers are considered the main therapeutic targets.

42 entify novel PDAC-specific biomarkers and/or therapeutic targets.

43 ease processes and reveal new biomarkers and therapeutic targets.

44 sease mechanisms, and the discovery of novel therapeutic targets.

45 on of their function and their validation as therapeutic targets.

46 sors and increasingly considered as putative therapeutic targets.

47 e myeloma (MM), and thus represent potential therapeutic targets.

48 guide prognosis and selection of actionable therapeutic targets.

49 provides potential diagnostic biomarkers and therapeutic targets.

50 id in GSC isolation, diagnostic imaging, and therapeutic targeting.

51 n cells and pathways that may be amenable to therapeutic targeting.

52 EpAT as a risk marker and its potential as a therapeutic target against cardiovascular disease.

53 induced Treg cells can serve as a promising therapeutic target against ILC2-dependent asthma.

54 uced antihyperalgesia, and establish it as a therapeutic target against inflammatory and neuropathic

55 ect, and indicates that ABHD5 is a potential therapeutic target against mCRPC, the deadly aggressive

56 marker, and identifies LOXL2 as a potential therapeutic target against tumor progression.

57 The HBZ/NRF-1/TDP1 axis provides new therapeutic targets against ATL and might explain genomi

58 excessive scarring than modulation of either therapeutic target alone.

59 n preclinical validation of IDO1 as a cancer therapeutic target and on the discovery and development

60 ion will be highly dependent on the specific therapeutic target and the stage of PVR.

61 I conclude by highlighting novel therapeutic targets and approaches with particular promi

62 novel findings may guide us to discover new therapeutic targets and develop effective vaccines for W

63 which has led to the identification of novel therapeutic targets and improved stratification of risk.

64 TGFbeta1 in fibroblasts could be attractive therapeutic targets and lack upstream toxicity.

65 ite adipogenesis from human progenitors: new therapeutic targets and the caveats associated with the

66 mutations in FL, discuss their potential as therapeutic targets, and offer my perspective on unexplo

67 vely treat, and innovative interventions and therapeutic targets are needed.

68 Consequently, new therapeutic targets are urgently required to achieve thi

69 ogenesis, and aging and constitute important therapeutic targets, are prone to oxidative damage.

70 accurately and may lead to further effective therapeutic targets, better prognosis, and improved outc

71 or to the pathogenesis of MI and a potential therapeutic target, bolstering the idea that GM-CSF is a

72 Transcallosal pathways represent a promising therapeutic target, but their role in post-stroke recove

73 eg cell behavior and affects the efficacy of therapeutics targeting cancer checkpoints.

74 n disease studies, and the list of potential therapeutic targets continues to expand.

75 ement, we serendipitously identified a novel therapeutic target: DAT oligomer complexes.

76 Therefore, discovery and validation of therapeutic targets derived from the hypoxic tumor micro

77 ondary DNA structures are uniquely poised as therapeutic targets due to their molecular switch functi

78 considering multiple correlated pathways for therapeutic targets especially in proximal colon cancer.

79 vanced breast cancer, and validate HER2 as a therapeutic target even after multiple lines of previous

80 gests that P2X7R may constitute an important therapeutic target for a variety of neurological disorde

81 recovery, suggesting that TGF-beta1 may be a therapeutic target for acute brain injury.

82 t Ep3 receptor activation may be a promising therapeutic target for acute MI.

83 tate and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia.

84 em cell as the potential origin of and a key therapeutic target for acute myeloid leukemia (AML) and

85 ulating autophagy and establishes ErbB2 as a therapeutic target for AD.

86 ronal aging and position PERK as a promising therapeutic target for age-dependent brain malfunction.S

87 nt5a, Tgm2, and LTs, which might represent a therapeutic target for airway inflammation and remodelin

88 Thus, Dyrk1A might be an ideal therapeutic target for Alzheimer's disease, especially f

89 ogenesis and point to its potential as a new therapeutic target for angiogenesis-related diseases.

90 ncer supports the identification of FYN as a therapeutic target for breast tumors with heterozygous o

91 HDAC6, further implicating it as a potential therapeutic target for CF.

92 e identified the Nrf2 pathway as a promising therapeutic target for CKD.

93 d MPV might act as a marker of prognosis and therapeutic target for CRC.

94 the Hsp90 machinery has become an attractive therapeutic target for diseases such as cancer.

95 o, suggesting that DGKalpha is an attractive therapeutic target for DN.

96 tion in patients with EoE and is a potential therapeutic target for EoE and related eosinophilic and

97 l differentiation, thus offering a potential therapeutic target for HCC.

98 ys and suggest that Gab2 might be a powerful therapeutic target for HCC.

99 ts suggest that Foxp1 might be an attractive therapeutic target for HD.

100 ults suggest that KDM3A might be a potential therapeutic target for human breast cancer treatment and

101 OSM is thus a potential biomarker and therapeutic target for IBD, and has particular relevance

102 these novel findings identify claudin-3 as a therapeutic target for inhibiting overactivation of Wnt-

103 The GR is widely recognized as a therapeutic target for its ability to counter proinflamm

104 biomarker and diagnostic tool and a possible therapeutic target for limiting the impact of PANR in PD

105 e, implying that CDK20 is a novel, promising therapeutic target for lung cancer.

106 Although hFPPS is a well-established therapeutic target for lytic bone diseases, the currentl

107 The tip complex represents a promising therapeutic target for many important T3SS-containing pa

108 r metastasis and suggest PLD2 as a potential therapeutic target for metastatic breast cancer.

109 glycome may therefore be considered as a key therapeutic target for modulating the chronic inflammato

110 sm and demonstrate that SRPK2 is a potential therapeutic target for mTORC1-driven metabolic disorders

111 leotide repeats and reveal a novel promising therapeutic target for neuroprotection.

112 bral adenosine A2A receptor is an attractive therapeutic target for neuropsychiatric disorders.

113 tential to be a safer alternative peripheral therapeutic target for obesity.

114 Thus UBR5 may be an attractive therapeutic target for ovarian cancer treatment.

115 development as both a serum biomarker and a therapeutic target for ovarian cancer.

116 roptotic signaling, which may serve as a new therapeutic target for pathological remodeling and heart

117 lopment and suggest that NOX4 is a potential therapeutic target for PDAC.

118 hagy, a downstream pathway of mTOR, as a new therapeutic target for PKD.

119 3 and the type I IFN response as a potential therapeutic target for post-MI cardioprotection.

120 nsolidation, making this process a potential therapeutic target for posttraumatic stress disorder (PT

121 oint to the stria vascularis as an important therapeutic target for preventing cisplatin ototoxicity.

122 dicates that platelet miR-223 is a potential therapeutic target for prevention of arterial thrombosis

123 ory axis may therefore represent a potential therapeutic target for PSC treatment.

124 hlights the significance of KDM3A as a novel therapeutic target for resistant ovarian cancer.

125 ical role after SCI, and may provide a novel therapeutic target for SCI.

126 the ubiquitin pathway has shown promise as a therapeutic target for several forms of cancer.

127 and identifies alpha7 nAChRs as a promising therapeutic target for stress-related psychiatric disord

128 d indicating in OPA1 an attractive potential therapeutic target for TBI.

129 aintenance of TCL and represents a potential therapeutic target for TCL.

130 support the notion that SPHK1 is a bona fide therapeutic target for the treatment of AML.

131 (JAK2) has garnered attention as a promising therapeutic target for the treatment of CKD.

132 , these results identify USP7 as a promising therapeutic target for the treatment of hematological ma

133 ght that this system is a possible potential therapeutic target for the treatment of hypertension.

134 he metastatic process and its potential as a therapeutic target for the treatment of neuroblastoma.

135 for Tet2 and suggest that Tet2 may present a therapeutic target for the treatment of non-hematologic

136 galanin-opioid interactions and offers a new therapeutic target for the treatment of opioid use disor

137 pathogenesis and underscore its promise as a therapeutic target for this deadly disease.

138 at JNK/c-Jun/Notch1 signaling is a potential therapeutic target for TNBC.

139 capacity and highlight RHAMM as a candidate therapeutic target for treating advanced prostate cancer

140 CD4 T cells, highlighting its potential as a therapeutic target for treating autoimmune diseases.

141 these findings support the use of SnCs as a therapeutic target for treating degenerative joint disea

142 received increasing attention as a possible therapeutic target for treating disorders that stem from

143 h C. albicans, indicating that JNK1 may be a therapeutic target for treating fungal infection.

144 ional signaling pathway offers an innovative therapeutic target for treating hypoxic-ischemic human d

145 for UM progression and could be a potential therapeutic target for treating UM in the clinic.

146 en demonstrated as an essential molecule and therapeutic target for various cancer stem cells (CSCs)

147 s further investigation, as it may yield new therapeutic targets for acute stroke injury and other ne

148 ization in vivo and may represent attractive therapeutic targets for asthma.

149 ation of monocyte activity may provide novel therapeutic targets for attenuating this inflammation an

150 r progression in smokers, representing novel therapeutic targets for breast cancer patients who smoke

151 BET proteins are considered to be attractive therapeutic targets for cancer and other human diseases.

152 hold strong promise as novel biomarkers and therapeutic targets for cancer.

153 tissue identifies these cells as attractive therapeutic targets for CKD in humans.

154 ts suggest that RORalpha/gamma are important therapeutic targets for cutaneous inflammation and sugge

155 ds such as allopregnanolone may be potential therapeutic targets for depression and anxiety in tradit

156 t/HIF-1alpha pathway, thereby suggesting new therapeutic targets for disease treatment.

157 f these persulfurated species as well as the therapeutic targets for diseases in which these molecule

158 or role in tumorigenesis and offer promising therapeutic targets for HCC and other cancers.

159 d in vascular tissues and identify potential therapeutic targets for hypertension.

160 ms and the pathogen transporter may serve as therapeutic targets for infectious diseases.

161 intestinal barrier dysfunction may be novel therapeutic targets for intervention to suppress CKD-rel

162 pain in EAE, which may ultimately offer new therapeutic targets for mitigating pain in multiple scle

163 to monitor disease progression and identify therapeutic targets for patients.

164 N-terminal kinase and NF-kappaB as potential therapeutic targets for prevention of squamous cell carc

165 the potential of lipid metabolism and ROS as therapeutic targets for reducing tumor recurrence in bre

166 interactor, LR/37/67 kDa, could be potential therapeutic targets for schwannomas and other Merlin-def

167 Recent studies have suggested possible therapeutic targets for some patients with early-onset g

168 markers of specific biological processes or therapeutic targets for specific diseases or patient typ

169 bolic pathways, which may identify potential therapeutic targets for the disease.

170 Several of these processes may be potential therapeutic targets for the prevention and treatment of

171 work for the identification of new potential therapeutic targets for this devastating condition.

172 quently recur, making the discovery of novel therapeutic targets for this disease imperative.

173 ption and AD, and therefore we present novel therapeutic targets for this disease.

174 ey activate have been identified as possible therapeutic targets for treating lung disease.

175 Sebaceous gland ACC represents an attractive therapeutic target given its central role in formation o

176 Clinical validation of FGFR as a therapeutic target has been demonstrated in bladder, liv

177 Class B GPCRs are important therapeutic targets; however, our understanding of their

178 organisms, and a bioinformatics platform for therapeutic target identification and validation, respec

179 stic biological research, disease modelling, therapeutic target identification, drug testing and rege

180 contributes to NCGN and provides a potential therapeutic target in AAV.

181 tributor to skin inflammation and a possible therapeutic target in AD and psoriasis.

182 beta metabolism and defining a potential new therapeutic target in AD.

183 t-versus-leukemia effects, unveiling a novel therapeutic target in aGVHD treatment or prevention.

184 ls, provide evidence that CD8(+) cells are a therapeutic target in ANCA-associated vasculitis, and su

185 Th17 cells are an important therapeutic target in autoimmunity.

186 CYP27A1 is considered a potential therapeutic target in breast cancer and age-related neur

187 at Cdc6 is a potential prognostic marker and therapeutic target in breast cancer patients.

188 Our results validate Plk4 as a therapeutic target in cancer patients and reveal a new r

189 This interaction may represent a therapeutic target in cancers that express ephrinB1.

190 hibition studies suggested ATX as a possible therapeutic target in CLDs.

191 These data suggest that Shp2 is a relevant therapeutic target in demyelinating diseases such as mul

192 nd inflammation, which may serve as a future therapeutic target in DKD.

193 phoid stroma polarization and as a potential therapeutic target in FL patients.

194 ta1-JAG1-NOTCH signaling axis as a candidate therapeutic target in glioma patients.

195 ant cells, emphasizing PDH as an interesting therapeutic target in HD.

196 ruton's tyrosine kinase (BTK) is an emerging therapeutic target in IgE receptor (IgER)-cross-linked b

197 renal dysfunction, thus it could represent a therapeutic target in late stage of CKD.

198 ng neddylation as a potential and attractive therapeutic target in liver fibrosis.

199 We conclude that BCL6 is a new therapeutic target in NSCLC and combination therapy that

200 it is increasingly recognized as a potential therapeutic target in oncology.

201 y express AR, emphasizing its potential as a therapeutic target in patients with CRPC.

202 tor of PD-1 function and SHP2 as a potential therapeutic target in patients with XLP.

203 f-of-principle that validates uPA as a novel therapeutic target in rheumatic diseases.

204 om aggressive treatment and activin may be a therapeutic target in severe acute pancreatitis.

205 oncogenic roles and reveal RUNX1 as a novel therapeutic target in T-ALL.

206 Notch1 gene is a major oncogenic driver and therapeutic target in T-cell acute lymphoblastic leukemi

207 Thus, G9a is a potential therapeutic target in the DNA repair pathway.

208 on-like peptide-1 receptor (GLP-1R) is a key therapeutic target in the management of type II diabetes

209 ay represent a key modifiable risk factor or therapeutic target in the preclinical phases of AD.

210 artilaginous tissue and serve as a potential therapeutic target in the treatment of OA.

211 ese data suggest that the Bim may be a novel therapeutic target in the treatment of SLE.

212 G4's function and its capacity to serve as a therapeutic target in this tumor type are unknown.

213 elated kinase CDK7 as a driver and candidate therapeutic target in TNBC.

214 P/STRA6 signaling axis may represent a novel therapeutic target in type II diabetes.

215 d they offer a mechanistic rationale for its therapeutic targeting in this disease.

216 Chromatin-based mechanisms offer therapeutic targets in acute myeloid leukemia (AML) that

217 forms of genetic variation as diagnostic and therapeutic targets in ASD.

218 recruitment and as predictors and potential therapeutic targets in BC patients.

219 Her2 (ERBB2) is one of the most established therapeutic targets in breast and gastric cancer but age

220 (SHH) morphogen pathways are well-validated therapeutic targets in cancer, including medulloblastoma

221 that such synthetic-essential genes would be therapeutic targets in cancers that harbour specific tum

222 ogenic functions in cancer, and potential as therapeutic targets in disease.

223 brogate acquired SR as well as new potential therapeutic targets in HCC.

224 ese genes represent potential biomarkers and therapeutic targets in human vitiligo.

225 hways that have been identified as important therapeutic targets in inflammatory bowel disease.

226 CVB3-induced myocarditis and might serve as therapeutic targets in inflammatory cardiomyopathies.

227 warrant further exploration as potential new therapeutic targets in MS.

228 eins, which present promising diagnostic and therapeutic targets in PDAC.

229 y atlas with the aim of identifying putative therapeutic targets in the context of liver steatosis an

230 tors EphB3 and EphB4 and ADAM10 as potential therapeutic targets in the treatment of fibrotic disease

231 erest in Foxp3+ T-regulatory (Treg) cells as therapeutic targets in transplantation is largely focuse

232 tection of glaucoma and for circuit-specific therapeutic targets in treatment of this blinding diseas

233 n and prioritization of chemically tractable therapeutic targets is a significant challenge in the di

234 ting its target proteins may provide a novel therapeutic target of lung cancer.

235 fferences may have clinical significance, as therapeutic targeting of a signaling pathway such as NG2

236 Purpose Therapeutic targeting of Bruton tyrosine kinase (BTK) wi

237 lung fibrosis and offer proof of concept for therapeutic targeting of CD44V6 in lung fibrosis disorde

238 However the success of the therapeutic targeting of CXCR2 is threatened by our rela

239 Therapeutic targeting of endothelial FABP4 by siRNA in v

240 tisense RNA) provide compelling evidence for therapeutic targeting of HOTAIR in cancer, but targeting

241 ns for UNO peptide in diagnostic imaging and therapeutic targeting of MEMs in solid tumors.

242 at can be targeted for mechanistic study and therapeutic targeting of peanut allergy.

243 and may illuminate strategies for selective therapeutic targeting of PGC1alpha-dependent LRH-1 signa

244 ings strengthen the evidence base supporting therapeutic targeting of the gut microbiota for brain-gu

245 te adaptive autoimmune responses, suggesting therapeutic targeting of the microbiota as a treatment f

246 Therapeutic targeting of these pathways can prevent an L

247 SC tumor growth, and provide a rationale for therapeutic targeting of this pathway for treatment of O

248 olves a longstanding mystery and will enable therapeutic targeting of this potential drug target.

249 herosclerosis and offer novel prevention and therapeutic targets of this disease.

250 pe 1 (HIV-1) capsid protein is an attractive therapeutic target, owing to its multifunctionality in v

251 OS were, however, widely distributed across therapeutic targets-ranging between 0 (thyroid, ascites)

252 esis, mechanisms involved, and potential for therapeutic targeting remain poorly understood, and are

253 or and identification of new disease-related therapeutic targets remains a major goal for this diseas

254 The 5-HT4 receptor has emerged as a new therapeutic target since agonists of this receptor induc

255 Despite intense therapeutic targeting, structural and mechanistic insigh

256 The purpose of our study was to develop a therapeutic target that can reduce Abeta and Drp1 levels

257 with the palmitoylation of Ras, a high value therapeutic target that is mutated in up to a third of h

258 nous clearance of tumor cell debris is a new therapeutic target that may complement cytotoxic cancer

259 TSPO may be a viable therapeutic target that requires further investigations

260 ty of an alternative class of biomarkers and therapeutic targets that are primate-specific.

261 ways in opportunistic pathogens are putative therapeutic targets that may be associated with less pot

262 Our results provide potential therapeutic targets that may be useful as treatments for

263 traditionally been successfully treated with therapeutics targeting the IL-1 pathway; however, there

264 aid the discovery process for development of therapeutics targeting the mitochondrial machinery.

265 or the development of specific and effective therapeutics targeting this nontranslational function.

266 Thus, TRX1 is an actionable CRPC therapeutic target through its protection against AR-ind

267 hus constitute a platform to engage multiple therapeutic targets through a single protein, and they m

268 ical contexts and may therefore be potential therapeutic targets through either activation or inhibit

269 ematopoietic recovery and has potential as a therapeutic target to accelerate balanced hematopoietic

270 y receptor, sCD40R, may serve as a potential therapeutic target to attenuate renal function decline.

271 ing of transmitted seeds may represent a new therapeutic target to combat the spread of synucleinopat

272 ng mitochondrial fission and provide a novel therapeutic target to control excessive fission and asso

273 highlight the gut microbiome as a potential therapeutic target to counteract salt-sensitive conditio

274 elated endophenotypes and a potential future therapeutic target to explore.

275 overdose and identified GSK3 as a potential therapeutic target to improve liver regeneration after A

276 e polycystins/TAZ complex may be a potential therapeutic target to increase bone mass.

277 rivers of cell division and are an important therapeutic target to inhibit aberrant proliferation.

278 ages and indicates a potential host-directed therapeutic target to limit the damaging inflammation as

279 Thus, MICU1 could serve as an important therapeutic target to normalize metabolic aberrations re

280 gy of isolated lungs, we aimed to identify a therapeutic target to optimize lung preservation leading

281 sults suggest that MCAM may serve as a novel therapeutic target to overcome chemoresistance in SCLC.

282 We suggest that MCJ may represent a therapeutic target to prevent and rescue liver injury ca

283 in beta-cells and reveal IP-10 as a primary therapeutic target to prevent beta-cell-induced inflamma

284 ies suggest that the MEK1/2 pathway may be a therapeutic target to promote the resolution of inflamma

285 age colony-stimulating factor is a potential therapeutic target to reduce esophageal eosinophilia and

286 of PERK phosphorylation could be a potential therapeutic target to restore memory deficits after TBI.

287 increasing O-GlcNAcylation could be a novel therapeutic target to treat seizure disorders and epilep

288 ibody-secreting cells may serve as potential therapeutic targets to enhance antiviral responses postv

289 ir spiking, which could pave the way for new therapeutic targets to increase endogenous NPY release i

290 le for NPC:glioma interactions and potential therapeutic targets to limit glioma invasion.

291 We discuss the two major candidate therapeutic targets to lower amyloid-beta in a preventiv

292 These might serve as potential biomarkers or therapeutic targets to prevent relapse and improve survi

293 is gene and its expressed protein are viable therapeutic targets to prevent the onset, or delay neuro

294 signaling pathways may be considered as new therapeutic targets to tune adequate physiological proce

295 Our findings highlight TBX2 as a novel therapeutic target upstream of WNT3A, where WNT3A antago

296 nd copy-number alterations in genes that are therapeutic targets were identified.

297 lth and disease, as well as K(+) channels as therapeutic targets, were contributed by Ye Chen-Izu, Gi

298 r modifiers represent an opportunity for new therapeutic targets, whose manipulation could be used to

299 ivate memory B cells and identify these as a therapeutic target with disease-transforming potential.

300 Our data identified Runx1 as a novel therapeutic target with translational potential to count