ライフサイエンスコーパス: therapeutic use

1 all molecules and biologics that could be of therapeutic use.

2 pment of new classes of hGGT1 inhibitors for therapeutic use.

3 ombocytopenia thereby limiting its potential therapeutic use.

4 xic effects and developing safer vectors for therapeutic use.

5 r identity over time could be unsuitable for therapeutic use.

6 ivo, but their anticoagulant activity limits therapeutic use.

7 injury, alternative compounds are needed for therapeutic use.

8 toxic in vivo, which makes it unsuitable for therapeutic use.

9 generation vaccines and for prophylactic and therapeutic use.

10 osition of the tablets and on their possible therapeutic use.

11 f adult HSCs and early progenitors for human therapeutic use.

12 ed with severe side effects that limit their therapeutic use.

13 etabolism, generating increasing interest in therapeutic use.

14 operties make them attractive candidates for therapeutic use.

15 es are under development for prophylactic or therapeutic use.

16 used frequently as functional medicines for therapeutic use.

17 fy potential H(2)S donors and inhibitors for therapeutic use.

18 inflammatory cytokines hampers its potential therapeutic use.

19 n emphasis on translational implications for therapeutic use.

20 robes and, in the longer term, for potential therapeutic use.

21 p these new anti-influenza agents for better therapeutic use.

22 in vitro and in vivo expansion of Tregs for therapeutic use.

23 blishing a safe, clinical grade of cells for therapeutic use.

24 ein and peptide sequences for diagnostic and therapeutic use.

25 develop functional alloreactive NK cells for therapeutic use.

26 and cardiovascular side effects limit their therapeutic use.

27 logues with improved properties for possible therapeutic use.

28 rent classes of p53 activators for potential therapeutic use.

29 esign chemically modified siRNA destined for therapeutic use.

30 the cells derived from iPSCs for any future therapeutic use.

31 ture, for the design of partial agonists for therapeutic use.

32 for developing novel antimicrobial agents of therapeutic use.

33 egulatory T cell function and their possible therapeutic use.

34 vere side-effects, limiting their widespread therapeutic use.

35 will have to be considered in planning their therapeutic use.

36 oliferation plays an important role in their therapeutic use.

37 ogenesis under normoxic conditions may be of therapeutic use.

38 n the clinic and agents that failed to reach therapeutic use.

39 differentiate these into cells of potential therapeutic use.

40 crucial step in developing safer vectors for therapeutic use.

41 ctions for harnessing adult neurogenesis for therapeutic use.

42 and drugs that target NRs are in widespread therapeutic use.

43 new agents targeting PSMA for diagnostic and therapeutic use.

44 of polymyxin B could further discourage its therapeutic use.

45 diagnostic, investigative, and, ultimately, therapeutic use.

46 gical functions and have great potential for therapeutic use.

47 dies have failed to harness this finding for therapeutic use.

48 w opportunities for genetic manipulation and therapeutic use.

49 ifferent cell types can also be produced for therapeutic use.

50 oviral particles have broad applications for therapeutic use.

51 omers to optimize DNA binding properties for therapeutic use.

52 om biomaterials development to peptides with therapeutic uses.

53 probabilistic associations between drugs and therapeutic uses.

54 lecule inflammation suppressant for possible therapeutic uses.

55 r protein to tumor cells, PTEN-Long may have therapeutic uses.

56 interest for food preservation and possible therapeutic uses.

57 progenitor populations for both research and therapeutic uses.

58 itate the optimization of ADCs for a host of therapeutic uses.

59 other small molecules has numerous potential therapeutic uses.

60 hologically active sites and their potential therapeutic uses.

61 e quest to induce islets from stem cells for therapeutic uses.

62 ndent functions of EBI3 could compromise its therapeutic uses.

63 of selective PAR2 antagonists for a range of therapeutic uses.

64 orable combination of effector functions for therapeutic use against infections.

65 ggest new candidate targets for clinical and therapeutic use against oncocytic tumors.

66 nd support the translation of 25(OH)D in the therapeutic use against these chemical agents.

67 nflammatory inhibitor could potentially have therapeutic uses against fungal infections that have an

68 ents a summary of protein-PEG conjugates for therapeutic use and alternative technologies in various

69 gs, with over 50 such molecules approved for therapeutic use and hundreds more currently in clinical

70 is of protein/peptide-polymer conjugates for therapeutic use and other applications.

71 for ADHD, but the association between their therapeutic use and suicide is unclear.

72 iction; these properties limit its long-term therapeutic use and this has led to a quest for therapeu

73 the present study, we explored the potential therapeutic uses and mechanisms of action of eritoran in

74 Consequently, methods to expand Tregs for therapeutic use are of great interest.

75 that inhibition of these proteins could have therapeutic use as a diuretic strategy.

76 function of Vpr might lead to its potential therapeutic use as a tumor suppressor.

77 esults suggest that AC inhibitors might find therapeutic use as adjuvant therapy for advanced melanom

78 ells indicating its potential application in therapeutic use as an anti-fibrotic agent.

79 compounds with high added value due to their therapeutic use as drugs and their remarkable biological

80 To be of therapeutic use, autologous stem cells derived from pati

81 These compounds may also be of therapeutic use because they have distinct functional an

82 esearch requires pre-clinical testing of new therapeutics using both in-vitro and in-vivo models.

83 immune response, which is crucial for their therapeutic use, demonstrated that constitutive expressi

84 New, simpler therapeutics using direct-acting antivirals that target

85 on of human embryonic stem cells (hESCs) for therapeutic use, drug screening and disease modelling wi

86 Therapeutic Use Exemptions containing objective evidence

87 d we expect that HYPR-Ad-IL4 will have broad therapeutic use for all solid tumors that have hypoxia o

88 interfere with this interaction could be of therapeutic use for Alzheimer disease.

89 l post-irradiation, and point to a potential therapeutic use for anti-miR-34 as a radiosensitizing ag

90 eviously recognized and identify a potential therapeutic use for dsRNA in targeted gene activation.

91 Recent evidence suggests that there may be a therapeutic use for HDACi in the management of preterm b

92 and in pathology, as well as their potential therapeutic use for lymphatic regeneration.

93 opment of specific cell-cycle inhibitors for therapeutic use for pediatric cancer.

94 omboembolism in mice, suggesting a potential therapeutic use for soluble Mer in the treatment of clot

95 ay have the potential to be developed into a therapeutic use for the treatment of mTORC1-driven tumor

96 ntific and medical interest in its potential therapeutic use for the treatment of psychopathologies a

97 These studies suggest numerous therapeutic uses for ferrostatins, and that lipid peroxi

98 n be exploited to investigate nontraditional therapeutic uses for H1 and H2 biased agonists in malign

99 We also describe how therapeutics used for psychiatric disorders act on the p

100 Proteins are important biologic therapeutics used for the treatment of various diseases.

101 CIN through the BMI1-AURKA axis and suggest therapeutic use from inhibiting Aurora A in head and nec

102 sm, but development of NMDAR antagonists for therapeutic use has been a challenge, in part due to sev

103 cules have been investigated; however, their therapeutic use has been hampered by poor pharmacokineti

104 s analogues are potent PI3K inhibitors whose therapeutic use has been impeded by inherent defects suc

105 s, but progress in developing inhibitors for therapeutic use has been limited largely due to challeng

106 er, a more ambitious goal is to develop cell therapeutics using hPSCs to generate and replace somatic

107 As such, they may be of therapeutic use in a variety of acute and chronic inflam

108 Cs) as a source of embryonic-derived AMs for therapeutic use in acute and chronic airway diseases has

109 cal role of RSA as well as its any potential therapeutic use in cardiac disease.

110 ore efficacious compounds to be explored for therapeutic use in CF.

111 farnesoid X receptor (FXR) and its potential therapeutic use in cholestatic liver diseases.

112 on of TGF-beta1, suggesting that it may have therapeutic use in CKD treatment.

113 prescribed drug for humans, may find further therapeutic use in demyelinating diseases.

114 f potent antiresorptive agents with possible therapeutic use in diseases characterized by increased b

115 est that miR-661 be further investigated for therapeutic use in down-regulating the expression of MTA

116 viral monoclonal antibody (mAb) approved for therapeutic use in humans, and remains a prophylactic tr

117 ssive properties and have been advocated for therapeutic use in humans.

118 e immune responses to evaluate its potential therapeutic use in mucosal inflammation.

119 th types of compounds hold great promise for therapeutic use in multiple hormonal disorders involving

120 r hyperlipidemia in humans, may find further therapeutic use in multiple sclerosis.

121 his suggests that calcitonin has a potential therapeutic use in nephrogenic diabetes insipidus.

122 These factors may have therapeutic use in osteoclastogenic removal of mineral d

123 le that an apelin receptor agonist may be of therapeutic use in PAH in humans.

124 monoamine levels and could potentially be of therapeutic use in psychiatric conditions such as depres

125 l target for the development of ligands with therapeutic use in several pathophysiological states.

126 onists can be developed further for possible therapeutic use in systemic lupus erythematosus, and ana

127 AP2 inhibitors are clearly not optimized for therapeutic use in the clinic.

128 observation of furoxan activity of potential therapeutic use in the CNS warrants further studies.

129 rtant homeostatic process with potential for therapeutic use in the future.

130 in dopaminergic neurons that can be used for therapeutic use in treating Parkinson's disease.

131 , in combination with Le(b) glycoconjugates, therapeutic use in treatment of drug-resistant H. pylori

132 , survival, and tolerability, supporting its therapeutic use in untreated metastatic urothelial cance

133 , survival, and tolerability, supporting its therapeutic use in untreated metastatic urothelial cance

134 wt % siRNA, and Abraxane, the gold standard therapeutic used in metastatic breast cancer.

135 mental mechanisms of action and differential therapeutic uses in cardiovascular diseases.

136 ecular targets) have been proposed for novel therapeutic uses in neuroprotection, cognitive impairmen

137 s as an ECM scaffold at MTJs, with potential therapeutic uses in tendon strengthening and repair.

138 centrations achieved support a potential for therapeutic uses in the gastrointestinal tract.

139 is a new lead for the development of better therapeutics used in treating wounds of diabetics.

140 Therapeutic use includes visualization of the coronary v

141 (desferrioxamine B mesylate), a chelator in therapeutic use, increased the rates to 8-fold (p<0.001)

142 Its therapeutic use is limited by hypercalcaemic toxicity.

143 However, its therapeutic use is limited by nephrotoxicity, in part me

144 Our aim was to develop unique CXCR4-targeted therapeutics using lipopeptide GPCR modulators called pe

145 eveloping TWEAK- or Fn14-targeted agents for therapeutic use, much more basic science research is req

146 s available by prescription for cosmetic and therapeutic use, no cases of botulism with detectable se

147 proliferation, may place restrictions on the therapeutic use of a Cdk1 inhibitors.

148 However, the actual therapeutic use of a CocH in cocaine addiction treatment

149 An emerging concept of bacteriotherapy, the therapeutic use of a defined mixture of harmless, health

150 The authors investigated the therapeutic use of a novel recombinant form of fH, CR2-f

151 Thus, we propose the therapeutic use of Abs for the treatment of intracellula

152 is study provides the first evidence for the therapeutic use of Abs in Francisella-infected individua

153 une thrombocytopenia (ITP) has justified the therapeutic use of anti-CD20 antibodies such as rituxima

154 mune liver disease and emphasize caution for therapeutic use of anti-IL-6R antibody.

155 Our findings have implications for the therapeutic use of antibodies and suggest that high leve

156 forward, this review discusses the potential therapeutic use of antigen-specific tolerance strategies

157 crobiology, Liu et al. (2016) show that even therapeutic use of antimicrobials in dairy calves has an

158 The therapeutic use of antisense and siRNA oligonucleotides

159 re, this work provides new insights into the therapeutic use of ATP-competitive RAF inhibitors.

160 cy and also provide a proof of principle for therapeutic use of autophagy enhancers.

161 These data provide the rationale for therapeutic use of avelumab in metastatic urothelial car

162 Therapeutic use of blocking antibodies to PD-L1 or its r

163 In the capacity of therapeutic use of BMSCs other than structural repair an

164 This finding raised the possibility of therapeutic use of Bmx tyrosine kinase inhibitors, which

165 uld prove very useful in guiding the desired therapeutic use of BR3-Fc for autoimmune diseases in the

166 ABSTRACT: Therapeutic use of c-kit(+) cardiac progenitor cells (CP

167 zed, and have important implications for the therapeutic use of cannabinoid receptor antagonists in h

168 y shifts in the legality of recreational and therapeutic use of cannabis in the United States, as wel

169 The therapeutic use of cardiac glycosides (CGs), agents comm

170 results strengthen the case for the possible therapeutic use of caspase inhibitors under certain neur

171 ntial implications for our understanding and therapeutic use of CD8(+) T cells, as well as mechanisms

172 gs have implications for the development and therapeutic use of cells that are reprogrammed by any me

173 However, the practical therapeutic use of CRISPR/Cas9 is still questionable due

174 at facilitate physical isolation, study, and therapeutic use of culture-expanded, stromal cell subpop

175 The therapeutic use of cyclosporin A (CsA) is limited by nep

176 ting on autophagy, providing a rationale for therapeutic use of DBS and synaptic stimulation in tauop

177 -dependent fashion, supporting the potential therapeutic use of DOR agonists in pain management under

178 The discovery, development, and therapeutic use of drugs that inhibit MAO-B are major ch

179 Future therapeutic use of engineered site-directed nucleases, l

180 However, therapeutic use of estrogens in this and other regards r

181 Therapeutic use of ex vivo-expanded natural CD4+ CD25+ T

182 Therapeutic use of FDA-approved perampanel treatment mig

183 We summarize the latest information on therapeutic use of fecal microbial transplantation and p

184 These results support the potential therapeutic use of FGF2 or related molecules in the trea

185 ave important implications for the potential therapeutic use of FLT3 inhibitors in that patients with

186 Despite the broad-spectrum therapeutic use of GC, the biochemical rationale for loc

187 s study provides an improved approach to the therapeutic use of GHRH agonists in the treatment of dia

188 These results support the therapeutic use of GHRH-R agonists for stimulating endog

189 The therapeutic use of guanidine is limited, however, becaus

190 ant implications for mechanism of action and therapeutic use of HDAC inhibitors.

191 on and may also provide implications for the therapeutic use of HDAC inhibitors.

192 Two major hurdles for therapeutic use of Hsp90 inhibitors are systemic toxicit

193 her study of the genomic consequences of the therapeutic use of hydroxyurea.

194 ng hypothermia, significance of hypothermia, therapeutic use of hypothermia, and invasive and noninva

195 Therapeutic use of IFN-I can trigger the onset of SLE an

196 Our findings caution against the therapeutic use of IKKbeta/NF-kappaB inhibitors in acute

197 These data suggest that therapeutic use of IL-15 in the setting of ART might fac

198 r exercise tolerance provide a rationale for therapeutic use of IL-37 in the treatment of inflammatio

199 tiating and regulating immune responses, the therapeutic use of individual cytokines as anticancer im

200 nd important to define, given the widespread therapeutic use of inhaled GCs.

201 The key phrase used was therapeutic use of insulin.

202 In addition, the therapeutic use of iPSCs relies on the development of ef

203 iTreg differentiation and may facilitate the therapeutic use of iTregs in immune disorders.

204 rovide further support for investigating the therapeutic use of IVIG in Alzheimer's disease.

205 ve important implications with regard to the therapeutic use of l-arginine and the methylarginine-NOS

206 due to its impaired brain delivery prevents therapeutic use of leptin in overweight and moderately o

207 less well-known clinical application is the therapeutic use of low-dose biophotonics termed photobio

208 A major challenge for the therapeutic use of many peptides and proteins is their s

209 Our findings suggest the potential therapeutic use of MAP4343 for the treatment of DDs, bas

210 search is needed in all areas related to the therapeutic use of marijuana in oncology.

211 d create the basis for future studies on the therapeutic use of melatonin in retinal degeneration.

212 Also, we consider the potential therapeutic use of memory T cell inflation as a vaccine

213 Cmec element, some 14 years before the first therapeutic use of methicillin.

214 Here the authors demonstrate the in-vivo therapeutic use of micromotors to treat H. pylori infect

215 rovide a cogent foundation for the potential therapeutic use of miRNA-facilitated gene delivery strat

216 We describe here an approach for the therapeutic use of monoclonal antibodies based on contex

217 les control MSC responses and may impact the therapeutic use of MSCs.

218 equent adverse condition associated with the therapeutic use of mTOR inhibitors.

219 The therapeutic use of muscle stem cells for improving muscl

220 in other areas of stem cell biology and the therapeutic use of neural stem cells in neurodegenerativ

221 vide a conceptual framework for the combined therapeutic use of neurotrophic factors in degenerative

222 We investigated the potential therapeutic use of nongenotoxic p53 activation by a smal

223 signaling in AML and elucidate the potential therapeutic use of Notch receptor agonists in the treatm

224 The therapeutic use of organ allograft transplantation is de

225 del of PV and (ii) investigate the potential therapeutic use of p38MAPK inhibition to block blister f

226 ion of p75(NTR) and open new avenues for the therapeutic use of p75(NTR) inhibition to combat diabete

227 effects and, thus, do not limit a potential therapeutic use of PDGF-CC inhibition in renal fibrosis.

228 many would make terrific drugs; however, the therapeutic use of peptides is limited by poor metabolis

229 ide a preclinical rationale for the possible therapeutic use of PF-956980 in conjunction with convent

230 in the colon and may provide the basis for a therapeutic use of PHD inhibitors in inflammatory mucosa

231 ector designs, targeted gene delivery or the therapeutic use of pluripotent stem cells, herald the ad

232 ition, this study provides rationale for the therapeutic use of prolyl hydroxylase inhibitors in the

233 These results suggest the potential therapeutic use of ranolazine and GS-967 and call for fu

234 Despite advances in the therapeutic use of recombinant granulocyte colony-stimul

235 ough purely chemical means, which would make therapeutic use of reprogrammed cells safer and more pra

236 These data also suggest a potential for therapeutic use of ribavirin for human EBOV infections.

237 Therapeutic use of SDF-1 in hindlimb ischemia may be cha

238 g brain plasticity and support the potential therapeutic use of selective GABA(A) alpha5 NAMs to trea

239 ur strategy for therapeutic applications.The therapeutic use of single-chain antibodies (VHHs) is lim

240 nistic studies to explore the diagnostic and therapeutic use of smoking-related microRNAs.

241 es may limit the prognostic, diagnostic, and therapeutic use of SNP markers such as those in MAMDC1.

242 lity and testosterone deficiency through the therapeutic use of stem cells.

243 Although this raises safety issues for therapeutic use of such cells, the frequent observation

244 e myeloid leukemia and suggest a potentially therapeutic use of synthetic miR-29b oligonucleotides as

245 Our results strongly suggest an important therapeutic use of test compounds, especially TQ, in the

246 tective, this study provides support for the therapeutic use of the chimeric HIF-1alpha/VP16 protein

247 nmet medical need, and our results suggest a therapeutic use of the pertinent antagonists in clinical

248 ests that clinicians can make diagnostic and therapeutic use of their responses to patients.

249 However, the therapeutic use of these agents is associated with serio

250 The possible therapeutic use of these GSLs has been studied in many w

251 The potential therapeutic use of these peptides, however, is limited b

252 hese findings strongly support the potential therapeutic use of this antibody in the treatment of sys

253 antitumor immunity, supporting the potential therapeutic use of this novel immunomodulator in the tre

254 ole in the complications associated with the therapeutic use of tPA in stroke is not yet available.

255 Interest in the therapeutic use of turmeric and the relative ease of iso

256 Furthermore, therapeutic use of type I IFN is associated with PAH.

257 HIV-1 replication, in spite of the fact that therapeutic use of unmodified antisense RNAs has general

258 There is escalating interest in the therapeutic use of vasopressin in septic shock.

259 This supports therapeutic use of vitamin B3 in glaucoma and potentiall

260 de a mechanistic rationale for exploring the therapeutic use of vitamin C for CRCs with KRAS or BRAF

261 which impacts Th2 responses and supports the therapeutic use of vitamin D in diseases regulated by OX

262 vation may be important when considering the therapeutic use of VLPs.

263 ly, we provide an outlook on possible future therapeutic uses of BAT in the treatment of obesity and

264 butes to human AD neuropathology and suggest therapeutic uses of blocking LilrB2 function.

265 ld provide a powerful and useful addition to therapeutic uses of brain-machine interfaces.

266 cent in vivo studies demonstrating potential therapeutic uses of catalytic nanomaterials.

267 Therefore, successful therapeutic uses of conjugated antibodies have been limi

268 PR35 signaling and for identifying potential therapeutic uses of GPR35.

269 pact of IFN-I signaling, discuss the current therapeutic uses of IFN-I, and explore the strategy of b

270 N-beta, interferon receptors, activities and therapeutic uses of interferons, and the side effects of

271 We discuss the main therapeutic uses of polymeric drugs as sequestrants, ant

272 asis, with a specific focus on the roles and therapeutic uses of protein chaperones.

273 of the in vivo microenvironment and also for therapeutic uses of stem cells.

274 h as functional analysis of the pathways and therapeutic uses of the drugs.

275 Recent literature continues to support therapeutic uses of the technique.

276 basis for the different binding, action, and therapeutic uses of these drugs remains unknown.

277 repositioning histaminergic ligands for new therapeutic uses, or even including agonists of the hist

278 For therapeutic uses, our predictions significantly overlapp

279 e monoclonal antibody was approved for human therapeutic use over a decade ago, the realization that

280 cell-penetrating peptide being developed for therapeutic use, (R-Ahx-R)(4).

281 In addition to therapeutic uses, recombinant proteins also have a varie

282 gies included have shown varying promise for therapeutic use, specifically having been used to delive

283 We have developed an antivascular tumor therapeutic using the F3 peptide to target cisplatin-loa

284 With regard to therapeutic use, the compound exhibited a rapid clearanc

285 advances that have been made in HIV research/therapeutics using these models.

286 nical development of RNA interference (RNAi) therapeutics using these small RNAs.

287 of selective targeting of specific GEFs for therapeutic use, this notion is largely unexplored for S

288 on of the viral life cycle and has potential therapeutic use to reduce virus production with low asso

289 id regulating brain development as well as a therapeutic used to relieve the negative components of p

290 Erythropoietin (EPO) is one of the main therapeutics used to treat anemic patients, greatly impr

291 There is an opportunity to repurpose therapeutics used to treat other diseases to treat type

292 sed as a tool for the further development of therapeutics used to treat RVFV infection.

293 f chronic lymphocytic leukemia (CLL) and the therapeutics used to treat this disease.

294 e development of human variants suitable for therapeutic use, we determined the structure of human l-

295 report of endoscopic sphincterotomy in 1974, therapeutic uses were possible for diseases that previou

296 d clinical stages, including 48 approved for therapeutic use, were collected and used to construct is

297 cells (iPSCs) are attractive candidates for therapeutic use, with the potential to replace deficient

298 pathogen that has been widely developed for therapeutic uses, with only limited success to date.

299 nds, many in clinical trials or approved for therapeutic use, yielded >200 hits.

300 sessing potential efficacy and toxicities of therapeutics use young mice.