ライフサイエンスコーパス: therapeutically

1 tem and how we might modulate these circuits therapeutically.

2 ced hallmarks of pathology when administered therapeutically.

3 s in genes and pathways that can be targeted therapeutically.

4 identify new mechanisms that can be targeted therapeutically.

5 n various Tauopathies and could be exploited therapeutically.

6 tions for targeting Tfh cells and/or B cells therapeutically.

7 SC-selective target(s) that can be exploited therapeutically.

8 tract with the aim of boosting such defences therapeutically.

9 ion of features indicating when to intervene therapeutically.

10 current challenges in targeting this pathway therapeutically.

11 how best to target this family of receptors therapeutically.

12 ing of this novel way to target alpha7 nAChR therapeutically.

13 al consequences of manipulating HLA-C levels therapeutically.

14 irway inflammation both prophylactically and therapeutically.

15 lone or BI-BTK-1, either prophylactically or therapeutically.

16 ions in cancer cells that might be exploited therapeutically.

17 ment of NASH when given prophylactically and therapeutically.

18 mall molecule, and to exploit this mechanism therapeutically.

19 t be activated in tumourigenesis and limited therapeutically.

20 ies may be used to target MCs and MC effects therapeutically.

21 ally inhibit Th2 responses when administered therapeutically.

22 llustrate how macrophages might be exploited therapeutically.

23 ulated molecular pathways cannot be targeted therapeutically.

24 s, but direct antagonism is poorly tolerated therapeutically.

25 s for immunomodulation that can be exploited therapeutically.

26 ce, suggesting AR blockade could be employed therapeutically.

27 sion of INCL and can be effectively targeted therapeutically.

28 -WAS clinical spectrum and could be targeted therapeutically.

29 etabolic vulnerability that can be exploited therapeutically.

30 Moreover, LGR4-ECD therapeutically abrogated RANKL-induced bone loss in thr

31 To identify therapeutically actionable genetic dependencies in SS, w

32 l-biological vulnerability for TNBCs lacking therapeutically actionable mutations.

33 iated cancer predisposition and represents a therapeutically actionable target with potential clinica

34 they represent bona fide cancer drivers and therapeutically actionable targets, requires functional

35 astatic progression and potentially identify therapeutically actionable, metastasis-specific genomic

36 nanoparticles were effective at delivering a therapeutically active dose of KAFAK to bovine cartilage

37 rotein (ASGPR)-mediated targeted delivery of therapeutically active siRNAs to hepatocytes in vivo.

38 cellular uptake, Ara-C is converted into its therapeutically active triphosphate metabolite, Ara-CTP,

39 Strategies are needed to identify and therapeutically address previously undetected AF.

40 In conclusion, therapeutically administered arenavirus replicates in ca

41 enous netrin-1 to examine the endogenous and therapeutically administered impact of netrin-1.

42 re cholesterol synthesis inhibitors that are therapeutically administered to 12.5% of the U.S.

43 Therapeutically adverse characteristics were reversible,

44 lly with HOCl hydrogel both preventively and therapeutically against established lesions.

45 l and limitations of B. bacteriovorus acting therapeutically against K. pneumoniae in serum, informin

46 we reported that MEDI551, an anti-CD19 mAb, therapeutically ameliorates experimental autoimmune ence

47 reveal a temporally discrete and potentially therapeutically amenable functional role for Treg cells

48 Therapeutically antagonizing TNF (etanercept) or S1P (JT

49 Therapeutically, anti-inflammatory therapy, meibomian gl

50 Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti

51 nistically targeted GSK3 substrates offers a therapeutically applicable approach to potentiate the re

52 Second, in a more therapeutically applicable approach, we administered ASO

53 Therapeutically, as AXL inhibition has shown EMT reversa

54 beta-catenin activity have the potential to therapeutically attenuate articular cartilage degenerati

55 inoma (PDA), making developmental regulators therapeutically attractive.

56 ar outcomes after ICH onset, suggesting that therapeutically augmenting efferocytosis may improve fun

57 t that increasing SLC16A11 function could be therapeutically beneficial for T2D.

58 tivities of GCs may preferentially exert the therapeutically beneficial GC antiinflammatory propertie

59 xpression of NOS-M in skeletal muscle may be therapeutically beneficial in DMD and other muscle disea

60 ai/o-biased endocannabinoid signaling may be therapeutically beneficial in HD.

61 The anti-HMGB1 antibody (m2G7) is therapeutically beneficial in multiple inflammatory cond

62 ologic interference with C3 signaling proved therapeutically beneficial in suppressing leptomeningeal

63 of mechanistic co-factors and potential for therapeutically beneficial interventions.

64 approach have shown prolonged expression of therapeutically beneficial levels of factor IX.

65 It might therefore be therapeutically beneficial to promote epithelial identit

66 entation of HDAC inhibitors has proven to be therapeutically beneficial, particularly for hematologic

67 eting these small, cytotoxic forms should be therapeutically beneficial.

68 tal activity of both receptor types could be therapeutically beneficial.

69 dy, we show that stabilizing PPI may also be therapeutically beneficial.

70 This suggests that targeting IL-13 may be therapeutically beneficial.

71 Importantly, when administered therapeutically, BI-BTK-1 reversed established proteinur

72 Therapeutically, blockade of chemokine (C-C motif) ligan

73 ht endogenous coping responses that might be therapeutically bolstered to treat PD.

74 In an attempt to therapeutically break the stability of the Th17 phenotyp

75 fertility and could potentially be addressed therapeutically by alternative routes for oocyte formati

76 ular biosynthetic pathway that is attenuated therapeutically by statins.

77 molecular subset of PMM that can be targeted therapeutically by the combination of a MEK inhibitor wi

78 in the brain and that blocking A2AR activity therapeutically can attenuate neurological symptoms in A

79 e, our data show that blocking A2AR activity therapeutically can attenuate neurological symptoms in A

80 f therapy improved and facilitated, or is it therapeutically challenged?

81 implantable medical devices that results in therapeutically challenging chronic infections, especial

82 patients with elevated phospho-Akt levels to therapeutically combat the heterogeneity of EGFR tyrosin

83 al NR small-molecule modulators that combine therapeutically desirable effects in specific target tis

84 ew mechanism of intercellular communication; therapeutically, ECVs may be a vehicle by which RNA ther

85 against PRAME+HLA-A2+ leukemia cells and was therapeutically effective against mouse xenograft models

86 the chemotherapeutic doxorubicin reduces the therapeutically effective dose of the drug by more than

87 t pharmacological inhibition of PPARgamma is therapeutically effective in a preclinical murine model

88 reveal that light-based interventions may be therapeutically effective in improving sleep regularity

89 emonstrate here that these nanobiologics are therapeutically effective in several scenarios of resist

90 insulin-sensitizing effects, rFGF1 could be therapeutically effective in the treatment of NAFLD.

91 o modulate the drug delivery dosage within a therapeutically effective range, while improving safety

92 ) that remains stable for up to 4-6 d and is therapeutically effective, like the recombinant human fa

93 PC progression, and suggest that ADTs may be therapeutically enhanced by blocking lipid biosynthetic

94 oreover, expression of TnC L48Q after the MI therapeutically enhances cardiac function and performanc

95 Our finding provides a rationale for therapeutically enhancing VISTA-mediated pathways to ben

96 e of disease, similar treatment administered therapeutically exacerbated chronic disease course.

97 oreover, our data support the possibility to therapeutically exploit miR-9 and miR-200 to inhibit the

98 pulations, coupled with a limited ability to therapeutically exploit their weaknesses, have been limi

99 Collectively, we identify a therapeutically exploitable posttranslational mechanism

100 t of ErbB2-positive breast cancer and may be therapeutically exploited as an alternative strategy for

101 that the targeting of this pathway could be therapeutically exploited for clinical benefit.

102 onine metabolic flux has the potential to be therapeutically exploited for diabetes treatment.

103 ing breast cancer aggressiveness that can be therapeutically exploited in combination with PML-based

104 sed glutaminolysis, and this property can be therapeutically exploited through the pharmacological in

105 over central carbon metabolism, which can be therapeutically exploited.

106 iples and nodes of communication that can be therapeutically exploited.

107 itively impact this process and therefore be therapeutically exploited.

108 ulnerabilities downstream of RB1 that can be therapeutically exploited.

109 type in Th17 cells in the kidney that may be therapeutically exploited.

110 all VHL mutated renal cancers that could be therapeutically exploited.

111 Alternatively, therapeutically exploiting endogenous stem cells to rege

112 vel in vivo platform for mechanistically and therapeutically exploring SF3B1 mutated MDS-RS.

113 d relapse of disease and need to be targeted therapeutically for future curative strategies in MDSs.

114 chieved in patients when tPA is administered therapeutically for stroke.

115 romising ways in which PARPs may be targeted therapeutically for the treatment of disease.

116 OTR antagonist, atosiban, is currently used therapeutically for the treatment of preterm labor.

117 Therapeutically, GH supplementation was able to correct

118 flammatory cytokines and chemokines, whereas therapeutically, GM-CSF blockade markedly reduces cardia

119 nflammation and propose that inflammation be therapeutically guided in TBI patients rather than globa

120 The promise of targeting TFH cells therapeutically has been limited by fragmentary understa

121 Therapeutically, hepatocyte-specific nanoparticle-delive

122 icity of approximately 3,000 gRNAs across 30 therapeutically implicated loci.

123 A clearly indicated that Inh2-B1 serves as a therapeutically important "antibiotic-resistance-breaker

124 Constitutive COX-2 expression is therapeutically important because NSAIDs cause cardiovas

125 ated histones and controls the expression of therapeutically important gene regulatory networks throu

126 growth factor A (VEGF) is a biologically and therapeutically important growth factor because it promo

127 ed mRNAs, thereby facilitating expression of therapeutically important proteins.

128 pecific antigens to identify and study rare, therapeutically important T cells.

129 t the endovanilloid system might be targeted therapeutically in acute inflammation.

130 iation and suggest that LDHA may be targeted therapeutically in autoinflammatory diseases.

131 egulate inflammation and have been exploited therapeutically in inflammatory skin diseases.

132 rabilities that can potentially be exploited therapeutically in other contexts.

133 onstrated in MDS HSPCs and is being targeted therapeutically in preclinical and early clinical studie

134 low-avidity T cells previously thought to be therapeutically inefficient to be considered for ATT.

135 tion of LTbetaR augmented the engraftment of therapeutically injected ADSCs, which was associated wit

136 widely recognized as an attractive means to therapeutically intervene in disease states.

137 ibition of COT should be a valid approach to therapeutically intervene in the pathogenesis of macroph

138 functioning would suggest when and where to therapeutically intervene.

139 Targeting TRIM25 therapeutically is attractive because it governs a broad

140 e diagnosis and can provide opportunities to therapeutically manage affected individuals.

141 NAs as biomarkers of disease, and efforts to therapeutically manipulate miRNAs to improve disease out

142 g within scar-associated fibroblasts, may be therapeutically manipulated for alleviating inflammation

143 two novel regulatory proteins that could be therapeutically manipulated to limit IL-4-induced IRS-2

144 n adult eSCs, report a preclinical assay for therapeutically manipulating eSC EMT within a healthy hu

145 sk factor into biologically, clinically, and therapeutically meaningful insights.

146 rn microbiota and the microbiota is targeted therapeutically, microbiota reprogramming may need to in

147 n in ECs is a potentially important means of therapeutically modifying PMN-mediated vascular inflamma

148 OXPHOS and PPARalpha as potential targets to therapeutically modulate downstream effects of type 1 IF

149 d provide a foundation for understanding and therapeutically modulating immune aspects in retinal dis

150 hese results also raise the possibility that therapeutically modulating TFEB activity may improve pod

151 in tau pathobiology and to determine whether therapeutically modulating this acetylation-phosphorylat

152 s and highlight a new effective approach for therapeutically modulating this fundamental signaling ax

153 Despite recent developments to therapeutically overcome the underlying functional defec

154 This suggested that seviteronel may have therapeutically relevant activities in addition to its a

155 with a propensity for potent binding across therapeutically relevant adenosine receptors (A1, A2a, a

156 ansferases (SULTs) with high specificity and therapeutically relevant affinities.

157 the same pathway, linking chemotherapy to a therapeutically relevant anticancer immune response.

158 gineered TRAIL-expressing hADSCs exhibit the therapeutically relevant behavior of "seek-and-destroy"

159 and evaluate the inhibition profile against therapeutically relevant carbonic anhydrase (CA) zinc me

160 ) phenotype and could be readily expanded to therapeutically relevant cell doses.

161 bled assignment of the correct structures of therapeutically relevant compounds in cases where experi

162 acid acts as a non-competitive antagonist at therapeutically relevant concentrations, in a voltage- a

163 resulted in thermostabilization of USP14 at therapeutically relevant concentrations.

164 However, for extrapolation to therapeutically relevant doses and plasma concentrations

165 We found that human C1INH, at therapeutically relevant doses, blocks severe malaria pa

166 of ionizing radiation on macrophages, using therapeutically relevant doses, is not well understood.

167 ated genes, may uncover new biologically and therapeutically relevant driver mutations.

168 s were exquisitely sensitive to ibrutinib at therapeutically relevant drug concentrations.

169 for the detection and quantification of the therapeutically relevant drug molecule methotrexate (MTX

170 ic modulators of NMDA receptor function have therapeutically relevant effects on multiple processes i

171 Targeting this pathway may be therapeutically relevant for ischemia-related conditions

172 ol for discovery of new lead chemotypes with therapeutically relevant functional profiles.

173 For further analysis, we focus on 12 therapeutically relevant genes and consider how genetic

174 in vivo glucose responsiveness demonstrated therapeutically relevant glycemic control.

175 However, lack of detectable NO at therapeutically relevant GTN concentrations (</=1 mum) i

176 f target engagement of memantine, as well as therapeutically relevant information that could further

177 Numerous therapeutically relevant interactions were identified, a

178 The failure of therapeutically relevant isradipine levels to protect SN

179 neuroprotection by in vivo pretreatment with therapeutically relevant isradipine plasma levels, or Ca

180 eate across the intact human skin barrier to therapeutically relevant levels into both the epidermis

181 be applicable in the pursuit of synthesizing therapeutically relevant macrocycles.

182 ls is an attractive strategy for expanding a therapeutically relevant number of stem cells.

183 eins identified in our screening may offer a therapeutically relevant panel of drug targets to correc

184 Therapeutically relevant phages, with their low endotoxi

185 uman cardiac mesenchymal cells (CMSCs) are a therapeutically relevant primary cell population.

186 with appropriate solvent systems can deliver therapeutically relevant quantities of peptide to mouse

187 ociated immune and stromal cell types, their therapeutically relevant ratios, as well as an improved

188 tifying selective small molecule ligands for therapeutically relevant RNAs.

189 Numerous therapeutically relevant small molecules have been ident

190 rks the emergence of a heritably altered and therapeutically relevant state in diverse cancers.

191 amily HECTs and proved useful for modulating therapeutically relevant targets of HECT E3s in cells an

192 ed to identify specific DUBs associated with therapeutically relevant targets of Ub.

193 controllably cleaving biotechnologically or therapeutically relevant targets.

194 stering is important for signaling among the therapeutically relevant TNFR superfamily of receptors.

195 xpression profiles that are biologically and therapeutically relevant.

196 itivity and whether these could be exploited therapeutically remain unexplored.

197 ce of multiple soluble factors released by a therapeutically remodeled TME remains largely unexplored

198 rapy is capable of automatically sensing and therapeutically responding to this vulnerable moment in

199 ing, possibly offering a junction to exploit therapeutically.Significance: Binding of the transcripti

200 ystems and applying them to the synthesis of therapeutically significant glycoconjugates (glycosamino

201 Background In the United States, prices for therapeutically similar drugs vary widely, which has pro

202 have identified those that might be targeted therapeutically, such as fusions in the FGFR2 gene and m

203 ins unclear whether liposomal doxorubicin is therapeutically superior to free doxorubicin.

204 In addition, we discuss efforts to therapeutically target disordered proteins with small mo

205 ant cancer mediators, but are challenging to therapeutically target due to imperfect selectivity that

206 on in prostate cells has hampered efforts to therapeutically target ERG.

207 (iii) clinical research that seeks to either therapeutically target fusion transcripts and proteins o

208 fers novel in silico screening strategies to therapeutically target homodimeric oncogenic proteins co

209 totic progression and suggest new avenues to therapeutically target KRAS-mutant tumours and stratify

210 hese pathways will require identification to therapeutically target LPA production in pulmonary fibro

211 es the need for more selective strategies to therapeutically target NF-kappaB.

212 int to a novel disease-modifying strategy to therapeutically target the TRPV4-mediated mechanotransdu

213 se of this, there has been a major effort to therapeutically target these noncoding RNAs.

214 becular bone, with potential implications to therapeutically target this process in patients.

215 sis-promoting pathway in Ewing Sarcoma, with therapeutically targetable components.

216 This barrier may be therapeutically targetable in inflammatory CNS disease.

217 This report reveals a therapeutically targetable mechanism for GOF p53 depende

218 ndependent activation of RALB signaling is a therapeutically targetable mechanism of escape from NRAS

219 of NLGN3 binding in glioma, and determine a therapeutically targetable mechanism of secretion.

220 Seventy-five percent of cases harboured 1-3 therapeutically targetable mutations/case (median 79 mut

221 currence by molecular imaging agents against therapeutically targetable receptors, such as c-Met, wou

222 ted genes, allow for early identification of therapeutically targetable tumor cell subpopulations, an

223 eptibility gene mutations, some of which are therapeutically targetable, will be missed if current fa

224 ted during prostate cancer metastasis and is therapeutically targetable.

225 rimentally demonstrated to be functional and therapeutically targetable.

226 leading to epigenetic dependencies that are therapeutically targetable.

227 an important macrophage function that can be therapeutically targeted after SCI.

228 an important macrophage function that can be therapeutically targeted after SCI.SIGNIFICANCE STATEMEN

229 nd ClfA are pathogenic factors that could be therapeutically targeted against Saureus hematogenous im

230 y signaling in the mucosal epithelium can be therapeutically targeted by the pharmacological inhibiti

231 of the SIV and HIV reservoir that should be therapeutically targeted for a functional HIV-1 cure.

232 ta-mediated catabolic response that could be therapeutically targeted in OA.

233 vival and metabolic fitness pathway is being therapeutically targeted in ongoing clinical trials that

234 tify p75 cleavage as a mechanism that can be therapeutically targeted to enhance SC-mediated axon rem

235 Our studies also suggest that lncRNAs can be therapeutically targeted to minimize poststroke brain da

236 ionally, we identified a pathway that can be therapeutically targeted to mitigate the effects of airw

237 9, an immunosuppressive molecule that can be therapeutically targeted to restore effector T-cell func

238 used in cancer diagnosis, whereas others are therapeutically targeted with small-molecule inhibitors.

239 drug delivery to pancreatic tumors have been therapeutically targeted, but enzymes involved in mucin

240 n as a unifying mechanism in PAH that can be therapeutically targeted.

241 event in PAH pathogenesis and thus could be therapeutically targeted.

242 es several cell death modalities that can be therapeutically targeted.

243 ribute to their radioresistance and could be therapeutically targeted.

244 D arises, progresses, and may be effectively therapeutically targeted.-Nixon, R.

245 of bile acids to NAFLD and the potential for therapeutically targeting bile-acid-related pathways to

246 l in cancer development and the potential of therapeutically targeting cholesterol homeostasis is a c

247 Therefore, therapeutically targeting endocytosis may represent an a

248 dysfunction in malnutrition, with a view to therapeutically targeting immune pathways as a novel mea

249 represents a glucogenic protein hormone, and therapeutically targeting it may be beneficial in type I

250 challenging this view, with implications for therapeutically targeting Mdm2.

251 Furthermore, therapeutically targeting mitochondria and oxidant burde

252 discuss the current and future prospects for therapeutically targeting mTOR in the clinic.

253 levant function has provided a rationale for therapeutically targeting proteostasis regulators (e.g.,

254 ysiology and reveal potential strategies for therapeutically targeting RBCs to reduce thrombosis.

255 neity and resistance to therapy, and suggest therapeutically targeting such mechanisms within the tum

256 carcinogenesis, stressing the importance of therapeutically targeting the cytokine itself rather tha

257 and GVHD, and speculate on possibilities of therapeutically targeting the IL-1 pathway in hematologi

258 ells, and review several approaches aimed at therapeutically targeting the immune system for GBM trea

259 Collectively, our findings suggest that therapeutically targeting the leukemia-infiltrated hemat

260 e in the development of diverse cancers, and therapeutically targeting them has remained a challenge.

261 These data suggest that therapeutically targeting tumor stiffness or the endothe

262 ave identified key disease pathways that are therapeutically testable and could potentially lead to t

263 Therapeutically, the indiscriminate targeting of wild-ty

264 stration timing (prophylactically [proST] or therapeutically [therST]) on the longitudinal clinical c

265 Therapeutically, these visible photons have been combine

266 Therapeutically, this places USP18 as a promising target

267 f BRCA2-deficient cells and can be exploited therapeutically through development of specific inhibito

268 to identify patients most likely to respond therapeutically to a PARP inhibitor.

269 eg numbers and function could thus be useful therapeutically to alleviate FIRS in preterm infants.

270 Although helminths have been used therapeutically to ameliorate inflammatory conditions, t

271 This antibody was used therapeutically to block autoimmunity in a classic mouse

272 in cardiomyocytes, which might be exploited therapeutically to enhance cardiac regeneration.

273 ss how TSCM cell stemness could be leveraged therapeutically to enhance the efficacy of vaccines and

274 Induction of lymphopenia has been exploited therapeutically to improve immune responses to cancer th

275 y interventions that act prophylactically or therapeutically to induce antigen-specific tolerance mig

276 The S1P signalling pathway is being targeted therapeutically to inhibit autoreactive T cell trafficki

277 t induces regulatory B cells and can be used therapeutically to limit autoimmune uveitis in mice.

278 small molecule SIK inhibitors may be applied therapeutically to mimic skeletal effects of PTH.

279 e cultured, characterized and then delivered therapeutically to rats after LPS intratracheal instilla

280 enous adaptive response that can be enhanced therapeutically to repair the heart after MI.

281 lls under starvation that could be exploited therapeutically to target tumours resistant to PI3K/mTOR

282 ates memory, the data suggest strategies for therapeutically treating memory dysfunction.

283 R)), confirms that proteasome inhibitors are therapeutically useful against neoplastic disease, in pa

284 uggests that administration of EBI3 could be therapeutically useful by binding free p28 and p35 to ge

285 Pol would be relevant in efforts to identify therapeutically useful compounds that perturb the ratio

286 Applying the method to the therapeutically useful enzyme yeast cytosine deaminase,

287 be governed by PrP(C), a partial, but still therapeutically useful, role in human disease may soon b

288 derlying tonic inhibition is likely to prove therapeutically useful.

289 nd that, this potentially could be exploited therapeutically using PARP inhibitors in combination wit

290 efficiency of ds DNA photocleavage, the most therapeutically valuable type of DNA cleavage.

291 redients (API) per nano-liposome that enable therapeutically viable API-loaded nano-liposomes, referr

292 ic mechanisms, and may represent a novel and therapeutically viable approach for treating metastatic

293 tions of neutrophil function may represent a therapeutically viable concept for the modification of n

294 Our studies illustrate that metals can be therapeutically viable enzyme inhibitors; moreover, enzy

295 chanisms and may advance efforts to generate therapeutically viable toxin-trafficking inhibitors.

296 -type UCH activity of these mutants might be therapeutically viable.Significance: Combined computatio

297 n order to harness this degradative response therapeutically, we also describe a natural sugar called

298 everal early attempts to target this pathway therapeutically were unsuccessful because of toxicity, l

299 mechanism, which potentially can be targeted therapeutically with beta-arrestin-biased AT1R ligands.

300 en used for decades to modulate inflammation therapeutically, yet there is a paucity of data on their