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2 dscape of non-small-cell lung cancer (NSCLC) therapy, with 2 approvals from the US Food and Drug Admi
4 r in addition to bone scanning, radionuclide therapy with (223)Ra may be more effective and have more
6 per week for 15 weeks, followed by combined therapy with 250 mg intravenous REP 2139 and 180 mug sub
8 apy, rifampicin monotherapy, and combination therapies with 3 to 4 months of isoniazid and rifampicin
9 easy-to-control asthma were defined as daily therapy with 500 mug of fluticasone or greater with or w
11 es were observed due to patient condition or therapy, with 96.1% and 99.3% glucose results meeting th
12 ed as possible targets for weight management therapies, with a preponderance of studies focusing on t
13 atients received HDCT as third-line or later therapy with a 2-year PFS of 49% (95% CI, 36% to 61%).
14 three patients received HDCT as second-line therapy with a 2-year PFS of 63% (95% CI, 57% to 68%), a
15 notherapy, individuals receiving combination therapy with a baseline eGFR of 60 ml/min per 1.73 m(2)
16 es against each other, including combination therapy with a biologic and immunomodulator compared to
17 t least 16 years that compared psychological therapy with a control intervention or usual treatment w
19 umor at diagnosis, during therapy, and after therapy with a histologic response and event-free surviv
20 tment of TB requires six months of multidrug therapy with a mixture of broad spectrum and mycobacteri
21 d the efficacy and tolerance of the standard therapy with a potentially less toxic combination consis
22 on triple therapy and 8 weeks of maintenance therapy with a proton pump inhibitor; and 4) patients re
23 ver 1 year in subjects randomized to medical therapy with a sham procedure (right heart catheterizati
24 Of 3949 eligible participants, 16% started therapy with a statin, 11% with an ACEI/ARB, and 5% with
27 tis despite previous conventional therapy or therapy with a tumor necrosis factor antagonist were ran
29 tive and promising candidate for radioligand therapy, with a favorable preliminary safety profile and
30 Shot provides an overview of CLL biology and therapy, with a focus on genetics and microenvironmental
31 ts had received a median of 3 prior lines of therapy, with a previous hematologic CR in only 5 patien
32 s is important as it can enable personalized therapy with abatacept, a CTLA-4 mimetic, and inform gen
36 g-term microbiologic outcomes of periodontal therapy with adjunctive antibiotics either in T1 or T2 w
43 tionally, we found that response to targeted therapy with all-trans retinoic acid in vivo was depende
45 death sooner than 24 h after the index date, therapy with an active antibiotic for at least 2 days wh
46 MZL of all subtypes who received >/=1 prior therapy with an anti-CD20 antibody-containing regimen we
47 ng-guided catheter-directed endothelial cell therapy with an intraportal technique for the treatment
50 ic strategy to be implemented in combination therapies with anti-CD20 monoclonal antibodies and open
52 ongoing clinical trials that combine cancer therapies with antimalarial drugs for the treatment of a
53 comparison of PFO closure plus antiplatelet therapy with antiplatelet therapy alone was performed wi
54 ing clinically available, anti-proliferative therapies with ART could result in functional cure withi
56 erwent aggressive titration of vasoactive HF therapies with assessment of central aortic waveforms an
57 or older; had been treated with two lines of therapy (with at least a partial response after second-l
58 study to report results of a PD-L1-targeted therapy, with atezolizumab treatment resulting in a clin
59 arge B-cell lymphoma who received CAR T-cell therapy with axi-cel had high levels of durable response
65 sical or emotional stress, for which current therapy with beta-blockers is incompletely effective.
66 bevacizumab, many specialists might initiate therapy with bevacizumab when visual acuity is good (ie,
67 on of early immunosuppression or combination therapy with biologicals in high-risk patients, combined
68 ve Crohn disease who were scheduled to begin therapy with biologics (infliximab or adalimumab) were i
69 therapy and which should receive combination therapy with both NUC and pegylated interferon remain un
70 on emission tomography (PET)-adapted salvage therapy with brentuximab vedotin (BV) and augmented ifos
71 ednisone 40 mg/d for 2 weeks and maintenance therapy with budesonide/formoterol 400/12 mug twice dail
73 ggest the possibility that anti-inflammatory therapy with canakinumab targeting the interleukin-1beta
74 8 to <70 years on suppressive antiretroviral therapy with CD4+ counts >350 cells/muL and detectable p
81 d Prevention (CDC) currently recommends dual therapy with ceftriaxone and azithromycin for gonorrhea
82 To investigate the association of biological therapy with changes in coronary artery disease progress
86 Dabrafenib plus trametinib represents a new therapy with clinically meaningful antitumour activity a
87 tients with PD receiving stable dopaminergic therapy with coexistent EDS, as assessed by an Epworth S
88 ponse after up-front treatment and frontline therapy with combined bortezomib, melphalan, and dexamet
91 ls, published in any language, comparing ICD therapy with conventional care and reporting mortality o
93 ed worsening in respiratory health requiring therapy with corticosteroids and/or antibiotics, and sev
94 of the lower GI tract, who do not respond to therapy with corticosteroids, have a dismal prognosis.
96 ale sex, multiple comorbidities, concomitant therapy with cyclosporine, and a high Psoriasis Area and
97 igned to receive two cycles of consolidation therapy with cytarabine 100 mg/m(2) daily for 5 days, et
99 failed to achieve SVR on previous NS5A-based therapy with daclatasvir (DCV) plus pegylated interferon
100 The addition of 24 months of antiandrogen therapy with daily bicalutamide to salvage radiation the
101 0 copies/mL for 6 months or longer on triple therapy with darunavir/ritonavir and 2 nucleos(t)ides (t
102 ssess the therapeutic noninferiority of dual therapy with darunavir/ritonavir and lamivudine compared
104 /ritonavir and lamivudine compared to triple therapy with darunavir/ritonavir plus 2 nucleos(t)ides f
105 to receive standard chemotherapy (induction therapy with daunorubicin and cytarabine and consolidati
106 eactions were compared following single-dose therapy with DEC or IVM to assess whether these reaction
107 intervention studies have shown that enteral therapy, with defined formula diets, helps children with
108 tors of response to short-course combination therapies with direct-acting antiviral drugs that might
110 lic parameters, demonstrating that combining therapies with distinct mechanism(s) can alleviate advan
111 T-DES study (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents) according to sex and t
113 D ADAPT-DES (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents) was a prospective, mul
114 T-DES study (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents) were stratified accord
115 APT-DES [the Assessment of Dual AntiPlatelet Therapy with Drug-Eluting Stents], THIN [The Health Impr
116 HIV-1) infection currently requires lifelong therapy with drugs that are used in combination to contr
117 RATIONALE: Randomized data comparing triple therapy with dual inhaled corticosteroid (ICS)/long-acti
118 h three cycles of RVD and then consolidation therapy with either five additional cycles of RVD (350 p
119 C were randomly assigned to receive adjuvant therapy with either letrozole (2.5 mg) or anastrozole (1
120 erapy will potentially complement definitive therapy with either neo- or adjuvant therapy to improve
121 remission following completion of front-line therapy with either rituximab plus cyclophosphamide, dox
124 before and 6 months after the initiation of therapy with elvitegravir, cobicistat, emtricitabine, an
125 with oral selinexor at 35 mg/m(2) is a safe therapy with encouraging and durable anticancer activity
126 ng-term efficacy and safety during long-term therapy with evolocumab, a monoclonal antibody against p
127 There is a need for hepatitis C virus (HCV) therapies with excellent efficacy across genotypes and i
128 ity lipoprotein cholesterol (LDL-C)-reducing therapy with ezetimibe/simvastatin compared with simvast
129 ntensive low-density lipoprotein cholesterol therapy with ezetimibe/simvastatin in IMPROVE-IT (IMProv
131 limited effectiveness as single agent cancer therapies, with feedback mechanisms inherent to the sign
134 sponded to at least 3 months of conventional therapy with glucocorticosteroids, thiopurines, or metho
135 n NS3 from GT1a-infected patients who failed therapy with grazoprevir (in combination with elbasvir,
136 ore likely to be alive at 1 year on original therapy with >/=75-m improvement in 6-minute walk distan
137 ti-vascular endothelial growth factor (VEGF) therapy with >1 year follow-up at an academic retina ser
138 ts Undergoing Mechanical Circulatory Support Therapy With HeartMate 3) compares the HM3 LVAS with the
139 outcomes have been reported after definitive therapy with hematopoietic stem cell transplantation and
141 l E1900 (#NCT00049517) showed that induction therapy with high-dose (HD) daunorubicin (90 mg/m(2)) im
142 aunorubicin and cytarabine and consolidation therapy with high-dose cytarabine) plus either midostaur
143 mine the association of diabetes and insulin therapy with hospitalization for infection and 28-day mo
148 nabling combinations of molecularly targeted therapies with immunotherapies that are pharmacologicall
149 e different strategies that combine targeted therapies with immunotherapy approaches, and discuss pas
152 arinic antagonist (LAMA), licensed as triple therapy with inhaled corticosteroid and long-acting beta
156 ds in the AH from Rb eyes undergoing salvage therapy with intravitreous injection of melphalan, the r
160 er, promising data on the use of combination therapy with lenalidomide, bortezomib, and dexamethasone
161 tive schedule of extended adjuvant endocrine therapy with letrozole, including intermittent administr
162 ys; group A) or a 10-day modified sequential therapy with Levofloxacin 500 mg id instead of Clarithro
165 2499 patients underwent primary proton beam therapy, with local tumor control and globe preservation
166 rom 16% at diagnosis to 31% post-neoadjuvant therapy, with loss of LBM (-3.0 +/- 5.4 kg, P < 0.0001),
167 ncontrolled IOP on maximum-tolerated medical therapy, with medicated IOP >/=20 and </=35 mm Hg and vi
168 against drug-resistant strains in adjunctive therapy with meropenem, a standard-of-care antibiotic, c
169 7 adults with bipolar disorder who initiated therapy with methylphenidate between 2006 and 2014.
173 rent-delivered CBT or solution-focused brief therapy, with minimisation for age, sex, anxiety severit
176 -year follow-up, 1 year of extended adjuvant therapy with neratinib, administered after chemotherapy
179 ent (NIAT) were randomly assigned to 6-month therapy with NIAT and 375 mg/m(2) intravenous rituximab
180 phase I dose-escalation study of concurrent therapy with nivolumab (NIVO) and ipilimumab (IPI) in pa
181 r overall survival occurred with combination therapy with nivolumab plus ipilimumab or with nivolumab
182 ized controlled trials comparing IBD medical therapies with no restrictions on language, country of o
184 and-ship paradigm also benefit from bridging therapy, with no statistically significant difference co
185 ion This study demonstrates that maintenance therapy with norethandrolone significantly improves surv
187 ned a subset of patients in which adjunctive therapy with omalizumab was associated with attainment o
190 ere randomly assigned to receive maintenance therapy with one infusion of rituximab every 2 months, e
191 level of safety of (177)Lu-PSMA radioligand therapy, with only minimal grade 3 and 4 toxicities repo
194 on survival of salvage androgen deprivation therapy with or without agents shown to prolong survival
198 (AIs) are the preferred first-line endocrine therapy, with or without the cyclin-dependent kinase inh
199 ative effectiveness trial comparing systemic therapy with oral corticosteroids and immunosuppression
202 east cancer, and combinations of AR-targeted therapies with other agents have been investigated for o
204 s support evaluation of this antibody in AML therapy, with particular appeal to patients resistant to
206 y be possible to develop novel combinatorial therapies with PBD- and tubulysin-based ADC and immuno-o
209 constructed for combined chemo-photothermal therapy with pinpointed drug delivery and release capabi
210 prostate cancer; and compared bone-targeted therapies with placebo, usual care, or other active trea
211 I trial compared lenalidomide as maintenance therapy with placebo in elderly patients with DLBCL who
212 ling and is prevented by upfront combination therapy with PLX8394 and either an EGFR or mTOR inhibito
213 chronic hepatitis B patients under long-term therapy with potent nucleos(t)ide analogues is currently
214 ither access therapy alone (group 1), access therapy with PRF (group 2), or access therapy with PRF a
217 access therapy alone; 2) group 2 had access therapy with PRF; and 3) group 3 had access therapy with
218 llness and 26.7% received rescue oxygenation therapy with prone ventilation, extracorporeal life supp
220 fractionated administration and combination therapy with radiation sensitizers, chemotherapy, and ot
222 ntroduction of peptide receptor radionuclide therapy with radiolabeled sstr agonists, such as [(90)Y-
223 , and phosphate-buffered saline, combination therapy with RF hyperthermia and chemotherapy induced th
229 ng approach has also been pursued for dengue therapy, with several compounds tested in clinical trial
230 ERK1/2 pathway inhibitors are used in cancer therapy, with severe and noncharacterized ocular side ef
231 s administered intensity-modulated radiation therapy with simultaneous integrated boost (SIB-IMRT) vs
234 ensitizer and light irradiation, combination therapy with SN-38-encapsulated nanoporphyrin micelles (
235 rapy (photothermal-, photodynamic- and chemo-therapy) with SN-NPM demonstrated dramatically enhanced
236 tional cohort study, direct-acting antiviral therapy with SOF/ledipasvir, ombitasvir/paritaprevir/rit
237 viously failed direct-acting antiviral-based therapies with sofosbuvir-velpatasvir plus ribavirin for
238 nfection before, during, and after antiviral therapy with sofosbuvir and velpatasvir, we found that i
243 the association of preceding antithrombotic therapy with stroke severity and in-hospital outcomes.
245 with BSI due to ESBL-E who received empiric therapy with such drugs (other active drugs [OADs]) or c
246 ized, controlled trials that compare medical therapy with surgical therapy in patients with type 2 di
248 atients with advanced cirrhosis, but current therapy with systemic vasoconstrictors is ineffective in
249 tive MBC, but one third of patients received therapy with T-DM1 for >/= 6 months, which suggests a cl
250 ere using mouse models, we show that topical therapy with tacrolimus, an anti-T-cell immunosuppressiv
252 non-Hispanic whites when they initiated AET therapy with tamoxifen (OR, 0.54; 95% CI, 0.31 to 0.93)
253 uate the off-treatment eGFR after 3 years of therapy with telbivudine (LdT) or entecavir (ETV) and to
254 We tested the hypotheses that reperfusion therapy with tenecteplase would be superior to alteplase
255 locally defined viral failure on first-line therapy with tenofovir plus a cytosine analogue (lamivud
257 rallel-group trial, we evaluated combination therapy with tezacaftor and ivacaftor in patients 12 yea
259 our aim was to compare the two psychological therapies with the brief psychosocial intervention, we f
260 harmacokinetic profiles could yield improved therapies with the potential of higher efficacy and grea
265 y, we evaluate objective response rate after therapy with the gamma-secretase inhibitor PF-03084014 i
266 in uveal melanoma patients after proton beam therapy with the main focus on outcomes according to dif
267 nts were offered salvage radiopharmaceutical therapy with the novel NTR1 antagonist (177)Lu-3BP-227.
269 HGF in tumors for planning any HGF-targeted therapy, with the potential to improve clinical outcomes
270 The risk of thrombosis during anticoagulant therapy with these treatments is not well studied but is
271 scular endothelial growth factor (anti-VEGF) therapy, with these participants having baseline visual
276 ents with leprosy should receive combination therapy with three antibiotics: rifampicin, clofazimine,
277 s with multiple myeloma to receive induction therapy with three cycles of RVD and then consolidation
279 loading and maintenance of dual antiplatelet therapy with ticagrelor and the influence of timing on t
281 were randomly assigned to receive induction therapy with tofacitinib (10 mg twice daily) or placebo
282 ere randomly assigned to receive maintenance therapy with tofacitinib (either 5 mg or 10 mg twice dai
284 f either pertuzumab or placebo to first-line therapy with trastuzumab and docetaxel for patients with
285 ata are available for the efficacy of triple therapy with two long-acting bronchodilators and an inha
286 mmended components of initial antiretroviral therapy with two nucleoside reverse transcriptase inhibi
287 ta are available for the efficacy of "triple therapy" with two long-acting bronchodilators and an inh
291 e risk of AKI in children during concomitant therapy with vancomycin and 1 antipseudomonal beta-lacta
292 hose, 377 were randomly assigned to hormonal therapy with vigabatrin (186) or hormonal therapy alone
293 sed in 133 (72%) of 186 patients on hormonal therapy with vigabatrin compared with 108 (57%) of 191 p
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