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1 se intervention coverage and impact, and may thereby accelerate progress towards the desired endpoint
3 ptimal geometry for mechanical interlocking, thereby achieving significant adhesion strength ( 1.6Ncm
4 ctrically modified to reach this transition, thereby achieving the maximum absorptive coupling across
5 ion mediated by all nuclear RNA polymerases, thereby acting as a positive modifier of global gene exp
7 l swelling induced by osmotic challenges and thereby activated TRPV4-mediated transmembrane currents.
10 cal events that affect influential nodes and thereby affect information flow could have a strong effe
13 ntrols the chloroplast reductive status and, thereby, affects isoprene emission, but they do not supp
15 ion of autophagy receptors (OPTN and NDP52), thereby alleviating amyloid-beta-induced loss of synapse
16 Fbx4, an Skp1-Cul1-F box E3 ligase subunit, thereby alleviating proteasomal degradation of TRF1, lea
18 scription factor 3 in response to TGF-beta1, thereby allowing LC differentiation marked by a low cyto
19 ng more active area for analyte interaction, thereby allowing more rapid interfacial electron transfe
20 he cholesterol signal from loop 1 to loop 7, thereby allowing separation of the loops and facilitatin
21 om those arising from (13)C-labeled tracers, thereby allowing the enrichment of a tracer to be simply
22 eneral chromatin modifier to specific genes, thereby allowing the execution of hepatocyte transdiffer
23 rol of how motifs are placed into sequences, thereby allowing the investigation of the rules that gov
24 ning contrast agent in a region of interest, thereby allowing the retention or clearance of an agent
26 treat TS decrease both phasic and tonic DA, thereby also reducing the propensity for both tic learni
27 es formed early on one of multiple pathways, thereby altering the structural core and external morpho
28 ess stimulates secondary structure-formation thereby amplifying the potential for genome instability.
29 o reduced expression of MDR transporters and thereby an increased accumulation of sorafenib in the ca
30 evelopment, plasticity, and gene expression, thereby answering fundamental questions in neurobiology.
31 induced phosphorylation of PIF3 in vivo, and thereby are critical components of a transcriptionally c
32 ctively modulates tissue characteristics and thereby attenuates immune cell attraction and activation
36 ractions with more than two participants and thereby avoids the need to first expand these into multi
37 ole in influencing nTS neuronal activity and thereby basal and reflex cardiorespiratory function is u
38 in children growing up on traditional farms, thereby being exposed to a wide spectrum of microbes.
39 -regulate detoxification and immunity genes, thereby benefiting nestmates, many agrochemical pesticid
42 aBalpha for substrate binding to IKKbeta and thereby blocks IkappaBalpha phosphorylation and NF-kappa
43 nit of interleukin-23 and interleukin-12 and thereby blocks the activity of these cytokines, inhibiti
44 pled receptor kinase 2 upon phosphorylation, thereby bridging MAP kinase and G-Protein-Coupled Recept
48 ecules sometimes alter the energy landscape, thereby changing the ensemble of likely low-energy confo
52 imines that are potent DNA damaging agents, thereby confirming an earlier mechanism of action hypoth
54 loped hyperglycemia and glucose intolerance, thereby confirming that DHHC7 represents the principal P
56 nuates p27's inhibitory activity on CDK2 and thereby contributes to increased G1-S phase transitions
57 fficiently scavenge their chemokine ligands, thereby contributing to gradient maintenance and termina
58 iating a feedback loop of p38-p53 signaling, thereby contributing to growth inhibition and suppressio
60 fate in distinct zones of the shoot meristem thereby controlling the spatio-temporal dynamics of stem
61 H3K27) demethylase Jumonji d3 (Jmjd3), which thereby controls the expression of inflammation-related
62 e complex, targets DMRT1 for degradation and thereby controls the mitosis-meiosis transition in mouse
63 orce plant species-environment associations, thereby creating a fairly cryptic and fine-scale dimensi
64 ithout disrupting neuron-specific targeting, thereby creating a molecular vehicle capable of deliveri
65 itogen-activated protein kinases (MAPKs) and thereby critically modulate cell proliferation and diffe
66 t to increase maintenance energy demands and thereby decrease available resources for yield formation
68 tment selectively reduced the dwell time and thereby decreased the confinement of GABAARs at inhibito
69 rmation of schwertmannite to goethite, which thereby decreases the bioavailability of solid-phase Fe(
70 cision support and personalize trajectories, thereby decreasing adverse events and optimizing cancer
71 -WNV immune response when Tregs lacked MAVS, thereby demonstrating that Treg detection of the presenc
72 ion to MDC nodes can enhance learning rates, thereby demonstrating their causal role in the learning
73 structural perturbation in the A2 domain and thereby destabilizes the domain by approximately 10 kJ/m
75 iate and deep layers of the SCm and SCl, and thereby determined the main input structures to these su
76 work that controls synapse properties, which thereby determines the precise responses of synapses to
77 -deficient biofilms of a DeltagroEL1 mutant, thereby differentiating the process of aggregation from
78 -nitroindazole, competes for ATP binding and thereby diminishes FADH degrees formation, which demonst
80 ure over the duration of the experiment, and thereby discover trial-to-trial variability in the spike
83 is function results in severe human disease, thereby emphasizing a critical role for NK cells in huma
86 ng drug responses in patient tumors ex vivo, thereby enabling preclinical testing of novel drugs and
87 natural and non-natural amino acid analogs, thereby enabling screens in a much diverse chemical spac
88 grating amplitude due to shadowing effects, thereby enabling tailoring of the damping processes and
89 e the intramolecular exchange with FA+ ions, thereby enabling the formation of dense and compact FASn
90 rage and dendrite suppression, respectively, thereby enabling the stable operation of lithium metal e
91 ameters on the robustness of screen results, thereby enabling users to build intuition and insights t
92 n and cytokine production of macrophages and thereby enhanced migration of VEGFR1(+) myeloid cells, w
93 N219 to switch to its high-affinity mode and thereby enhances JA signaling under continuous FR light
94 hich promote polarization of M2 macrophages, thereby enhancing expansion of the Treg cell population
96 g term interactions of pDCs with Treg cells, thereby enhancing suppression of Th1 anti-tumour immunit
97 ing cochlear partition mechanical impedance, thereby ensuring effective transfer of OHC isometric for
98 em-like cell type in Caenorhabditis elegans, thereby ensuring proper temporal cell fate patterning.
99 till will have suffered cytotoxic stress and thereby enter a stem cell-like state, the seeds for recu
100 omb factors within minutes of its occupancy, thereby establishing a new mechanism for the widespread
102 it fine-tunes the open Orai channel gating, thereby establishing authentic CRAC channel activity.
103 differential binding to Hippo core kinases, thereby establishing MOB1 variants with selective loss-o
104 emoresistance mediator in colorectal cancer, thereby establishing the microbiota as a potential thera
105 rocyclic peptides with diverse modifications thereby expanding the accessible chemical space and redu
106 ogenous circular RNAs may generate proteins, thereby expanding the eukaryotic proteome and revealing
107 ces as the protospacer adjacent motif (PAM), thereby expanding the target range of Cpf1-mediated geno
110 e to background oxidation of the isonitrile, thereby explaining the improved performance of reactions
111 ent led to depectination of the outer layers thereby exposing xylan polymers and increasing the extra
112 tylated lysine residues on histone tails and thereby facilitate the reading of the histone code.
114 ppressed in the second and third trimesters, thereby facilitating an increased supply of iron into th
117 role in NEBD, by recruiting PLK-1 to the NE thereby facilitating phosphorylation of critical downstr
118 ic acids, often with high stereoselectivity, thereby facilitating synthesis of the alkyl boronic acid
119 s but is released upon IL-1beta stimulation, thereby facilitating TRAF6 auto-ubiquitination as well a
120 , causing truncation of actin microfilament, thereby failing to support the Sertoli cell morphology a
122 n a transient manner and not simultaneously, thereby forming incomplete and distorted versions of the
124 rtant for generating exosomes and ectosomes, thereby generally implicating the ESCRT machinery in EV
125 " ecological processes and interactions, and thereby generating new scaling relationships for ecologi
126 ly for mean phenotype values and plasticity, thereby generating varieties with both high mean phenoty
127 MPES reduces the overall energy requirements thereby greatly expanding the range of semiconductors th
128 ational changes localized to the bulge site, thereby having minimal impact on the cleavage site.
129 ure was higher than lightning-started fires, thereby helping expand the geographic and seasonal niche
130 (CC/CXC) and chemokine receptor (CCR) mRNAs, thereby helping to resolve physiological inflammation.
131 emodels telomeres into the t-loop structure, thereby hiding telomere ends from double-stranded break
132 e and learned food reward-driven responding, thereby highlighting endocrine and neuropeptidergic sign
134 isolates and two Trichodesmium metagenomes, thereby identifying highly conserved, novel genomic sign
136 an reverse these chromatin modifications and thereby impact the expression of key metabolic genes.
137 -1 was recently shown to be expressed on and thereby impair the functions of tumor-infiltrating murin
138 ce by promoting its proteasomal degradation, thereby impairing its functions in cargo binding and PTS
139 from temporally aggregated interaction data, thereby implicitly assuming that interactions are fixed.
140 , indicating differences in age at onset and thereby implying differences in the underlying etiology.
141 ysiological severity CFR >/=2.3 to CFR <2.0, thereby implying high-risk quantitative severity potenti
142 relies on Ku to thread onto DNA termini and thereby improve the affinity of the NHEJ enzymatic compo
143 that specifically target these cells and can thereby improve the efficacy of cancer immunotherapies.
144 m MK2i release as well as hemocompatibility, thereby improving anti-neointimal activity of synthetic
145 educe the number of benign lesions biopsied, thereby improving patient outcomes and reducing health c
146 t the effects of adverse cardiac remodeling, thereby improving survival and quality of life among pat
147 ned, homogeneous samples of women with PMDD, thereby improving the clarity of studies seeking to char
148 they alter the planar membrane structure and thereby increase the activation energy required for fusi
149 a prolonged reproductive growth phase, and, thereby, increased seed yield suggest that cytokinin reg
151 permatogenesis and the sperm's mitochondria, thereby increasing migration velocity and inhibiting rev
152 s increased ER binding to the NEMO promoter, thereby increasing NEMO expression, NFkappaB activation,
153 te the constraints of individual components, thereby increasing phenotypic variation that selection c
155 ch enhances the LMR properties of zinc oxide thereby increasing the conductivity and hence the sensit
156 s, like food and sex, activate this pathway, thereby increasing the likelihood of further consummator
157 ent kinases, and blocked G1 arrest after TBI thereby increasing the number of S phase cells in crypts
158 enon yields a heterogeneous cell population, thereby increasing the potential of differentiation of t
159 idates since they can be resource demanding, thereby increasing the risk of failure of the overall an
162 lic outcomes in overweight and obese adults, thereby indicating that supplementation may improve fibe
163 as similarly deregulated in recurrent tumors thereby indicating that the latter can "normalize" some
165 s cyclic nucleotide-gated (CNG) channels and thereby induces a Ca(2+) influx, which leads to the incr
166 onor T cells compete with NK cells for IL-15 thereby inducing profound defects in NK-cell reconstitut
167 and that Mdm30 targets Ubp2 for degradation thereby inducing Rsp5-mediated desaturation of fatty aci
168 class cytochrome P450 monooxygenases (CYPs), thereby influencing the detoxification of co-occurring s
171 TM reduces copper levels and MAPK signaling, thereby inhibiting BRAF(V600E)-driven melanoma tumor gro
174 the K63-linked polyubiquitination of RIG-I, thereby inhibiting the activation of downstream sensors
175 ed "evasins," which bind to host chemokines, thereby inhibiting the recruitment of leukocytes to the
177 pathway to inhibit autolysosome generation, thereby leading to evasion of this important innate immu
178 unds such measurement of genetic dependency, thereby leading to false-positive results in copy number
179 improving the identification of entities and thereby leading to potential new therapeutic avenues.
181 s into the follicular mature compartment and thereby likely increasing the risk for seeding of autoim
182 ence of active lysyl oxidase-like 2 (LOXL2), thereby limiting effects to fibroblasts or cancer cells,
185 inhibitory molecules PD-1, Lag-3, and TIGIT, thereby limiting NK cell-mediated control of pulmonary m
186 han activating Fcgamma receptors (FcgammaR), thereby limiting the efficacy of mAb immunotherapy.
188 s in random expression of these factors and, thereby, lineage scrambling that is disconnected from TC
189 ease is through promotion versus protection, thereby linking statistical association to biological me
191 processing and memory in the right amygdala, thereby making a direct link between human and animal re
193 ssion of translocator protein (TSPO) 18 kDa, thereby making the TSPO expression a marker for neuroinf
194 (19)F-NMR analyte fingerprint is pH-robust, thereby making them particularly well-suited for medical
197 also entrain endogenous brain oscillations, thereby modulating cognitive processes supported by thos
198 ic sites of the DNA particle-linker strands, thereby modulating dye-nanoparticle distance (three diff
199 rt-circuit current density, fill factor, and thereby much higher power conversion efficiency (PCE) va
201 esses sensitive to male sex hormone actions, thereby not only affecting the pathogenesis of male-spec
202 of tyrosine hydroxylase phosphorylation and, thereby, of dopamine synthesis, supporting a major presy
203 uoromalonyl coenzyme A (CoA) building block, thereby offering the potential to generate a broad range
204 to any biological knowledge graph, and will thereby open up the increasing amount of Semantic Web ba
205 with several orthogonal split intein pairs, thereby opening the way to the creation of multiplexed s
206 amage through expression of type 2 cytokines thereby participating in the pathogenesis of immune-medi
207 ed by the field of supramolecular chemistry, thereby permitting the bottom-up engineering of increasi
209 ting the stem cell niche in many organs, and thereby pivotally modulates development, homeostasis, an
210 t if it acts orthogonal to sexual selection, thereby placing limitations on the evolution of sexual d
211 tum coherence times on the order of seconds, thereby placing silicon at the forefront of efforts to c
212 er microfibrils into a load-bearing network, thereby playing a central role in wall mechanics and gro
213 ular composition locally in the islet graft, thereby playing a role in the autoimmune destruction.
214 , growth hormone (GH), and prolactin levels, thereby presumably fostering efficient adaptive immune r
215 eatitis maintains VAMP8-dependent secretion, thereby preventing accumulation of activated trypsin.
216 enitor proliferation after genotoxic injury, thereby preventing both IR- and cyclophosphamide-induced
217 argets for attenuating this inflammation and thereby preventing CKD-associated cardiovascular disease
218 ImmunoCloak interrupts antigen presentation thereby preventing early T cell activation and interfere
219 n of multiple cell cycle-promoting proteins, thereby preventing epithelial cells from exiting the cel
220 in 30 seconds after fusion with a sperm [3], thereby preventing further fertilization events, it is u
222 g their surface and binding phage particles, thereby preventing their attachment to the cell exterior
223 (P6) and older, outer segments were absent, thereby preventing trafficking of outer segment proteins
224 ollectively preclude their final maturation, thereby preventing untimely tRNA and mRNA binding and er
225 es DR5 clustering at the plasma membrane and thereby primes tumor cells to caspase-mediated apoptosis
227 d extremely high photonic density of states, thereby promising novel applications for high performanc
228 pha2 for ubiquitination and degradation, and thereby promotes activation of the mTOR-HIF1alpha pathwa
231 of neurotrophic factors in the lesion site, thereby promoting axonal regeneration and locomotor func
232 llergy and affects the epigenome of T cells, thereby promoting stable Treg differentiation and functi
235 s in dampening variation in gene expression, thereby protecting cell identity, and in controlling dra
236 e sensitivity of the germline to DNA damage, thereby protecting the integrity of gamete genomes that
237 ment of the AMPK-TORC1 metabolic checkpoint, thereby protecting tumour cells from MYC-driven cell dea
238 entiation to form whole bioengineered teeth, thereby providing a potential off-the-shelf scaffold for
239 ield plays the role of the transverse field, thereby providing a practical route for tuning appropria
240 dysregulated polyamine metabolism in cancer, thereby providing an elegant and efficient approach to c
241 ne sensitivity losses showed a relationship, thereby providing an opportunity to divide patients into
242 etection of probable spinal bone metastases, thereby providing an opportunity to reduce imaging time
243 hat is essential for TNBC cell invasiveness, thereby providing implications toward developing an effe
244 s metastasis of carcinoma cells to the lung, thereby providing insights into the mechanisms of progre
246 splay only weak toxin neutralizing activity, thereby providing structural insights into specific resi
247 ctions agree with experimental observations, thereby providing, to our knowledge, new insight into ho
248 capacity of the endoplasmic reticulum (ER), thereby provoking a cellular state of "ER stress." Susta
252 f and loss of beta-catenin from the nucleus, thereby reducing expression of microphthalmia-associated
253 ite performance or increase immune function, thereby reducing infection risk or the intensity of exis
254 either autophagy or proteasomal degradation, thereby reducing intracellular accumulation of mutant co
255 c microvascular transcriptional programs and thereby regulate angiodiversity are largely elusive.
258 various chiral supramolecular architectures, thereby regulating the chiral directional "bonding" of g
259 jarosite may undergo reductive dissolution, thereby releasing As, Sb, and Fe(2+) coincident with a r
261 n multiple primary human somatic cell types, thereby representing a highly attractive gene transfer s
262 y enhancing H3K9me2/3 at the CIITA promoter, thereby repressing its expression through NO and p38 MAP
263 of categories such as objects and phonemes, thereby requiring a solution to the cue combination prob
265 to synapse with reintroduced photoreceptors, thereby restoring vision in patients blinded by retinal
266 really interesting new gene (RING)-type E3s, thereby restricting it to homologous to E6AP C-terminus
267 carry-over toxicity in subsequent exposures, thereby resulting in a sequence effect-but only when tox
268 nity of synaptobrevin-2 for the 1:1 complex, thereby retarding SNARE assembly and vesicle docking in
269 aps of ligands binding to protein receptors, thereby revealing structural details of the interaction,
270 and stabilizes the Ofd1-Rps23-Nro1 complex, thereby sequestering Ofd1 from binding Sre1, which is th
272 be incorporated into macrocyclic structures, thereby significantly expanding the scope and complexity
273 odified microtubules for cargo transport and thereby spatially restrict focus formation to the perinu
275 to two distinct sites of the SMN2 pre-mRNA, thereby stabilizing a yet unidentified ribonucleoprotein
277 ted UBIAD1 variant inhibited reductase ERAD, thereby stabilizing the enzyme and contributing to enhan
278 PP2A dephosphorylates MYPT1(pThr696) and thereby stimulates MP activity inducing dephosphorylatio
279 es the local concentration of free radicals, thereby strongly influencing particle growth rate and th
280 ic, pharmacological and chemical properties, thereby substantially expediting the pace of drug develo
281 the effective thickness of ZIF-8 membranes, thereby substantially improving their propylene permeanc
282 d dynein-driven retrograde axonal transport, thereby suggesting a potential approach of modulating Ab
283 sk factors and subtypes of vascular disease, thereby suggesting differing roles in the pathogenesis o
284 motor output following months of inactivity, thereby supporting a major neuroscience hypothesis in a
285 structure and electrophysiological function, thereby supporting the benefits of drug-containing antio
288 art of temporarily stalled replication forks thereby suppressing the firing of new replication origin
289 l pathways for oxidation and ROS generation, thereby sustaining cancer cell survival in hypoxia.
291 a function of the transmission path length, thereby the depth of signal generation is inherently enc
292 ose ceramide glucosyltransferase production, thereby tipping the balance between GC formation and deg
293 the hyperexcitability of sensory neurons and thereby to reduce pain in patients treated with this che
295 nteract with the nascent neural network, and thereby trigger immediate plastic and reversible sinusoi
296 des a means to control the surface features, thereby tuning the catalytic property of the material.
297 enter a quiescent, chemoresistant state and thereby underscore the need for combinatorial approaches
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