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1 ectly from conventional AFM F-Z experiments, thereby creating a common platform for the analysis of c
2 orce plant species-environment associations, thereby creating a fairly cryptic and fine-scale dimensi
3 ithout disrupting neuron-specific targeting, thereby creating a molecular vehicle capable of deliveri
4 is function results in severe human disease, thereby emphasizing a critical role for NK cells in huma
5 omb factors within minutes of its occupancy, thereby establishing a new mechanism for the widespread
6 s renders them susceptible to HBV infection, thereby establishing a physiologically relevant model of
8 ci produced malignant fibrosarcomas in mice, thereby exhibiting a positive relationship between trans
10 s to facilitate recovery of disturbed areas, thereby imparting a level of systemic resilience and aid
11 processing and memory in the right amygdala, thereby making a direct link between human and animal re
12 er microfibrils into a load-bearing network, thereby playing a central role in wall mechanics and gro
13 ular composition locally in the islet graft, thereby playing a role in the autoimmune destruction.
14 entiation to form whole bioengineered teeth, thereby providing a potential off-the-shelf scaffold for
15 ield plays the role of the transverse field, thereby providing a practical route for tuning appropria
16 capacity of the endoplasmic reticulum (ER), thereby provoking a cellular state of "ER stress." Susta
17 n multiple primary human somatic cell types, thereby representing a highly attractive gene transfer s
18 of categories such as objects and phonemes, thereby requiring a solution to the cue combination prob
19 to two distinct sites of the SMN2 pre-mRNA, thereby stabilizing a yet unidentified ribonucleoprotein
20 17 and the polyQ become largely unstructured-thereby suggesting a mechanism for how N17 regulates Htt
21 d dynein-driven retrograde axonal transport, thereby suggesting a potential approach of modulating Ab
22 motor output following months of inactivity, thereby supporting a major neuroscience hypothesis in a
23 g the enantioselective reduction of allenes, thereby yielding access to motifs commonly used in medic
24 eatitis maintains VAMP8-dependent secretion, thereby preventing accumulation of activated trypsin.
26 cision support and personalize trajectories, thereby decreasing adverse events and optimizing cancer
28 ion of autophagy receptors (OPTN and NDP52), thereby alleviating amyloid-beta-induced loss of synapse
29 nce, treatment, and event-related mortality, thereby addressing an important unmet clinical need.
30 of the hypothalamic-pituitary-adrenal axis, thereby affecting an individual's ability to regulate th
31 imines that are potent DNA damaging agents, thereby confirming an earlier mechanism of action hypoth
32 ng the longitudinal axis of the hippocampus, thereby establishing an associative positive-feedback lo
33 ppressed in the second and third trimesters, thereby facilitating an increased supply of iron into th
34 egion may impact NSP2 gene/protein function, thereby informing an understanding of the reassortment r
35 dysregulated polyamine metabolism in cancer, thereby providing an elegant and efficient approach to c
36 ne sensitivity losses showed a relationship, thereby providing an opportunity to divide patients into
37 etection of probable spinal bone metastases, thereby providing an opportunity to reduce imaging time
38 understand FA utilization within the tumor, thereby providing an unprecedented opportunity to study
39 ted with multiple abrin-specific antibodies, thereby concentrating and extracting all the isoforms.
41 m MK2i release as well as hemocompatibility, thereby improving anti-neointimal activity of synthetic
42 capsule polysaccharide in shielding OmpA and thereby inhibiting anti-OmpA MAb binding to clinical iso
44 ion mediated by all nuclear RNA polymerases, thereby acting as a positive modifier of global gene exp
46 jarosite may undergo reductive dissolution, thereby releasing As, Sb, and Fe(2+) coincident with a r
49 it fine-tunes the open Orai channel gating, thereby establishing authentic CRAC channel activity.
50 ase and prevents its oxidative inactivation, thereby preventing Axin1-dependent degradation of (2)b-c
51 of neurotrophic factors in the lesion site, thereby promoting axonal regeneration and locomotor func
55 enitor proliferation after genotoxic injury, thereby preventing both IR- and cyclophosphamide-induced
56 TM reduces copper levels and MAPK signaling, thereby inhibiting BRAF(V600E)-driven melanoma tumor gro
58 of viral components at virological synapses, thereby facilitating cell-to-cell viral transmission.
59 s in dampening variation in gene expression, thereby protecting cell identity, and in controlling dra
61 ng enzyme catalyzing ceramide glycosylation, thereby regulating cellular ceramide levels and the synt
63 argets for attenuating this inflammation and thereby preventing CKD-associated cardiovascular disease
64 also entrain endogenous brain oscillations, thereby modulating cognitive processes supported by thos
66 gative bacteria to tune the immune response, thereby limiting collateral damage to the host and the r
67 ith existing computational proteomics tools, thereby facilitating comprehensive quantitative analysis
68 , particularly in North America, is lacking, thereby hindering conservation and management programs.
69 protein levels via two distinct mechanisms, thereby inhibiting critical cell functions, including ce
71 , indicating differences in age at onset and thereby implying differences in the underlying etiology.
72 sk factors and subtypes of vascular disease, thereby suggesting differing roles in the pathogenesis o
75 ic sites of the DNA particle-linker strands, thereby modulating dye-nanoparticle distance (three diff
76 ImmunoCloak interrupts antigen presentation thereby preventing early T cell activation and interfere
77 ing cochlear partition mechanical impedance, thereby ensuring effective transfer of OHC isometric for
78 ence of active lysyl oxidase-like 2 (LOXL2), thereby limiting effects to fibroblasts or cancer cells,
79 ylate] allows O2 access to reduced site IIf, thereby making electron donation to O2 possible, explain
80 e and learned food reward-driven responding, thereby highlighting endocrine and neuropeptidergic sign
81 autophagy and maintains endosomal recycling, thereby preventing endosomes and autophagosomes from rea
84 n of multiple cell cycle-promoting proteins, thereby preventing epithelial cells from exiting the cel
87 ure was higher than lightning-started fires, thereby helping expand the geographic and seasonal niche
88 hich promote polarization of M2 macrophages, thereby enhancing expansion of the Treg cell population
90 in children growing up on traditional farms, thereby being exposed to a wide spectrum of microbes.
91 f and loss of beta-catenin from the nucleus, thereby reducing expression of microphthalmia-associated
92 may be used to characterize Ov populations, thereby elucidating features of Ov population biology pr
96 evelopment, plasticity, and gene expression, thereby answering fundamental questions in neurobiology.
97 in 30 seconds after fusion with a sperm [3], thereby preventing further fertilization events, it is u
98 5 K and 20 </= S </= 40 in natural seawater, thereby allowing high quality pHT measurements in polar
99 ysiological severity CFR >/=2.3 to CFR <2.0, thereby implying high-risk quantitative severity potenti
100 er access to anion redox at high potentials, thereby promising high energy densities for lithium-ion
101 isolates and two Trichodesmium metagenomes, thereby identifying highly conserved, novel genomic sign
104 hat is essential for TNBC cell invasiveness, thereby providing implications toward developing an effe
105 amage through expression of type 2 cytokines thereby participating in the pathogenesis of immune-medi
106 carry-over toxicity in subsequent exposures, thereby resulting in a sequence effect-but only when tox
107 n a transient manner and not simultaneously, thereby forming incomplete and distorted versions of the
108 ite performance or increase immune function, thereby reducing infection risk or the intensity of exis
109 the system reaches limit cycle oscillations, thereby gaining information on the key parameters that g
110 s metastasis of carcinoma cells to the lung, thereby providing insights into the mechanisms of progre
111 either autophagy or proteasomal degradation, thereby reducing intracellular accumulation of mutant co
112 really interesting new gene (RING)-type E3s, thereby restricting it to homologous to E6AP C-terminus
115 ce by promoting its proteasomal degradation, thereby impairing its functions in cargo binding and PTS
120 y enhancing H3K9me2/3 at the CIITA promoter, thereby repressing its expression through NO and p38 MAP
121 scription factor 3 in response to TGF-beta1, thereby allowing LC differentiation marked by a low cyto
123 t if it acts orthogonal to sexual selection, thereby placing limitations on the evolution of sexual d
125 ng concentrations of superoxide dismutase-2, thereby reducing lung tissue reactive oxidative species
130 pled receptor kinase 2 upon phosphorylation, thereby bridging MAP kinase and G-Protein-Coupled Recept
133 velength (and not primarily by temperature), thereby avoiding microscopic reversibility since the pho
134 permatogenesis and the sperm's mitochondria, thereby increasing migration velocity and inhibiting rev
135 ational changes localized to the bulge site, thereby having minimal impact on the cleavage site.
136 differential binding to Hippo core kinases, thereby establishing MOB1 variants with selective loss-o
137 ng more active area for analyte interaction, thereby allowing more rapid interfacial electron transfe
140 s increased ER binding to the NEMO promoter, thereby increasing NEMO expression, NFkappaB activation,
141 -regulate detoxification and immunity genes, thereby benefiting nestmates, many agrochemical pesticid
142 " ecological processes and interactions, and thereby generating new scaling relationships for ecologi
143 al cells via the ERK/Akt/HIF-1alpha pathway, thereby suggesting new therapeutic targets for disease t
144 inhibitory molecules PD-1, Lag-3, and TIGIT, thereby limiting NK cell-mediated control of pulmonary m
146 of a unique, IT prefrontal cell population, thereby defining novel circuitry and cellular actions fo
147 d extremely high photonic density of states, thereby promising novel applications for high performanc
148 n physiological and pathological conditions, thereby providing novel therapeutic avenues for cardiac
149 wellhead (1,505 m depth) to the sea surface, thereby matching observed volatile organic compound (VOC
150 and stabilizes the Ofd1-Rps23-Nro1 complex, thereby sequestering Ofd1 from binding Sre1, which is th
154 educe the number of benign lesions biopsied, thereby improving patient outcomes and reducing health c
155 resenilin 1 with N-cadherin and VE-cadherin, thereby compromising pericyte-endothelial cell interacti
157 ase results in intracellular iron depletion, thereby impairing PHD activity and leading to HIF activa
158 te the constraints of individual components, thereby increasing phenotypic variation that selection c
159 role in NEBD, by recruiting PLK-1 to the NE thereby facilitating phosphorylation of critical downstr
162 perturbation of the IAV polymerase complex, thereby limiting polymerase activity and subsequent vira
163 ng drug responses in patient tumors ex vivo, thereby enabling preclinical testing of novel drugs and
164 onor T cells compete with NK cells for IL-15 thereby inducing profound defects in NK-cell reconstitut
165 ome and progressive loss of kidney function, thereby encouraging prompt initiation of immunosuppressi
166 em-like cell type in Caenorhabditis elegans, thereby ensuring proper temporal cell fate patterning.
167 Fbx4, an Skp1-Cul1-F box E3 ligase subunit, thereby alleviating proteasomal degradation of TRF1, lea
169 and that Mdm30 targets Ubp2 for degradation thereby inducing Rsp5-mediated desaturation of fatty aci
170 natural and non-natural amino acid analogs, thereby enabling screens in a much diverse chemical spac
171 omotes the interaction of Sema4A with Scrib, thereby removing Scrib from its complex with the Rac/Cdc
172 he cholesterol signal from loop 1 to loop 7, thereby allowing separation of the loops and facilitatin
174 ptimal geometry for mechanical interlocking, thereby achieving significant adhesion strength ( 1.6Ncm
175 tum coherence times on the order of seconds, thereby placing silicon at the forefront of efforts to c
176 nity of synaptobrevin-2 for the 1:1 complex, thereby retarding SNARE assembly and vesicle docking in
177 llergy and affects the epigenome of T cells, thereby promoting stable Treg differentiation and functi
178 ease is through promotion versus protection, thereby linking statistical association to biological me
179 splay only weak toxin neutralizing activity, thereby providing structural insights into specific resi
180 aps of ligands binding to protein receptors, thereby revealing structural details of the interaction,
182 IFN production or its downstream mediators, thereby allowing successful infection of the host to occ
183 attentional bias toward reward-related cues, thereby allowing such cues to exert relatively greater c
184 -(omega-azidoalkyl-N,N-dialkylhydroxylamines thereby making such functionality available for use in c
185 g term interactions of pDCs with Treg cells, thereby enhancing suppression of Th1 anti-tumour immunit
186 t the effects of adverse cardiac remodeling, thereby improving survival and quality of life among pat
188 ic acids, often with high stereoselectivity, thereby facilitating synthesis of the alkyl boronic acid
189 grating amplitude due to shadowing effects, thereby enabling tailoring of the damping processes and
190 emodels telomeres into the t-loop structure, thereby hiding telomere ends from double-stranded break
191 loped hyperglycemia and glucose intolerance, thereby confirming that DHHC7 represents the principal P
192 -WNV immune response when Tregs lacked MAVS, thereby demonstrating that Treg detection of the presenc
193 strains from the outbreak-unrelated strains, thereby demonstrating that WGS is valuable for local out
194 lic outcomes in overweight and obese adults, thereby indicating that supplementation may improve fibe
195 as similarly deregulated in recurrent tumors thereby indicating that the latter can "normalize" some
196 photons trapped in the high-quality cavity, thereby revealing that (in such a many-body resonance) f
197 which is relatively neutral on blood lipids, thereby suggesting that cashews could have effects that
198 ctrically modified to reach this transition, thereby achieving the maximum absorptive coupling across
200 om those arising from (13)C-labeled tracers, thereby allowing the enrichment of a tracer to be simply
201 eneral chromatin modifier to specific genes, thereby allowing the execution of hepatocyte transdiffer
202 rol of how motifs are placed into sequences, thereby allowing the investigation of the rules that gov
203 ning contrast agent in a region of interest, thereby allowing the retention or clearance of an agent
204 es formed early on one of multiple pathways, thereby altering the structural core and external morpho
205 ess stimulates secondary structure-formation thereby amplifying the potential for genome instability.
206 ting bioactive products from NRPSs and PKSs, thereby augmenting the contribution of molecular biology
208 was performed using a fused-core C18 column, thereby avoiding the coelution of main ellagitannins, su
209 gnaling and impairing mammosphere formation, thereby blocking the tumor-forming ability and invasive
211 ecules sometimes alter the energy landscape, thereby changing the ensemble of likely low-energy confo
212 fate in distinct zones of the shoot meristem thereby controlling the spatio-temporal dynamics of stem
213 tened synaptically evoked inhibitory pauses, thereby demonstrating the involvement of A-type potassiu
214 -deficient biofilms of a DeltagroEL1 mutant, thereby differentiating the process of aggregation from
215 e the intramolecular exchange with FA+ ions, thereby enabling the formation of dense and compact FASn
216 rage and dendrite suppression, respectively, thereby enabling the stable operation of lithium metal e
217 ,5-triazinanes have nearly planar backbones, thereby enhancing the density and thermal stability.
218 h 2-imidazolecarboxaldehyde (ZIF-90 linker), thereby enlarging the effective aperture size of ZIF-8.
219 emoresistance mediator in colorectal cancer, thereby establishing the microbiota as a potential thera
220 rocyclic peptides with diverse modifications thereby expanding the accessible chemical space and redu
221 ogenous circular RNAs may generate proteins, thereby expanding the eukaryotic proteome and revealing
222 ces as the protospacer adjacent motif (PAM), thereby expanding the target range of Cpf1-mediated geno
223 n network that is crucial for transcription, thereby explaining the details of initiation-to-elongati
224 e to background oxidation of the isonitrile, thereby explaining the improved performance of reactions
225 upload their own data as additional tracks; thereby facilitating the rapid identification of potenti
226 arrier is higher for [1,5]H-shift (2 --> 4), thereby favoring the kinetically controlled product (3a-
228 ed on their metabolite profile similarities, thereby highlighting the common metabolite patterns and
229 ally reduces the enzymatic activity of EPT1, thereby hindering the final step in phosphatidylethanola
230 ned, homogeneous samples of women with PMDD, thereby improving the clarity of studies seeking to char
231 ch enhances the LMR properties of zinc oxide thereby increasing the conductivity and hence the sensit
232 motion was seen to increase the CL velocity thereby increasing the contribution from transient condu
233 s, like food and sex, activate this pathway, thereby increasing the likelihood of further consummator
234 ent kinases, and blocked G1 arrest after TBI thereby increasing the number of S phase cells in crypts
235 tivate PKR by enhancing binding affinity and thereby increasing the population of productive complexe
236 enon yields a heterogeneous cell population, thereby increasing the potential of differentiation of t
237 al pens to allow continuous flow of the ink, thereby increasing the printing capacity of the system.
238 idates since they can be resource demanding, thereby increasing the risk of failure of the overall an
239 class cytochrome P450 monooxygenases (CYPs), thereby influencing the detoxification of co-occurring s
240 the K63-linked polyubiquitination of RIG-I, thereby inhibiting the activation of downstream sensors
241 ed "evasins," which bind to host chemokines, thereby inhibiting the recruitment of leukocytes to the
242 han activating Fcgamma receptors (FcgammaR), thereby limiting the efficacy of mAb immunotherapy.
243 ssion of translocator protein (TSPO) 18 kDa, thereby making the TSPO expression a marker for neuroinf
245 uoromalonyl coenzyme A (CoA) building block, thereby offering the potential to generate a broad range
246 s at thermoelectrically cooled temperatures, thereby opening the possibility of polarisation-based qu
247 with several orthogonal split intein pairs, thereby opening the way to the creation of multiplexed s
248 ed by the field of supramolecular chemistry, thereby permitting the bottom-up engineering of increasi
249 at it cross-links to tRNAs, mRNAs and rRNAs, thereby placing the protein on translating ribosomes.
250 eates an iron(III)-hydroperoxo intermediate, thereby preventing the possible thiolate dioxygenation s
251 nhibit the recruitment of the cyanobacteria, thereby preventing the reoccurrence of cyanobacterial bl
252 terol in chemokine receptor oligomerization, thereby promoting the formation of a signaling hub enabl
253 e sensitivity of the germline to DNA damage, thereby protecting the integrity of gamete genomes that
254 in a molecular history of cis-element usage, thereby reducing the steps necessary to revive effector
255 various chiral supramolecular architectures, thereby regulating the chiral directional "bonding" of g
256 ted UBIAD1 variant inhibited reductase ERAD, thereby stabilizing the enzyme and contributing to enhan
257 structure and electrophysiological function, thereby supporting the benefits of drug-containing antio
258 art of temporarily stalled replication forks thereby suppressing the firing of new replication origin
259 ose ceramide glucosyltransferase production, thereby tipping the balance between GC formation and deg
260 he IL-10 promoter, but not the TNF promoter, thereby tipping the balance towards inflammation rather
261 des a means to control the surface features, thereby tuning the catalytic property of the material.
263 within enhancers that have opposite effects, thereby buffering their impact on enhancer activity.
264 ion to MDC nodes can enhance learning rates, thereby demonstrating their causal role in the learning
266 ate their potential of phenotypic variation, thereby increasing their opportunities of establishing c
267 eins mediating efflux of administered drugs, thereby keeping their intracellular concentration below
268 k factors for serious adverse events (SAEs), thereby limiting their influence on sedation practice an
269 g their surface and binding phage particles, thereby preventing their attachment to the cell exterior
270 kinase and non-kinase clients-including Tsc2-thereby preventing their ubiquitination and proteasomal
271 of proinflammatory cytokines by macrophages, thereby suggesting their recognition by specific pattern
272 (19)F-NMR analyte fingerprint is pH-robust, thereby making them particularly well-suited for medical
274 fficiently scavenge their chemokine ligands, thereby contributing to gradient maintenance and termina
275 iating a feedback loop of p38-p53 signaling, thereby contributing to growth inhibition and suppressio
277 , causing truncation of actin microfilament, thereby failing to support the Sertoli cell morphology a
278 (CC/CXC) and chemokine receptor (CCR) mRNAs, thereby helping to resolve physiological inflammation.
279 pathway to inhibit autolysosome generation, thereby leading to evasion of this important innate immu
280 unds such measurement of genetic dependency, thereby leading to false-positive results in copy number
281 improving the identification of entities and thereby leading to potential new therapeutic avenues.
282 activity and inhibits fatty acid oxidation, thereby leading to the accumulation of lipid droplets an
283 ctions agree with experimental observations, thereby providing, to our knowledge, new insight into ho
284 at attenuates alpha-synuclein neurotoxicity, thereby pointing toward regulation of neuronal cholester
285 s but is released upon IL-1beta stimulation, thereby facilitating TRAF6 auto-ubiquitination as well a
286 (P6) and older, outer segments were absent, thereby preventing trafficking of outer segment proteins
289 rofiles RNA Polymerase III-derived SINE RNA, thereby identifying transcriptionally active SINE loci.
293 ment of the AMPK-TORC1 metabolic checkpoint, thereby protecting tumour cells from MYC-driven cell dea
294 ollectively preclude their final maturation, thereby preventing untimely tRNA and mRNA binding and er
295 ameters on the robustness of screen results, thereby enabling users to build intuition and insights t
296 ly for mean phenotype values and plasticity, thereby generating varieties with both high mean phenoty
297 to synapse with reintroduced photoreceptors, thereby restoring vision in patients blinded by retinal
298 disrupt the endogenous human MRP RNA locus, thereby attaining what has eluded RNAi and RNase H exper
300 ent led to depectination of the outer layers thereby exposing xylan polymers and increasing the extra
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