ライフサイエンスコーパス: thermal hyperalgesia

1 Freund's Adjuvant)-induced inflammation and thermal hyperalgesia.

2 V1 receptors may play a role in inflammatory thermal hyperalgesia.

3 cation channel required for certain types of thermal hyperalgesia.

4 gion in spinal lamina II, leading to reduced thermal hyperalgesia.

5 dly exhibit deficits in inflammation-induced thermal hyperalgesia.

6 l allodynia but no significant reductions in thermal hyperalgesia.

7 TRPV1, or PKC may abrogate protease-induced thermal hyperalgesia.

8 M-1 also blocked neutrophil accumulation and thermal hyperalgesia.

9 th the development of morphine tolerance and thermal hyperalgesia.

10 e development of both morphine tolerance and thermal hyperalgesia.

11 but blocked prostaglandin E2 (PGE2)-induced thermal hyperalgesia.

12 nt of both morphine tolerance and associated thermal hyperalgesia.

13 ical allodynia and inflammatory pain but not thermal hyperalgesia.

14 the endogenous amino acid L-cysteine, induce thermal hyperalgesia.

15 itivity to noxious heat, a phenomenon termed thermal hyperalgesia.

16 atic nerve produces mechanical allodynia and thermal hyperalgesia.

17 ein structure of gp120 blocked gp120-induced thermal hyperalgesia.

18 (48 nmol) completely blocked the SP-induced thermal hyperalgesia.

19 Trk inhibitor GNF-5837 prevented C5a-induced thermal hyperalgesia.

20 pain sensation and for tissue injury-induced thermal hyperalgesia.

21 and thus provides a mechanism for peripheral thermal hyperalgesia.

22 to highly noxious stimuli and mechanical and thermal hyperalgesia.

23 1 receptors (CRFR1s) reduces stress-induced thermal hyperalgesia.

24 duced apoptosis mice abolished C5a-dependent thermal hyperalgesia.

25 s and may be critical in the pathogenesis of thermal hyperalgesia.

26 ay an impaired sensation of noxious heat and thermal hyperalgesia.

27 P causes sensitization of TRPV1 and produces thermal hyperalgesia.

28 (FeTMPyP(5+)) dose-dependently reversed this thermal hyperalgesia.

29 gesia and allodynia as well as taxol-induced thermal hyperalgesia.

30 exhibited symptoms of tactile allodynia and thermal hyperalgesia.

31 the TRPV1 channel, and contributes to acute thermal hyperalgesia.

32 rawal to radiant heat in mice, indicative of thermal hyperalgesia.

33 urons, and thereby sensitizes TRPV1 to cause thermal hyperalgesia.

34 blocked CFA-induced mechanical allodynia and thermal hyperalgesia 1 day post-CFA injection.

35 und's adjuvant model of chronic inflammatory thermal hyperalgesia ( 32, 15).

36 (ED(50) approximately 100 mg/kg, i.p.), and thermal hyperalgesia after intraplantar complete Freund'

37 ons, and attenuated mechanical allodynia and thermal hyperalgesia after SCI.

38 nM to 1microM) affected tactile allodynia or thermal hyperalgesia after SNL, but it increases cold al

39 econdary, but not primary, mechanical and/or thermal hyperalgesia after topical mustard oil applicati

40 f C5a into the mouse hindpaw produced strong thermal hyperalgesia, an effect that was absent in TRPV1

41 show that epinephrine-induced mechanical and thermal hyperalgesia and acetic acid-associated hyperalg

42 hronic pain states, including mechanical and thermal hyperalgesia and allodynia.

43 ose-dependent inhibition of mGluR-1-mediated thermal hyperalgesia and by colocalization of the antibo

44 The development of mechanical and thermal hyperalgesia and increased production of PGE(2)

45 significantly inhibited carrageenan-induced thermal hyperalgesia and indomethicin inhibited paw infl

46 The development of thermal hyperalgesia and mechanical allodynia after CCI

47 = 10-15 micromolkg s.c.) in attenuating both thermal hyperalgesia and mechanical allodynia after chro

48 and DM (15 mg/kg) effectively reversed both thermal hyperalgesia and mechanical allodynia although e

49 of these neurons resulted in a reduction of thermal hyperalgesia and mechanical allodynia associated

50 sation through TRPV1, and enduringly reduced thermal hyperalgesia and mechanical allodynia caused by

51 -/-) mice, and this correlated with enhanced thermal hyperalgesia and mechanical allodynia in Pap(-/-

52 ganglion (DRG) neurons and the responses to thermal hyperalgesia and mechanical allodynia in strepto

53 Thermal hyperalgesia and mechanical allodynia occurred i

54 egulation by PD98059 resulted in exacerbated thermal hyperalgesia and mechanical allodynia reversible

55 eloped a rat model of NGF-induced persistent thermal hyperalgesia and mechanical allodynia to determi

56 Lastly, both thermal hyperalgesia and mechanical allodynia to i.t. gp

57 Thermal hyperalgesia and mechanical allodynia were also

58 Additionally, thermal hyperalgesia and mechanical allodynia were endur

59 e development of neuropathic pain behaviors (thermal hyperalgesia and mechanical allodynia) induced b

60 Pain behaviors (thermal hyperalgesia and mechanical allodynia) were esta

61 he same substances that are known to mediate thermal hyperalgesia and mechanical allodynia.

62 degrees C stimulation, thereby demonstrating thermal hyperalgesia and mechanical allodynia.

63 normal motor performance but have increased thermal hyperalgesia and mechanical allodynia.

64 (i.th.) administration of ligand 14 reversed thermal hyperalgesia and mechanical hypersensitivity in

65 l group II mGluRs inhibits forskolin-induced thermal hyperalgesia and nociceptor heat sensitization,

66 n and morphine were able to block or reverse thermal hyperalgesia and normalize gait in the CARR mode

67 Behavioral analysis revealed thermal hyperalgesia and perturbation of accurate paw pl

68 , but it significantly prevented progressive thermal hyperalgesia and prevented C-fiber atrophy, dege

69 ing behavior, as well as carrageenan-induced thermal hyperalgesia and tactile allodynia.

70 MHC-II in myelinating Schwann cells reduces thermal hyperalgesia and, to a lesser extent, also dimin

71 in response thresholds to both heat stimuli (thermal hyperalgesia) and light tactile stimuli (mechani

72 Both lowering of thermal pain threshold (thermal hyperalgesia) and lowering of response threshold

73 oTx elicits nonneurogenic inflammatory pain, thermal hyperalgesia, and mechanical allodynia, of which

74 d in the development of analgesic tolerance, thermal hyperalgesia, and tactile allodynia in response

75 P acting at the NK1 receptor causes chronic thermal hyperalgesia, and that the reduced opioid effica

76 Tests of tactile and thermal hyperalgesia are additional markers of neural hy

77 c nerve developed significant mechanical and thermal hyperalgesia as tested by the withdrawal respons

78 (2)(*-) (1 microM) led to the development of thermal hyperalgesia associated with a profound localize

79 fibre nociceptors and is responsible for the thermal hyperalgesia associated with inflammatory pain.

80 Animals exhibited moderate thermal hyperalgesia at this time.

81 While DM alone was effective in reducing thermal hyperalgesia at three tested doses (15, 30 or 60

82 but not spinally, reduced carrageenan-evoked thermal hyperalgesia but had no effect by any route with

83 MAPK signaling pathway in the production of thermal hyperalgesia, but not inflammation, in the mouse

84 geenan) produced a significant inhibition of thermal hyperalgesia, but not inflammation.

85 also plays a critical role in development of thermal hyperalgesia, but the underlying mechanism remai

86 eby phosphoinositide turnover contributes to thermal hyperalgesia by disinhibiting the channel.

87 suggest that complement fragment C5a induces thermal hyperalgesia by triggering macrophage-dependent

88 The thermal hyperalgesia caused by UVB irradiation was inhib

89 vivo, 52 fully reversed carrageenan-induced thermal hyperalgesia (CITH) in rats and dose-dependently

90 IkappaBalpha-dn mice had less mechanical and thermal hyperalgesia compared to WT mice post-CCI.

91 PAR2-induced thermal hyperalgesia depends on sensitization of transie

92 opment of permanent mechanical allodynia and thermal hyperalgesia due to interruption and subsequent

93 Intradermal NADA also induces VR1-mediated thermal hyperalgesia (EC(50) = 1.5 +/- 0.3 microg).

94 omol/kg, mouse) and efficacy in pain models (thermal hyperalgesia, ED 50 = 72 micromol/kg, rat).

95 c indwelling intrathecal catheters the acute thermal hyperalgesia evoked by the spinal delivery of su

96 uration reversal of mechanical allodynia and thermal hyperalgesia for at least 4 weeks.

97 displayed time-related tactile allodynia and thermal hyperalgesia (i.e., opioid-induced "pain"); plac

98 uction and increased formation of PGE(2) and thermal hyperalgesia in a dose-dependent manner.

99 Compound 46ad also reversed thermal hyperalgesia in a model of inflammatory pain, wh

100 ption, and reversed mechanical allodynia and thermal hyperalgesia in a model of neuropathic pain.

101 as effective at reversing both allodynia and thermal hyperalgesia in a standard Chung (spinal nerve l

102 inhibitors blocked mechanical allodynia and thermal hyperalgesia in all three pain models although t

103 CFA-induced inflammatory pain produced thermal hyperalgesia in both males and females that was

104 Wild-type mice exhibited mechanical but not thermal hyperalgesia in both paws 1 d after acid injecti

105 ignificantly increased tactile allodynia and thermal hyperalgesia in both the early (first week) and

106 eletion of the P2X3 receptor causes enhanced thermal hyperalgesia in chronic inflammation.

107 EAE and attenuated mechanical allodynia and thermal hyperalgesia in EAE.

108 ype V1) plays a key role in the induction of thermal hyperalgesia in inflammatory pain models, we eva

109 Mechanical and thermal hyperalgesia in mice is correlated with live bac

110 ts BD-1063 and S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced ac

111 nd currents in HEK 293 cells, and suppressed thermal hyperalgesia in mice.

112 tral sensitisation to produce mechanical and thermal hyperalgesia in rats and humans.

113 development of taxol-induced mechanical and thermal hyperalgesia in rats.

114 Cdk5 activity is associated with attenuated thermal hyperalgesia in TGF-beta1 receptor conditional k

115 ehaviorally result in chronic persistence of thermal hyperalgesia in the ipsilateral forepaw.

116 ) reduced complete Freund's adjuvant-induced thermal hyperalgesia in the rat.

117 the TRPV1 antagonist decreased inflammatory thermal hyperalgesia in transgenic but not wild-type ani

118 intra-CeA infusion of tetrodotoxin produced thermal hyperalgesia in unstressed rats and blocked the

119 eral inflammation, mechanical allodynia, and thermal hyperalgesia in vector control animals that pers

120 cation of cis-45, which was shown to reverse thermal hyperalgesia in vivo in the spinal nerve ligatio

121 hecal administration of bradykinin induces a thermal hyperalgesia in vivo, which is reduced by inhibi

122 2-f-LIGRLO-NH(2) stimulated PAR(2)-dependent thermal hyperalgesia in vivo.

123 hermore, activin administration caused acute thermal hyperalgesia in wild-type mice, but not in TRPV1

124 NGF negated both neutrophil accumulation and thermal hyperalgesia, indicating the dependence of NGF o

125 s displayed enhanced scratching behavior and thermal hyperalgesia indicative of peripheral neuroinfla

126 sevanol (1-10 mg/kg) significantly reversed thermal hyperalgesia induced by complete Freund's adjuva

127 s; however, it was ineffective at preventing thermal hyperalgesia induced by complete Freund's adjuva

128 in rats) and was also effective at reducing thermal hyperalgesia induced by complete Freund's adjuva

129 sensitization of capsaicin receptors and the thermal hyperalgesia induced by PGE2, and suggest that p

130 nce P (SP; 20 nmol) or NMDA (2 nmol) and the thermal hyperalgesia induced by the injection of carrage

131 Thermal hyperalgesia is dramatically reduced after ablat

132 of hairy hind foot skin in rats, a transient thermal hyperalgesia lasting <2 h, and longlasting prima

133 hibitor, rolipram (1 mug/kg), rapidly evokes thermal hyperalgesia (lasting >5 h).

134 We find that UV-treated larvae develop both thermal hyperalgesia, manifested as an exaggerated respo

135 lantation (TCI) produces bone cancer-related thermal hyperalgesia, mechanical allodynia, spontaneous

136 in a model of inflammatory pain (CFA-induced thermal hyperalgesia, MED = 0.83 mg/kg, p.o.).

137 These findings suggest that inflammatory thermal hyperalgesia mediated by TRPV1 may be further ag

138 f 42 mumol/kg (ip) in a rat post-carrageenan thermal hyperalgesia model of inflammatory pain.

139 t saline, demonstrated tactile allodynia and thermal hyperalgesia of the hindpaws (during the DAMGO i

140 of melatonin alone was effective in reducing thermal hyperalgesia only at the highest dose (120 mg/kg

141 ith the development of tactile allodynia and thermal hyperalgesia, spinal CaMKIIalpha activity was si

142 us opioid enkephalin (ENK) in the RVM during thermal hyperalgesia, suggesting potential in situ inter

143 ministration of A-784168 blocked CFA-induced thermal hyperalgesia, suggesting that both peripheral an

144 Robust thermal hyperalgesia (tail-flick, TF, and Hargreaves tes

145 are involved in the mechanical allodynia and thermal hyperalgesia that develop following cold injury

146 (intrathecal, IT) application of SP produces thermal hyperalgesia that is mediated by activation of t

147 inducing but not maintaining mechanical and thermal hyperalgesia that is mediated by CaMKIIalpha sig

148 emin, neurturin, GDNF, or NGF produced acute thermal hyperalgesia that lasted up to 4 h; combined inj

149 on of spinal neurons, and the mechanical and thermal hyperalgesia that normally occurs after peripher

150 Each peptide evoked dose-dependent thermal hyperalgesia that required activation of the mit

151 into mouse hindpaw led to the development of thermal hyperalgesia that was attenuated by administrati

152 ceramide (10 mug) led to the development of thermal hyperalgesia that was dependent on induction of

153 njection of a PAR2 agonist caused persistent thermal hyperalgesia that was prevented by antagonism or

154 Avoiders exhibited thermal hyperalgesia that was reversed by systemic or in

155 t MK-801 blocked both morphine tolerance and thermal hyperalgesia that were potentiated by PDC.

156 e ligation reversed mechanical allodynia and thermal hyperalgesia; the antiallodynic effect lasted 6

157 ng the initiation of mechanical allodynia or thermal hyperalgesia, these cells may not be as importan

158 als from developing mechanical allodynia and thermal hyperalgesia throughout the 96 h after CFA.

159 serum blocked tactile allodynia and reversed thermal hyperalgesia to above baseline levels (i.e., ant

160 F-kappaB expression and nerve injury-induced thermal hyperalgesia using a rat model of constriction s

161 lthough local administration of NGF mediates thermal hyperalgesia via mechanisms involving concomitan

162 Much longer lasting thermal hyperalgesia was apparent in glabrous skin (1 h

163 Carrageenan-induced thermal hyperalgesia was associated with increased 3-nit

164 their ability to develop carrageenan-induced thermal hyperalgesia was completely absent.

165 In these studies, carrageenan-induced thermal hyperalgesia was evaluated in the mouse and the

166 Thermal hyperalgesia was examined on day 0 and postopera

167 Accordingly, leukotriene B4-induced thermal hyperalgesia was mediated through BLT1 and TRPV1

168 In behavioral testing, PGE(2)-induced thermal hyperalgesia was significantly diminished in Del

169 Notably, NGF-induced thermal hyperalgesia was unaffected by macrophage deplet

170 By focusing on the mechanisms of C5a-induced thermal hyperalgesia, we show that this process requires

171 sponses assessed by mechanical allodynia and thermal hyperalgesia were almost identical in the two mo

172 Swelling and mechanical and thermal hyperalgesia were assessed before and for 28 day

173 of TRPA1 in vitro but did not cause pain or thermal hyperalgesia when injected into the hind paw of

174 nical hyperalgesia, mechanical allodynia and thermal hyperalgesia, which are blocked following co-inj

175 pression and the behavioral manifestation of thermal hyperalgesia, which is likely to be mediated thr

176 an induced a time-dependent inflammation and thermal hyperalgesia, which was maximal 4 h post adminis

177 SR 141716A evoked thermal hyperalgesia with an ED50 of 0.0012 fmol.

178 al administration of either compound blocked thermal hyperalgesia with similar potency.

179 GF either systemically or in the skin causes thermal hyperalgesia within minutes.