ライフサイエンスコーパス: thermogenic

1 ich they are associated is not significantly thermogenic.

2 Perhaps leptin "gates" the thermogenic action of TRH in the hindbrain by invoking t

3 o mitochondrial dynamics are required for BA thermogenic activation and for the control of energy exp

4 nock-out (Lcn2(-/-)) mice have defective BAT thermogenic activation caused by cold stimulation and de

5 Both cold-induced and pharmacological thermogenic activation enhances HDL remodelling, which i

6 ing and leptin but were related to increased thermogenic activation of brown adipose tissue and induc

7 of Ffar4 agonist (GW9508) recapitulated the thermogenic activation of EPA by increasing oxygen consu

8 ochondrial dysfunction, thereby antagonizing thermogenic activation of sWAT.

9 Impairment of thermogenic activation was correlated with diminished ex

10 dissipate chemical energy as heat, and their thermogenic activities can combat obesity and diabetes.

11 ded that the K(+) channel TASK1 controls the thermogenic activity in brown adipocytes through modulat

12 irectly measure BAT temperature and to track thermogenic activity in vivo.

13 RACT: Promoting beige/brite adipogenesis and thermogenic activity is considered as a promising therap

14 cell recruitment into WAT and by supporting thermogenic activity of BAT.

15 c proteins (BMPs) regulate the formation and thermogenic activity of BAT.

16 dies showed that Lcn2 deficiency reduces the thermogenic activity of brown adipocytes.

17 expenditure by controlling the oxidative and thermogenic activity of brown adipose tissue (BAT).

18 The thermogenic activity of interscapular brown adipose tiss

19 ction and fat metabolism indicated increased thermogenic activity, despite the absence of UCP1, where

20 Lack of PVAT, which results in loss of its thermogenic activity, impaired vascular homeostasis, whi

21 st but also in quantifying the mitochondrial thermogenic activity.

22 offspring BAT had lower Ucp1 expression and thermogenic activity.

23 ks act in concert to regulate key aspects of thermogenic adipocyte biology remains largely unknown.

24 ing visceral white adipocyte precursors to a thermogenic adipocyte fate, and suggest a novel strategy

25 bally profiled lncRNA gene expression during thermogenic adipocyte formation and identified Brown fat

26 es resembling those of a recruitable form of thermogenic adipocytes (that is, beige adipocytes).

27 However, whether the activation of thermogenic adipocytes affects the metabolism and anti-a

28 e the notion that high metabolic activity of thermogenic adipocytes confers atheroprotective properti

29 ortance, how placental mammals license their thermogenic adipocytes to participate in postnatal uncou

30 Two types of thermogenic adipocytes with distinct developmental and a

31 ), results in the accumulation of beige-like thermogenic adipocytes within multiple visceral adipose

32 t advances in our understanding of inducible thermogenic adipose tissue, also referred to as beige fa

33 The total mass and activity of thermogenic adipose tissues are also tightly linked to s

34 required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat.

35 We measured formation temperatures of thermogenic and biogenic methane using a "clumped isotop

36 Thermogenic and biogenic sources were compositionally di

37 om the addition of deltaD-CH4 to distinguish thermogenic and biogenic sources.

38 f beige adipocytes ('beige adipogenesis'), a thermogenic and energy-dissipating function mediated by

39 perties of visceral fat, including decreased thermogenic and increased inflammatory gene expression a

40 ss to type I IFN in adipose cells to promote thermogenic and mitochondrial function.

41 te fat resulted in reduced expression of the thermogenic and mitochondrial genes in mice housed at am

42 hermogenesis by transcriptional induction of thermogenic and mitochondrial genes involved in energy m

43 4 as a cell-autonomous mediator for both the thermogenic and proinflammatory programs in adipocytes c

44 brown adipose tissue activates the canonical thermogenic and uncoupling gene expression program.

45 ate brown adipose tissue enhancers to ensure thermogenic aptitude.

46 Activation of thermogenic beige adipocytes has recently emerged as a p

47 ormone that converts white fat into the more thermogenic beige fat.

48 ed increases in sympathetic nerve traffic to thermogenic brown adipose tissue (BAT) but does not alte

49 y expenditure by increasing energy-utilizing thermogenic brown adipose tissue.

50 Thermogenic brown and beige adipose tissues dissipate ch

51 P15 differentially controls the formation of thermogenic brown fat.

52 te the effects of moderate alcohol intake on thermogenic brown/beige adipocyte formation and glucose

53 conclusion, moderate alcohol intake induces thermogenic brown/beige adipocyte formation and promotes

54 Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevatin

55 and characterization of beige fat cells, the thermogenic "brown-like" cells that can develop in white

56 The molecular regulation underlying the thermogenic browning process has not been entirely eluci

57 emphasizing how differences in locomotor and thermogenic capabilities influence thermoregulatory beha

58 n adipose tissue was associated with reduced thermogenic capacity and mitochondrial biogenesis.

59 This is characterised by reduced thermogenic capacity and mitochondrial content, accompan

60 esity-resistant mice exhibit markedly higher thermogenic capacity compared with cells isolated from o

61 CL316,243, was employed to evaluate whether thermogenic capacity could be impaired by the fall in ox

62 In turn, quantitative analysis of thermogenic capacity determined by estimating the propor

63 This study investigated the regulation of thermogenic capacity in classical brown adipose tissue (

64 ovides an alternative mechanism that reduces thermogenic capacity in core areas and increases it in p

65 in human BAT and potentially to differential thermogenic capacity in human populations.

66 be induced to undergo "browning" and acquire thermogenic capacity in response to physiological stimul

67 aimed at restoring total brown-fat-mediated thermogenic capacity in the body, is sufficient to maint

68 nt paradigm for obesity assumes that reduced thermogenic capacity increases susceptibility to obesity

69 romyscus maniculatus) have demonstrated that thermogenic capacity is under strong directional selecti

70 Increasing the thermogenic capacity of adipose tissue has been proposed

71 ansition from warm to cold may determine the thermogenic capacity of an individual in a changing temp

72 ranscriptional mechanisms that determine the thermogenic capacity of brown adipose tissue before envi

73 Importantly, despite reducing the thermogenic capacity of classical BAT, exercise increase

74 This thermogenic capacity of PVAT plays an important protecti

75 dation revealed that a HF diet increased the thermogenic capacity of the interscapular and aortic bro

76 ocular adipocytes and serves to increase the thermogenic capacity of the organism.

77 susceptibility to obesity, whereas enhanced thermogenic capacity protects against obesity.

78 rmoneutral mice increases beige fat mass and thermogenic capacity to ameliorate pre-established obesi

79 ate that highland deer mice have an enhanced thermogenic capacity under hypoxia compared with lowland

80 l mice have increased white fat browning and thermogenic capacity, decreased adipose tissue expansion

81 e adipose tissue (WAT) with respect to their thermogenic capacity, we examined two essential characte

82 w pace of life may be incompatible with high thermogenic capacity.

83 ding the discovery of beige fat cells, a new thermogenic cell type.

84 ed triglycerides and cholesterol, into these thermogenic cells.

85 ptor antagonist carvedilol before or after a thermogenic challenge of MDMA.

86 Here, we identify the efferent beige fat thermogenic circuit, consisting of eosinophils, type 2 c

87 In particular, with time, thermogenic-competent beige adipocytes progressively gai

88 ly derived from biogenic sources, although a thermogenic contribution could not be excluded.

89 a and Macrozamia macleayi during their daily thermogenic cycle.

90 enerated both by biological processes and by thermogenic decomposition of fossil organic material, wh

91 hibit signs of metabolic imbalance including thermogenic defects in brown adipose tissue (BAT).

92 pecifically in adipose tissue have only mild thermogenic defects, suggesting the presence of addition

93 k fat and characterized their adipogenic and thermogenic differentiation.

94 rm of triglycerides, brown adipose tissue is thermogenic, dissipating energy as heat via the unique e

95 e-specific deletion of Ip6k1 (AdKO) enhanced thermogenic EE, which protected mice from high-fat diet-

96 lls support the ability of DHEA to produce a thermogenic effect in differentiating preadipocytes, whi

97 supplementation, dihydrocapsiate had a small thermogenic effect of approximately 50 kcal/d, which is

98 Although the thermogenic effect of CCRT has the potential to produce

99 ing metabolic rate (RMR); and 3) if VMH BDNF thermogenic effects are mediated by uncoupling protein 1

100 Together with the orexigenic and thermogenic effects of CART, this finding suggests a rol

101 Thermogenic emissions did not resume to cause the renewe

102 box-model analysis suggests that diminishing thermogenic emissions, probably from the fossil-fuel ind

103 increases in FGF21 impact metabolic but not thermogenic endpoints.

104 ence of brown adipose tissue responsible for thermogenic energy dissipation has been revealed in adul

105 adipocyte features, including a capacity for thermogenic energy expenditure mediated by uncoupling pr

106 D by decreasing energy intake and increasing thermogenic energy expenditure.

107 T UCP1 mRNA expression, indicating increased thermogenic energy expenditure.

108 simulations of experimental results from 28 thermogenic events from 3 different cones, each simulate

109 BMP8B is induced by nutritional and thermogenic factors in mature BAT, increasing the respon

110 e cells are a distinct and inducible type of thermogenic fat cell that express the mitochondrial unco

111 Thermogenic fat cells that convert chemical energy into

112 eciated that there are two distinct types of thermogenic fat cells, termed brown and beige adipocytes

113 evidence revealing the metabolic impacts of thermogenic fat in humans.

114 Thus, Rev-erbalpha acts as a thermogenic focal point required for establishing and ma

115 thermAC as a promising new tool for studying thermogenic function in brown adipocytes of both murine

116 Our data suggest that attenuation of BAT thermogenic function may be a key mechanism linking mate

117 We hypothesize that the thermogenic function of PVAT regulates intravascular tem

118 Although neither presence nor thermogenic function of uncoupling protein 1(+) beige ad

119 hite adipose tissue contributes to brown fat thermogenic function or compensates for partial deficien

120 ired for beige adipocyte differentiation and thermogenic function.

121 ramides, which directly compromise beige fat thermogenic function.

122 e BAT (18)F-FDG uptake independently of UCP1 thermogenic function.

123 Mitochondrial oxidative and thermogenic functions in brown and beige adipose tissues

124 Thermogenic gases yield formation temperatures between 1

125 e the transcription factors and cofactors in thermogenic gene activation and identified zinc finger a

126 indings suggest respiratory capacity governs thermogenic gene expression and BAT function via mitocho

127 fat displays an abnormal morphology, reduced thermogenic gene expression and elevated expression of m

128 kout of IRF4 in UCP1(+) cells causes reduced thermogenic gene expression and energy expenditure, obes

129 as a transcriptional driver of a program of thermogenic gene expression and energy expenditure.

130 e to beta3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis

131 cutaneous inguinal white adipose tissue lost thermogenic gene expression and multilocular morphology

132 nRNPU) ribonucleoprotein complex to activate thermogenic gene expression in adipocytes.

133 ages, which secrete catecholamines to induce thermogenic gene expression in brown adipose tissue and

134 expression of PGC-1alpha are unable to cause thermogenic gene expression in the absence of IRF4.

135 Control of thermogenic gene expression occurs via the induction of

136 ue (inguinal WAT) with upregulated oxidative/thermogenic gene expression, and downregulated lipolysis

137 cytes and is sufficient to promote increased thermogenic gene expression, energy expenditure, and col

138 ld, whereas administration of IL-4 increased thermogenic gene expression, fatty acid mobilization and

139 cytosolic Ca(2+) is sufficient to attenuate thermogenic gene expression, indicating that cytosolic C

140 ilocular brown/beige adipocytes and elevated thermogenic gene expression.

141 obesity-induced inflammation, and control of thermogenic gene expression.

142 p38alpha MAPK linking PKA to the control of thermogenic gene expression.

143 epigenetic regulation of adipocyte fate and thermogenic gene expression.

144 re (27-33 degrees C) can directly activate a thermogenic gene program in adipocytes in a cell-autonom

145 Zbtb7b is required for activation of the thermogenic gene program in brown and beige adipocytes.

146 trates that SR1555 induced expression of the thermogenic gene program in fat depots.

147 h transcription factor EBF2 to stimulate the thermogenic gene program.

148 nduced alternative macrophage activation and thermogenic gene responses.

149 r signatures of brown fat, including the key thermogenic gene Ucp1.

150 tGPAT) and increased expression of oxidative/thermogenic genes (CPT1 and UCP2).

151 tion, fat utilization, and the expression of thermogenic genes (Ucp1 and Ppargc1a) in subcutaneous WA

152 caused a sharp decrease in the expression of thermogenic genes and a reduction in uncoupled cellular

153 al that IL-10 represses the transcription of thermogenic genes in adipocytes by altering chromatin ac

154 ese mice greatly increased the expression of thermogenic genes in adipose tissue, resulting in simila

155 , harmine potently induced the expression of thermogenic genes in both brown and white adipocytes, wh

156 cytosolic Ca(2+) reverses the attenuation of thermogenic genes in brown adipocytes with impaired resp

157 nitrate not only increases the expression of thermogenic genes in brown adipose tissue but also induc

158 ner to increase expression of UCP1 and other thermogenic genes in fat tissues.

159 y of FGF21 to increase the expression of key thermogenic genes in interscapular and visceral WAT.

160 -1 deficiency induced browning and activated thermogenic genes program in WAT but not in BAT by promo

161 WAT and BAT depots but higher expression of thermogenic genes such as Ucp1.

162 as heat, in accordance with upregulation of thermogenic genes UCP1 and DIO2.

163 tional properties, including upregulation of thermogenic genes, increased mitochondrial content, and

164 ratory capacity, triggers down-regulation of thermogenic genes, promoting a storage phenotype in BAT.

165 tes, whereas it stimulates the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Pp

166 d macrophages failed to induce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1),

167 In scWAT, DKO mice had reduced expression of thermogenic genes, the de novo lipogenic program and the

168 anscription of fatty acid beta-oxidation and thermogenic genes, we hypothesized that the increased fa

169 ts and express constitutively high levels of thermogenic genes, whereas inducible 'brown-like' adipoc

170 mption, together with elevated expression of thermogenic genes.

171 of mitochondria, and increased expression of thermogenic genes.

172 t of PPARgamma to the regulatory elements of thermogenic genes.

173 nation occurred, the relative proportions of thermogenic hydrocarbon gas (e.g., CH4, (4)He) were sign

174 Climate-sensitive gas hydrates may modulate thermogenic hydrocarbon seepage during deglaciation.

175 en species (ROS) signal to support adipocyte thermogenic identity and function.

176 ivo physiological studies suggested that the thermogenic impact of TRH in the hindbrain is amplified

177 This strongly implicates thermogenic interactions between upwelling fluids and mi

178 ostasis, we hypothesized that there might be thermogenic lipokines that activate BAT in response to c

179 tic peptides (NPs) are also able to activate thermogenic machinery in adipose tissue.

180 e that FGF21 acts to activate and expand the thermogenic machinery in vivo to provide a robust defens

181 reveal a novel role of DOR in the control of thermogenic markers and energy expenditure, and they pro

182 Here we report a robust UCP1-independent thermogenic mechanism in beige fat that involves enhance

183 es the paradox that elimination of the major thermogenic mechanism in the animal reduces rather than

184 Our study uncovers a noncanonical thermogenic mechanism through which beige fat controls w

185 genesis in brown adipocytes, the identity of thermogenic mechanisms that can be activated to reduce a

186 We conclude that alternative thermogenic mechanisms, based in part upon the enhanced

187 likely possess alternative UCP1-independent thermogenic mechanisms.

188 a lower cold-induced peak metabolic rate and thermogenic metabolic scope than temperate species, a fi

189 tion or disinhibition of MnPO neurons evoked thermogenic, metabolic and cardiac responses that mimick

190 differences in visceral and subcutaneous WAT thermogenic metabolism and demonstrate the distinct meta

191 dictions of the major features of the cones' thermogenic metabolism compare favorably with the estima

192 all, these data provide a timeline of global thermogenic metabolism in adipose depots during acute co

193 ne hydrates, terrigenous organic matter, and thermogenic methane and CO2 from hydrothermal vent compl

194 with reach mass-balance modeling to estimate thermogenic methane concentrations and fluxes in groundw

195 Modeling indicates a groundwater thermogenic methane flux of about 0.5 kg d(-1) dischargi

196 sotopically light carbon from the release of thermogenic methane occurred owing to the intrusion of G

197 rbon isotope signatures are a consequence of thermogenic methane oxidation at depth.

198 reflecting a more biogenic or mixed biogenic/thermogenic methane source.

199 2)H-CH(4) values, are consistent with deeper thermogenic methane sources such as the Marcellus and Ut

200 Thermogenic methane was detected in two aquifer wells in

201 se of Ucp1 expression, which encodes the key thermogenic mitochondrial uncoupling protein-1.

202 enzymes, and uncoupling protein 3 (UCP3), a thermogenic mitochondrial uncoupling protein.

203 utilization needed to ensure that increased thermogenic needs are met.

204 anscriptional repressor, links circadian and thermogenic networks through the regulation of brown adi

205 mmunication, which in turn leads to either a thermogenic or storage mode.

206 Brown adipose tissue (BAT) is a highly thermogenic organ that converts lipids and glucose into

207 Brown adipose tissue is a thermogenic organ that dissipates chemical energy as hea

208 that the emitted methane is predominantly of thermogenic origin.

209 s larger than -30 per thousand, typical of a thermogenic origin.

210 intact gene may contribute to an alternative thermogenic pathway for the maintenance of body temperat

211 on and that loss of heat production from one thermogenic pathway leads to increased recruitment of th

212 Here we report that elimination of two major thermogenic pathways encoded by the mitochondrial uncoup

213 y emerges in which the inactivation of major thermogenic pathways force the induction of alternative

214 lling with several thyroid-hormone-dependent thermogenic pathways, including expression of the genes

215 Our findings suggest that the enhanced thermogenic performance of highland deer mice is largely

216 ere, we integrate measures of whole-organism thermogenic performance with measures of metabolic enzym

217 e male cycad cones en masse during the daily thermogenic phase, when cone temperatures and volatile e

218 al WAT is resistant to adopting a protective thermogenic phenotype characterized by the accumulation

219 regulatory loop to drive adipogenesis toward thermogenic phenotype.

220 oratory investigations of the bio-physics of thermogenic plants.

221 K acting primarily as a regulator of chronic thermogenic potential in brown adipose tissue, and not i

222 n human preadipocytes that could predict the thermogenic potential of the cells once they were matura

223 lating the acute metabolic state and chronic thermogenic potential of this metabolically unique tissu

224 ively isolate adipose progenitors with great thermogenic potential using the cell surface marker CD29

225 Enhanced WAT thermogenic potential, brown adipose tissue differentiat

226 own and brite adipocytes, suggesting similar thermogenic potentiality.

227 f locally produced catecholamines during the thermogenic process.

228 where most geologists generally assume that thermogenic processes are the only source of natural gas

229 This results in up-regulation of thermogenic processes for temperature maintenance at the

230 id combustion occurs as part of the adaptive thermogenic processes in BAT.

231 ing a functional interplay between these two thermogenic processes.

232 Kcnk3 is transcriptionally wired into the thermogenic program by PRDM16, a master regulator of the

233 ssion positively regulates the BAT-selective thermogenic program by stabilizing the PRDM16 protein.

234 the result of an increased activation of the thermogenic program in brown adipose tissue.

235 AC1 negatively regulates the brown adipocyte thermogenic program, and inhibiting Hdac1 promotes BAT-s

236 yet synergizes with PGC-1alpha to induce the thermogenic program.

237 transcriptional suppressor of the adipocyte thermogenic program.

238 of the beige phenotype and activation of its thermogenic program.

239 a negative regulator of the brown adipocyte thermogenic program.

240 ecreted protein can alter the physiology and thermogenic properties of adipose tissue to reduce obesi

241 We demonstrated that PVAT has thermogenic properties similar to BAT in response to col

242 of full-length Angptl4 reveals lipolytic and thermogenic properties with therapeutic relevance to obe

243 similar to capsaicin, which is known for its thermogenic properties.

244 Whether such thermogenic property also plays a role in body weight re

245 show that squirrel UCP1 acts as the typical thermogenic protein in vitro.

246 Our results indicate that BMP8B is a thermogenic protein that regulates energy balance in par

247 Beige fat, which expresses the thermogenic protein UCP1, provides a defense against col

248 spite substantial decreases in mitochondrial thermogenic proteins in brown fat, mice lacking YY1 in t

249 an absence of leptin, animals cannot produce thermogenic reactions to cold stress.

250 an absence of leptin, animals cannot produce thermogenic reactions to cold stress.

251 21 (FGF21) plays a physiologic role in this thermogenic recruitment of WATs.

252 ed disease modeling and unbiased screens for thermogenic regulators.

253 on factors in the nucleus in response to the thermogenic requirements of the animal.

254 an dissipate chemical energy as heat through thermogenic respiration, which requires uncoupling prote

255 signaling, thereby attenuating lipolysis and thermogenic respiration.

256 R signaling is not essential for appropriate thermogenic response after cold exposure.

257 L(2.1)KOs and D(2.1)KOs both mount a robust thermogenic response and rapidly increase Tc.

258 e were able to use did not elicit a relevant thermogenic response in humans.

259 rones (Pet-1(-/-)) would have: (1) a reduced thermogenic response to a mild drop in ambient temperatu

260 pups: (1) brainstem 5-HT is critical for the thermogenic response to a mild drop in environmental tem

261 dy, we investigated the effect of SIT on the thermogenic response to beta-adrenergic receptor (beta-A

262 insulin sensitivity but does not affect the thermogenic response to beta-AR stimulation.

263 n the tail skin vasoconstriction response or thermogenic response to cold.

264 gamma have defects in Ucp1 induction and the thermogenic response to cold.

265 t repression is a fundamental feature of the thermogenic response to cold.

266 t mice lacking D2 (D2KO) exhibit an impaired thermogenic response to cold.

267 vs. 6079 +/- 297 kJ day(1); P = 0.51) or the thermogenic response to isoproterenol (6, 12 and 24 ng (

268 0% higher daytime food intake, an 85% higher thermogenic response to the beta3 agonist BRL 35135, and

269 or 'uncoupling protein-3') have a diminished thermogenic response to the drug MDMA (3,4-methylenediox

270 The thermogenic response to the test meal was ascertained by

271 es to mild cooling that reflect this reduced thermogenic response, and (3) a reduced ventilatory resp

272 red 30 mins before MDMA had no effect on the thermogenic response.

273 mediates not only sympathetic and shivering thermogenic responses but also metabolic and cardiac res

274 orm-specific role of NT-PGC-1alpha, adaptive thermogenic responses of adipose tissue were evaluated i

275 nergy expenditure and body weight, including thermogenic responses to diet and cold exposure and 'bei

276 ormone [TRH] to activate hindbrain-generated thermogenic responses.

277 g hormone (TRH) in the hindbrain to generate thermogenic responses.

278 ormone [TRH] to activate hindbrain generated thermogenic responses.

279 cterial composition of the gut and modulated thermogenic responses.

280 and also to integrate systemic metabolic and thermogenic responses.

281 tual exercise-related differences in beta-AR thermogenic responsiveness and the possible influence of

282 Thermogenic responsiveness to beta-AR stimulation is aug

283 Differences in thermogenic responsiveness to beta-AR stimulation, perha

284 We further establish that thermogenic ROS alter the redox status of cysteine thiol

285 duced by the CO2 reduction pathway, not from thermogenic shale gas.

286 s > -50 per thousand, indicating a potential thermogenic source.

287 Variation within thermogenic sources are detected and tabulated.

288 Large differences between biogenic and thermogenic sources are observed.

289 eta-adrenergic stimulation favors the active thermogenic state, whereas sympathetic denervation or gl

290 Furthermore, thermogenic stimulation promotes HDL-cholesterol clearan

291 Here we show that in response to thermogenic stimuli, peroxisomes in brown fat tissue (BA

292 ng in horizontal wells, is the main cause of thermogenic stray gas migration in this oil- and gas-pro

293 A total of 42 water wells contained thermogenic stray gas originating from underlying oil an

294 the control of food intake, body weight, and thermogenic sympathetic outflow by leptin but does not p

295 These cones generate diel midday thermogenic temperature increases as large as 12 degrees

296 s in UCP protein expression in two important thermogenic tissues after resveratrol treatment may cont

297 sing the expressions of brown adipogenic and thermogenic transcriptional factors via the PI3K/Akt and

298 Thus, HDAC3 uniquely primes Ucp1 and the thermogenic transcriptional program to maintain a critic

299 gy homeostasis by dissipating energy through thermogenic uncoupling.

300 Thermogenic visceral WAT improves cold tolerance and pre