ライフサイエンスコーパス: thermolabile

1 early intracellular folding intermediate is thermolabile.

2 ster protecting groups that additionally are thermolabile.

3 can be eaten raw, while indole compounds are thermolabile.

4 s the wild type enzyme, whereas GK(K414E) is thermolabile.

5 rminal ATPase domain nucleotide depleted and thermolabile.

6 tions of DnaC reveals that their activity is thermolabile.

7 erence, their activity in DNA binding is not thermolabile.

8 olase activity in vitro, but were profoundly thermolabile.

9 ombinant wild-type enzyme, which is somewhat thermolabile.

10 tide has been functionalized with either the thermolabile 4-hydroxy-1-butyl or the 4-phosphato-/thiop

11 The thermolabile 4-methylthio-1-butyl phosphate/thiophosphat

12 gated the utility of primers with one or two thermolabile 4-oxo-1-pentyl phosphotriester modification

13 oach in PCR where primers contain one or two thermolabile, 4-oxo-1-pentyl (OXP) phosphotriester (PTE)

14 is synthetic phenotype is due to a naturally thermolabile activity that confers a telomere-specific d

15 Cells containing the ksg1.12 thermolabile allele exhibit pleiotropic phenotypes, incl

16 (1p36.3), and two common alleles, the C677T (thermolabile) allele and the A1298C allele, have been de

17 omparison with strains harboring other cdc28 thermolabile alleles.

18 has revealed a strong bias against specific thermolabile amino-acid residues (i.e. N and Q) in hyper

19 da albicans guanylyltransferase Cgt1 is also thermolabile and is stabilized by binding to Cet1(232-26

20 tion, has been reported to render the enzyme thermolabile and less active and has been associated wit

21 e-to-valine substitution, renders the enzyme thermolabile and may cause elevated plasma levels of the

22 in the absence of Ca(2+), the P8 subunit is thermolabile and unstable, manifested by a slow alpha-he

23 n alpha-helix (approximately 40%), is highly thermolabile, and is characterized by noncooperative unf

24 uctase activity of this mutant was extremely thermolabile, and the rate of fatty acid synthesis measu

25 l mutations, which render the mature protein thermolabile, and tsf (temperature sensitive folding) mu

26 s highly serovar-specific and dependent upon thermolabile antigens.

27 at both Gsalpha R258W and Gsalpha R258A were thermolabile at higher temperatures and that denaturatio

28 is lethal in vivo and renders Cet1 activity thermolabile at physiological temperatures in vitro.

29 This study extends the list of thermolabile bacterial toxins, suggesting that this qual

30 ecreased ATP concentration exacerbates their thermolabile behavior, we suggest that the F231S and W23

31 ecules showed that excessive accumulation of thermolabile collagen II was associated with the activat

32 We propose that thermolabile collagen molecules are able to bind to fibr

33 two major components, one corresponding to a thermolabile complex with transition temperature, T(m(la

34 d beans indicates a coparticipation of their thermolabile components.

35 o both of the alleles is responsible for the thermolabile defect and lag in DNA synthesis of these mu

36 37 degrees C, and mutant extract exhibits a thermolabile defect in Pol II transcription.

37 Apple PPO was thermolabile, denaturing after 10min at 70 degrees C.

38 The thermolabile dimeric organolead hydride was synthesized

39 sense mutation within this domain results in thermolabile DNA binding and conditional lethality in ye

40 37 degrees C during amplification using the thermolabile DNA polymerases Sequenase 1.0, Sequenase 2.

41 in contrast to the thermostable domains, the thermolabile domains are able to accommodate amino acid

42 of the first endothermic peak where the two thermolabile domains melt.

43 o previously identified independently folded thermolabile domains, one in each half of the module, th

44 the growth phenotype, although one exhibited thermolabile enzyme activity in vitro.

45 efficient homocysteine metabolism, creates a thermolabile enzyme with reduced activity.

46 homozygous state for the 677C-->T (so-called thermolabile) enzyme variant (TT genotype), is associate

47 wild-type (WT) coat protein by protecting a thermolabile folding intermediate from aggregation, ther

48 egation pathway, sequential multimers of the thermolabile folding intermediates, have been directly i

49 sitive alleles of either Rho1p or Cdc42p are thermolabile for fusion.

50 A thermolabile form of MTHFR, associated with a C677T gene

51 ons are identical to those of a gene for the thermolabile form of PST in humans, STM; a rat PST gene;

52 ntrifugal separation of the thermostable and thermolabile fractions revealed that almost all the tran

53 h in air), but the purified enzyme was more thermolabile (half-lives at 90 degrees C of 1 and 25 h,

54 ch was due to increased transcription of the thermolabile hemolysin (tlh).

55 nactivation method (except for subjects with thermolabile hexosaminidase B) and may be helpful in gen

56 Tay-Sachs disease, including a patient with thermolabile hexosaminidase B, had less than 2% of nonca

57 However, tHcy was significantly higher in thermolabile homozygotes than in nonthermolabile homozyg

58 trength between 0.2 and 0.5kV/cm, AAO became thermolabile (i.e. increase in inactivation rate (k valu

59 t that the F231S and W233L substitutions are thermolabile in ATP binding, which correlates with defec

60 no change in cofactor affinity but was more thermolabile in the absence of NADPH as judged by CD spe

61 anylyltransferase activity of Ceg1 is highly thermolabile in vitro (98% loss of activity after treatm

62 This opens new possibilities for introducing thermolabile ingredients in bakery products.

63 SAA-mediated effects were thermolabile, inhibitable by anti-SAA antibody, and also

64 of the GroE chaperonin, indicating that the thermolabile intermediate is a physiological substrate f

65 uggest that many proteins are likely to have thermolabile intermediates in their intracellular foldin

66 of Streptococcus mutans NG8 which produces a thermolabile L-(+)-lactate dehydrogenase (LDH) activity.

67 s between the thermostable TS09-C strain and thermolabile LaSota strain using reverse genetics techno

68 soform differed from wild-type COMT by being thermolabile, leading to 2-3-fold lower levels of produc

69 ents of cleaved RNA are all held together by thermolabile linkages, indicating the presence of tether

70 ture-sensitive mutant was shown to produce a thermolabile lipoyltransferase and a tagged version of t

71 al terms as a need to reduce the build-up of thermolabile metabolic intermediates that would be susce

72 Overall, the thermolabile modified primers present a novel and exciti

73 n and identification of semi/nonvolatile and thermolabile molecules.

74 gnificant difference in plasma tHcy level or thermolabile MTHFR allele frequency between subjects and

75 lates in RBCs only from individuals with the thermolabile MTHFR is consistent with the hypothesis tha

76 studies suggest that the reduced activity of thermolabile MTHFR is due to the inappropriate loss of i

77 Individuals with thermolabile MTHFR may have a higher folate requirement

78 Although the thermolabile MTHFR mutation is very common, it does not

79 We examined the relations between thermolabile MTHFR, plasma homocysteine, plasma folate,

80 o maintain the complex integrity of the more thermolabile mTORC2 during isoelectric focusing and dete

81 owth arrest in a cell line which expresses a thermolabile mutant of p53 and extended the in vitro lif

82 mortalized by retroviral transduction with a thermolabile mutant Simian virus 40 (SV40) large T antig

83 us capable of transferring a gene encoding a thermolabile mutant simian virus 40 T antigen (SV40ts).

84 Homozygotes for the thermolabile mutation (TT genotype) of the methylenetetr

85 or V Leiden, hemoglobin C, hemoglobin S, the thermolabile mutation of methylenetetrahydrofolate reduc

86 mostability along the collagen molecule with thermolabile N-terminal domains and thermostable C-termi

87 s affecting the ASE extraction efficiency of thermolabile natural compounds.

88 thermostable NDV could be engineered into a thermolabile NDV vaccine strain for developing novel the

89 Rather, a detergent-soluble and thermolabile OmpF species resembling monomers accumulate

90 forms two domains, a thermostable one and a thermolabile one, leaving the rest of the module to be r

91 BP3 was found to be due to the presence of a thermolabile PBP3 in the strain used in that study.

92 igh degree of structural elucidation for the thermolabile phenolic constituents.

93 oplasts indicated that (a) this Hsp protects thermolabile photosystem II and, consequently, whole-cha

94 esented, and methods to avoid loss of highly thermolabile plant ribosomal RNA species are discussed.

95 catalytic core of RSV IN exhibited the same thermolabile properties for 3' OH processing and strand

96 ester oxidation with iodine accompanied by a thermolabile protecting group (TPG) is presented.

97 for modulating the stability of 2-Pyridinyl Thermolabile Protecting Groups (2-Py TPGs) in the "chemi

98 nucleophilicity and stability of 2-Pyridinyl Thermolabile Protecting Groups in thermal deprotection.

99 Protonation of 4-amino 2-Pyridinyl Thermolabile Protecting Groups is demonstrated by (1)H-(

100 ent of the bacterial SRP, by stabilizing the thermolabile protein.

101 dative protein unfolding in vitro and target thermolabile proteins for irreversible aggregation in vi

102 apid degradation observed for many exogenous thermolabile proteins.

103 A mutation at the dimer-dimer interface in a thermolabile psychrophilic homologue of ht-ADH, ps-A25Y,

104 emonstrated that chondrocytes expressing the thermolabile R992C mutant collagen II molecules endured

105 ng base pairs G1-G9* and G4*-G1, is the most thermolabile region of the DNA quadruplex in all three c

106 ollectively, our results show that EftM is a thermolabile, SAM-dependent methyltransferase that direc

107 sociation of the small peptide with PCNA was thermolabile, suggesting that portions of p21 adjoining

108 os containing the targeted expression of the thermolabile SV40Tag in SN DA neurons.

109 n other P22 structural proteins and from the thermolabile temperature-sensitive mutants described for

110 2 and Dpo3 are much less functional and more thermolabile than Dpo1 and Dpo4 in vitro but have bypass

111 ther characteristic superantigenic toxins or thermolabile toxins believed to be staphylococcal alpha-

112 ts20 is a mutant cell line that contains a thermolabile ubiquitin-activating enzyme (E1) that is in

113 cells at the restrictive temperature for its thermolabile ubiquitin-activating enzyme (E1).

114 tor MG132, analysis in CHO-ts20 cells with a thermolabile ubiquitin-activating enzyme, and direct det

115 polymerized and in a mutant cell harboring a thermolabile ubiquitin-activating enzyme, E1.

116 ensitive mutant cell line, which expresses a thermolabile ubiquitin-activating enzyme, we observed a

117 ity, and interestingly, this activity is not thermolabile under the assay conditions used.

118 is in vivo impairment in the activity of the thermolabile variant of MTHFR and that this impairment r

119 nzyme in one-carbon metabolism, results in a thermolabile variant of the MTHFR enzyme with reduced ac

120 ranes, exposing isolated SR membranes to the thermolabile water soluble free radical initiator, 2,2'-

121 itive mutants were also found to be markedly thermolabile when grown at the permissive temperature, s

122 The N-terminal region appears more thermolabile, yet most of the thermostabilizing mutation