ライフサイエンスコーパス: theta-defensin

1 y equals or exceeds that of normal alpha- or theta-defensins.

2 rallel disulfide bonds, is characteristic of theta-defensins.

3 in the structure, stability, and activity of theta-defensins.

4 Rhesus theta-defensin 1 (RTD-1) is a unique tridisulfide, cycli

5 We evaluated the efficacy of rhesus theta-defensin 1 (RTD-1), a novel cyclic antimicrobial p

6 fensins (hominid retrocyclins 1-3 and rhesus theta-defensins 1-3) and four human alpha-defensins (hum

7 We tested rhesus theta-defensins 1-3, retrocyclins 1-3, and several analo

8 The peptide, termed rhesus theta defensin-1 (RTD-1), is microbicidal for bacteria a

9 Development of modified theta-defensin analogs provides an approach for creating

10 ta-defensins and illustrate the potential of theta-defensin analogues as scaffolds for peptide drug d

11 theta-Defensin analogues with different numbers and comb

12 dings also suggest that interactions between theta-defensins and gp41 may contribute to the ability o

13 n addition, we compared the ability of these theta-defensins and HNP-1 to protect J53-BL cells (an in

14 ide insights into the mechanism of action of theta-defensins and illustrate the potential of theta-de

15 Anti-theta-defensin antibody localized the peptides in circul

16 alpha, beta, and theta defensins are effectors of the innate immune syste

17 We recently reported that theta defensins are miniature lectins that bind gp120 of

18 Theta-defensins are circular octadecapeptides that conta

19 Theta-defensins are cyclic octadecapeptides encoded by t

20 theta-Defensins are cyclic octadecapeptides found in non

21 Theta-defensins are lectin-like, cyclic octadecapeptides

22 Theta-defensins are macrocyclic antimicrobial peptides t

23 theta-Defensins are ribosomally synthesized cyclic pepti

24 with lectin-like properties exist in plants, theta-defensins are the first such molecules to be ident

25 Equal amounts of each theta-defensin bound to E. coli cells, indicating that t

26 llowing for the prediction of 10 theoretical theta-defensins (BTD-1 to BTD-10) produced by binary, he

27 We now report the characterization of baboon theta-defensins (BTDs) expressed in bone marrow and peri

28 We previously reported that synthetic theta-defensins called retrocyclins can neutralize and a

29 Because retrocyclin-1, an ancestral hominid theta-defensin, can protect human cells in vitro from in

30 i-disulfide ladder, and arginine residues of theta-defensins contributed substantially to these prote

31 Theta-defensins (cyclic octadecapeptides found in nonhum

32 3) whose sequences were inferred from human theta-defensin (DEFT) pseudogenes.

33 blotting disclosed the presence of putative theta-defensins, distinct from RTD-1, in leukocyte extra

34 ides of many if not all vertebrates, and the theta-defensins found in certain non-human primates.

35 and RC2, humanized versions of the antiviral theta-defensins found in the leukocytes of certain nonhu

36 Human theta-defensin genes contain a premature stop codon that

37 theta-Defensins have multiple arginines and a ladder-lik

38 This study compares the ability of six theta-defensins (hominid retrocyclins 1-3 and rhesus the

39 We found that members of the alpha- and theta-defensins, magainins and cathelicidins had substan

40 ure, and multiple host defense activities of theta-defensins make them intriguing potential therapeut

41 Low concentrations of theta-defensins not only killed vegetative cells of B. a

42 Growing evidence suggests that theta-defensins offer the best opportunity for therapeut

43 and in vivo led us to examine the effects of theta-defensins on Bacillus anthracis (Sterne).

44 of broad-spectrum antiviral peptides termed theta-defensins, potently inhibits Abeta oligomer and fi

45 Four cDNAs encoding theta-defensin precursors were characterized, allowing f

46 Overall, these findings suggest that theta-defensins provide molecular templates that could b

47 a-defensins HNP-1 and HD-5 and the synthetic theta-defensin RC-101, but not beta-defensins hBD-1 and

48 Here we show that the theta-defensin retrocyclin 2 (RC2) inhibited influenza v

49 To test the activity of a synthetic theta-defensin, retrocyclin (RC)-2, in a murine herpes s

50 The most potent theta-defensin, retrocyclin-2, bound with exceptionally

51 theta-Defensin RTD-1 is a noncompetitive inhibitor of an

52 The rhesus theta-defensin RTD-1 protects mice from an experimental

53 (Crp-4), beta-defensins (HBD-2, HBD-3), and theta-defensins (RTD-1, BTD-7), we show how these peptid

54 Two new theta-defensins, RTD-2 and RTD-3, were purified by rever

55 The peptides included rhesus theta defensins (RTDs) 1 to 3, originally isolated from

56 disulfide bridges of RTD-1, a member of the theta-defensin subfamily, could be replaced with noncova

57 gh degree of sequence conservation among the theta-defensins tested.

58 Retrocyclin (RC)-101 is a cationic theta-defensin that inhibits HIV-1 entry.

59 t progress in our understanding of alpha and theta-defensins - the two structural classes composed of

60 g and the antiviral properties of alpha- and theta-defensins, the lectin-like behavior of defensins m

61 theta-Defensins, the only cyclic peptides of animal orig

62 We tested the ability of 20 synthetic theta defensins to protect cells from infection by type

63 Five of the predicted theta-defensins were purified from baboon leukocytes, an

64 Thus, baboons express numerous theta-defensins which appear to differentially contribut

65 ong, widespread downregulation of alpha- and theta-defensins with anti-HIV activity, which are not ex

66 Synthetic theta-defensins with sequences that correspond to those