ライフサイエンスコーパス: thiol

1 ht by alkylation of the isomerization active thiol.

2 cation is produced in the presence of excess thiol.

3 , presumably upon encountering intracellular thiol.

4 g reaction mechanism of 1,3-benzoxazine with thiols.

5 plification, as well as optical detection of thiols.

6 nge of enantioenriched tertiary alcohols and thiols.

7 be easily removed by the addition of non-GSH thiols.

8 ant to maintain the reduced state of protein thiols.

9 f ferrous ions and the photolysis of organic thiols.

10 the well-known H-atom transfer chemistry of thiols.

11 teins in solution indicated a preference for thiols.

12 results in minimal S-nitrosation of protein thiols.

13 er allyl side chains to low molecular weight thiols.

14 o Hg(II) complexes with low-molecular-weight thiols.

15 both reactions were determined for different thiols.

16 SNO), a redox-based modification of cysteine thiols.

17 more reactive to two-electron oxidants than thiols.

18 opy in oxygenated buffer without addition of thiols.

19 rhodamines [e.g., tetramethylrhodamine (TMR)-thiols].

20 suggest that direct and reversible cysteine thiol 144 may play a functional role in SIRT6-dependent

21 Amino acids containing a thiol, a thioether, or an extra amine group such as argi

22 ia led to extensive S-nitrosation of protein thiols across all cellular compartments.

23 ve center for vacancy-driven gelation with a thiol-activated terminal such as four-arm poly(ethylene

24 e to this understanding, such as kinetics of thiol addition reactions, bioactivities, as well as ster

25 ces good yields of dA, whereas less reactive thiols afford lower yields presumably due to a polarity

26 ts, such as sulfur dioxide or ascorbic acid, thiols, amino acids, and numerous polyphenols.

27 ible diastereoisomers from the addition of a thiol and an alkene to an alpha,beta-unsaturated aldehyd

28 t and complete conversions for a more acidic thiol and balanced equilibrium concentrations in case of

29 the parent amine cleanly under the action of thiol and base.

30 eC double bond peak for (meth)acrylates, H-S thiol and C horizontal lineC double bond peak in thiol-e

31 manipulating pathways that induce oxidative, thiol and metal stress in bacteria could be a useful str

32 through simultaneous induction of oxidative, thiol and metal stress responses in bacteria.

33 ce influences the reactivity between a given thiol and Michael acceptor.

34 ich effectively inactivate the corresponding thiols and alter the electronic and physical properties

35 ght-promoted cross-coupling reaction between thiols and aryl halides for the construction of C-S bond

36 Cis lipids can be converted by thiols and free radicals into trans lipids, which are th

37 by an equal contribution from NOM associated thiols and HgS(s) for Hg(II).

38 orchestrated by antioxidant enzymes, reduced thiols and NADP(H) cofactors, which is critical for canc

39 the relative rate constants of O((3)P) with thiols and other functional groups were found.

40 by its lack of significant response to other thiols and potential interfering agents from biological

41 ng the cellular environment via detection of thiols and then releasing CO when triggered with visible

42 s of MeHg, sulfide, eight low molecular mass thiols and thiol groups associated with natural organic

43 naminones with a broad range of heterocyclic thiols and thiones using cross dehydrogenative coupling

44 el reactions in complex mixtures of multiple thiols and/or acceptors remains largely unknown.

45 ast, PGRP-induced thiol stress (depletion of thiols) and metal stress (increase in intracellular free

46 The reactions involve quinones, hydrazines, thiols, and 1,3-cyclohexadiene.

47 Nitrogenous bases, thiols, and lanthanides do not interfere in the fluorome

48 2mim][OAc] is not just capable of dissolving thiol- and disulfide-containing compounds, but is able t

49 Cysteine thiols are among the most reactive functional groups in

50 Varietal thiols are key aroma compounds in wine issued from multi

51 hange and thio-Michael addition, sharing the thiol as the common building block.

52 ineN bond in acyl hydrazones, using aromatic thiols as nucleophilic catalysts.

53 we decided to study the reaction of NO with thiols as potential sources of HNO.

54 anaerobic conditions aliphatic and aromatic thiols (as well as selenols) are able to convert NO to H

55 n contrast to NO generation upon reaction of thiols at iron nitrite species, at copper this conversio

56 enic acids, which reacted with the resolving thiols at the active sites to produce disulfides (i.e. C

57 decanoic acid (MUDA) and 11-amino-1-undecane thiol (AUT) monolayers were used as tethers on gold surf

58 the material's robustness, which improve the thiol availability to bind with mercury as determined by

59 To address this, we report a new thiol-based HNO-responsive trigger that can compete agai

60 and propose that its activity is linked to a thiol-based transfer of reducing equivalents in bacteria

61 containing PEG moieties and a tethered redox thiol, both markers are detectable across clinically rel

62 lfide followed by the deprotonation of Cys56-thiol by Glu47-carboxylate and (ii) a second thiol-disul

63 > 1 x 10(10) M(-1) s(-1)) radicals, besting thiols by as little as 1 order and as much as 4 orders o

64 changes in solvent accessibility of cysteine thiols by differential isotopic chemical footprinting.

65 As thiols can be oxidized into catalytically inactive disul

66 Thiols can engage favorably with aromatic rings in S-H/p

67 dure to develop antibacterial surfaces using thiol-capped gold nanoparticles (AuNPs) is shown, which

68 ease "cyclopentylation" of amines, alcohols, thiols, carboxylic acids, and other heteroatoms is intro

69 A small-molecule thiol catalyst was found to override the inherent diaste

70 eous phases were dominated by NOM associated thiol complexes for MeHg and by an equal contribution fr

71 d aggregation or the formation of Hg(II)-DOM thiol complexes with high bioavailability.

72 A series of thiol compounds were identified to elevate cellular GSH

73 xperimental data indicate that intracellular thiol concentrations are approximately six times higher

74 found to be highly stable in the presence of thiols, conferring greater stability relative to ODIBO.

75 NRs (AuNRs@RF) than with polyethylene glycol thiol-conjugated AuNRs.

76 maleimide linker (Au102_C6MI) for maleimide-thiol conjugation to nanocapsid cysteines.

77 g that these two Cys residues act as vicinal thiols, consistent with C119S/C162S being incapable of s

78 , using DTT as an external stimulus, and the thiol constituents were successfully isolated.

79 Thiols, including organothiol and thiol-containing biomolecules, are among the most import

80 These small thiol-containing compounds were examined for their abili

81 ble to facile modification with a variety of thiol-containing molecules and macromolecules.

82 The thiol-containing molecules l-cysteine and d-cysteine bot

83 dibenzyl azodicarboxylate and oxygenated or thiol-containing nucleophiles affording stable precursor

84 y effects via reversible Michael addition to thiol-containing proteins in key signaling pathways.

85 Thiol-containing silica UVM7-SH showed the greatest inac

86 We have determined thiol-coupled products in dilute solutions arise mainly

87 s sulfide in a time-, pH-, temperature-, and thiol-dependent manner.

88 Thiol-dependent redox regulation allows the rapid adapta

89 Thiol-dependent redox regulation of enzyme activity play

90 isms of action have been proposed, including thiol depletion and generation of hydrogen peroxide and

91 led storage with more intense tryptophan and thiols depletion, higher protein carbonylation and more

92 Orthogonal maleimide and thiol deprotections were combined with thiol-maleimide c

93 neutral pH that are caused by activation and thiol deprotonation of beta-subunit cysteines.

94 cating that GADD34 is induced by arsenite, a thiol-directed oxidative stressor, in the absence of eIF

95 ytb6f complex and is very likely involved in thiol-disulfide biochemistry at the thylakoid membrane.

96 design the two antiparallel chemistries are thiol-disulfide exchange and thio-Michael addition, shar

97 thiol by Glu47-carboxylate and (ii) a second thiol-disulfide exchange between the Cys56-thiolate and

98 which emphasizes that the thermochemistry of thiol-disulfide exchange in PDI is influenced by the pre

99 sis by protein disulfide isomerase (PDI) and thiol-disulfide exchange is mostly enthalpy-driven (entr

100 mutant variants, we determined the rates of thiol-disulfide exchange reactions between selected pair

101 y can recruit/release monomeric RRM2 through thiol-disulfide exchange reactions.

102 The auto-induction is initiated by a thiol-disulfide exchange that leads to the generation of

103 The reaction proceeds in two stages: (i) a thiol-disulfide exchange through nucleophilic attack of

104 ase in the Gibbs energy barrier of the first thiol-disulfide exchange.

105 Possible reasons were thiol-disulfide interchange reactions, caused either by

106 During this process, the periplasmic thiol-disulfide oxidoreductase DsbA is thought to cataly

107 erminal cis-proline, signature features of a thiol-disulfide oxidoreductase.

108 ram-negative bacteria carry genes coding for thiol-disulfide oxidoreductases in their genomes.

109 reast epithelium, including a more favorable thiol/disulfide balance, greater extents of multidrug re

110 lfide bond formation obviates the need for a thiol/disulfide oxidoreductase in that compartment.

111 s well as influencing metabolic pathways and thiol/disulfide redox balance.

112 In contrast, reduced thiol donors have been shown to delay fatigue or increas

113 tantly the regulatory potential of molecular thiol-driven master switches such as Nrf2/Keap1 or NF-ka

114 lfur species and efficacy in the presence of thiols (e.g., glutathione in mM concentrations).

115 on of voltammetry, preparative electrolysis, thiol-electrode modifications, and kinetic isotope studi

116 The digestion efficiency of the, thiol-ene based, immobilized enzyme reactor (IMER) is co

117 Based on these findings, thiol-ene chemistry is employed to achieve rapid light-c

118 tactic vinyl-functionalized polymers via the thiol-ene click and photocuring reactions readily produc

119 highest yields ever achieved for the radical thiol-ene coupling of a substrate and oligonucleotide.

120 After UV-induced thiol-ene cross-linking, the core of the PFC emulsion re

121 A thiol-ene crosslinking reaction accomplishes the formati

122 Off-stoichiometric thiol-ene is utilized as both bulk material and as a mon

123 ere turned into thermoresponsive polymers by thiol-ene modification to introduce pendant carboxylic a

124 Furthermore, thiol-ene polymerized triacrylates are used as permanent

125 lycol) were installed via postpolymerization thiol-ene reactions.

126 Implications of this new paradigm for the thiol-ene reactivity fall in an interdisciplinary resear

127 l and C horizontal lineC double bond peak in thiol-ene systems, C-O epoxy peak for epoxy resins).

128 ces were fabricated using off-stoichiometric thiol-ene-epoxy (OSTEMER) polymer resulting in hard-poly

129 The alpha,gamma-dienyl thiol esters provide for a one-pot tandem 1,4-addition-n

130 ions with alpha,beta-gamma,delta-unsaturated thiol esters, with the exception of (t)BuMgCl, which gav

131 opening and closing by a technique known as thiol exchange.

132 ating Enzyme 4a) > Enox2 (Ecto-NOX Disulfide-Thiol Exchanger 2) > Ube2d2 (Ubiquitin-conjugating enzym

133 Several mitochondrial protein thiols exposed to the mitochondrial matrix were selectiv

134 conjugate acceptor (1) as a latent source of thiol for signal amplification, as well as optical detec

135 ve trigger that can compete against reactive thiols for HNO.

136 nd is expected to react fast toward reactive thiols from peroxiredoxins (Prxs).

137 h of which form strong complexes with Hg via thiol-functional groups.

138 s fabricated based on a silver nanoparticles/thiol functionalized graphene quantum dot (AgNPs/thiol-G

139 This issue is addressed by creating a thiol functionalized porous organic polymer (POP) using

140 actions of NO2-CLA with low molecular weight thiols (glutathione, cysteine, homocysteine, cysteinylgl

141 DNA/AuNPs were assembled through pH-assisted thiol-gold bonding of single stranded DNA and salt aging

142 l functionalized graphene quantum dot (AgNPs/thiol-GQD) nanocomposite for the measurement of 2,4,6-Tr

143 ch to employ silver nanoparticle (AgNPs) and thiol graphene quantum dots (GQD-SH) as the nanomaterial

144 ection of NDBF render it superior to Bhc for thiol group caging.

145 ollectively, these findings suggest that the thiol group in NAC is required for its effects on glial

146 rough covalent binding at its cysteine (Cys) thiol group, followed by stepwise catalyzed degradation

147 ially react with the disulfide bond, but not thiol group.

148 fied by 3-glycidopropyltrimethoxysilane with thiol groups and 5nm gold nanoparticles (GNPs) was estab

149 ing capacity, protein-bound carbonyl groups, thiol groups and metal chelation activities in addition

150 sulfide, eight low molecular mass thiols and thiol groups associated with natural organic matter (NOM

151 Many of these platforms rely on thiol groups to tether DNA to gold surfaces, but this me

152 ent during the dough stage that insufficient thiol groups were available for forming dough layer inte

153 , non-functionalised and functionalised with thiol groups, to inhibit PPO activity in the model syste

154 s: binding to humic/fulvic acids, binding to thiol-groups, or a combination of both.

155 he direct amination reaction of heterocyclic thiols has been developed in the presence of the nonhaza

156 steine and an attacking low molecular-weight thiol have a dramatic effect on the protein's mechanical

157 s suggests that complexes of Hg(II) with DOM thiols have similar bioavailability to Hg(II) complexes

158 Thiol, hydroxyl, and aliphatic-based side chains at the

159 MSH) is the major low molecular weight (LMW) thiol in Actinomycetes.

160 cysteine 97 (Cys-97) to be the only reactive thiol in human MCU that undergoes S-glutathionylation.

161 g-opening reactions of 1,3-benzoxazines with thiols in absence of solvents where acidity predominates

162 ount the steady state between disulfides and thiols in all living cells, the collapse of the dendrime

163 Overall these data highlight the role of thiols in controlling Zn speciation during its transfer

164 o observed with glutathione, suggesting that thiols in DOM likely played an essential role in affecti

165 NO results in the nitrosylation of cysteine thiols in proteins and low molecular weight thiols such

166 NAr mechanism with a broad range of aromatic thiols in the presence of a base.

167 f NO2(-)-dependent S-nitrosation of proteins thiols in vivo Using this approach, called SNOxICAT (S-n

168 Thiols, including organothiol and thiol-containing biomo

169 The addition of a thiol initiates the reversible ring-opening polymerizati

170 We report that the oxidation state of PEG-thiol is key to anisotropic silica coating, with the dis

171 aring cysteine-containing peptides where the thiol is masked with an NDBF group.

172 ive and sensitive detection of intracellular thiols is important for revealing cellular function.

173 enable more comprehensive identification of thiol isomerase substrates and better elucidation of the

174 Thiol isomerases such as protein-disulfide isomerase (PD

175 tocaged 5'-S-phosphorothiolate linkage or 5'-thiol-labeled RNAs is also further investigated.

176 d the protective effects of NAC, whereas the thiol-lacking molecule N-acetyl-S-methyl-l-cysteine fail

177 silica coating, with the disulfide, not the thiol, leading to side silica coating.

178 e pot, the polymerization is terminated by a thiol-linker to serve as a conjugation point to carrier

179 The addition of amine and thiol linkers have shown a significant effect on cytotox

180 The major function of O-acetyl-Ser-(thiol) lyase (OAS-TL; EC 2.5.1.47) is the formation of l

181 e and thiol deprotections were combined with thiol-maleimide coupling to synthesize discrete oligomer

182 trito complex [Cl2NNF6]Cu(kappa(2)-O2N).THF, thiols mediate reduction of nitrite to NO.

183 tion was accompanied by MSH depletion in the thiol-metabolome.

184 Thiol-Michael "click" reactions are essential synthetic

185 ing functionalized acrylates synthesized via thiol-Michael addition, which are then polymerized using

186 Despite increasing efforts to apply thiol-Michael chemistry in a controlled fashion, the sel

187 selectivity of base- or nucleophile-promoted thiol-Michael reactions in complex mixtures of multiple

188 rovide insights into the design of selective thiol-Michael reactions that can be used for the synthes

189 ough fundamental study of the selectivity of thiol-Michael reactions through a series of 270 ternary

190 y, one-pot quaternary, and sequential senary thiol-Michael reactions were designed and their selectiv

191 ctrochemical aptasensor via self-assembly of thiol-modified aptamer on gold electrodes.

192 on mixed self-assembled monolayers (SAMs) of thiol-modified oligonucleotides and alkanethiols on gold

193 f FCU allows for the direct incorporation of thiol-modified pyrimidines into nascent mRNAs.

194 wo carbons that could potentially react with thiols, modulating signaling actions and levels.

195 In the thiol monolayer supported DDA, the gelation of neutral l

196 -Phosphoethanolamine (DOPE) were tethered on thiol monolayers in the absence and presence of gold nan

197 Independently of the used thiol, N-phenylbenzoxazine and the thiols reacted to equ

198 ferent approaches involving SAMs of aromatic thiols, namely p-mercaptobenzoic acid (p-MBA) and p-amin

199 nolayers of biotinylated polyethylene glycol thiols, neutravidin and biotinylated antibodies to immob

200 Quantifying S-nitrosated protein thiols now allows determination of modified cysteines ac

201 NO formation from thiols occurs from the reaction of RSNO and a copper(II)

202 enzymes, which catalyze the addition of the thiol of Cys to dehydrated Ser residues during the biosy

203 robust C-S couplings of bromoindazoles with thiols of varying electronic nature in the presence of l

204 The insertion of thiol-oligonucleotides into p-ATP monolayers previously

205 s between two Michael acceptors and a single thiol or between a single Michael acceptor and two thiol

206 ntrast to classical approaches starting from thiols or their derivatives, our TrNSO-based approach fa

207 r that may act as a bioisostere of hydroxyl, thiol, or amine groups.

208 ng the structures of these cubes in water by thiol- or photo-induced crosslinking was developed.

209 But a large part of thiol origin still remains unknown.

210 1Q mutations in human CblC unmask its latent thiol oxidase activity and are correlated with increased

211 pha- and beta-faces of cobalamin promote the thiol oxidase activity of ceCblC but mute it in wild-typ

212 alamin coordination chemistry and enable the thiol oxidase activity of ceCblC.

213 sible to ceCblC-bound cobalamin supports its thiol oxidase activity via a glutathionyl-cobalamin inte

214 itis elegans (ceCblC) also exhibits a robust thiol oxidase activity, converting reduced GSH to oxidiz

215 ing of ambient dissolved O2 The mechanism of thiol oxidation catalyzed by ceCblC is not known.

216 ant principles that contribute to productive thiol oxidation in complex, crowded, dynamic environment

217 ctrolyte composition of aqueous solutions on thiol oxidation kinetics was studied, using glutathione

218 lation in response to NO correlates with GC1 thiol oxidation, but the physiological mechanism that re

219 how here that NaOCl stress causes widespread thiol-oxidation including protein S-mycothiolation resul

220 analyse protein S-mycothiolation, reversible thiol-oxidations and their impact on gene expression in

221 The scope of aryl halides and thiol partners includes over 60 examples and therefore p

222 minal such as four-arm poly(ethylene glycol)-thiol (PEG-SH) via chemisorption.

223 rods with poly(ethylene glycol) methyl ether thiol (PEG-thiol) prior to silica coating, but such resu

224 e effects of surface modification with small thiol-PEG ligands on protein adsorption are also demonst

225 f a photoinitiator and a free monofunctional thiol, photodegradation is achieved.

226 correlation between intrinsic reactivity and thiol pKa, and the absence of deuterium solvent kinetic

227 th clickable (azide, alkyne, double bond, or thiol precursor) moieties, starting from the native lipi

228 Thus, we only have an incomplete picture of thiol precursors and there is a lack of knowledge on pre

229 ation and the quantification of new varietal thiol precursors in must.

230 Despite aromatic thiols present a remarkably different behavior from alka

231 oly(ethylene glycol) methyl ether thiol (PEG-thiol) prior to silica coating, but such results have be

232 s shows that the reaction between NO and the thiol produces a free radical adduct RSNOH(*), which rea

233 ored the use of nitrodibenzofuran (NDBF) for thiol protection by preparing cysteine-containing peptid

234 Substitution of the thiol proton in cysteine with m-carborane furnished 2-am

235 the used thiol, N-phenylbenzoxazine and the thiols reacted to equilibrium with comparable amounts of

236 method analysis with the membrane-impermeant thiol reactive reagent p-chloromercuribenzene sulfonate

237 the purified protein, in detergent, with the thiol-reactive N-ethylmalemide (NEM), results in modific

238 firm that most of these compounds are either thiol-reactive or aggregators.

239 gnificant current challenges in the field of thiol-reactive probes for biomedical research and diagno

240 Studies of accessibility with thiol-reactive reagents revealed that the beta-ball and

241 onitrile (BAN) and bromoacetamide (BAM) were thiol-reactive.

242 brated and applied an N-acetylcysteine (NAC) thiol reactivity assay as a surrogate for thiol reactivi

243 ed among genotoxicity, cytotoxicity, and NAC thiol reactivity for all disinfected samples.

244 dearth of information exists relevant to the thiol reactivity of natural products and their analogues

245 In contrast, thiol reactivity was a crucial factor in solvent-free re

246 C) thiol reactivity assay as a surrogate for thiol reactivity with biological proteins (glutathione)

247 NAC thiol reactivity, although excluding the possible effect

248 In addition, we show that pH-triggered thiol rearrangements in K28 can cause the release of cyt

249 re we identify pH-triggered, toxin-intrinsic thiol rearrangements that crucially control toxin confor

250 hioredoxin reductase (TrxR) system maintains thiol redox homeostasis.

251 Here, we report that a cysteine thiol redox sensor contributes to the role of SIRT6 in c

252 The interaction between the two thiol redox systems is indispensable to sustain photosyn

253 culum redox protein folding and cell-surface thiol-redox control of thrombosis and vascular remodelin

254 We extended the thiol-redox proteomic technique, isotope-coded affinity

255 he backbone of His55 and Cys56 and the Cys56-thiol result in an increase in the Gibbs energy barrier

256 uples the conjugate acceptor to release more thiols, resulting in a self-propagating cycle that conti

257 sion proceeds through nucleophilic attack of thiol RSH on the bound nitrite in [Cu(II)](kappa(2)-O2N)

258 anization centered on the interaction of the thiol S-H with the aromatic ring of an adjacent molecule

259 from strongly chemisorbed monolayers such as thiol self-assembled monolayers (SAMs) to physisorbed mo

260 ffers using electrodes such as Au-honeycomb, thiol self-assembled monolayers coated Au, 2D material (

261 onds, epoxy groups) or the MIR region (e.g., thiol signal).

262 SL(*) --> SL'(*)) that are slowly reduced by thiol (SL'(*) + SH --> SL'H + S(*)).

263 We also show that CuNPs are not etched by thiol solutions as previously reported, and address the

264 Zn-cell wall complexes, respectively) and Zn-thiol species were observed in the roots, rhizomes and s

265 med primarily into silver sulfide and silver thiol species.

266 By contrast, PGRP-induced thiol stress (depletion of thiols) and metal stress (inc

267 12.8), under reducing conditions (biological thiols such as glutathione) and in human plasma.

268 thiols in proteins and low molecular weight thiols such as GSH.

269 A much larger preference was observed for thiols, sulfides, and alkenes over aromatic groups.

270 e for primary thiols was observed over other thiols, sulfides, and alkenes.

271 on-heme iron containing PDO and rhodanese, a thiol sulfurtransferase, exist in some bacteria.

272 Applying the thiol terminated aptamer (5TR1) as a recognition layer l

273 A thiol terminated DNA aptamer with affinity for HER2 was

274 g across self-assembled monolayers (SAMs) of thiol-terminated derivatives of oligo(ethylene glycol) (

275 the single-molecule junction conductance of thiol-terminated silanes with Ag electrodes are higher t

276 We also demonstrate that conductance of thiol-terminated silanes with Pt electrodes is lower tha

277 CO2 at functionalized Au surfaces with three thiol-tethered ligands: 2-mercaptopropionic acid, 4-pyri

278 NO2(-) may act by S-nitrosating protein thiols, thereby altering protein activity.

279 subcluster ([4Fe-4S]H) linked by a cysteine thiol to an azadithiolate-bridged 2Fe subcluster ([2Fe]H

280 Additions of cysteine thiols to Michael acceptors underpin the mechanism of ac

281 e, we demonstrate that the addition of small thiols to Mtb drug treatment shifted the menaquinol/mena

282 chemical reactivities of surface amines and thiols to synthesize protein-DNA conjugates with 36 even

283 tection consisted of tert-butylthiol (StBu), thiol-trimethoxyphenyl (STmp), trityl (Trt), 4-methoxytr

284 allyl monosulfide, alkylates both amines and thiols under physiologically relevant conditions via iso

285 or between a single Michael acceptor and two thiols using three different catalysts/initiators (triet

286 of the dendrimers to a multitude of smaller thiols was intracellularly assessed as a means to disrup

287 henylbenzoxazine with aliphatic and aromatic thiols was investigated in solvent-mediated and solvent-

288 A small preference for primary thiols was observed over other thiols, sulfides, and alk

289 rystalline Ag2S and amorphous Ag2S and/or Ag-thiol were identified.

290 However, thiols, which are highly reactive with O((3)P) in the ga

291 formed upon reaction of an additional equiv thiol with [Cu(II)]-OH.

292 ivatives from the corresponding heterocyclic thiols with amines in good to excellent yields.

293 ctance trend is reversed when we replace the thiols with amines, highlighting the impact of metal-S c

294 t the combination of cysteine or other small thiols with either isoniazid or rifampicin prevents the

295 lanced equilibrium concentrations in case of thiols with high pKa values.

296 The strong influence of thiols with low pKa values emphasizes the relevance of t

297 and the relative reactivities of biological thiols with Michael acceptors under physiological condit

298 owing to its high reactivity with biological thiols (with rate constants as high as 10(9) M(-1) s(-1)

299 Here we analyzed protein thiols within mouse hearts in vivo using quantitative pr

300 ure facilitated by the removal of the formed thiols yielding up to 95% recovered 1,3-benzoxazine.