ライフサイエンスコーパス: thioredoxin reductase

1 esidue (which is essential for the mammalian thioredoxin reductases).

2 budding yeast lacking the TRR1 gene encoding thioredoxin reductase.

3 et of these indolequinones was identified as thioredoxin reductase.

4 tivated p53 nor relieved the requirement for thioredoxin reductase.

5 e reductase, Fd:NADP+ oxidoreductase, and Fd:thioredoxin reductase.

6 selenocysteine residue in the active site of thioredoxin reductase.

7 n by a peroxide and reduction by thioredoxin/thioredoxin reductase.

8 analysis identified this enzyme activity as thioredoxin reductase.

9 semisynthetic method for preparing mammalian thioredoxin reductase.

10 small, dithiol thioredoxin proteins and one thioredoxin reductase.

11 ral redox-sensitive processes subordinate to thioredoxin reductase.

12 The latter was partially due to thioredoxin reductase.

13 on the reducing activity of thioredoxin and thioredoxin reductase.

14 tional stability and remains a substrate for thioredoxin reductase.

15 he reduction of the active site disulfide by thioredoxin reductase.

16 nol-thiol pair near the C terminus of animal thioredoxin reductase.

17 very that selenocysteine occurs in mammalian thioredoxin reductase.

18 in via NADPH and the associated enzyme, NADP-thioredoxin reductase.

19 carried mutations in the TRR1 gene encoding thioredoxin reductase.

20 activated with dithiothreitol or thioredoxin/thioredoxin reductase.

21 0-521) is structurally like Escherichia coli thioredoxin reductase.

22 was sensitive to auranofin, an inhibitor of thioredoxin reductase.

23 e by distinct mechanisms in the two forms of thioredoxin reductase.

24 supplying NADPH to glutathione reductase or thioredoxin reductase.

25 ng system, usually involving thioredoxin and thioredoxin reductase.

26 icient tsa1 cells inactivated TRR1, encoding thioredoxin reductase.

27 s reduced by a glutaredoxin rather than NADP-thioredoxin reductase.

28 Therefore, we hypothesized that thioredoxin reductase 1 (TR), a component of several red

29 enzymatic activities and Sec insertion into thioredoxin reductase 1 (TR1) and glutathione peroxidase

30 proteins is Trx1 itself, which together with thioredoxin reductase 1 (TR1) and peroxiredoxins (Prxs)

31 ither the glutathione peroxidase 4 (GPx4) or thioredoxin reductase 1 (TR1) gene were generated by cre

32 ent apoptosis and to be potent inhibitors of thioredoxin reductase 1 (TR1) in MIA PaCa-2 cells at con

33 Thioredoxin reductase 1 (TR1) is a key component in the

34 Thioredoxin reductase 1 (TR1) is one of the major antiox

35 om B. anthracis in the presence of NADPH and thioredoxin reductase 1 (TR1), whereas thioredoxin 2 (Tr

36 ition or in its close proximity in mammalian thioredoxin reductase 1 (TR1).

37 argeted insertion of Cys at the UGA codon of thioredoxin reductase 1 (TR1).

38 bust cytosolic thioredoxin system, driven by thioredoxin reductase 1 (TrxR1 or TXNRD1).

39 Thioredoxin reductase 1 (TrxR1) in cytosol is the only k

40 Thioredoxin reductase 1 (TrxR1) is a selenocysteine-cont

41 peroxiredoxin 2 (Prx2)/thioredoxin 1 (Trx1)/thioredoxin reductase 1 (TrxR1) network.

42 The human selenoprotein thioredoxin reductase 1 (TrxR1), encoded by the TXNRD1 g

43 transcriptome profiles showed an increase in thioredoxin reductase 1 (TXNRD1) and sulfiredoxin (SRXN1

44 In contrast, thioredoxin reductase 1 (TXNRD1) is regulated by NRF2 bu

45 es in GPx3 activity, plasma, and erythrocyte thioredoxin reductase 1 concentrations and lymphocyte gl

46 Addition of the thioredoxin reductase 1 inhibitor (TXNRD1) auranofin (AF

47 targets of ATM in rheumatoid arthritis (RA), thioredoxin reductase 1 or 2.

48 ression of housekeeping selenoproteins (e.g. thioredoxin reductase 1) in liver but not stress-related

49 Three genes-aldose reductase, thioredoxin reductase 1, and glucose-6-phosphate 1-dehyd

50 e conditions, the expression and activity of thioredoxin reductase 1, another selenoprotein, is incre

51 r the thioredoxin reductase domain of TGR or thioredoxin reductase 1.

52 ene, whereas other selenoproteins, including thioredoxin reductases 1 and 3 and glutathione peroxidas

53 Drosophila melanogaster thioredoxin reductase-1 (DmTrxR-1) is a key flavoenzyme

54 The mammalian thioredoxin reductase-1 (TR) is an oxidoreductase seleno

55 Here we demonstrate that thioredoxin reductase-1 (TR1), a selenium-containing pyr

56 l specific glutathione peroxidase-2 (GPx-2), thioredoxin reductase-1 (TrxR-1) and selenoprotein P (Se

57 ented by TRX-1 oxidation using inhibitors of thioredoxin reductase-1 (TrxR-1).

58 H) transfers intracellular reducing power to thioredoxin reductase-1 (TrxR1) and glutathione reductas

59 tivity of curcumin on the antioxidant enzyme thioredoxin reductase-1 (TxnRd1) is required for curcumi

60 terization, we identified that inhibition of thioredoxin reductase-1 (TXNRD1), one of the key antioxi

61 metabolism of ROS, including suppression of thioredoxin reductase 2, an enzyme participating in ROS

62 ied by thioredoxin-2 (Trx2) and, ultimately, thioredoxin reductase-2 (TrxR2).

63 Specifically, upregulation of mitochondrial thioredoxin reductase-2 occurred with both HFHS and Ex i

64 Furthermore, upregulation of thioredoxin reductase-2 plays a critical role in preserv

65 y HFHS diet, in part through upregulation of thioredoxin reductase-2.

66 lic glutathione peroxidase and mitochondrial thioredoxin reductase 3 were the most and least affected

67 produces the first 487 amino acids of mouse thioredoxin reductase-3 as an intein fusion protein in E

68 of human glutathione peroxidase (58 nt) and thioredoxin reductase (51 nt).

69 redox signaling and ntra/ntrb (defective in thioredoxin reductases a and b) double mutants that are

70 xpression of the chloroplast NADPH-dependent thioredoxin reductase, a central hub in chloroplast redo

71 s against various cellular targets including thioredoxin reductase, a known target of several gold co

72 showed that auranofin inhibits the bacterial thioredoxin reductase, a protein essential in many Gram-

73 Evolution has produced two forms of thioredoxin reductase, a protein in prokaryotes, archaea

74 prostaglandins covalently modify and inhibit thioredoxin reductase, a selenoprotein that governs p53

75 was reversed by a reductase system involving thioredoxin reductase, a selenoprotein.

76 By inhibiting thioredoxin reductase activity and increasing intracellu

77 inones were found to be potent inhibitors of thioredoxin reductase activity both in pancreatic cancer

78 ion, results presented here demonstrate that thioredoxin reductase activity plays an essential role i

79 , metallothionein transcripts, inhibition of thioredoxin reductase activity, and cell death.

80 paraquat reductase from the cells contained thioredoxin reductase activity, and purified rat liver t

81 ut endogenous cellular factors that modulate thioredoxin reductase activity.

82 t 4-hydroxy-2(E)-nonenal, or an inhibitor of thioredoxin reductase all resulted in increased expressi

83 Thioredoxin reductase, an enzyme implicated in the growt

84 and accepted electrons from Escherichia coli thioredoxin reductase and atypical Trx2.

85 sulfide was not a substrate for reduction by thioredoxin reductase and delayed the reduction of the a

86 ed to thiol metabolism, such as thioredoxin, thioredoxin reductase and enzymes involved in cysteine a

87 An Escherichia coli strain that lacks both thioredoxin reductase and glutathione reductase grows ex

88 mide dehydrogenase) and antioxidant defense (thioredoxin reductase and glutathione reductase).

89 her electrophilic agents should also inhibit thioredoxin reductase and impair its governance of redox

90 ure-activity relationships for inhibition of thioredoxin reductase and impairment of p53 by electroph

91 Whereas all three components (thioredoxin 1, thioredoxin reductase and NADPH) in the thioredoxin redu

92 ioredoxin system, consisting of thioredoxin, thioredoxin reductase and NADPH, is known to protect cel

93 y be attributable, in part, to inhibition of thioredoxin reductase and several redox-sensitive proces

94 ditions by the thioredoxins with the help of thioredoxin reductase and the glutaredoxins with the sma

95 Thioredoxin reductase and thioredoxin also reduce cystin

96 Thioredoxin reductase and thioredoxin constitute the cel

97 e thioredoxin redox cycle (comprising NADPH, thioredoxin reductase and thioredoxin) is emphasized by

98 by the NADP/thioredoxin system (NADPH, NADP-thioredoxin reductase and thioredoxin; in plants, the h

99 ecule dithiol oxidases and NADP(+)-dependent thioredoxin reductases and provide insights for understa

100 fer systems (glutathione/GSH and thioredoxin/thioredoxin reductase) and have developed several enzyma

101 tion) contains genes encoding a thioredoxin, thioredoxin reductase, and an additional oxidoreductase

102 ivator receptor, serine/threonine kinase 15, thioredoxin reductase, and CDC28 protein kinase 2, as we

103 arbonylation was suppressed by inhibition of thioredoxin reductase, and cellular thioredoxin was upre

104 s, analogous to those proposed for bacterial thioredoxin reductase, and cycling of these enzymes betw

105 mide dehydrogenase, trypanothione reductase, thioredoxin reductase, and mercuric reductase.

106 catalytic components (H(2)O(2), thioredoxin, thioredoxin reductase, and NADPH) was necessary, indicat

107 In the presence of thioredoxin, thioredoxin reductase, and NADPH, this protein was shown

108 isulfide isomerization involves thioredoxin, thioredoxin reductase, and the DsbC, DsbG, and DsbD prot

109 ipoxygenase were poor inhibitors of isolated thioredoxin reductase, and the overexpression of 5-lipox

110 etic mechanism-namely ferredoxin, ferredoxin-thioredoxin reductase, and thioredoxin.

111 ncodes many genes annotated as thioredoxins, thioredoxin reductases, and glutaredoxin-like proteins.

112 three potential thioredoxins, two potential thioredoxin reductases, and three glutaredoxin-like prot

113 TrxR, a glutaredoxin-like thioredoxin and a thioredoxin reductase; and NrdI, a flavodoxin essential

114 nt parasites, contain a low molecular weight thioredoxin reductase, apparently of bacterial origin.

115 only catalytic amounts of thioredoxin 1 and thioredoxin reductase are required.

116 Mammalian cytosolic and mitochondrial thioredoxin reductases are essential selenocysteine-cont

117 hane, and hemin with responses comparable to thioredoxin reductase (ARE regulator) or quinone reducta

118 an effective substrate for recombinant human thioredoxin reductase as well as native rat thioredoxin

119 reductases, glutaredoxins, thioredoxins, and thioredoxin reductases, as well as glutathione- and thio

120 Transcriptional profiling and thioredoxin reductase assays suggested that auranofin ta

121 of GSSG reductase (bischoloronitrosourea) or thioredoxin reductase (auranofin) was effective in causi

122 es (e.g., glutathione S-transferase [MGST2], thioredoxin reductase beta, and peroxiredoxin 2) have be

123 dly and effectively rereduced by thioredoxin/thioredoxin reductase but not glutathione.

124 reased activity of glutathione reductase and thioredoxin reductase, but not catalase.

125 The NADPH-dependent thioredoxin reductase C (NTRC) is involved in redox-rela

126 e, the recently identified chloroplast NADPH thioredoxin reductase C (NTRC), plays a role specificall

127 Here, we show that NADPH-thioredoxin reductase C (NTRC), previously reported as e

128 utant lacking both glutathione reductase and thioredoxin reductase cannot grow because RNR is disulfi

129 s specifically with Arabidopsis ferredoxin : thioredoxin reductase catalytic subunit (AtFTRc), a key

130 Ferredoxin:thioredoxin reductase catalyzes the reduction of thiored

131 group of bacterial flavoproteins related to thioredoxin reductase contain an additional approximatel

132 lutathione reductase and mercuric reductase, thioredoxin reductase contains a redox active disulfide

133 Mammalian thioredoxin reductase contains the rare amino acid selen

134 The latter process was markedly inhibited in thioredoxin reductase-deficient HepG2 cells, suggesting

135 2,4-dinitro-1-chlorobenzene (an inhibitor of thioredoxin reductase) delayed the reduction of oxidized

136 deletion suppressed the inhibitory effect of thioredoxin reductase deletion, suggesting that accumula

137 hioredoxin-deficient HeLa cells with mutated thioredoxin reductase denitrosate S-nitrosothiols less e

138 of these six cysteine substitutions relieved thioredoxin reductase dependence.

139 doxin-dependent peroxidase, while another, a thioredoxin reductase-dependent protein disulphide isome

140 amed deazaflavin-dependent flavin-containing thioredoxin reductase (DFTR).

141 with azelaic acid, a specific inhibitor for thioredoxin reductase, did not alter the effect of flow

142 D. melanogaster lack glutathione reductase, thioredoxin reductase (DmTrxR) is particularly important

143 hich could receive electrons from either the thioredoxin reductase domain of TGR or thioredoxin reduc

144 roteins, we showed that the glutaredoxin and thioredoxin reductase domains of TGR could independently

145 Thioredoxin reductase (EC 1.6.4.5) is a widely distribut

146 The results suggested that p53 dependence on thioredoxin reductase either was indirect, perhaps media

147 Inhibition of thioredoxin-thioredoxin reductases enabled identification of additio

148 Thioredoxin reductases encoded by the full-length genes

149 Thioredoxin reductase (encoded by trxB) protects Staphyl

150 ently discovered member of the selenoprotein thioredoxin reductase family in mammals.

151 an alternative mechanism to thioredoxin and thioredoxin reductase for Prx2 recycling.

152 Two distinct thioredoxin reductases found in eukaryotes have differen

153 Thioredoxin reductase from Drosophila melanogaster (DmTr

154 High-M(r) thioredoxin reductase from the malaria parasite Plasmodi

155 nic photosynthesis is mediated by ferredoxin:thioredoxin reductase (FTR), a novel class of disulfide

156 I by means of ferredoxin (Fdx) to ferredoxin-thioredoxin reductase (FTR), which catalyses the two-ele

157 o a range of broad-spectrum antibiotics) and thioredoxin reductase genes (which reduce oxidative stre

158 a coli with mutations in the glutathione and thioredoxin reductase genes yielded 60% more soluble PvM

159 Mammalian high molecular weight thioredoxin reductase (H-TrxR) is evolutionarily diverge

160 Thioredoxin reductase has an N-terminal redox-active dis

161 nase are now available; another drug target, thioredoxin reductase, has been demonstrated to be essen

162 To date, however, only one selenoprotein, thioredoxin reductase, has been detected in Caenorhabdit

163 The results suggest that cells lacking thioredoxin reductase have diminished capacity to detoxi

164 nal evolutionarily linked proteins include a thioredoxin reductase homolog and two thiol:disulfide ox

165 lated proteins, including a newly identified thioredoxin reductase homolog, YcgT.

166 ous thioredoxin reductase system composed of thioredoxin reductase, human or Escherichia coli thiored

167 redoxin (IC(50) approximately 8 micrometer), thioredoxin reductase (IC(50) approximately 0.2 micromet

168 itrosylation, and identified thioredoxin and thioredoxin reductase in a biochemical screen.

169 etabolites of 15-lipoxygenase-1 also inhibit thioredoxin reductase in HEK-293 cells that harbor a 15-

170 s observed to be important for expression of thioredoxin reductase in response to oxidative challenge

171 thioredoxin reductase as well as native rat thioredoxin reductase in the presence of NADPH.

172 of additional transgenes encoding Mn-SOD or thioredoxin reductase in the same genetic background als

173 olites of 15-lipoxygenase-1 inhibit purified thioredoxin reductase in vitro.

174 ol increased glutathione and glutathione and thioredoxin reductases in osteoclast-like cells in vitro

175 to have similarities to that of ferredoxin, thioredoxin reductase, in that one electron is transferr

176 In contrast, inhibitors of thioredoxin reductase, including auranofin and 1-chloro-

177 observed in intact dopaminergic neurons with thioredoxin reductase inhibition, implicating this mecha

178 tathione synthesis inhibitor) and auranofin (thioredoxin reductase inhibitor) induces oxidative burst

179 n by mercaptoethanol and was enhanced by the thioredoxin-reductase inhibitor auranofin.

180 Mammalian thioredoxin reductase is a homodimeric pyridine nucleoti

181 oxin) is emphasized by the confirmation that thioredoxin reductase is essential for the survival of i

182 The enzyme thioredoxin reductase is overexpressed in cancer cells,

183 These methods suggest that thioredoxin reductase is the only Sec-containing protein

184 In contrast to two other mammalian thioredoxin reductases, it contains an N-terminal glutar

185 toplasmic bacterial expression system with a thioredoxin reductase knock-out strain of BL21(DE3) to p

186 ivergent from bacterial low molecular weight thioredoxin reductase (L-TrxR).

187 an be dissected into two functional units, a thioredoxin reductase-like C-terminus (containing FAD an

188 the well characterized low molecular weight thioredoxin reductases (LMW TrxRs), is an NADP(+)-indepe

189 t a truncated version of mouse mitochondrial thioredoxin reductase missing this C-terminal tail will

190 PhoA degradation was reduced in a thioredoxin-reductase mutant (trxB), which allowed PhoAD

191 In the presence of reductant (thioredoxin/thioredoxin reductase/NADPH or DTT), the enzyme inactiva

192 e reduction using the ubiquitous thioredoxin/thioredoxin reductase/NADPH system.

193 that had been assigned as an NADPH-dependent thioredoxin reductase (NTR).

194 NADPH-dependent thioredoxin reductases (NTRs) contain a flavin cofactor

195 nown cytosolic DSBP, such as peroxiredoxins, thioredoxin reductase, nucleoside-diphosphate kinase, an

196 ted that led to small molecule inhibitors of thioredoxin reductase of Mycobacterium tuberculosis (MtT

197 Sequence data indicate that the thioredoxin reductase of Trichomonas differs fundamental

198 ws these fundamental differences between the thioredoxin reductases of some parasites and their hosts

199 expression of 5-lipoxygenase did not inhibit thioredoxin reductase or cause a G cell cycle arrest.

200 n reductase activity, and purified rat liver thioredoxin reductase or recombinant enzyme possessed pa

201 The protein is generally similar to thioredoxin reductases present in other lower eukaryotes

202 ed that auranofin targets the E. histolytica thioredoxin reductase, preventing the reduction of thior

203 ng RNAP, Spx and trxA (thioredoxin) or trxB (thioredoxin reductase) promoter DNA was undertaken to un

204 rom a -35-like element upstream of the trxB (thioredoxin reductase) promoter to positions -36 and -11

205 arboxylase), resistance to oxidative stress (thioredoxin reductase), quorum sensing (Pfs), and severa

206 pe of thioredoxin, reduced by NADPH via NADP-thioredoxin reductase, reduces disulfide bonds of target

207 The selenoenzyme thioredoxin reductase regulates redox-sensitive proteins

208 Inhibition of thioredoxin reductase represents a potential novel targe

209 me P450 reductase, biliverdin reductase, and thioredoxin reductase, resulting in a concomitant reduct

210 imilar manner and suggested that thioredoxin/thioredoxin reductase signal transduction could be a put

211 insulin reduction, catalyzed by thioredoxin/thioredoxin reductase signaling in a dose-dependent mann

212 t-2-enyl diphosphate synthase and ferredoxin:thioredoxin reductase suggests that HMBPP binds to the F

213 n 1, thioredoxin reductase and NADPH) in the thioredoxin reductase system are essential for mediating

214 nked peroxidase activity using a thioredoxin-thioredoxin reductase system as electron donor, and anti

215 Nevertheless, the thioredoxin reductase system can promote the iron-sulfur

216 protein-2 are substrates for the ubiquitous thioredoxin reductase system composed of thioredoxin red

217 and that the presence of the thioredoxin and thioredoxin reductase system could significantly protect

218 otubule-associated protein-2 with either the thioredoxin reductase system or small molecule reductant

219 HepG2 cells, suggesting that the thioredoxin/thioredoxin reductase system tends to maintain intracell

220 by dithiothreitol or the E. coli thioredoxin/thioredoxin reductase system under anaerobic conditions.

221 results indicate that in the presence of the thioredoxin reductase system, Escherichia coli IscA bind

222 cU fails to bind iron in the presence of the thioredoxin reductase system, suggesting that the iron b

223 thiol groups in IscA are re-reduced with the thioredoxin reductase system, the iron binding activity

224 In the presence of the thioredoxin reductase system, which emulates the intrace

225 thione or by incubation with the thioredoxin/thioredoxin reductase system.

226 a more potent inhibitor for Escherichia coli thioredoxin reductase than comparable simple inorganic o

227 The semisynthetic version of thioredoxin reductase that we produce in this manner has

228 an iron-sulfur disulfide enzyme, ferredoxin-thioredoxin reductase, that receives photosynthetic elec

229 ajor thiol antioxidants, and glutathione and thioredoxin reductases, the enzymes responsible for main

230 of sigR, rsrA, mshA and mca, as well as the thioredoxin reductase-thioredoxin system, generating an

231 ses and that the inducible expression of the thioredoxin reductase/thioredoxin genes trxB2/trxC and a

232 cing equivalents from thioredoxin (Trx1) and thioredoxin reductase to reduce alkyl hydroperoxides.

233 re altered by H(2)O(2)-mediated oxidation in thioredoxin reductase (TR) and acetylcholinesterase (Ach

234 Thioredoxin reductase (TR) and thioredoxin (Trx) define

235 c technique permitted the isolation of human thioredoxin reductase (TR) as a critical regulator of IF

236 Mammalian thioredoxin reductase (TR) contains a rare selenocystein

237 Thioredoxin reductase (TR) from Drosophila melanogaster

238 ltransferase (TTase), thioredoxin (Trx), and thioredoxin reductase (TR) in the lens, the present stud

239 Mammalian thioredoxin reductase (TR) is a selenocysteine (Sec)-con

240 Thioredoxin reductase (TR) is an oxidoreductase responsi

241 One of the GRIMs was human thioredoxin reductase (TR), a redox enzyme.

242 f the GRIMs, GRIM-12, was identical to human thioredoxin reductase (TR), an enzyme that controls intr

243 for TTase, TRx, glutathione reductase (GR), thioredoxin reductase (TR), and glyceraldehyde-3-phospha

244 ecreased activities of thioredoxin (Trx) and thioredoxin reductase (TR), concomitant with diminution

245 Grx2 showed glutathione (GSH)-dependent and thioredoxin reductase (TR)-dependent peroxidase activity

246 A surrogate target for Trx-1 may be thioredoxin reductase (TR).

247 GRIM cDNAs, GRIM-12, was identical to human thioredoxin reductase (TR).

248 system, is a 57 kDa protein with homology to thioredoxin reductase (TrR) from Escherichia coli.

249 terminus of AhpF is 35% identical to that of thioredoxin reductase (TrR) from Escherichia coli.

250 ive stress response, Rho5 interacts with the thioredoxin reductase Trr1, a key component of the cytop

251 show here that thioredoxins (TRX1, TRX2) and thioredoxin reductase (TRR1) are also required for prote

252 We have characterized the thioredoxin reductase (trr1) genes from Pneumocystis car

253 -specific thioredoxin (Trx2) and NADP-linked thioredoxin reductase (TRR2).

254 Thioredoxin reductases (TRs) are important redox regulat

255 Animal thioredoxin reductases (TRs) are selenocysteine-containi

256 High-molecular weight thioredoxin reductases (TRs) catalyze the reduction of t

257 Most high M(r) thioredoxin reductases (TRs) have the unusual feature of

258 activity in vitro that required thioredoxin-thioredoxin reductase (Trx-TrxR).

259 Double mutants lacking thioredoxin reductase (trxB) and glutathione reductase (

260 Two genes, thioredoxin (trxA) and thioredoxin reductase (trxB), are transcriptionally indu

261 homeostasis, such as thioredoxin (trxA) and thioredoxin reductase (trxB).

262 In addition, it was shown that the thioredoxin reductase (TrxB)/Trx system is the major or

263 f the complexes were comparatively tested as thioredoxin reductase (TrxR) and glutathione reductase (

264 They exclusively receive electrons from thioredoxin reductase (TrxR) and not from mycothiol, the

265 Pirazzini et al. observed that inhibitors of thioredoxin reductase (TrxR) blocked TeNT and BoNT actio

266 Thioredoxin reductase (TrxR) catalyzes the reduction of

267 center, is an unusual member of the low-M(r) thioredoxin reductase (TrxR) family.

268 In thioredoxin reductase (TrxR) from Escherichia coli, cycl

269 ased intracellular H2O2 levels by inhibiting thioredoxin reductase (TrxR) in cells expressing CRBN, c

270 species of the human malaria parasites, and thioredoxin reductase (TrxR) is an enzyme involved in th

271 Thioredoxin reductase (TrxR) is an essential enzyme requ

272 Mammalian thioredoxin reductase (TrxR) is an NADPH-dependent homod

273 Herein we show that thioredoxin reductase (TrxR) is responsible for actin de

274 Thioredoxin reductase (TrxR) is the homodimeric flavoenz

275 activity and NO sensitivity because the Trx/thioredoxin reductase (TrxR) system maintains thiol redo

276 Unexpectedly, inhibitor data pointed to thioredoxin reductase (TrxR), an essential component req

277 The thioredoxin reductase (TrxR), the estrogen receptor (ER)

278 uitinases, b-AP15 inhibits the selenoprotein thioredoxin reductase (TrxR).

279 inhibit the activity of a key selenoenzyme, thioredoxin reductase (TrxR).

280 CN1, microtubule-associated protein (MAP)1B, thioredoxin reductase (TrxR)1 cytoplasmic isoform 3, glu

281 molecular weight proteins that together with thioredoxin reductases (TrxR) participate in the mainten

282 hat the respective electron delivery enzyme (thioredoxin reductase, TrxR), although structurally simi

283 h the endogenous reducing system of NrdH and thioredoxin reductase (TrxR1).

284 Thioredoxin reductases (TrxRs) are flavin-containing dit

285 Thioredoxin reductases (TrxRs) regulate the intracellula

286 nticancer compounds are strong inhibitors of thioredoxin reductases (TrxRs), selenoenzymes involved i

287 lso display higher levels of thioredoxin and thioredoxin reductase, two enzymes critical for maintain

288 v) is less able to up-regulate expression of thioredoxin reductase under oxidative stress.

289 responses are consistent with inhibition of thioredoxin reductase via 15-lipoxygenase-1 overexpressi

290 =10,000 cancer-related genes, expression of thioredoxin reductase was up-regulated >3-fold.

291 e chaperonin heat shock protein (Hsp) 90 and thioredoxin reductase were identified by mass spectromet

292 Most recently, thioredoxin/thioredoxin reductases were shown to mediate both basal

293 mes, glutathione reductase, thioredoxin, and thioredoxin reductase, were unaffected by sporidesmin.

294 We now report that the parasite contains thioredoxin reductase, which functions together with thi

295 nstead, they contain a high molecular weight thioredoxin reductase, which shares common ancestry with

296 -1 belongs to the family of dimeric, high Mr thioredoxin reductases, which catalyze reduction of thio

297 Here we show that the truncated thioredoxin reductase will catalyze the reduction of met

298 We produced the semisynthetic thioredoxin reductase with a total yield of 24 mg from 6

299 non-enzymatic rearrangement product inhibit thioredoxin reductase with IC(50) = 13 +/- 1.5 microm an

300 aA, we could produce mammalian selenoprotein thioredoxin reductases with unsurpassed purity and yield