ライフサイエンスコーパス: thousands of

1 on models, to survey the dynamics of tens of thousands of 3' UTR sequences during early zebrafish emb

2 Tens of thousands of A-to-I editing events are defined in the mo

3 same mechanism is likely to function in the thousands of additional species with similar behaviors.

4 Thousands of alternative proteins are detected in proteo

5 Neurexins, expressed in thousands of alternatively spliced isoforms, are central

6 ranscript usage (DTU) have been observed for thousands of Arabidopsis thaliana, Zea mays and Vitis vi

7 sm (CD) spectra of typical biomolecules with thousands of atoms is presented.

8 nments and phylogenies for a given loci from thousands of available genomes.

9 Because a PheWAS can test thousands of binary phenotypes, and most of them have un

10 Naphthenic acids (NAs) and thousands of bitumen-derived organics were characterized

11 Furthermore, bioinformatics analysis of thousands of cancer genomes revealed that none of these

12 Analyzing data from thousands of cancer lines and tumors, we find that those

13 a set of tools to rapidly clone and stratify thousands of cancer mutations at base resolution.

14 chnology with integrated imaging to sequence thousands of cancer nuclei in parallel from fresh or fro

15 The framework has been validated on thousands of cancer samples, using gene expression, DNA

16 We construct atomic resolution models of thousands of candidate substrate-enzyme complexes for ea

17 Thousands of cells build mounds in which some differenti

18 l microfluidic platform capable of screening thousands of cells in a few hours, we observe differenti

19 f bacterial cultures with high cell density (thousands of cells per frame) and complete cell cycle im

20 nge that facilitates tagging and tracking of thousands of cells simultaneously.

21 ent epithelial tissues consisting of tens of thousands of cells, with a level of detail inaccessible

22 ment on 50 markers for more than hundreds of thousands of cells.

23 samples, on a scale of thousands or tens of thousands of cells.

24 s, affected individuals can have hundreds to thousands of cerebral microinfarcts, which cause measura

25 Since then, thousands of chemicals have entered the food system.

26 e and at work, humans are exposed to tens of thousands of chemicals, many of which have not been eval

27 heir grant to collect high-quality data from thousands of children with World Health Organization-def

28 ISCs and progenitors of both major lineages, thousands of cis elements that control expression of lin

29 rated using Sanger sequencing, and one using thousands of clone pools.

30 icroarrays have allowed the interrogation of thousands of common genetic markers in thousands of indi

31 ctural features) often favor hundreds if not thousands of competing phylogenies.

32 profiling of 978 representative genes across thousands of compound treatments.

33 composition is well recognised, however with thousands of compounds in wine the exact nature of indiv

34 specialized metabolism produces hundreds of thousands of compounds, offering striking examples of th

35 ase containing gene expression signatures of thousands of compounds, to predict candidate drugs with

36 pectrometry (TOF-MS) allows the detection of thousands of compounds.

37 nge, and ability to characterize hundreds to thousands of compounds.

38 three-soliton bound states over hundreds of thousands of consecutive cavity roundtrips, identifying

39 Second, the chromosome can be present at thousands of copies in a single cell (in contrast to two

40 thousand nuclear DNA genes plus hundreds to thousands of copies of the maternally inherited mitochon

41 rning with approximately 90% accuracy across thousands of courses in diverse settings with minimal ef

42 s demonstrated by performing several tens of thousands of cycles of device operation.

43 Syrian war that had resulted in hundreds of thousands of deaths and created millions of refugees.

44 us respiratory infection causing hundreds of thousands of deaths annually worldwide.

45 zard to human health that causes hundreds of thousands of deaths annually.

46 spiratory infections in humans, resulting in thousands of deaths annually.

47 the most significant, being responsible for thousands of deaths each year in Asia.

48 virus (JEV) is a Flavivirus responsible for thousands of deaths every year for which there are no sp

49 dous pesticides is likely to prevent tens of thousands of deaths every year.

50 a large-scale measurement of the activity of thousands of designed promoters at six different levels

51 f repeated sequences and the introduction of thousands of designer changes may affect genome organiza

52 inbred Drosophila wild isolates, identifying thousands of developmental-stage-specific and shared QTL

53 st polymorphic within the human genome, with thousands of different allelic variants known within the

54 Metabolism is highly complex and involves thousands of different connected reactions; it is theref

55 teria have the collective capacity to encode thousands of different cyclic peptides, few of which wou

56 NCE STATEMENT The vertebrate brain generates thousands of different neuron types.

57 Despite the identification of thousands of disease-associated genetic variants through

58 mixtures such as the cytosol may consist of thousands of distinct components.

59 as editosomes collaborate to accurately edit thousands of distinct editing sites in vivo.

60 pair barcodes representing binding proteins, thousands of distinct interactions can be screened in a

61 le well to studies with hundreds of taxa and thousands of DNA base pairs.

62 Tens to thousands of DNA copies can be reliably quantified with

63 goal was to produce in as little as one week thousands of doses of an intervention for a new pathogen

64 Every night, the human brain produces thousands of downstates and spindles during non-REM slee

65 on factors, which regulate the expression of thousands of downstream genes.

66 nes in a single duplexed reaction containing thousands of droplets.

67 Although thousands of drugs interact with these receptors, our mo

68 Analyses of thousands of ectopically expressed variants demonstrate

69 ly 10(6) enhancers encoded in the genome the thousands of enhancers that drive the gene programs that

70 Throughout the Americas, thousands of enslaved Africans managed to escape captivi

71 mber of mixtures that can be formed from the thousands of environmental chemicals is enormous, and te

72 histicated coleoid cephalopods, with tens of thousands of evolutionarily conserved sites.

73 Assessment of water quality evolution in the thousands of existing and future mine pit lakes worldwid

74 ta sets, each a meta-analysis of hundreds to thousands of experiments, across eight plant species to

75 plosion in detection and characterization of thousands of extrasolar planets from the Kepler mission,

76 Of the thousands of extrasolar planets now known, only six have

77 se replication errors could generate tens of thousands of false-positive calls per genome.

78 olomics, it is now routine to detect tens of thousands of features from biological samples.

79 n DISC1 via solubility assessment of tens of thousands of fragments of recombinant DISC1.

80 -registered mechanical contact activation of thousands of gel compartments in series while circumvent

81 Although these screens affect thousands of gene products, the typical readout is based

82 to be evaluated with respect to hundreds or thousands of gene sets.

83 null mutant mouse ES cells is applicable to thousands of genes and repurposes existing IKMC Intermed

84 analysis showed that the expression of over thousands of genes and splicing efficiency in over 140 i

85 Thousands of genes have been well demonstrated to play i

86 skeleton involves the precise deployment of thousands of genes in distinct regions of the pharyngeal

87 We also observe massive removal of thousands of genes related to the transport process and

88 y, followed by RNA sequencing, we found that thousands of genes responded specifically to iAKI or to

89 Using an unbiased approach, we identified thousands of genes whose expression was enriched in tumo

90 Although M1BP associates with thousands of genes, its colocalization with TRF2 is larg

91 ysis revealed alternative polyadenylation of thousands of genes, most of which result in transcriptio

92 are cytokines that affect the expression of thousands of genes, resulting in profound cellular chang

93 reflecting the transcriptional modulation of thousands of genes.

94 Despite thousands of genetic loci identified to date, a large pr

95 iptional start site (TSS) usage, identifying thousands of genetic variants affecting transcript level

96 e been used to successfully identify tens of thousands of genetic variants associated with complex tr

97 ation studies (GWAS) have identified tens of thousands of genetic variants associated with hundreds o

98 the Roadmap Epigenomics Consortium, contains thousands of genome-wide epigenomic datasets that descri

99 l is needed, that will rapidly scan hundreds/thousands of genomes or sequence fragments and detect ca

100 abase contains several million proteins from thousands of genomes organized into hundreds of clusters

101 eimplantation embryos and found that tens of thousands of genomic loci exhibited de novo DNA methylat

102 -target cutting, we demonstrate with tens of thousands of guides both the nucleotide position-depende

103 reparations made from the pooled plasma from thousands of healthy donors and are being tested in prec

104 pooled normal IgG formulation prepared from thousands of healthy donors' plasma, is extensively used

105 to quickly and accurately discriminate among thousands of highly similar complex objects demands rapi

106 search in Teaching (DART), which can analyze thousands of hours of STEM course audio recordings quick

107 Hundreds of thousands of human genomes are now being sequenced to ch

108 Over the past decade, thousands of human genomes have been sequenced, contribu

109 ructures facilitate the 3'-end processing of thousands of human mRNAs by juxtaposing poly(A) signals

110 Worldwide, hundreds of thousands of humans have had their genomes or exomes seq

111 sing candidates for capturing and processing thousands of individual cells for whole-transcriptome or

112 dvances that enable genome-wide profiling of thousands of individual cells have provided the tantaliz

113 To isolate and analyze thousands of individual cells in multiplexed conditions,

114 nalysis to study chromosome conformations in thousands of individual cells, and discover a continuum

115 gh-precision micro-models containing tens of thousands of individual elements.

116 Thousands of individual fibers were measured (number, le

117 f single nucleotide polymorphisms (SNPs) for thousands of individual samples, enabling, among other a

118 s, large sample sizes of tens to hundreds of thousands of individuals are required for adequately pow

119 on of thousands of common genetic markers in thousands of individuals from the same population (terme

120 rge genotyping studies involving hundreds of thousands of individuals, standard approaches are no lon

121 latively easy to grow and screen hundreds or thousands of individuals.

122 Since then, this CIV has caused thousands of infections in dogs in multiple states.

123 They allow for counting and recording thousands of input pulses and responding to pulses of le

124 The human genome folds to create thousands of intervals, called "contact domains," that e

125 s, resulting in the formation and release of thousands of invasive merozoites into the bloodstream.

126 across millions of base pairs in hundreds or thousands of isolates.

127 uses pairs of guide RNAs (gRNAs) to program thousands of kilobase-scale deletions that deeply scan a

128 ported over 6 years on objects that traveled thousands of kilometers across the Pacific Ocean to the

129 c distribution of migratory species can span thousands of kilometers.

130 -consumers that may migrate over hundreds to thousands of kilometers.

131 traced to a marine origin, being transported thousands of kilometres before re-entering the ocean.

132 rizontally extensive (continuous for tens to thousands of km) layers comprise fish and zooplankton an

133 Although these forces are "encoded" in the thousands of known protein structures, "decoding" them i

134 e and the millions of fish currently held in thousands of laboratories worldwide.

135 The algorithm places thousands of landmarks throughout the facial surface and

136 We find that thousands of loci are selectively closed in rods relativ

137 ation studies have enabled identification of thousands of loci for hundreds of traits.

138 Mammalian genomes contain thousands of loci that transcribe long noncoding RNAs (l

139 SS is required for H3K4me3 implementation on thousands of loci, generation of catalytically mutant ML

140 ew genetic markers can now be addressed with thousands of loci.

141 Thousands of long noncoding RNAs (lncRNAs) have been ann

142 Thousands of long noncoding RNAs (lncRNAs) have been dis

143 The human genome produces thousands of long noncoding RNAs (lncRNAs)-transcripts >

144 seq) as a means of simultaneously generating thousands of low-pass single-cell libraries for detectio

145 Honeybees form societies in which thousands of members integrate their behaviours to act a

146 ximal coverage, this method can still detect thousands of metabolites, allowing the analysis of a lar

147 partitioning of the sample into hundreds or thousands of minute reactions.

148 the nematode Caenorhabditis elegans in 1993, thousands of miRNAs have been discovered in animals and

149 performing global sensitivity analyses using thousands of model-simulated wound-healing scenarios, we

150 datasets with censored survival outcomes and thousands of molecular features.

151 Thousands of monogenic diseases have yielded definitive

152 pitation revealed that Pum1 and Pum2 bind to thousands of mRNAs, with at least 694 common targets in

153 Although thousands of nanoparticle formulations have been designe

154 Of the thousands of natural product antibiotics discovered to d

155 Experimental results on tens of thousands of ncRNA sequences available from the Rfam dat

156 aryotic cells, and is encoded by hundreds to thousands of nearly identical gene copies, only a subset

157 with 10 variable-length guides per gene and thousands of negative controls targeting non-functional,

158 stainable development indices in hundreds of thousands of neighborhoods and show that their statistic

159 Tens of thousands of new lenses are expected to be discovered wi

160 ect to the existing network via formation of thousands of new synapses.

161 Nm-seq uncovered thousands of Nm sites in human mRNA with features sugges

162 hile the largest genome fraction is encoding thousands of non-coding RNAs.

163 The discovery of thousands of noncoding RNAs (ncRNAs) has expanded our vi

164 different body sizes and sequences, and (ii) thousands of novel intronic circular RNAs (IcircRNAs) ar

165 eta-N-acetylglucosamine (O-GlcNAc) regulates thousands of nuclear, cytoplasmic, and mitochondrial pro

166 smell is the ability to identify hundreds of thousands of odours.

167 formed to investigate the regulatory role of thousands of oligonucleotide sequences simultaneously.

168 plines, data are highly decentralized across thousands of online databases (repositories, registries,

169 substitutions per neutral site), identifying thousands of orthologous enhancers with conserved or div

170 Thousands of papers have been published on these topics.

171 ery of long-term potentiation (LTP) in 1973, thousands of papers have been published on this intrigui

172 his assumption has led to its application in thousands of papers.

173 ior, has been the subject of hundreds if not thousands of papers.

174 s without interference from the many tens of thousands of parent compounds in the oil.

175 tation is a curative therapy for hundreds of thousands of patients with end-stage organ failure.

176 oosing an anti-VEGF drug for the hundreds of thousands of patients with nAMD treated each year worldw

177 MS/MS spectra, each of which might comprise thousands of peaks although a very small percentage of t

178 multi-organ pathologies, killing hundreds of thousands of people annually.

179 fic spectral search algorithm, we identified thousands of peptides bound to 16 different HLA class I

180 These chemicals may be used in thousands of personal care and consumer products as well

181 rising the human kinome catalyze hundreds of thousands of phosphorylation events to regulate a divers

182 We estimate that there are likely thousands of phosphorylation mediated switches yet to be

183 Proteomics techniques can identify thousands of phosphorylation sites in a single experimen

184 (hs-cTn) assays have been used clinically by thousands of physicians in many countries throughout the

185 ification chain reactions within hundreds to thousands of picoliter-sized droplets.

186 compared 3,837 bacterial genomes to identify thousands of plant-associated gene clusters.

187 he contact angle was measured at hundreds of thousands of points for three samples after twenty pore

188 Thousands of potential combinations of these three eleme

189 urate specific energy, and (iii) the tens of thousands of power-demanding duty cycles required for st

190 To do nothing would allow thousands of pregnant women to expose their fetuses to a

191 Surprisingly, this analysis revealed thousands of previously unreported degeneracies that red

192 We use Seq-Well to profile thousands of primary human macrophages exposed to Mycoba

193 eprogramming and the initiation of RNAPII at thousands of promoters.

194 the addition of the O-GlcNAc sugar moiety to thousands of protein substrates.

195 enables the simultaneous characterization of thousands of proteins across various tissues to pinpoint

196 gy of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cel

197 6) to enable the subcellular localization of thousands of proteins per experiment (hyperLOPIT), inclu

198 quantitative characteristics on the scale of thousands of proteins.

199 Despite thousands of publications on TLRs, the function of TLR10

200 lyses of human mRNA transcriptome identified thousands of putative intramolecular RG4s that readily a

201 Here we identified thousands of putative somatic transposon insertions in n

202 Radiomics is the process of extracting thousands of quantitative parameters from medical images

203 ability, our allele-specific method detected thousands of quantitative trait loci (QTLs) that influen

204 riendly tool has been developed to integrate thousands of recently available and anthropologically re

205 istence of large reference panels-comprising thousands of reference haplotypes-and assumes that the r

206 e association studies (GWAS) have identified thousands of regions in the genome that contain genetic

207 with quantitative chemical proteomics to map thousands of reversible small molecule-protein interacti

208 lectrode array, we recorded from hundreds to thousands of RGCs simultaneously at pan-retinal level, i

209 association studies (GWASs) have identified thousands of risk loci for many complex traits and disea

210 PRC2 has been shown to interact with thousands of RNA species in vivo, but understanding the

211 Hundreds of thousands of Rotary volunteers have provided support for

212 enable intuitive and interactive browsing of thousands of samples based on their molecular similarity

213 ed to handle multi-omic data for hundreds of thousands of samples to explore complexity using genetic

214 sequenced reference panel and on hundreds of thousands of samples with whole-genome sequencing data.

215 To meet the demand of analyzing hundreds to thousands of samples within a given experiment, we have

216 ets comprising RNA-Seq data from hundreds or thousands of samples, often collected at multiple center

217 g (RNA-seq) experiments now span hundreds to thousands of samples.

218 ing of large data sets with hundreds or even thousands of samples.

219 kage disequilibrium with heading date QTL in thousands of samples.

220 anscriptional outputs of individual cells or thousands of samples.

221 Although thousands of scientific articles have been published abo

222 The strategy was validated on thousands of seasonal influenza A and B virus-positive s

223 y fragmented, with major elements missing in thousands of secondary care and hospital settings global

224 rmance metrics show scalability into tens of thousands of sequences, with options for scaling further

225 s and encompasses modifications ranging from thousands of single base changes to megabase-scale path

226 e or state by querying a database of tens of thousands of single cell profiles.

227 ation detection in DNA and RNA isolated from thousands of single cells from five CLL samples.

228 tem that enables 3' mRNA counting of tens of thousands of single cells per sample.

229 ding both the images and emission spectra of thousands of single fluorescent molecules stochastically

230 erve current blockade at room temperature in thousands of single-cluster junctions.

231 Clades were separated by thousands of single-nucleotide polymorphisms, but within

232 s of environmental samples routinely detects thousands of small molecules, the vast majority of which

233 Through the measure of thousands of small-molecule metabolites in diverse biolo

234 t lead the drops to burst spontaneously into thousands of smaller droplets.

235 suited, the application of MSI for comparing thousands of spatially defined spotted samples has been

236 ertree methods were designed for, containing thousands of species and many subset trees.

237 ydrocarbons exhibit enormous complexity with thousands of species and reactions for all but the very

238 Tens of thousands of species are threatened with extinction as a

239 are able to support the analysis of several thousands of species from biological samples, enabling d

240 emical mixtures that can contain hundreds to thousands of species in attoliter volumes at the most ab

241 dable roadmap to high-quality references for thousands of species.

242 ce between pairwise MS/MS runs consisting of thousands of spectra.

243 habitat models show that penguins traversed thousands of square kilometers to areas of low sea surfa

244 ort simulations of relatively large domains (thousands of square nanometers) and indicate a no-slip D

245 ds $1 billion annually, and operates through thousands of staff and millions of volunteers in dozens

246 it to characterize the genetic structure of thousands of strains from more than 125 species in more

247 Plants produce hundreds of thousands of structurally diverse specialized metabolite

248 years ago and has been the focus of tens of thousands of studies in diverse fields of biology and me

249 CA seeks a holistic estimation of impacts of thousands of substances across multiple media, including

250 Flagellar filaments are assembled from thousands of subunits that are exported through a narrow

251 r assays in which we monitored Psi levels at thousands of synthetically designed sequence variants co

252 roteomics workflows depend on acquisition of thousands of tandem mass spectrometry (MS/MS) spectra wi

253 metabolism, trafficking, and localization of thousands of target genes.

254 Mammalian PRC2 binds RNA promiscuously, with thousands of target transcripts in vivo.

255 plied to the human genome, our model detects thousands of template switch events during the evolution

256 By identifying thousands of TERRA target sites in the mouse genome, we

257 -wide association studies, where hundreds or thousands of tests are conducted simultaneously to ident

258 hundreds of experimental phase diagrams, and thousands of thermodynamic data sets from experiments an

259 arboring m(6)As have shorter half-lives, and thousands of these mRNAs have increased half-lives (twof

260 s diverse processes in eukaryotic cells, and thousands of threonine phosphorylations have been identi

261 ts from outcrossing to selfing have occurred thousands of times across the tree of life.

262 should be only a few large (several tens of thousands of times larger than those on the Sun) convect

263 ed in nickel-zinc alkaline cells hundreds to thousands of times without undergoing passivation or mac

264 t, Brazil ranks 11th in apple production and thousands of tons of apple pomace are produced every yea

265 genic scores, which aggregate the effects of thousands of trait-associated DNA variants discovered in

266 lows for genome-wide association analyses in thousands of traits and has great potential to enable id

267 llions of SNPs must currently be compared to thousands of transcripts.

268 ing raw and processed structural data across thousands of transcripts.

269 cs, we observed the cryptic transcription of thousands of treatment-induced non-annotated TSSs (TINAT

270 and high-efficiency hydroxychlorination with thousands of turnover numbers.

271 We identify thousands of unannotated transcription start and end sit

272 -Seq) data from human cancer samples reveled thousands of uncharacterized non-coding RNAs including l

273 wild boar (Sus scrofa), (ii) wild boar used thousands of understory plants to construct birthing nes

274 tic analyses have recently uncovered tens of thousands of unique circular (circ)RNAs, but their compl

275 hree-dimensional nanostructures from tens of thousands of unique components, including a 0.5-gigadalt

276 We observed thousands of unique HPV16 genomes; very few women shared

277 We identified thousands of unique plasma eccDNAs in the three subjects

278 By rapidly creating libraries of thousands of unique, miniaturized reactors, droplet micr

279 to identify molecular rhythms in humans from thousands of unordered expression measurements.

280 batch effects that complicate comparison of thousands of untargeted peaks.

281 wide ribosome profiling studies suggest that thousands of uORFs initiate with non-AUG start codons.

282 Bioinformatics explorations based on thousands of variants have been used to interrogate path

283 ET of spleen revealed thousands of virions released by individual cells and di

284 e used fMRI to characterize the responses of thousands of voxels in retinotopically organized human c

285 into unique native structures stabilized by thousands of weak interactions that collectively overcom

286 ays: producing swarms comprising a queen and thousands of workers or producing males (drones).

287 stimated to have originated and evolved over thousands of years alongside modern human populations.

288 Humans have been making wine for thousands of years and microorganisms play an integral p

289 Thousands of years before the maize-based agriculture pr

290 Inuit have lived for thousands of years in an extremely cold environment on a

291 These crops were derived via several thousands of years of human selection that transformed w

292 as succeeded as a human pathogen for tens of thousands of years thanks to its ability to resist and a

293 intervals are generally long (10s to 100s of thousands of years) relative to conventional paleoseismi

294 Alcoholic beverages have been consumed for thousands of years, attracting great human interest for

295 eages have recently expanded in the space of thousands of years, rather than the millions of years as

296 Humans have interacted with fire for thousands of years, yet the utilization of fossil fuels

297 o their nutritional and medicinal value, for thousands of years.

298 land dwarfing known thus far took place over thousands of years.

299 s been consumed in some regions of China for thousands of years.

300 d consumption has been a common practice for thousands of years; however, combination of these traits