ライフサイエンスコーパス: threonine

1 O-GlcNAc modification on either a serine or threonine.

2 ein in place of the proteinogenic amino acid threonine.

3 8, compared with other isotypes that contain threonine.

4 ine codon (minor-allele frequency = 0.43) to threonine.

5 clear and cytoplasmic proteins on serine and threonine.

6 40), whereas it decreased phosphorylation of threonine 1007 (Thr-1007).

7 Phosphorylation of histone H3 threonine 118 (H3 T118ph) weakens histone DNA-contacts,

8 Interestingly, mutations of threonine 153 (T153) in Kir7.1 that reduce constrained p

9 TDP-43 dual phosphorylation by MEK, at threonine 153 and tyrosine 155 (p-T153/Y155), was dramat

10 hydroflavonol reductase and SbCCR1, residues threonine-154 and tyrosine-310 were pinpointed as being

11 Threonine-154 of SbCCR1 and other CCRs likely confers st

12 We propose that the lumen-exposed residues, threonine 162 and glutamic acid 173, form stabilizing hy

13 site within the activation segment of NEK3, threonine 165 (Thr-165), was identified.

14 HG-mediated energy depletion activates AMPK (Threonine 172), blunting protein synthesis and mTOR sign

15 We show that the phosphorylation of threonine 173 (T173) residue within the Runt domain of R

16 e threonine string, and PrP mutants in which threonine 191 was replaced by valine, alanine, or prolin

17 cated in the phosphotyrosine binding domain, threonine 206, had no phenotype.

18 rentially up-regulated and phosphorylated at threonine 206-an early molecular event during membrane f

19 L tumor biopsies and a recurrent mutation of threonine 223 in the DNA-binding domain of OCT2.

20 W7 recognizes a conserved degron surrounding threonine 236 (T236) in SOX9 that is phosphorylated by G

21 w that Akt-mediated activation of PRAS40 via threonine 246 phosphorylation is both necessary and suff

22 ive ERK phosphorylation sites, we identified threonine 264 in the N-terminal ankyrin repeat domain as

23 RK1A and DYRK1B kinases phosphorylate ID2 on threonine 27 (Thr27).

24 CaMK2N1 knockdown prevents a decrease of threonine-286 (T286) autophosphorylation of alphaCaMKII

25 in-mediated phosphorylation of histone H3 at threonine 3 (H3T3ph) promotes proper deposition of Auror

26 o II recruits Ipl1 via the Haspin-histone H3 threonine 3 phosphorylation pathway.

27 ector of TGF-alpha but not EGF signaling via threonine 308-phosphorylated Akt.

28 ting muscle cells through phosphorylation of threonine 372.

29 es CAR activation, by placing phosphorylated threonine 38 as the common target for both direct and in

30 otein phosphatase 2A (PP2A) dephosphorylates threonine 38 to activate CAR.

31 constitutive activity by phosphorylation at threonine 38.

32 with an unusual domain architecture and an L-threonine:4-nitrophenylacetaldehyde transaldolase respon

33 by Cdk5-mediated phosphorylation at position threonine-407(mouse)/T406(rat).

34 own studies revealed that phosphorylation at threonine-468 of a CB1R distal C-terminus 14-mer peptide

35 ial nitric oxide synthase phosphorylation at threonine 495 levels in human cardiac microvascular endo

36 horylation of the human SIRT1 deacetylase on Threonine 530 (T530-pSIRT1) modulates DNA synthesis.

37 consensus sites and that mutation of either threonine 56 or 61 to alanine restricts apoptin to the c

38 n and IL-10 secretion, indicating a role for threonine 567 phosphorylation of ezrin in limiting IL-10

39 Phosphorylation of RSK2 at threonine 577 is essential for activation of LARG-RhoA.

40 d is dependent on phosphorylation of KCC2 at threonines 906 and 1007 by the Cl(-)-sensing kinase WNK1

41 vealed the low concentration of amino acids (threonine, alanine, citrulline and GABA) and organic aci

42 The equivalent Neurogenin2 Threonine also regulates DNA binding and proneural activ

43 These patterns are enriched for serine/threonine amino acid codons and genes related to protein

44 a few representative cancer-relevant serine/threonine and tyrosine kinases and their interplay with

45 letion/20-bp insertion in DSTYK (dual serine-threonine and tyrosine protein kinase) in all four affec

46 ranscription are profoundly shaped by serine/threonine and tyrosine signaling kinases and components

47 orresponding ester hydrochlorides of serine, threonine, and cystine as a nitrogen source.

48 ses that phosphorylate extracellular serine, threonine, and tyrosine residues of numerous proteins ha

49 agocytosis that led to pH-dependent serine-, threonine-, and cysteine-sensitive protease-dependent Ag

50 minal propeptides protecting the active-site threonines are autocatalytically released only on comple

51 Additionally, we show that two threonines are key determinants of product specificity.

52 fied and cloned a pollen-expressed P. rhoeas threonine-aspartate-tyrosine (TDY) MAPK, PrMPK9-1 Rather

53 A threonine at one end of the pore engages in vital intera

54 D and a missense variant encoding alanine or threonine at position 391 in the zinc transporter solute

55 n mice eliminated phosphorylation of eEF2 at threonine at position 56, resulting in increased protein

56 influenced by the introduction of serine or threonine at sequence position 69 (Eos notation) and use

57 of HT-29 cell lysates with a model probe of threonine beta-lactone.

58 In the second class of mutants, threonine biosynthesis was more broadly affected.

59 hat predicts the substitution of a conserved threonine by proline at position 387 (T387P) in hEAAT1.

60 Rqc2p-mediated Carboxy-terminal Alanine and Threonine (CAT) tail elongation-can be recapitulated in

61 de by adding a carboxyl-terminal alanine and threonine (CAT) tail through a noncanonical elongation r

62 Using improved FlAsH-based serine-threonine clusters beta-arrestin2 conformational biosens

63 a-arrestins, formed by phosphorylated serine-threonine clusters in the receptor's C terminus and two

64 a dynamic combinatorial library made from a threonine containing peptide building block, which, by i

65 ulatory region consisting of high serine and threonine content, and a C-terminal ESCRT-III domain, su

66 mmitted enzymes in the biosynthetic network: threonine deaminase (also named l-O-methylthreonine resi

67 m-thrCB operon was derepressed unmasking the threonine dehydratase activity of the threonine synthase

68 ine residues, and consequently, we find that threonine-directed phosphorylation occurs late in the ce

69 PKC inhibition or the exchange of threonine for alanine in the C-terminal PDZ-binding moti

70 ation of a model substrate, Ndd1, depends on threonine identity of its Cdk target sites.

71 e residue and, to a lesser extent, serine or threonine in its penultimate position.

72 The presence of asparagine or threonine in over 99% of all human seasonal influenza vi

73 timulates the phosphorylation of a conserved threonine in the cytosolic AMT1 C terminus, which allost

74 bon-oxygen of aspartate/glutamate and serine/threonine in zinc-peptide complexation.

75 ment of ataxia-telangiectasia mutated serine/threonine kinase (ATM) to the damaged site, where it pla

76 ion of Gene 33 triggers DDR in an ATM serine/threonine kinase (ATM)-dependent fashion and through pat

77 protein kinase B-Raf proto-oncogene, serine/threonine kinase (BRAF) is an oncogenic driver and thera

78 aining both an ion channel pore and a serine/threonine kinase (chanzyme).

79 ously determined that a transmembrane serine/threonine kinase (IreK) and its cognate phosphatase (Ire

80 ric inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK-1).

81 -activated protein kinase interacting serine/threonine kinase 1 activation significantly suppresses T

82 ivated protein kinase and phospho-AKT serine/threonine kinase 1 signaling pathways, as well as increa

83 in kinase) and MNK1 (MAPK-interacting serine/threonine kinase 1) signaling.

84 fibroblasts from receptor interacting serine/threonine kinase 1-knockout mice or their WT littermates

85 The tumor suppressor serine/threonine kinase 11 (LKB1/STK11) is one of the most freq

86 The tumor suppressor serine/threonine kinase 11 (STK11 or LKB1) is mutated in 20-30%

87 (LKB1) tumor suppressor gene, Stk11 (serine threonine kinase 11), in the fetal Mullerian duct mesenc

88 and in vivo by microtubule-associated serine/threonine kinase 3 (MAST3 kinase), an enzyme of previous

89 cally depends on receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase doma

90 lin-1) by RIPK4 (receptor-interacting serine-threonine kinase 4) during epidermal differentiation.

91 We identified GCK-1, a conserved serine/threonine kinase [8], as a putative novel anillin intera

92 The p.E80K mutation abolished serine/threonine kinase activity, resulting in altered ICK subc

93 hosphatidylinositol-3-OH kinase), the serine-threonine kinase Akt and the metabolic checkpoint kinase

94 Here we examined the role of the serine/threonine kinase Akt in the generation of protective imm

95 phate (PIP3), and the activity of the serine/threonine kinase AKT.

96 ion of general control nonrepressed 2 serine/threonine kinase and increased expression of mammalian t

97 ion of general control nonrepressed 2 serine/threonine kinase and mammalian target of rapamycin (both

98 ATIONALE: LKB1 (liver kinase B1) is a serine/threonine kinase and tumor suppressor, which regulates t

99 ement within the RAS/ERK pathway, the serine/threonine kinase BRAF plays a key role in development an

100 show that the kinase activity of the serine/threonine kinase encoded by TAOK2 is required for spine

101 , we find that phosphorylation of the serine/threonine kinase ERK (pERK) preferentially occurs in end

102 sactivation of microtubule associated serine/threonine kinase family member 4 (MAST4).

103 arget of rapamycin complex 1 (mTORC1) serine/threonine kinase from the lysosomal membrane.

104 in vitro functional studies, a novel serine/threonine kinase gene, unc-51-like kinase 4 (ULK4), as a

105 53Ser46(P) by binding and stabilizing serine-threonine kinase HIPK2.

106 The serine/threonine kinase IL-1R-associated kinase (IRAK)4 is a cr

107 mTOR is a serine/threonine kinase involved in a variety of cellular activ

108 PRL activates the serine/threonine kinase NEK3, which was reported to enhance bre

109 The polo family serine threonine kinase Plk4 has been proposed as a therapeutic

110 terphase of the cell cycle by NEK7, a serine-threonine kinase previously linked to mitosis.

111 coupled receptor kinase 5 (GRK5) is a serine/threonine kinase previously shown to mediate polymicrobi

112 ike kinase 1 (ALK1) is an endothelial serine-threonine kinase receptor for bone morphogenetic protein

113 Type 1 Serine/Threonine Kinase Receptors (STKR1) transduce a wide spec

114 e translocation and activation of the serine/threonine kinase ROCK1, a downstream target of the RhoA

115 ORC1 activation deploys the ribosomal serine/threonine kinase S6K1 and Polycomb proteins at genomic r

116 fibrosis-relevant tyrosine kinase and serine/threonine kinase signaling pathways.

117 d by mass spectrometry identified the serine-threonine kinase SPEG as the only novel binding partner

118 d by mass spectrometry identified the serine-threonine kinase SPEG as the only novel binding partner

119 o interferes with the activity of the serine/threonine kinase StkP, the central regulator of pneumoco

120 dentifying degrader hits based on the serine/threonine kinase TANK-binding kinase 1 (TBK1) and have g

121 enerated Taok3(-/-) mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic defects

122 LKB1 is a multi-functional serine/threonine kinase that associates with actin at the cellu

123 protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase that functions in development and tumor

124 t cyclin-dependent kinase 5 (Cdk5), a serine-threonine kinase that is highly active in postmitotic ne

125 1-like kinase 1 (ULK1) is a conserved serine-threonine kinase that plays a central role in the initia

126 is a highly conserved and pleiotropic serine/threonine kinase that promotes many prosurvival and proi

127 re we identify Stk2, a staphylococcal serine/threonine kinase that provides efficient immunity agains

128 Tumor progression locus 2 (Tpl2) is a serine-threonine kinase that regulates Th1 differentiation, sec

129 n of the MTOR complex 1 (RAPTOR), the serine/threonine kinase V-Akt murine thymoma viral oncogene hom

130 AMPK is a conserved serine/threonine kinase whose activity maintains cellular energ

131 racting protein kinase 3 (RIPK3) is a serine/threonine kinase with essential function in necroptosis.

132 One such protein, the serine/threonine kinase YopO (YpkA in Yersinia pestis), uses mo

133 ng protein kinase (HIPK) 2, a nuclear serine/threonine kinase, activates CREB through Ser271 phosphor

134 We previously showed that the serine/threonine kinase, glycogen synthase kinase, GSK-3alpha/b

135 , we identified PIM1, a non-essential serine-threonine kinase, in a synthetic lethal interaction with

136 a target of casein kinase 2 (CK2), a serine/threonine kinase, in proliferating myoblasts.

137 ycin (TOR), an evolutionary conserved serine/threonine kinase, in the plant defense response.

138 Protein kinase C (PKC) theta, a serine/threonine kinase, is involved in TH2 cell activation and

139 optosis signal-regulating kinase 1, a serine/threonine kinase, leads to improvement in inflammation a

140 reen, we identified a mitotic-related serine/threonine kinase, NEK6, as a mediator of androgen-indepe

141 The Akt protein, a serine/threonine kinase, plays important roles in cell survival

142 llular penicillin-binding-protein and serine/threonine kinase-associated (PASTA) domains which bind m

143 terial Penicillin-binding-protein And Serine/Threonine kinase-Associated (PASTA) kinases is of partic

144 activating phosphorylation by Mst1, a serine/threonine kinase.

145 epends on the RTKs activating the AKT serine/threonine kinase.

146 well appreciated that eukaryotic-like serine/threonine kinases (eSTKs) control essential processes in

147 led to reduced phosphorylation of the serine/threonine kinases ATM and Chk2 and of histone H2AX after

148 nd protein phosphatase-1, as well the serine/threonine kinases CaMKII and PKA.

149 an evolutionarily conserved family of serine/threonine kinases involved in mitosis and meiosis.

150 -activated protein kinase-interacting serine-threonine kinases MAP kinase-interacting kinase 1 (Mnk1/

151 We found that RhoA activated the serine-threonine kinases PKN1 and PKN2 that bind and phosphoryl

152 In eukaryotes, serine/threonine kinases play a central role in antiviral respo

153 Dysregulated oncogenic serine/threonine kinases play a pathological role in diverse fo

154 RIPK1 and RIPK3, a pair of homologous serine/threonine kinases previously implicated in the regulatio

155 CK) is a member of a diverse group of serine/threonine kinases that feature cytoskeletal association.

156 NEK family kinases are serine/threonine kinases that have been functionally implicated

157 ceptor-associated kinases (IRAKs) are serine/threonine kinases that play critical roles in initiating

158 polo-like kinases (PLK), a family of serine/threonine kinases with well-known roles in cell cycle re

159 Akt is a family of three serine-threonine kinases, Akt1, Akt2, and Akt3.

160 expression of the oncogenic PIM1/2/3 serine/threonine kinases, and as PIMs modulate transcriptional

161 The protein kinase D family of serine/threonine kinases, particularly PKD1, has been implicate

162 Necroptosis is driven by two serine threonine kinases, RIPK1 (Receptor Interacting Protein K

163 PAK4 is a member of the PAK family of serine/threonine kinases, which act as effectors for several sm

164 segment conformation of tyrosine and serine/threonine kinases.

165 the protein kinase D (PKD) family of serine/threonine kinases.

166 s that includes l-asparagine, l-glutamine, l-threonine, l-arginine, l-glycine, l-proline, l-serine, l

167 We report that l-threonine may substitute for l-serine in the beta-substi

168 hat nitrogen metabolism, glycine, serine and threonine metabolism, aminoacyl-tRNA biosynthesis and ta

169 this mutation by introducing the alanine to threonine mutation at position 778 of mouse Hdac4 (corre

170 A highly conserved threonine near the C terminus of gp120 of human immunode

171 moieties to the hydroxyl group of serine or threonine on proteins/peptides.

172 nonstructural protein 4B (NS4B) with serine, threonine or alanine confers YFV resistance to BDAA with

173 consecutive nucleotide substitutions, via a threonine or cysteine intermediate, and are driven by se

174 hrough a synergistic pathway: the endogenous threonine pathway and the introduced citramalate pathway

175 e characterized and optimized the endogenous threonine pathway; then, a citramalate synthase (CimA) m

176 er replicator consisting of six units of the threonine peptide only when it is seeded with an octamer

177 Selective inhibitors for each serine/threonine phosphatase (PPP) are essential to investigate

178 Moreover, the PST/TPM and the threonine phosphatase activity are not required for in v

179 We also find that the threonine phosphatase activity plays only a minor role d

180 sphorylation by the calcium-dependent serine/threonine phosphatase calcineurin.

181 rprisingly, this structure revealed a serine/threonine phosphatase fold that unexpectedly targets tyr

182 cytosol, is resistant to the classic serine/threonine phosphatase inhibitors okadaic acid and microc

183 ne-Threonine)-rich transactivation domain, a threonine phosphatase motif (TPM), and a tyrosine protei

184 is dependent upon the activity of the serine/threonine phosphatase PP2A.

185 The serine/threonine phosphatase protein phosphatase 5 (PP5) regula

186 phosphatase-2A (PP2A) is an abundant serine/threonine phosphatase with anti-inflammatory activity.

187 Mycobacterium tuberculosis, only one serine/threonine phosphatase, PstP, has been identified.

188 s of highly expressed skeletal muscle serine/threonine phosphatases (PP1, PP2A, PP2B, and PP2C) on AS

189 In this review, we concentrate on serine/threonine phosphatases in apicomplexan parasites, with t

190 phatases modulate GPCR signaling, how serine/threonine phosphatases integrate with G protein signalin

191 P2A) is a member of the intracellular serine/threonine phosphatases.

192 rosine-phosphorylated peptides versus serine/threonine phospho-peptides and readily dephosphorylates

193 t report of the functional outcome of serine/threonine phosphorylation in gelsolin regulation and pro

194 An understanding of how threonine phosphorylation regulates biological function

195 tand how PRMT5 is regulated, we identified a threonine phosphorylation site within a C-terminal tail

196 regions (IDRs) that undergo multisite Serine/Threonine phosphorylation.

197 cesses in eukaryotic cells, and thousands of threonine phosphorylations have been identified.

198 Herein, we identified cellular serine/threonine Polo-like-kinase 1 (PLK1) as a positive effect

199 the p53 form with mutations of four serines/threonines previously shown to be crucial for PIN1 bindi

200 -specific phosphorylation at specific serine/threonine-proline sequences by their cognate kinases.

201 ruitment by PSD-95 occurs at specific serine-threonine/proline consensus motifs localized in the link

202 ssures that drove the proteasome to become a threonine protease.

203 The activating mutation of the BRAF serine/threonine protein kinase (BRAF V600E) is the key driver

204 he efficacy of the Raf proto-oncogene serine/threonine protein kinase (RAF) inhibitor, PLX8394, that

205 at knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1) increased both intrac

206 ain (TRADD), and receptor-interacting serine/threonine protein kinase 1 (RIPK1).

207 re we identify MAP kinase-interacting serine/threonine protein kinase 1a (MNK1a) as a novel AMPK targ

208 isc kinases (striated muscle-specific serine/threonine protein kinase and obscurin) was dramatically

209 or cells upon the DNA damage response serine/threonine protein kinase ATR.

210 ifically inhibit the master regulator serine/threonine protein kinase CK2 and the wild-type/mutated e

211 Polo-like kinase 3 (Plk3) is a serine/threonine protein kinase known to inhibit the cellular r

212 The PIM1 serine/threonine protein kinase mediates growth factor and surv

213 Polo-like kinase 1 (Plk1), a serine/threonine protein kinase normally expressed in mitosis,

214 MAPKAPK3 is a serine/threonine protein kinase of the p38 signaling pathway th

215 ch individual complex, stabilizes the serine-threonine protein kinase PINK1 on the mitochondrial oute

216 l inhibition of either IKKbeta or the serine/threonine protein kinase TAK1 in monocytes blocked TLR-i

217 in kinase B (PknB) is a transmembrane serine/threonine protein kinase that acts as an essential regul

218 Liver kinase B1 (LKB1) is a serine/threonine protein kinase ubiquitously expressed in mamma

219 soforms in A549 cells lacking LKB1, a serine/threonine protein kinase upstream of AMPK, failed to act

220 doxin-fold-containing eukaryotic-like serine/threonine protein kinase, is a virulence factor in Mycob

221 ng to light FadD32 phosphorylation by serine/threonine protein kinases and its correlation with the e

222 Although there are 11 serine/threonine protein kinases in Mycobacterium tuberculosis,

223 The serine-threonine protein phosphatase 1 (PP1) deactivates this p

224 Herein, cellular serine/threonine protein phosphatase 2A (PP2A) is identified as

225 ced phosphorylation and activation of serine/threonine protein phosphatase 2A (PP2A) regulatory subun

226 PP2A(Cdc55) is a highly conserved serine-threonine protein phosphatase that is involved in divers

227 s a calcium- and calmodulin-dependent serine/threonine protein phosphatase that plays a role in a wid

228 with the scaffolding A subunit of the serine/threonine protein phosphatase, PP2A, and that phosphoryl

229 ive inhibitor of certain forms of the serine/threonine protein phosphatase, PP2A, when phosphorylated

230 2A, PP4, and PP6, are multifunctional serine/threonine protein phosphatases involved in many cellular

231 The serine/threonine protein phosphatases type 2A (PP2A) are implic

232 Receptor-interacting serine/threonine-protein kinase (RIP)-3-mediated intestinal nec

233 2 by CDK2 impaired recruitment of the serine/threonine-protein kinase 1 (PAK1) to HER2, resulted in t

234 proteins such as receptor-interacting serine/threonine-protein kinase 1 (RIPK1), receptor-interacting

235 , the downstream receptor-interacting serine/threonine-protein kinase 2 (RIPK2), resulting in phospho

236 inase 1 (RIPK1), receptor-interacting serine/threonine-protein kinase 3 (RIPK3), TIR-domain-containin

237 OX40 ligand, and receptor-interacting serine/threonine-protein kinase 4 (RIPK4), were downregulated a

238 by which some melanoma cells adapt to Serine/threonine-protein kinase B-Raf (BRAF) inhibitor therapy

239 Serine/threonine-protein kinase proteins, also known as P21-act

240 e scaffolds, potent inhibitors of the serine/threonine-protein kinase STK10 were synthesized.

241 Ste20-like kinase (SLK) is a serine/threonine-protein kinase that has been implicated in spi

242 ed the functions of the Hippo pathway serine/threonine-protein kinases Lats1 and Lats2, which phospho

243 lterations in the non-miR-185 targets serine/threonine-protein phosphatase 2B catalytic subunit gamma

244 the mass spectrometry analysis of serine and threonine pyrophosphorylation, a protein modification th

245 AMP or ADP binding and phosphorylation of a threonine residue (Thr-172) within the activation loop o

246 vity, as evaluated by its phosphorylation at threonine residue 172 (AMPK-Thr(P)(172)).

247 vivo could result in O-glycosylation of the threonine residue in question and that this could boost

248 eoformans crystal structure, in particular a threonine residue that may serve as an additional point

249 single O-GlcNAc modification on a serine or threonine residue.

250 ly direct phosphorylation of the appropriate threonine residue.

251 phosphorylating highly conserved serine and threonine residues (S359/T360) within the activation loo

252 s is known about the glycosylation of serine/threonine residues by O-linked N-acetylglucosamine (O-Gl

253 The phosphorylation of threonine residues in proteins regulates diverse process

254 that a poxvirus kinase phosphorylates serine/threonine residues in the human small ribosomal subunit

255 c) sugar moiety to hydroxyl groups of serine/threonine residues of cytosolic and nuclear proteins.

256 a-N-acetylglucosamine (GlcNAc) to serine and threonine residues of intracellular proteins (O-GlcNAc),

257 inkage of beta-N-acetylglucosamine to serine/threonine residues of membrane, cytosolic, and nuclear p

258 P2X7R, a loop insertion (residues 73-79) and threonine residues T90 and T94, are required for high af

259 (rich in proline, glutamic acid, serine, and threonine residues) sequence in NFkappaB stripping, a mu

260 specifically counteracts phosphorylation on threonine residues, and consequently, we find that threo

261 that catalyzes O-GlcNAcylation of serine or threonine residues, interacts with UBN1, modifies HIRA,

262 the phosphorylation of several nearby serine/threonine residues, which constitute a phosphorylation h

263 ero-L-manno) and is beta-linked to serine or threonine residues.

264 ds between proline and phosphorylated serine/threonine residues.

265 ids engendered by dehydration of serines and threonines, respectively.

266 Notably, Ub E2 N termini are serine/threonine rich in many other Ub E2s, leading us to hypot

267 Eya proteins contain a PST (Proline-Serine-Threonine)-rich transactivation domain, a threonine phos

268 f the proline-, glutamic acid-, serine-, and threonine-rich (PEST) domain that are predicted to enhan

269 This inhibition is mediated by a serine/threonine-rich region that provides an array of surface-

270 of the IkappaBalpha proline-glutamate-serine-threonine-rich sequence with positively charged residues

271 ly 39, member 8 protein (SLC39A8 alanine 391 threonine, rs13107325) and replicated the association wi

272 d phosphorylates specific histone serine and threonine (S/T) residues.

273 BM samples were higher in threonine, serine, valine, and lower in orotic acid and

274 to the oxygen atom (O-linked) of serine and threonine side chains represent the two major protein gl

275 ylated by the MAP kinase ERK2 at a consensus threonine site (T38).

276 We studied the role of the threonine string on PrP conversion by analyzing mouse Pr

277 polymorphic residue at the beginning of the threonine string, and PrP mutants in which threonine 191

278 ng the threonine dehydratase activity of the threonine synthase ThrC.

279 PIN1 directly binds to phosphorylated threonine (T) 204 of BRD4 as revealed by peptide binding

280 , Smk1 is controlled by phosphorylation of a threonine (T) and a tyrosine (Y) in its activation loop.

281 ed by phosphorylation of its activation-loop threonine (T) and tyrosine (Y).

282 The high levels of serine (S) and threonine (T) residues within the Presenilin 1 (PS1) N-t

283 2 directs the addition of C-terminal alanine-threonine tails (CAT-tails), and a Cdc48 hexamer is recr

284 ts of ZIP8 with either an alanine (Ala) or a threonine (Thr) at residue 391.

285 s is noted when cytoplasmic serine (Ser) and threonine (Thr) residues are mutated.

286 os carry a C->A transversion, that changes a threonine to a lysine, in a residue next to a CMT-associ

287 ich is unusual due to the high propensity of threonine to form beta-sheets.

288 V2-based tyrosine-to-phenylalanine (Y-F) and threonine-to-valine (T-V) capsid mutants, designed to av

289 phosphotransfer (Hpt) domains and two have a threonine (Tpt) or serine (Spt) in place of the histidin

290 o present preliminary data suggesting that L-threonine transaldolases might be useful for the prepara

291 identifies further gene clusters encoding L-threonine transaldolases.

292 , phenylalanine, proline, sarcosine, serine, threonine, tryptophan, tyrosine, and valine.

293 nd Thr-318 by a DNA damage-responsive serine threonine/tyrosine protein kinase (RqkA).

294 ted protein kinase kinase 3 (MKK3) is a dual threonine/tyrosine protein kinase that regulates inflamm

295 from a single AA substitution (asparagine-->threonine) via a single nucleotide mutation (AAC-->ACC).

296 id polymorphism that arose when an ancestral threonine was mutated to alanine, greatly increasing res

297 amino acids, such as tryptophan, valine, and threonine, were determined in yacon syrup.

298 ine substitutions of all conserved serine or threonine, which is predicted to be a potential PKA phos

299 pha-helix 2 of PrP contains a string of four threonines, which is unusual due to the high propensity

300 ral conformationally restricted analogues of threonine with fixed spatial orientation of functional g

301 h as aspartate, lysine, glycine, leucine and threonine with no changes in the amounts of methionine a