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1 epends on the RTKs activating the AKT serine/threonine kinase.
2 activating phosphorylation by Mst1, a serine/threonine kinase.
3 phytochromes are autophosphorylating serine/threonine kinases.
4 amino acid sequences of human protein-serine/threonine kinases.
5 segment conformation of tyrosine and serine/threonine kinases.
6 the protein kinase D (PKD) family of serine/threonine kinases.
7 rylation at Ser133 by various protein serine/threonine kinases.
10 uired caspase-8, receptor-interacting serine/threonine kinase 1 (RIPK1), and Fas-associated death dom
11 -activated protein kinase interacting serine/threonine kinase 1 activation significantly suppresses T
13 lower levels of receptor-interacting serine-threonine kinase 1 and shorter survival times of patient
14 ivated protein kinase and phospho-AKT serine/threonine kinase 1 signaling pathways, as well as increa
15 Ripk1 (receptor (TNFRSF)-interacting serine-threonine kinase 1) expression, and miR-155-5p inhibitio
17 TBK1 (TANK-Binding Kinase 1)-AKT (AKT serine/threonine kinase 1)-IRF3 (interferon regulatory factor 3
18 ed levels of the receptor-interacting serine-threonine kinase 1, a mediator of necroptosis, in CRC ce
19 fibroblasts from receptor interacting serine/threonine kinase 1-knockout mice or their WT littermates
20 te-oriented kinase (LOK), also called serine threonine kinase 10 (STK10), is synthesized mainly in ly
24 (LKB1) tumor suppressor gene, Stk11 (serine threonine kinase 11), in the fetal Mullerian duct mesenc
25 Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) is a tumor suppressor mutate
26 served interactions included those of serine/threonine kinase 16 (STK16), hippocalcin-like 1 (HPCAL1)
28 mediated through receptor-interacting serine/threonine kinase 2, and the transcriptional regulator CC
29 and in vivo by microtubule-associated serine/threonine kinase 3 (MAST3 kinase), an enzyme of previous
30 cally depends on receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase doma
33 lin-1) by RIPK4 (receptor-interacting serine-threonine kinase 4) during epidermal differentiation.
36 KD2) is a member of the PKD family of serine/threonine kinases, a subfamily of the CAMK super-family.
37 ng protein kinase (HIPK) 2, a nuclear serine/threonine kinase, activates CREB through Ser271 phosphor
38 cificity kinase and both tyrosine and serine/threonine kinase activities are required for its functio
41 terms protein kinase activity/protein serine threonine kinase activity, response to heat and reactive
43 the mutation blocks both tyrosine and serine/threonine kinase activity, whereas Y243 and Y250 are mor
45 ing protein essential for positioning serine-threonine kinases adjacent to target phosphorylation sit
46 mice lacking specific isoforms of the serine/threonine kinase AKT and bone marrow chimeras, we found
47 hosphatidylinositol-3-OH kinase), the serine-threonine kinase Akt and the metabolic checkpoint kinase
57 ckpoint kinase complex mTORC2 and the serine-threonine kinase Akt, and loss of this activity restores
58 depends on the activation of PI3K and serine-threonine kinase Akt, and protein synthesis relies on th
61 activation-induced phosphorylation of serine-threonine kinases Akt and mechanistic target of rapamyci
63 kinases are tyrosine kinases, though serine/threonine kinases also play key roles in some malignanci
65 ion of general control nonrepressed 2 serine/threonine kinase and increased expression of mammalian t
66 ion of general control nonrepressed 2 serine/threonine kinase and mammalian target of rapamycin (both
67 focus on coordination of postsynaptic serine/threonine kinase and phosphatase signaling by scaffold p
69 ATIONALE: LKB1 (liver kinase B1) is a serine/threonine kinase and tumor suppressor, which regulates t
71 expression of the oncogenic PIM1/2/3 serine/threonine kinases, and as PIMs modulate transcriptional
73 We show that the apically localized serine/threonine kinase aPKC directly phosphorylates an N-termi
74 the protein kinase D (PKD) family of serine/threonine kinases are major targets for tumor-promoting
75 rum glucocorticoid kinase 1 (SGK1), a serine/threonine kinase, as an essential node downstream of IL-
76 ify CDK5, a predominantly cytoplasmic serine/threonine kinase, as an important regulator of DLC1 func
77 ous to penicillin-binding protein and serine/threonine kinase associated (PASTA) domains, and binds f
78 llular penicillin-binding-protein and serine/threonine kinase-associated (PASTA) domains which bind m
79 terial Penicillin-binding-protein And Serine/Threonine kinase-Associated (PASTA) kinases is of partic
81 1 is phosphorylated by the DNA damage serine/threonine kinase ATM, resulting in increased levels of F
82 led to reduced phosphorylation of the serine/threonine kinases ATM and Chk2 and of histone H2AX after
83 rations in FA-complex genes or in ATM serine/threonine kinase (ATM) exhibited significantly longer tr
84 ment of ataxia-telangiectasia mutated serine/threonine kinase (ATM) to the damaged site, where it pla
85 ion of Gene 33 triggers DDR in an ATM serine/threonine kinase (ATM)-dependent fashion and through pat
87 terized the activation process of the serine/threonine kinase Aurora-A by phosphorylation and by its
90 ement within the RAS/ERK pathway, the serine/threonine kinase BRAF plays a key role in development an
91 h a constitutively active form of the serine/threonine kinase BRAF was expressed in neurons gated by
93 protein kinase B-Raf proto-oncogene, serine/threonine kinase (BRAF) is an oncogenic driver and thera
94 ability, and the B-Raf protooncogene, serine/threonine kinase (BRAF), mutation) in the Nurses' Health
95 as PLK1 (Polo-like kinase 1), C-MYC, serine-threonine kinase BUB1B and regulates their expression.
97 Here we report that the conserved serine/threonine kinase, casein kinase II (CK2), promotes miRIS
99 he LNAA leucine for activation of the serine-threonine kinase complex mTORC1 and for expression of th
100 tion of their primary sequences, many serine-threonine kinases display a significant preference for s
102 ate 1970s, is composed of at least 10 serine/threonine kinases, divided into three groups based on th
103 apoptotic gene FASTKD2 (fas-activated serine/threonine kinase domains 2; rs7594645-G) with better mem
104 ral and signaling motifs, including 2 serine/threonine kinase domains, SK1 and SK2, present at the CO
105 show that the kinase activity of the serine/threonine kinase encoded by TAOK2 is required for spine
106 The Escherichia coli eukaryote-like serine/threonine kinase, encoded by yeaG, is expressed in respo
107 , we find that phosphorylation of the serine/threonine kinase ERK (pERK) preferentially occurs in end
108 nally reported as an inhibitor of the serine/threonine kinase ERK, a kinase that is distinct in the s
109 well appreciated that eukaryotic-like serine/threonine kinases (eSTKs) control essential processes in
110 ber of the protein kinase C family of serine/threonine-kinases, expression varies during human megaka
112 cting NEK2, a member of the NIMA-like serine-threonine kinase family, in a patient with congenital he
115 tein kinase C constitutes a family of serine-threonine kinases found in all eukaryotes and implicated
117 ein kinase (AMPK), a highly conserved serine/threonine kinase, functions as a critical metabolic sens
118 get of rapamycin (mTOR), an essential serine/threonine kinase, functions in biochemically distinct mu
120 in vitro functional studies, a novel serine/threonine kinase gene, unc-51-like kinase 4 (ULK4), as a
122 Biallelic inactivation of LKB1, a serine/threonine kinase, has been detected in 30% of lung adeno
128 ibrain (Mnb; also known as Dyrk1A), a serine/threonine kinase implicated in autism spectrum disorder
130 kinase kinase kinase 4 (MAP4K4) is a serine/threonine kinase implicated in the regulation of many bi
131 Protein kinase C (PKC) is a family of serine/threonine kinases implicated in a variety of physiologic
132 e c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the pathogenesis of vari
133 PKD) is a family of stress-responsive serine/threonine kinases implicated in the regulation of divers
135 point kinase 2 (CHK2) is an important serine/threonine kinase in the cellular response to DNA damage.
138 , we identified PIM1, a non-essential serine-threonine kinase, in a synthetic lethal interaction with
143 rylation-regulated kinase DYRK1A is a serine/threonine kinase involved in neuronal differentiation an
144 e-3 (GSK3) are ubiquitously expressed serine-threonine kinases involved in a plethora of functions ra
146 ously determined that a transmembrane serine/threonine kinase (IreK) and its cognate phosphatase (Ire
148 (CK1alpha), a ubiquitously expressed serine/threonine kinase, is a key negative regulator of oncogen
151 at casein kinase 1 alpha (Csnk1a1), a serine-threonine kinase, is essential for AML cell survival in
154 ber of the polo-like kinase family of serine-threonine kinases, is a master regulator of centriole du
155 PK1, a member of mammalian Ste20-like serine/threonine kinases, is lost in >95% pancreatic cancer thr
157 optosis signal-regulating kinase 1, a serine/threonine kinase, leads to improvement in inflammation a
158 kinase (called microtubule-associated serine/threonine kinase like [Mastl] in mammals) is essential f
159 revious study, we identified TRIB1, a serine-threonine kinase-like molecule, as a biomarker of chroni
164 ivity of the evolutionarily conserved serine/threonine kinase mammalian target of rapamycin (mTOR).
166 -activated protein kinase-interacting serine-threonine kinases MAP kinase-interacting kinase 1 (Mnk1/
168 show that the MAP kinase interacting serine/threonine kinase (MNK)-eukaryotic translation initiation
169 the mechanistic target of rapamycin (serine/threonine kinase; MTOR) pathway in the regulation of neu
170 ntify protein kinase C (PKC) gamma, a serine/threonine kinase mutated in the neurodegenerative diseas
173 reen, we identified a mitotic-related serine/threonine kinase, NEK6, as a mediator of androgen-indepe
174 canonical NF-kappaB signaling via the serine/threonine kinase NIK (NF-kappaB-inducing kinase) remains
177 of these binding partners include the serine/threonine kinases, p21-activated kinase 1 (PAK1), apopto
178 determined that d-flow activated the serine/threonine kinase p90RSK, which subsequently phosphorylat
184 The hypoxia-inducible, pro-oncogenic, serine-threonine kinase PIM1 (Proviral Integration site for Mol
186 We found that RhoA activated the serine-threonine kinases PKN1 and PKN2 that bind and phosphoryl
196 coupled receptor kinase 5 (GRK5) is a serine/threonine kinase previously shown to mediate polymicrobi
197 RIPK1 and RIPK3, a pair of homologous serine/threonine kinases previously implicated in the regulatio
198 horylated by the MST1 (Hippo homolog) serine-threonine kinase, previously shown to be an AR repressor
199 echanistic target of rapamycin (mTOR) serine/threonine kinase promotes myelination, but factors that
200 A bioinformatic screen identified the serine-threonine kinase protein kinase D2 (PRKD2) as a potentia
201 the expression of the Golgi-localized serine-threonine kinase protein kinase D3 (PKD3) is elevated in
202 dually suppressed RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK signaling through the intera
203 ike kinase 1 (ALK1) is an endothelial serine-threonine kinase receptor for bone morphogenetic protein
204 and both protein-tyrosine kinase and serine/threonine kinase receptor transactivation concomitantly
208 ediate signals via transactivation of serine/threonine kinase receptors, most notably the transformin
210 n synthase kinase-3 (GSK-3) family of serine/threonine kinases regulates several of these pathways, b
211 ng protein kinase (Hipk), a conserved serine-threonine kinase, regulates numerous factors during tiss
212 cell polarity protein Par-1 (MARK), a serine-threonine kinase, regulates the localization and activat
213 a B (AURKB) and Aurora C (AURKC), are serine/threonine kinases required for the control of mitosis (A
214 c approach identified PKCtheta as the serine/threonine kinase responsible for alphaPIX serine phospho
215 P-dependent protein kinase (PKA) is a serine/threonine kinase responsible for most of the effects of
216 siRNA-mediated inhibition of various serine/threonine kinases revealed ERK1/2 as a positive regulato
217 RNA virus, triggers activation of the serine-threonine kinases RIP1 and RIP3, which damages mitochond
220 e translocation and activation of the serine/threonine kinase ROCK1, a downstream target of the RhoA
221 ORC1 activation deploys the ribosomal serine/threonine kinase S6K1 and Polycomb proteins at genomic r
222 ess downregulates the activity of the serine/threonine kinase Shaggy (Sgg; also known as GSK-3).
224 d by mass spectrometry identified the serine-threonine kinase SPEG as the only novel binding partner
225 d by mass spectrometry identified the serine-threonine kinase SPEG as the only novel binding partner
227 kers, one (rs10937625) located in the serine/threonine kinase STK32B and one (rs17590046) in the tran
229 o interferes with the activity of the serine/threonine kinase StkP, the central regulator of pneumoco
231 Trans-membrane signaling involving a serine/threonine kinase (Stt7 in Chlamydomonas reinhardtii) dir
233 dentifying degrader hits based on the serine/threonine kinase TANK-binding kinase 1 (TBK1) and have g
234 enerated Taok3(-/-) mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic defects
235 that shRNA-mediated knockdown of the serine/threonine kinases TESK1 or LIMK2 promoted mesenchymal-to
238 MEKK2 (MAP/ERK kinase kinase-2) is a serine/threonine kinase that belongs to the MEKK/STE11 family o
239 istic target of rapamycin (mTOR) is a serine-threonine kinase that coordinates nutrient and growth fa
240 et of rapamycin (mTOR) is an atypical serine/threonine kinase that exerts its main cellular functions
241 et of rapamycin (mTOR) is a conserved serine/threonine kinase that forms two complexes, mTORC1 and mT
242 protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase that functions in development and tumor
243 Integrin-linked kinase (ILK) is a serine/threonine kinase that has been linked to human and exper
245 eta1 (LKB1, also known as STK11) is a serine/threonine kinase that has multiple cellular functions in
247 Escherichia coli is a eukaryote-like serine-threonine kinase that inhibits cell growth and induces p
248 eptor-interacting protein (RIP1) is a serine/threonine kinase that integrates inflammatory and necrop
249 Specifically, we show that NLK, a serine/threonine kinase that interacts with ATXN1, modulates di
251 t cyclin-dependent kinase 5 (Cdk5), a serine-threonine kinase that is highly active in postmitotic ne
252 osal and the activation of Akt/PKB, a serine/threonine kinase that is obligate for insulin-stimulated
253 osphatidylinositol 3-kinase-dependent serine/threonine kinase that is rapidly induced in response to
255 F2K), a Ca(2)(+)/calmodulin dependent serine/threonine kinase that phosphorylates eEF2 and regulates
256 1-like kinase 1 (ULK1) is a conserved serine-threonine kinase that plays a central role in the initia
257 p21-activated kinase-1 (Pak1) is a serine/threonine kinase that plays a key role in mediating anti
258 uiring enzyme 1alpha (IRE1alpha) is a serine-threonine kinase that plays crucial roles in activating
259 is a highly conserved and pleiotropic serine/threonine kinase that promotes many prosurvival and proi
260 re we identify Stk2, a staphylococcal serine/threonine kinase that provides efficient immunity agains
261 alian target of rapamycin (mTOR) is a serine/threonine kinase that regulates a diverse array of cellu
262 e A (PKA) is a ubiquitously expressed serine/threonine kinase that regulates a variety of cellular fu
263 alian target of rapamycin (mTOR) is a serine/threonine kinase that regulates processes including mRNA
264 Tumor progression locus 2 (Tpl2) is a serine-threonine kinase that regulates Th1 differentiation, sec
265 Integrin-linked kinase (ILK) is a serine-threonine kinase that transduces extracellular matrix-re
266 ed kinases (PAKs) are a family of six serine/threonine kinases that act as key effectors of RHO famil
267 OCK1 and ROCK2) are highly homologous serine/threonine kinases that act on substrates associated with
269 The p21-activated kinases (Paks) are serine/threonine kinases that are major effectors of the Rho gu
270 LegK1-4 proteins are eukaryotic-like serine/threonine kinases that are translocated by the Dot/Icm t
271 CK) is a member of a diverse group of serine/threonine kinases that feature cytoskeletal association.
273 nase catalytic subunit (DNA-PKcs) are serine-threonine kinases that orchestrate the cellular response
274 ceptor-associated kinases (IRAKs) are serine/threonine kinases that play critical roles in initiating
275 ho kinases, or ROCKs, are a family of serine-threonine kinases that serve as key downstream effectors
276 repeats, a transmembrane domain and a serine/threonine kinase, the rice (Oryza sativa) protein XA21 c
282 through binding and activation of the serine/threonine kinase type II TGF-beta receptor (TbetaRII), w
283 n of the MTOR complex 1 (RAPTOR), the serine/threonine kinase V-Akt murine thymoma viral oncogene hom
285 pe II (TbetaRII) and type I (TbetaRI) serine/threonine kinases, whereby Smad2 and Smad3 are phosphory
286 kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly active in the nervous s
287 CASK (a calcium/calmodulin-activated serine/threonine kinase), which binds to neurexins, and mutatio
288 interacts with calmodulin-associated serine/threonine kinase, which is implicated in X-linked mental
289 PAK4 is a member of the PAK family of serine/threonine kinases, which act as effectors for several sm
291 se II (CaMKII) is a calcium-regulated serine threonine kinase whose functions include regulation of s
292 protein kinase (AMPK) is a conserved serine/threonine kinase with a critical function in the regulat
293 ied MAST205 (a microtubule-associated serine/threonine kinase with a molecular mass of 205 kDa) as a
294 coupled receptor kinase 2 (GRK2) is a serine/threonine kinase with an important function in the desen
295 racting protein kinase 3 (RIPK3) is a serine/threonine kinase with essential function in necroptosis.
296 eting oncogenic mutations in the BRAF serine/threonine kinase with small molecule inhibitors can lead
297 polo-like kinases (PLK), a family of serine/threonine kinases with well-known roles in cell cycle re
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