ライフサイエンスコーパス: threonine phosphorylation

1 tein interactions are governed by serine and threonine phosphorylation.

2 n MAPK activity and a 4-fold increase in CAD threonine phosphorylation.

3 f cellular activities as effectors of serine/threonine phosphorylation.

4 ipper motif and a target sequence for serine/threonine phosphorylation.

5 ng events in B cells, focusing on serine and threonine phosphorylation.

6 and demonstrated increased levels of serine/threonine phosphorylation.

7 tory factors, as well as tyrosine and serine/threonine phosphorylation.

8 ntly activated by TNF-alpha through tyrosine/threonine phosphorylation.

9 a suggest that phytochromes signal by serine-threonine phosphorylation.

10 is accompanied by an increase in serine and threonine phosphorylation.

11 oprotein, and cAMP inhibited both serine and threonine phosphorylation.

12 profiles, perhaps transduced through serine-threonine phosphorylation.

13 that this effect may be regulated by serine/threonine phosphorylation.

14 phospholipid metabolism, and protein serine/threonine phosphorylation.

15 e pH, binds ATP noncovalently, and undergoes threonine phosphorylation.

16 PKCalpha-dependent ZO-1 and myosin 1C serine/threonine phosphorylation.

17 incident with PKCalpha-dependent ZO-1 serine/threonine phosphorylation.

18 regions (IDRs) that undergo multisite Serine/Threonine phosphorylation.

19 ion, and ERK1, JNK, and p38, which catalyzed threonine phosphorylation.

20 which can regulate ADAM17 activity by serine/threonine phosphorylation.

21 which itself is robustly activated by serine/threonine phosphorylations.

22 phosphorylated on its RTPPKSP motif and that threonine phosphorylation abolished the MAP-2c/Fyn bindi

23 initiates insulin signaling, whereas serine/threonine phosphorylation alters the ability of IRS-1 to

24 cell surface receptors via dual tyrosine and threonine phosphorylation and are thought to be involved

25 NOO(-) activates AMPK, resulting in enhanced threonine phosphorylation and consequent inhibition of F

26 volved inhibition of beta(1) integrin serine/threonine phosphorylation and decreased phosphorylation

27 rthermore, this same mutant showed increased threonine phosphorylation and decreased serine phosphory

28 antagonizes EGF signaling by increasing EGFR threonine phosphorylation and decreasing EGF-induced EGF

29 c-fos whose function is modulated by serine/threonine phosphorylation and fig is a predicted PP2C ph

30 This leads to the serine/threonine phosphorylation and redistribution of actin an

31 duced by mutations that prevented its serine-threonine phosphorylation and restored by phosphomimetic

32 equential signaling mediated by tyrosine and threonine phosphorylation and ubiquitination.

33 ck on EGFR signaling and trafficking by EGFR threonine phosphorylation, and Akt has a pivotal role in

34 a B alpha in vivo, induces multisite (serine/threonine) phosphorylation, and is required for the basa

35 nt Spc110p (Nuf1p) undergoes specific serine/threonine phosphorylation as the mitotic spindle apparat

36 ected by PTP101, an antibody that recognizes threonine phosphorylation at consensus motifs for ERK-in

37 ositol-4,5-bisphosphate (PIP2) binding and a threonine phosphorylation at position 567.

38 or p190RhoGAP is decreased due to its serine/threonine phosphorylation at this time.

39 ing; this interaction is dependent on serine/threonine phosphorylation but independent of tyrosine ph

40 Activation of BVR involved increased serine/threonine phosphorylation but not its protein or transcr

41 nthase (eNOS) is regulated in part by serine/threonine phosphorylation, but eNOS tyrosine phosphoryla

42 ed as the kinase responsible for the mitotic threonine phosphorylation by (1) immunodepletion of the

43 chondrial localization of PLS3 but abolished threonine phosphorylation by PKC-delta in vitro and AD19

44 the insulin receptor may be caused by serine/threonine phosphorylation by PKC.

45 s the capping enzymes and is a substrate for threonine phosphorylation by the Cdk9 kinase.

46 the plasma membrane through their serine and threonine phosphorylation by the phosphoinositide-depend

47 tner-switching mechanism in which serine and threonine phosphorylation controls protein interactions

48 Hyperphosphorylation (due to serine and/or threonine phosphorylation) correlates with the unrespons

49 Wild-type, but not a threonine phosphorylation-defective endoglin mutant bloc

50 r import of myopodin are regulated by serine/threonine phosphorylation-dependent binding of myopodin

51 port of myopodin are regulated by the serine/threonine phosphorylation-dependent binding of myopodin

52 d pharmacological manipulation of serine and threonine phosphorylation did not alter cGMP-dependent r

53 a argue that PKG mediates a conserved serine/threonine phosphorylation event specifically for flavivi

54 g paradigm in which the half-lives of serine/threonine phosphorylation events can be influenced by ac

55 osine kinase activation to downstream serine/threonine phosphorylation events regulating proliferatio

56 oach failed to detect significant changes in threonine phosphorylation following deoxygenation.

57 ger than 70 000 kilodaltons, and that serine/threonine phosphorylation follows tyrosine phosphorylati

58 ish tyrosine phosphorylation from serine and threonine phosphorylation for peptides containing a sing

59 cesses in eukaryotic cells, and thousands of threonine phosphorylations have been identified.

60 aqueous humor sCD44 was positive for serine-threonine phosphorylation; however, POAG sCD44 was hypop

61 ovR in vitro, these data suggest that serine/threonine phosphorylation impacts CovR-mediated regulati

62 been extensively studied, the role of serine/threonine phosphorylation in controlling these effectors

63 sent study we sought to identify the site of threonine phosphorylation in FcepsilonRIgamma and invest

64 t report of the functional outcome of serine/threonine phosphorylation in gelsolin regulation and pro

65 insulin has profound effects on IRS-1 serine/threonine phosphorylation in healthy humans.

66 eferred TGFbeta receptor kinase for endoglin threonine phosphorylation in HUVECs and indicate a role

67 To investigate the regulation of serine/threonine phosphorylation in IL-2 signaling, the roles o

68 (MS)-based analysis of HNF-4alpha serine and threonine phosphorylation in response to cytokine stimul

69 findings also suggest novel roles for serine/threonine phosphorylation in the assembly of protein-pro

70 BB3 as a result of the loss of an inhibitory threonine phosphorylation in the conserved juxtamembrane

71 duced a complex response including decreased threonine phosphorylation in the ERK1 and ERK2 activatio

72 Here, we tested the role of serine/threonine phosphorylation in the Mtb response to altered

73 although this is the first example of serine/threonine phosphorylation in the subfamily of CD33-like

74 cking all known sites of tyrosine and serine/threonine phosphorylation in their carboxyl-terminal tai

75 The late-specific threonine phosphorylation in this domain is essential fo

76 electrophoretic mobility retarded by serine/threonine phosphorylation) in M phase and the escape of

77 e-specific substitution mutations that block threonine phosphorylation increased ATF4 stability and a

78 Furthermore, serine and threonine phosphorylation increased the interaction of L

79 u hyperphosphorylation, inhibition of serine/threonine phosphorylation induced upregulation of cdk5 l

80 ified PECAM-1; 3) PKC-derived PECAM-1 serine/threonine phosphorylation inversely correlates with gamm

81 ne residue His197 and the presence of serine/threonine phosphorylation is an experimental artifact du

82 Our results provide evidence that serine/threonine phosphorylation is an important regulatory mec

83 Furthermore, TNF-alpha-induced Raf-1 threonine phosphorylation, kinase activity toward MEK1,

84 tion prevents apoptosis by increasing serine/threonine phosphorylation leading to either inactivation

85 This reduced threonine phosphorylation led to increased FGF-induced t

86 er, TGF-beta did not affect either serine or threonine phosphorylation levels of Ets1.

87 Threonine phosphorylation mapped to a single residue, th

88 or JNK3 alpha 1 activation and that a single threonine phosphorylation may be all that is needed for

89 We also provide evidence that Dab1 serine/threonine phosphorylation may be important for Dab1 tyro

90 of murine erythroleukemia cells, and serine/threonine phosphorylation may be involved in this proces

91 nthetic SSAP mRNAs encoding either serine or threonine phosphorylation mutants results in the failure

92 en together, these data indicate that serine/threonine phosphorylation negatively regulates IL-2 sign

93 The serine/threonine phosphorylation occurred subsequent to tyrosin

94 ogether, these data indicate that the serine/threonine phosphorylation of 66-kDa Shc impairs its abil

95 ovel mode of STAT activation, whereby serine-threonine phosphorylation of a cognate protein tyrosine

96 nsulin receptor substrate and Cbl, or serine/threonine phosphorylation of Akt.

97 Although serine and threonine phosphorylation of AMPA receptors has been wel

98 eral cross-linking of CD98 or ICAM-1 induces threonine phosphorylation of an approximately 160-kDa su

99 fication and functional characterization for threonine phosphorylation of an interleukin receptor.

100 man EGF receptor also resulted in the serine/threonine phosphorylation of approximately 50% of the 66

101 ng that both membrane association and serine/threonine phosphorylation of AQP5 are required for prope

102 ased by IL-1beta due to JNK-regulated serine/threonine phosphorylation of ASBT protein at both Ser-33

103 5-HT stimulated an increase in serine/threonine phosphorylation of BMPR1A, supporting the acti

104 Serine/threonine phosphorylation of Cas has previously been sho

105 acid, a PP2A inhibitor, augments the serine/threonine phosphorylation of Cas that occurs at mitosis.

106 TGFbeta treatment also caused threonine phosphorylation of Cdc2 in the TGFbeta RII-cyc

107 ion of Cdc25 appears to depend on the serine/threonine phosphorylation of Cdc25 and the presence of R

108 The functional consequence of threonine phosphorylation of CovR in GBS was evaluated u

109 ion of FeS protein in complex III, increased threonine phosphorylation of COX IV (cytochrome oxidase

110 We found DAG accumulation, increased threonine phosphorylation of EGFR, enhanced phosphorylat

111 dings negatively correlate with ERK-mediated threonine phosphorylation of EGFR, implicating it as a p

112 effect requires PRL-induced ERK activity and threonine phosphorylation of EGFR.

113 hatase 2A, suggesting that GH induced serine/threonine phosphorylation of ErbB-2.

114 ts demonstrated significantly greater serine/threonine phosphorylation of extracellular signal-regula

115 irectly correlates with increased C-terminal threonine phosphorylation of ezrin/moesin/radixin (ERM)

116 Notably, AMPK activation increased threonine phosphorylation of FAS, and this effect was bl

117 ng prevented ERK1/2 membrane recruitment and threonine phosphorylation of fibroblast receptor substra

118 embrane, thereby inhibiting ERK1/2-dependent threonine phosphorylation of FRS2alpha to promote activa

119 phorylation site and for the first time show threonine phosphorylation of human p53.

120 Serine/threonine phosphorylation of IL-2Rbeta by a staurosporin

121 IL-2 stimulation also induced serine/threonine phosphorylation of IL-2Rbeta, but not IL-2Rgam

122 hosphorylation of JAK3 and STAT5, and serine/threonine phosphorylation of IL-2Rbeta.

123 tion of IRS-1 from IM is dependent on serine/threonine phosphorylation of IM.

124 In addition, however, serine/threonine phosphorylation of important effector molecule

125 Serine/threonine phosphorylation of insulin receptor substrate

126 We found that PDGF causes serine/threonine phosphorylation of insulin receptor substrate

127 ation with okadaic acid increased the serine/threonine phosphorylation of IRS-1 and its degradation,

128 Serine/threonine phosphorylation of IRS-1 is affected by many f

129 Serine/threonine phosphorylation of IRS-1 might inhibit insulin

130 In conclusion, 1) PDGF causes serine/threonine phosphorylation of IRS-1, and PI3K, or a kinas

131 tyrosine phosphorylation followed by serine/threonine phosphorylation of multiple cytoplasmic STAT t

132 atal dopamine depletion increases the serine/threonine phosphorylation of multiple striatal proteins

133 eonine 574 to alanine dramatically decreases threonine phosphorylation of MyoGEF in transfected HeLa

134 The level of serine/threonine phosphorylation of Na(v) 1.6 and In Na(v)1.8 i

135 To resolve the controversy of whether serine/threonine phosphorylation of NDPK occurs as has been sug

136 ole for CaM kinase stimulation and resultant threonine phosphorylation of NMHC-IIA in RBL-2H3 m1 cell

137 cated that the p115HEF1 resulted from serine/threonine phosphorylation of p105HEF1.

138 t anti-HER2 antibody significantly decreases threonine phosphorylation of p27Kip1 protein at position

139 n that activation of p96h2bk requires serine/threonine phosphorylation of p96h2bk.

140 nd End3p may be regulated by Prk1p-dependent threonine phosphorylation of Pan1p within the consensus

141 hese data suggest that HGF can induce serine/threonine phosphorylation of paxillin most probably medi

142 ase kinase 3beta, as well as contributing to threonine phosphorylation of PKB.

143 tive PKC-delta, and AD198 treatment enhanced threonine phosphorylation of PLS3.

144 Threonine phosphorylation of pp31 by the virus-specific

145 g at 10 min, as well as increased serine and threonine phosphorylation of PP4.

146 activity and both agents also induce serine-threonine phosphorylation of PTP3.

147 inase (ERK) kinase/ERK signaling cassette by threonine phosphorylation of Raf-1, regulating prolifera

148 Similarly, S1P-elicited threonine phosphorylation of S1P1 Rs was suppressed by a

149 However, NGF still stimulates serine/threonine phosphorylation of SH2-Bbeta(S96A).

150 ealed that high glucose or PMA led to serine/threonine phosphorylation of similar peptides.

151 mulated feedback pathway in which the serine/threonine phosphorylation of SOS results in disassociati

152 PMA induced serine/threonine phosphorylation of Src, which was blocked by b

153 cer element, suggesting that both serine and threonine phosphorylation of SSAP are required for the a

154 at1alpha or Stat3; 3) marked serine, but not threonine phosphorylation of Stat5a and Stat5b; and 4) t

155 This results in serine/threonine phosphorylation of such important regulatory m

156 ther analyses demonstrated that tyrosine and threonine phosphorylation of the A17 membrane component

157 ) activity, which, in turn, increases serine/threonine phosphorylation of the adaptor protein, Gab-1

158 NaC regulation involving an ERK1/2-catalyzed threonine phosphorylation of the channel gamma subunit:

159 pounds that cause a 2- to 3-fold increase in threonine phosphorylation of the cotransporter which can

160 rt, we delineate a potential role for serine/threonine phosphorylation of the cytoplasmic tail of the

161 e EET effects were associated with increased threonine phosphorylation of the ENaC beta and gamma sub

162 to stimulate calcium mobilization and serine/threonine phosphorylation of the Erk1/2 mitogen-activate

163 lvement of protein kinase C (PKC) and serine/threonine phosphorylation of the insulin receptor in ins

164 Threonine phosphorylation of the MMAC1/ PTEN-PDZBD pepti

165 Serine/threonine phosphorylation of the nonstructural protein 5

166 revious data suggest that IR-mediated serine/threonine phosphorylation of the Ras guanine nucleotide

167 endent reporter gene, suggesting that serine/threonine phosphorylation of the transactivation domain

168 Here, we have studied the role of serine/threonine phosphorylation of TJ proteins in 15(S)-HETE-i

169 ine phosphorylation of ZO-2, also stimulates threonine phosphorylation of ZO-1 in the mediation of en

170 lly regulated SSAP activation is promoted by threonine phosphorylation on its transactivation domain,

171 r stimulated through a previously identified threonine phosphorylation pathway (TPP) share the proper

172 o B-cell-receptor signaling, critical serine/threonine phosphorylation pathways and apoptosis.

173 ed Cdc42 with SPRK alters the in vivo serine/threonine phosphorylation pattern of SPRK suggesting tha

174 significantly modified both the serine- and threonine-phosphorylation profile of proteasomes; multip

175 An understanding of how threonine phosphorylation regulates biological function

176 caALK1-mediated threonine phosphorylation required prior serine phosphor

177 Prevention of FRS2alpha threonine phosphorylation results in constitutive tyrosi

178 Finally, overexpression of the C-terminal threonine phosphorylation site mutant of ezrin has a dom

179 SP repeat domain (residues 502-823); and one threonine phosphorylation site observed in a KVPTPEK mot

180 idue, acts as a major determinant for serine-threonine phosphorylation site specificity.

181 The minor threonine phosphorylation site was demonstrated by two-d

182 tand how PRMT5 is regulated, we identified a threonine phosphorylation site within a C-terminal tail

183 P-CIP1 contains multiple consensus serine/threonine phosphorylation sites and a region predicted t

184 domain followed by multiple potential serine/threonine phosphorylation sites and a serine-rich C term

185 ting in identification of 101 tyrosine and 3 threonine phosphorylation sites and quantification of 87

186 Loss of serine or threonine phosphorylation sites from exon 3 of beta-cate

187 and putative regulatory roles for serine and threonine phosphorylation sites have yet to be fully cha

188 study in CHINA: Point mutations of serine or threonine phosphorylation sites in exon 3 of beta-cateni

189 be blocked by mutating three putative serine/threonine phosphorylation sites in hbeta4 (Thr-11/Ser-17

190 ion and relative quantification of 12 serine/threonine phosphorylation sites in HNF-4alpha.

191 Replacement of five serine or threonine phosphorylation sites in ORF63 with alanines r

192 ethod for the characterization of serine and threonine phosphorylation sites in proteins has been dev

193 , site-directed mutagenesis of the consensus threonine phosphorylation sites in the C-terminal domain

194 The serine/threonine phosphorylation sites in the linker region are

195 Twenty-two serine/threonine phosphorylation sites were identified; 15 were

196 nses from rhodopsin lacking native serine or threonine phosphorylation sites.

197 n actin binding protein with multiple serine/threonine phosphorylation sites.

198 invasive cancer, involved loss of serine or threonine phosphorylation sites.

199 -terminal tail containing clusters of serine/threonine phosphorylation sites.

200 C-terminal domain of pp31 failed to prevent threonine phosphorylation, suggesting that the virus-spe

201 potentially greater structural importance of threonine phosphorylation than serine phosphorylation du

202 first time IL13 induce Stat6 serine but not threonine phosphorylation that closely paralleled early

203 For ErbB-2, GH induces serine/threonine phosphorylation that dampens basal and EGF-ind

204 wild-type population, the additional serine/threonine phosphorylation that gives rise to the 120-kD

205 thus identified intrinsic pathways of serine-threonine phosphorylation that target chromatin regulato

206 e drugs is to activate, by a double tyrosine/threonine phosphorylation, the extracellular signal-regu

207 to the activation pathway mediated by serine/threonine phosphorylation, tyrosine phosphorylation of I

208 the case of p27, correspond to tyrosine and threonine phosphorylation, ubiquitination, and, ultimate

209 We found that EGF induces ERM c-terminal threonine phosphorylation via activation of the SK/S1P p

210 No serine/threonine phosphorylation was identified in NDPK2 or imp

211 In contrast, serine and threonine phosphorylation was necessary for the interact

212 The Ras-dependent increase in threonine phosphorylation was not observed in Ets2 prote

213 Heterogeneity in serine and threonine phosphorylation was observed at three sites or

214 ytes (CasL), and Chat-H-mediated CasL serine-threonine phosphorylation were required for T cell migra

215 n blocked OxPAPC-mediated S1P(1) activation (threonine phosphorylation), whereas silencing S1P(1) rec

216 hese CCCs are oppositely regulated by serine-threonine phosphorylation, which activates NKCC1 but inh

217 requires PKC-alpha translocation and serine/threonine phosphorylation, which eventually triggers EGF

218 nonalcoholic steatosis VDAC exhibits reduced threonine phosphorylation, which increases the influx of

219 tion is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be perfo

220 ve regulator of IRS-1, increasing its serine/threonine phosphorylation, which triggers degradation.

221 osphorylation of threonine, and 4) increased threonine phosphorylation with an increase in activation

222 reduces the p38 MAPK-related inhibitory KSRP threonine phosphorylation, without blocking p38 MAPK act