ライフサイエンスコーパス: threonyl

1 5)L-Lys-D-Ala-Gly4] linked to its C-terminal threonyl.

2 rate 4-fold higher than that for the cognate threonyl adenylate (Thr-AMP) while releasing 20% of Ser-

3 al tRNA2(Thr) and non-hydrolyzable analog of threonyl adenylate.

4 ld faster by the ThrRS catalytic domain than threonyl-adenylate.

5 or editing found in bacterial and eukaryotic threonyl- and all alanyl-tRNA synthetases is missing fro

6 required for a universal tRNA modification, threonyl carbamoyl adenosine (t6A), found in all tRNAs t

7 The difluoromethyl-allo-threonyl hydroxamate-based compound LPC-058 is a potent

8 potent LpxC inhibitors contain an essential threonyl-hydroxamate headgroup for high-affinity interac

9 s containing an additional aryl group in the threonyl-hydroxamate moiety, which expands the inhibitor

10 reover, we show that the enzyme will convert threonyl peptides to the corresponding ketone product, a

11 corresponding ketone product, and also allo-threonyl peptides, but with a significantly reduced effi

12 Protein seryl/threonyl phosphatase inhibitors such as calyculin A bloc

13 er RNA synthetases, such as histidyl (Jo-1), threonyl (PL-7), alanyl (PL-12), glycyl (EJ), and isoleu

14 of phospho-tyrosyl (pTyr) and phospho-seryl/threonyl (pSer/pThr) residues in specific proteins.

15 domain showed that the identified seryl and threonyl residues are necessary for the Rlm1 transcripti

16 and a long region that is rich in seryl and threonyl residues.

17 threonyl-tRNA 670-fold more efficiently than threonyl-RNA, and assign a role to FthC in fluorothreoni

18 When L-threonyl-S-pantetheine or L-threonyl-S-(N-acetyl)cysteamine was used as a small-mole

19 When L-threonyl-S-pantetheine or L-threonyl-S-(N-acetyl)cysteam

20 ored by providing CyCyA with the substrate L-threonyl-S-peptidyl carrier protein (PCP)-C2, suggesting

21 s a small-molecule thioester analogue of the threonyl-S-VibF acyl enzyme intermediate, the Cy domain(

22 lization validates a two-stage mechanism for threonyl, seryl, and cysteinyl heterocyclization domains

23 ms2t6A containing tRNA ASL indicate that the threonyl side chain adopts a conformation similar to tha

24 oninol and the adenylate analogue 5'-O-[N-(L-threonyl)sulfamoyl]adenosine (Thr-AMS), exhibited linear

25 ococcus aureus by sortase A, which links the threonyl (T) of its C-terminal LPXTG motif to peptidogly

26 odeling reveal similarity between MRP-L5 and threonyl-t-RNA synthetases, and a likely RNA binding sit

27 s) of a CyCyA fragment of VibF generated DHB-threonyl-thioester products of the condensation step but

28 e Rosetta was used to design a pocket within threonyl-transfer RNA synthetase from the thermophile Py

29 allotype was protective in adults with anti-threonyl-transfer RNA synthetase or anti-U RNP autoantib

30 er of C to U edited tRNAs to include all the threonyl tRNA isoacceptors.

31 that Saccharomyces cerevisiae mitochondrial threonyl-tRNA synthetase (MST1) could attach threonine t

32 Here, we show that yeast mitochondrial threonyl-tRNA synthetase (MST1), which lacks an editing

33 Threonyl-tRNA synthetase (TARS) is an autoantigen in the

34 These include angiogenesis, and human threonyl-tRNA synthetase (TARS) represents a potent pro-

35 A series of potent and bacteria-selective threonyl-tRNA synthetase (ThrRS) inhibitors have been id

36 Threonyl-tRNA synthetase (ThrRS) misactivates serine and

37 Threonyl-tRNA synthetase (ThrRS) must discriminate among

38 Threonyl-tRNA synthetase (ThrRS) participates in protein

39 pathways to the fidelity of Escherichia coli threonyl-tRNA synthetase (ThrRS) were investigated by ra

40 ears weakly related to an appended domain of threonyl-tRNA synthetase (ThrRS), but is unrelated to th

41 Borrelidin, a natural inhibitor of threonyl-tRNA synthetase (ThrRS), stands out for its pot

42 , the enzyme closely resembles the bacterial threonyl-tRNA synthetase (ThrRS).

43 e investigated the class II Escherichia coli threonyl-tRNA synthetase (ThrRS).

44 a known inhibitor of bacterial and eukaryal threonyl-tRNA synthetase (ThrRS).

45 tivities through the selective inhibition of threonyl-tRNA synthetase (ThrRS).

46 tase editing mechanism is also applicable to threonyl-tRNA synthetase and provides a paradigm for syn

47 anyl-, asparaginyl-, glycyl-, isoleucyl-, or threonyl-tRNA synthetase occur in approximately 25% of p

48 00 contains a mutation in THS1 (encoding the threonyl-tRNA synthetase).

49 A-binding proteins, ribosomal protein S4 and threonyl-tRNA synthetase, reveals a novel RNA-binding mo

50 nserved residue betaHis-265, as proposed for threonyl-tRNA synthetase, was excluded because replaceme

51 specificity of some synthetic inhibitors of threonyl-tRNA synthetase.

52 idelity by impairing the editing activity of threonyl-tRNA synthetase.

53 e similarity to the N-terminal end of the Ec threonyl-tRNA synthetase.

54 ryotic organism that expresses two different threonyl-tRNA synthetases, responsible for Thr-tRNA(Thr)