ライフサイエンスコーパス: through

1 or 4 consecutive days on days 1 through 4, 8 through 11, 15 through 18, and 22 through 25 of a 28-day

2 sured at baseline and then weekly at weeks 8 through 12.

3 ontinuously enrolled within a month of birth through 15 months who received at least 3 doses of dipht

4 e days on days 1 through 4, 8 through 11, 15 through 18, and 22 through 25 of a 28-day cycle, for 12

5 R imaging for screening or staging from 2010 through 2014 were included.

6 nd retrospective studies published from 2000 through 2015.

7 rough 4, 8 through 11, 15 through 18, and 22 through 25 of a 28-day cycle, for 12 weeks.

8 nce per day for 4 consecutive days on days 1 through 4, 8 through 11, 15 through 18, and 22 through 2

9 Clinical outcomes and health care use through 6 months were obtained from medical records and

10 of the RyRs by cytosolic and luminal Ca(2+) through a 'fire-diffuse-uptake-fire' (or FDUF) mechanism

11 nds the HCN cyclic nucleotide-binding domain through a 37-residue domain and the HCN C terminus throu

12 mobilized on screen printed electrodes (SPE) through a blend formation with poly(ethylene glycol) met

13 bulk of the protein-coding sequence evolved through a CAG repeat expansion.

14 signaling activated Pin1 isomerase activity through a cascade that was sensitive to ERK inhibitors a

15 and demonstrate the utility of the approach through a case study.

16 TK-11) which exerted its inhibitory efficacy through a covalent bond with BTK Cys481.

17 All functions of FlyPi can be controlled through a custom-written graphical user interface.

18 with and without a history of periodontitis through a deep-sequencing approach.

19 Propagation of coherent light through a disordered network is accompanied by randomiza

20 in cells expressing HPV E6 and E7 hinders HR through a distinct mechanism.

21 We also collected qualitative data through a focus group consultation and 19 key informant

22 didate loci for fiber-quality-related traits through a genome-wide association study.

23 videos of natural scenes, viewed immersively through a head-mounted display (panoramic VR).

24 nt merozoites to initiate sexual development through a hitherto unknown mechanism.

25 Next, the current that passed through a human subject during the attack was measured.

26 infer the economic well-being of individuals through a measure of their location and influence in the

27 ow that PTEN controls multicellular assembly through a membrane-associated regulatory protein complex

28 produce H2 catalytically via EECC mechanism through a Ni-centered hydride intermediate like the enzy

29 directly regulates vascular barrier function through a non-canonical, transcription-independent signa

30 ctin through its N terminus and microtubules through a novel dynein interacting site near its C termi

31 ctivate P2Y6 receptors to suppress GC growth through a novel SOCE/Ca(2+)/beta-catenin-mediated anti-p

32 with asymmetric wettability are synthesized through a one-step compartmentalized growth of a mesopor

33 ral growth regulator that senses amino acids through a pathway that converges on the Rag GTPases, an

34 s and subsequently escape the early endosome through a pH-triggered disassembly mechanism.

35 er ultrasound, which can permeabilize tissue through a phenomenon known as transient cavitation, can

36 allow both efficient photocurrent generation through a photovoltaic response and electroluminescence

37 Through a rational design approach we discovered a highl

38 We illustrate the use of this framework through a series of diverse ecological examples.

39 ent aspects of cell behavior are coordinated through a single receptor is not known.

40 that WHAMM interacts with alphabeta-tubulin through a small peptide motif within its MT-binding doma

41 iovascular complications may be accomplished through a sound understanding of the hemodynamic and phy

42 trafficking in neuronal dendrites and spines through a specialized GA-independent trafficking network

43 of micronuclei by targeting cellular ligases through a sT domain that also inhibits MCV large T oncop

44 ilization of biotinylated capture antibodies through a streptavidin bridge.

45 nergistically enhanced migration persistence through a synergistic induction of NF-kappaB-dependent M

46 Through a systematic and cost-effective PET discovery pr

47 ns induce a strong innate antiviral response through activating the ER stress pathway during viral in

48 Here, through adaptive evolutionary analyses of phototransduct

49 Dose reduction through adsorption to aluminium hydroxide (Al) is a prom

50 echanism for the effects of sildenafil that, through adverse effects on mitochondrial function and en

51 Mechanistically, this occurs through alteration of endothelial cell metabolism.

52 both nuclear and cytoplasmic Esrp1 isoforms through alternative splicing is phylogenetically conserv

53 ing in some contexts and that this may occur through an attention-based mechanism.

54 their passive targeting to cancerous tissues through an enhanced permeability and retention effect.

55 for polycistronic expression via translation through an internal ribosome entry site (IRES).

56 ly defined domains of target gene expression through an intrinsic and direct threshold-based readout

57 nificantly reduced invasion of Colo320 cells through an LEC monolayer.

58 Through an RNAi screen in the developing Drosophila eye,

59 octane in a highly diastereoselective manner through an unexpected intramolecular nucleophilic attack

60 anions to the pi-electron-deficient ClBDPPV through anion-pi electronic interactions is strongly cor

61 lysis used all data received at NRG Oncology through April 12, 2015.

62 fecal toxin result, from Oxford (April 2012 through April 2013) and Leeds (July 2012 through April 2

63 012 through April 2013) and Leeds (July 2012 through April 2013) microbiology laboratories underwent

64 male), enrolled in Germany from August 2013 through April 2014 and followed until July 2016.

65 ical findings, but this proportion increased through ASCUS, low-grade squamous intraepithelial lesion

66 -lapse movies of complex neural arborization through automated image registration.

67 N down-regulation may promote beta-oxidation through beta-catenin, whereas hypertrophy was dependent

68 XIII was found to affect synaptic integrity through binding the ColQ tail of acetylcholine esterase.

69 energy balance underlies obesity and occurs through both hypertrophy of existing cells and increased

70 retations: instead of a quantum wave passing through both slits, we have a localized particle with no

71 e have recently shown that IRF4 is activated through c-Src-mediated tyrosine phosphorylation in virus

72 ron production for primary antiviral defense through cascades controlled by protein ubiquitination an

73 oblem of how epigenetic states are inherited through cell division, with intriguing mechanistic links

74 er, which blocked their tumorigenic capacity through cellular senescence and apoptosis.

75 I, homologous chromosome pairing is promoted through chromosome movement mediated by nuclear envelope

76 functional monomer bound the sugar templates through cis-1,2-diol, cis-3,4-diol, and trans-4,6-diol.

77 dicals, which have been impossible to access through classical synthetic methods.

78 nserved functional modules can be identified through comparative analysis of biological networks.

79 Here we test the homology of these organs through comparisons with the architecture of rhizophore

80 st, we identified the optimal NP formulation through comprehensive analyses of release profiles and c

81 lowed by a 7 day depuration phase under flow-through conditions.

82 eviewed data from published trials performed through cooperative groups, consortia, and single instit

83 ndation, complex architectures were achieved through copolymerizations of selected diluents with a po

84 p received well-defined messages about water through counseling and daily text messages, a water bott

85 Circadian control occurs through cryptochromes (CRYs)-transcriptional repressors

86 Through curation of the scientific literature and by col

87 ect site because of increased hydraulic drag through damage site during filtration.

88 Through data integration and quality control, we provide

89 daily) was started on day -10 and continued through day +100 post-HCT.

90 lthcare System in Utah from January 1, 2001, through December 31, 2010, was performed.

91 njury of CNS nerve tracts remodels circuitry through dendritic spine loss and hyper-excitability, thu

92 Through dense phylogenomic sampling, we show the propens

93 thesis of large libraries of desired mutants through design and efficient organization of primers.

94 A two-step mechanism was elucidated through detailed kinetic analyses and suggests an enzyme

95 aviors, which are automatic, but do not fade through development.

96 e possibility to program adipose development through dietary fatty acids before birth.

97 ty of such CECs may be effectively preserved through direct conjugation, a previously overlooked risk

98 owever, simultaneous M-cell spikes generated through direct current injection were not sufficient to

99 gions of mRNA, and destabilizes target mRNAs through direct recruitment of the CCR4-NOT deadenylase c

100 our understanding of cellular heterogeneity through discovering novel quality attributes, optimizing

101 nted capability to harness reactive radicals through discrete, single-electron transfer (SET) events.

102 he balance between excitation and inhibition through distinct mechanisms.

103 osing, the use of customized dosing regimens through either evidence-based dosing nomograms or prefer

104 mediators such as H2; (ii) physical contact through electron-transfer proteins; or (iii) mediator-ge

105 s could promote oligomerization of kalata B1 through electrostatic intermolecular contacts via their

106 it is a relatively easy property to develop through evolution.

107 However, genomic islands can also arise through evolutionary processes unrelated to speciation,

108 bation rate in patients continuing treatment through extension week 96 (0.65, 0.56 to 0.75) remained

109 filtrate non-lymphoid tissue sites, maneuver through extracellular matrix and form lasting inflammato

110 Here we establish, through fine mapping, genome sequencing, genetic complem

111 Antibody-resistant strains arising through further gene deletion could compromise such a st

112 ptomatic HCHWA-D mutation carriers diagnosed through genetic testing and recruited through the HCHWA-

113 port an apple genome variation map generated through genome sequencing of 117 diverse accessions.

114 Through genome-scale integrated analysis of the HIF-alph

115 uccessfully supported high-need participants through HCV care and treatment, and SVR rates demonstrat

116 illin, by modulating microtubule acetylation through HDAC6 regulation, was shown to control centrosom

117 mpetent to support Hsp90-dependent signaling through heterologously expressed glucocorticoid receptor

118 s trio of temperature, oxygen and pH changes through heterotrophic plasticity.

119 people living with HIV who accessed services through HIV/AIDS sentinel hospital-based and ART service

120 Robustness of function through homeostasis may be ensured in any system through

121 ed Treg cells suppress syngeneic human ILC2s through ICOSL to control airway inflammation in a humani

122 to activate STAT3 signalling in hepatocytes through IL-6 produced in the liver microenvironment.

123 Importantly, through in vitro binding and activity assays, we showed

124 Data sharing can be facilitated through incentivizing collaboration, sharing statistical

125 Breeding high-yielding rice cultivars through increasing biomass is a key strategy to meet ris

126 tanding mechanisms of adverse health effects through inhalation exposure is critical to mitigating it

127 as a critical antagonist of CRC progression through inhibiting TAZ and YAP, effectors of WNT signali

128 tently suppress autoimmune responses in vivo through inhibition of the autophagic machinery in DCs in

129 l reactive iron is directly associated to OC through inner-sphere complexation in coastal sediments,

130 The reaction proceeds through inter- and intramolecular C-C and C-N bond forma

131 rved Rho-GTPase Cdc42p promotes yeast fusion through interaction with Fus2p, a pheromone-induced amph

132 tension is amplified and transported upward through interactions between ions and neutrals or ambipo

133 that regulate alternative splicing decisions through interactions with the splicing machinery.

134 t which spending appreciates in value (e.g., through interest, learning, or capacity building).

135 CI is directed to PDs through its interaction with P3N-PIPO.

136 the LPS receptor Toll-like receptor 4 (TLR4) through its N terminal and modulates STAT3 and TBK1 sign

137 Nesprin-2G engaged actin through its N terminus and microtubules through a novel

138 ly flexible molecules was determined largely through J-based configurational analysis, but has been f

139 From November 1994 through January 2002, we randomly assigned 731 men with

140 uction of beta-cell autoantigens via the gut through Lactococcus lactis (L. lactis) has been demonstr

141 on response to hyperglycemia in T1D patients through larger increases in RE, PGLO, and interleukin-18

142 2, -0.02) than the indirect effects mediated through later poverty at age 7-14 years (beta = -0.01, 9

143 f the unique regulation that can be accessed through light.

144 After screening through Lipinski's rule of five filter for oral bioavail

145 Many bacteria swim through liquids or crawl on surfaces by rotating long ap

146 leaf traits on soil nitrogen mineralization through litter quality.

147 ites, opening a window into fiber technology through low-energy manufacturing.

148 We then compared trajectories through maps both with and without high-order epistasis.

149 erwent surgical resection from November 2013 through May 2017, along with tumor-free liver tissues (c

150 se remains a challenge, as seizures manifest through mechanisms and features that span spatial and te

151 ugh homeostasis may be ensured in any system through mechanisms similar to those that we describe her

152 ption leads to myocardial lipid accumulation through mechanisms that are incompletely resolved.

153 We found that Ca(2+) entry through mechanosensitive TRPV4 channels during bladder f

154 ortium (PGC)-Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group.

155 Here, we demonstrate through metabolomic and transcriptomic profiling marked

156 electrode (Ni@f-MWCNT/GCE) were synthesized through microwave assisted method and examined for non-e

157 structural dynamics of Aqy1 during freezing through molecular dynamics simulations.

158 ful to monitor the Warburg effect in cancer, through MR detection of increased HP [1-(13)C]pyruvate-t

159 UTX regulates the development of iNKT cells through multiple epigenetic mechanisms.

160 We postulate that resistance to T-DM1 occurs through multiple mechanisms, one of which is impaired ly

161 icles, from the chemical synthesis of AMPDs, through nanoparticle preparative strategies, to the most

162 nging to access small luminal organs or pass through narrow luminal sections without potentially caus

163 The reaction proceeds through nucleation and growth of the new phase in corner

164 CBT materials and limited telephone support) through "OCFighter" or guided self-help (written CBT mat

165 ell proliferation of esophageal cancer cells through Orai1-mediated intracellular Ca(2+) oscillations

166 is described which are conjugatively linked through p-ter-phenyl (PPP), ter-thiophene (TTT) and alte

167 Linearity is evaluated through parameter estimation, concordance analysis and r

168 inase (LIMK), which regulates actin activity through phosphorylation of cofilin, an actin-depolymeriz

169 cute and chronic phases of infection in mice through physiologic functions apart from fatty acid meta

170 lity to impact plant-pollinator interactions through pollinator responses to differences in floral at

171 influenza A(H5N1) virus infection, detected through population-based active surveillance for influen

172 An understanding of fluid transport through porous materials is critical for the development

173 r, whether this attenuation is mediated only through PR-ER interaction remains unknown.

174 n after the discontinuation of reinforcement through prediction errors.

175 own to be ineffective in transducing signals through primate signal regulatory protein alpha.

176 Through principal component analysis, precursor and succ

177 that TEX19.1 likely acts, at least in part, through promoting the activity of the E3 ubiquitin ligas

178 uish genes whose association with disease is through promotion versus protection, thereby linking sta

179 ocation of an intracellular fragment of ODZ1 through proteolytic cleavage by signal peptide peptidase

180 Through quantitative mass spectrometry, we find that the

181 derm thinning by inducing tissue contraction through radial deep cell intercalations.

182 The indifference of HSC to nutrient sensing through RagA contributes to their molecular resilience t

183 d availability controls lysosome positioning through Ragulator-dependent, but mTORC1-independent, mod

184 of dissolved CO2 near the electrode surface through rapid equilibrium between bicarbonate and dissol

185 We show EVEs are acquired through recombination with specific classes of long term

186 prin-1alpha/Nesprin-1 in nuclear positioning through recruitment of Akap450-mediated MT nucleation ac

187 at provokes structural remodeling of the RMS through recruitment of MMP-2 by a previously unrecognize

188 on of phagosomes containing apoptotic cells, through recruitment of the Rab GTPase UNC108.

189 cancer cell invasion and anoikis resistance through redox homeostasis.

190 exhaust prey by causing involuntary fatigue through remote activation of prey muscles [4].

191 , regulate fluid homeostasis and arterial BP through renal actions involving increased GFR and vascul

192 AgNPs were not readily taken up into or through respiratory epithelium, with very low silver lev

193 tophagy by promoting autophagosome formation through reversible modification of ATG8.

194 adaptation and tissue response were assessed through RNA sequencing.

195 Through RNA-Seq analyses, we identified 137 genes that a

196 Two SAV1-MST2 heterodimers further dimerize through SAV1 WW domains to form a heterotetramer, in whi

197 , SiO2 and FeOx) used in paints and coatings through seven product applications, including constructi

198 energy profiles of explicit proton transport through several important D-channel mutants.

199 inducing angiogenesis and lymphangiogenesis through signaling via VEGF receptor (VEGFR)-2 and VEGFR-

200 rgy excited state, we observe its population through significant solvatochromic shifts in emission wa

201 ocyanins, the stability of blackberry purees through simulated in vitro digestion was also studied.

202 Through simulation we demonstrate that the gene tree pro

203 propose a model in which kinetochores mature through Ska complex recruitment and that this is require

204 Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including acti

205 T1 depletion abrogates KIT signaling cascade through Sp1/miR-29b network.

206 injections into various arms of the circuit through specific DA subpopulations to assess: (1) whethe

207 s which form DNA-RNA heteroduplex structures through specific hybridization with target DNA.

208 features, which have been partially revealed through spectroscopic, kinetic, and dynamic investigatio

209 ed using three classes of cyclic game models through stability analysis, Monte Carlo simulations and

210 ESAT-6 stimulates macrophage IL-6 production through STAT3 activation.

211 As shown through stopped-flow kinetic experiments, electron trans

212 y for conduction cardiovascular intervention through strengthening healthcare systems, priority setti

213 Many of the differences persist through subculture.

214 l order at the subnanometer scale, confirmed through synchrotron-based diffraction and aberration cor

215 lex associated with Wnt-responsive enhancers through T cell factors (TCF) and kept silent by Groucho/

216 the amplitude and frequency of Ca(2+) influx through T-type and L-type Ca(2+) channels.

217 s a form of gene drive to spread those genes through target populations.

218 that IL-37 induces pro-angiogenic responses through TGF-beta, which may act as the bridging molecule

219 Here we address this challenge through the analysis and modelling of human brain voltag

220 ity of these small hydrogels is demonstrated through the analysis of sub regions of a rat cerebellum

221 space as a sustained drug-eluting reservoir through the application of nanoparticle-based drug deliv

222 ntiretroviral drugs with optimal penetration through the blood-brain barrier should be considered eve

223 ically suppressed, while the overall current through the cell, correlating with the water splitting p

224 ement of voltage sensor movement and current through the channel pore.

225 th wearable monitors or estimated indirectly through the combination of time-activity and meteorologi

226 strength of this coupling can be manipulated through the configuration of the plasmonic molecules.

227 reversible modification of cellular proteins through the conjugation of small ubiquitin-related modif

228 antiviral properties of primary trophoblasts through the constitutive release of type III IFNs (IFNla

229 he outer blood-retina barrier is established through the coordinated terminal maturation of the retin

230 ng up to six ODNs were successfully prepared through the coupling of arylenethynylene macrocycles wit

231 retes cytotoxic bile acids into the duodenum through the cystic duct and common bile duct system.

232 d for analysis of real samples was evaluated through the determination of DNZ in soil, river water an

233 es of CJ-16,264 was designed and synthesized through the developed synthetic technologies and tested

234 l for the movement of misfolded polypeptides through the endoplasmic reticulum membrane.

235 e [3]rotaxane host recognises dicarboxylates through the formation of 1:1 stoichiometric sandwich com

236 nt episodic event that damages plant tissues through the formation of ice crystals at or below freezi

237 by intestinal distension as the meal passes through the gastrointestinal tract.

238 turned off by fixing the rate of fluid flow through the granular packing.

239 gnosed through genetic testing and recruited through the HCHWA-D patient association (Katwijk, Nether

240 We demonstrate that Si(OH)4 cycling through the Holocene alternates between being primarily

241 IFNgamma signals through the IFNgamma receptor, a protein complex that me

242 s and indicated that the SIR was facilitated through the induction of the NFkappaB pathway.

243 The inhibitory effect of F4 was not mediated through the inhibition of MAPKs and NF-kappaB activation

244 rophages, regulating innate immune responses through the initiation of a type I IFN-dependent DDR.

245 We report our findings through the ionization yields and the ratio (trans/cis)

246 demonstrated that 51 traits could be linked through the linkage disequilibrium of 115 associated loc

247 g that Treg detection of the presence of WNV through the MAVS signaling pathway is not required for g

248 ic reticulum proteins are retro-translocated through the membrane into the cytosol, where they are po

249 es linearly with temperature and then passes through the minimum that marks the 3D-2D crossover in th

250 s novel observation was further investigated through the multiple structural analyses including HPLC,

251 ex and to indirectly destabilize the complex through the N-terminal linker.

252 treme form of eye dominance, in which vision through the nondominant eye is degraded.

253 ualization system that facilitate navigation through the pathway hierarchy and enable efficient reuse

254 , blocking events of single-channel currents through the pore formed by recombinant ATOM40 were detec

255 eticulum and the Golgi apparatus, presumably through the recycling endosomes.

256 lopment and peripheral Treg cell homeostasis through the regulation of BIC/microRNA 155 (miR-155) and

257 genous DNA damage, and may control cell fate through the regulation of CHK1.

258 .25 mug), or placebo (2 puffs), administered through the Respimat device as add-on to background ther

259 n with CRIMP compression and multiple passes through the serpentine path provides the basis for a hig

260 t resulted in a decrease in the overall flux through the shikimate pathway, and a redirection of carb

261 llipodia, spreading, and fusion of myoblasts through the signaling function of the cytoplasmic domain

262 ce toward a building is limited by diffusion through the soil gas.

263 etups are limited by an averaged measurement through the solid and liquid parts.

264 water inputs because of increased water loss through the stomata.

265 Ks and NF-kappaB activation but was mediated through the suppression of c-Fos/AP-1 activity at transc

266 the in situ growth of electroactive polymers through the surface-initiated electrochemically mediated

267 h a 37-residue domain and the HCN C terminus through the TPR domains.

268 We show that signalling through the TrpA1 thermo-sensor is required for PMW, and

269 henotypic characteristics on medical imaging through the use of automated algorithms.

270 vidence-based dosing nomograms or preferably through the use of dosing software supplemented by thera

271 Through the use of optical sectioning structured illumin

272 teria sense and respond to their environment through the use of two-component regulatory systems.

273 veying perceptual content could be projected through the uterine wall and perceived by the fetus, dep

274 at the spatial acceleration of the blood jet through the valve is most significant (accounting for 99

275 t cohorts, from a single U.S. health system, through their hospitalization.

276 that display important physiological effects through their posttranscriptional regulation of messenge

277 sting T-cells, SAMHD1 blocks HIV-1 infection through this dNTP triphosphohydrolase activity by reduci

278 oxidation and reduction process are examined through time- and temperature-dependent transport measur

279 Effector T cell migration through tissues can enable control of infection or media

280 urified PF triggered activation of NF-kappaB through TLR2, as determined using a variety of TLR-trans

281 osteoblast proliferation and differentiation through transcriptional enhancer associate domain (TEAD)

282 cancer cell death both in vitro and in vivo through tumor-specific (1) O2 generation and subsequent

283 We revealed that Skp2 regulates CRPC through Twist-mediated oncogenic functions including epi

284 alpha (ERalpha) regulates gene transcription through two activation functions (ERalpha-AF1 and ERalph

285 tension was shown to be spatially regulated through two myosin-signaling pathways, myosin light chai

286 ecognizes U/AU-rich elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and p

287 Targeted protein degradation through ubiquitination is an important step in the regul

288 35 hijacks TRIM6 to promote EBOV replication through ubiquitination.

289 These particles are then stabilized through ultraviolet irradiation of a photo-crosslinkable

290 photocatalytic mechanisms were also explored through use of scavenger reagents.

291 hannels were also activated by Ca(2+) influx through voltage-gated Ca(2+) channels and synaptically a

292 common serious adverse events that occurred through week 24 were anaemia (10 [5%]), cardiac failure

293 haviour of single-crystal La2-xSrxCuO4 films through which an electrical current is being passed.

294 These results implicate biological pathways through which clozapine may act to cause this serious ad

295 lectively, these results identify mechanisms through which FGF signaling regulates inner cell mass li

296 diet and uncover a PDL1-dependent mechanism through which MZB cells use their innate immune properti

297 lts define the molecular and neural pathways through which parallel biogenic amine signaling tunes be

298 epression and offer insights into mechanisms through which RCL1 may be relevant for depression.

299 on protein to facilitate structural studies, through which we present a high-resolution cryo-electron

300 ates, and that information capacity measured through whole brain models is a theory-driven measure of